Daria Mochly-Rosen

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Common ALDH2 genetic variants predict development of hypertension in the SAPPHIRe prospective cohort: gene-environmental interaction with alcohol consumption
    Yi Cheng Chang
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    BMC Cardiovasc Disord 12:58. 2012
  2. pmc Protein kinase C, an elusive therapeutic target?
    Daria Mochly-Rosen
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California 94305 5174, USA
    Nat Rev Drug Discov 11:937-57. 2012
  3. ncbi request reprint Suppression of graft coronary artery disease by a brief treatment with a selective epsilonPKC activator and a deltaPKC inhibitor in murine cardiac allografts
    Masashi Tanaka
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Falk Cardiovascular Research Center, Stanford, CA 94305 5407, USA
    Circulation 110:II194-9. 2004
  4. pmc Mitochondrial import of PKCepsilon is mediated by HSP90: a role in cardioprotection from ischaemia and reperfusion injury
    Grant R Budas
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305 5174, USA
    Cardiovasc Res 88:83-92. 2010
  5. ncbi request reprint Protein kinase Cdelta activation induces apoptosis in response to cardiac ischemia and reperfusion damage: a mechanism involving BAD and the mitochondria
    Christopher L Murriel
    Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305 5174, USA
    J Biol Chem 279:47985-91. 2004
  6. pmc Pharmacological inhibition of βIIPKC is cardioprotective in late-stage hypertrophy
    Julio C B Ferreira
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305 5174, USA
    J Mol Cell Cardiol 51:980-7. 2011
  7. ncbi request reprint Inhibition of heart transplant injury and graft coronary artery disease after prolonged organ ischemia by selective protein kinase C regulators
    Masashi Tanaka
    Department of Cardiothoracic Surgery, Stanford University Medical Center, Falk Cardiovascular Research Center, Stanford, CA 94305, USA
    J Thorac Cardiovasc Surg 129:1160-7. 2005
  8. pmc Aberrant mitochondrial fission in neurons induced by protein kinase C{delta} under oxidative stress conditions in vivo
    Xin Qi
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Biol Cell 22:256-65. 2011
  9. ncbi request reprint Cardioprotection by epsilon-protein kinase C activation from ischemia: continuous delivery and antiarrhythmic effect of an epsilon-protein kinase C-activating peptide
    Koichi Inagaki
    Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, Calif 94305 5174, USA
    Circulation 111:44-50. 2005
  10. pmc Protein quality control disruption by PKCβII in heart failure; rescue by the selective PKCβII inhibitor, βIIV5-3
    Julio C B Ferreira
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 7:e33175. 2012

Research Grants

  1. Protein Kinase C Isozymes in Stroke-Therapeutic Target?
    Daria Mochly Rosen; Fiscal Year: 2006
  2. PROTEIN KINASE C ISOZYMES IN HEART
    Daria Mochly Rosen; Fiscal Year: 2006
  3. Hypertrophy, Heart Failure and PKC
    Daria Mochly Rosen; Fiscal Year: 2007
  4. MECHANISMS OF ETHANOL-INDUCED CARDIAC PROTECTION
    Daria Mochly Rosen; Fiscal Year: 2007
  5. MECHANISMS OF ETHANOL-INDUCED CARDIAC PROTECTION
    Daria Mochly Rosen; Fiscal Year: 2009
  6. Protein Kinase C Isozymes in Ischemic Heart
    Daria Mochly Rosen; Fiscal Year: 2009
  7. MECHANISMS OF ETHANOL-INDUCED CARDIAC PROTECTION
    Daria Mochly Rosen; Fiscal Year: 2009
  8. MECHANISMS OF ETHANOL INDUCED CARDIAC MYOCYTE PROTECTION
    Daria Mochly Rosen; Fiscal Year: 1999
  9. PROTEIN KINASE C ISOZYMES IN HEART
    Daria Mochly Rosen; Fiscal Year: 2002
  10. MECHANISMS OF ETHANOL-INDUCED CARDIAC PROTECTION
    Daria Mochly Rosen; Fiscal Year: 2003

Collaborators

Detail Information

Publications67

  1. pmc Common ALDH2 genetic variants predict development of hypertension in the SAPPHIRe prospective cohort: gene-environmental interaction with alcohol consumption
    Yi Cheng Chang
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    BMC Cardiovasc Disord 12:58. 2012
    ..Genetic variants near/within the ALDH2 gene encoding the mitochondrial aldehyde dehydrogenase 2 have been associated with blood pressure and hypertension in several case-control association studies in East Asian populations...
  2. pmc Protein kinase C, an elusive therapeutic target?
    Daria Mochly-Rosen
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California 94305 5174, USA
    Nat Rev Drug Discov 11:937-57. 2012
    ..Why does PKC remain an elusive drug target? This Review provides a short account of some of the efforts, challenges and opportunities in developing PKC modulators to address unmet clinical needs...
  3. ncbi request reprint Suppression of graft coronary artery disease by a brief treatment with a selective epsilonPKC activator and a deltaPKC inhibitor in murine cardiac allografts
    Masashi Tanaka
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Falk Cardiovascular Research Center, Stanford, CA 94305 5407, USA
    Circulation 110:II194-9. 2004
    ..Here, we examined whether limiting ischemia-reperfusion injury inhibits graft coronary artery disease (GCAD) and improves murine cardiac allografting...
  4. pmc Mitochondrial import of PKCepsilon is mediated by HSP90: a role in cardioprotection from ischaemia and reperfusion injury
    Grant R Budas
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305 5174, USA
    Cardiovasc Res 88:83-92. 2010
    ..Heat shock protein 90 (HSP90) is a cytoprotective protein chaperone that participates in mitochondrial import of a number of proteins. Here, we investigated the role of HSP90 in mitochondrial import of PKCepsilon...
  5. ncbi request reprint Protein kinase Cdelta activation induces apoptosis in response to cardiac ischemia and reperfusion damage: a mechanism involving BAD and the mitochondria
    Christopher L Murriel
    Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305 5174, USA
    J Biol Chem 279:47985-91. 2004
    ..Our data suggest that PKCdelta activation has a critical proapoptotic role in cardiac responses following ischemia and reperfusion...
  6. pmc Pharmacological inhibition of βIIPKC is cardioprotective in late-stage hypertrophy
    Julio C B Ferreira
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305 5174, USA
    J Mol Cell Cardiol 51:980-7. 2011
    ....
  7. ncbi request reprint Inhibition of heart transplant injury and graft coronary artery disease after prolonged organ ischemia by selective protein kinase C regulators
    Masashi Tanaka
    Department of Cardiothoracic Surgery, Stanford University Medical Center, Falk Cardiovascular Research Center, Stanford, CA 94305, USA
    J Thorac Cardiovasc Surg 129:1160-7. 2005
    ....
  8. pmc Aberrant mitochondrial fission in neurons induced by protein kinase C{delta} under oxidative stress conditions in vivo
    Xin Qi
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Biol Cell 22:256-65. 2011
    ..Our study suggests that PKCδ activation dysregulates the mitochondrial fission machinery and induces aberrant mitochondrial fission, thus contributing to neurological pathology...
  9. ncbi request reprint Cardioprotection by epsilon-protein kinase C activation from ischemia: continuous delivery and antiarrhythmic effect of an epsilon-protein kinase C-activating peptide
    Koichi Inagaki
    Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, Calif 94305 5174, USA
    Circulation 111:44-50. 2005
    ....
  10. pmc Protein quality control disruption by PKCβII in heart failure; rescue by the selective PKCβII inhibitor, βIIV5-3
    Julio C B Ferreira
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 7:e33175. 2012
    ..PQC disruption by increased PKCβII activity in vivo appears to contribute to the pathophysiology of heart failure, suggesting that PKCβII inhibition may benefit patients with heart failure. (218 words)...
  11. ncbi request reprint Peptides derived from the C2 domain of protein kinase C epsilon (epsilon PKC) modulate epsilon PKC activity and identify potential protein-protein interaction surfaces
    Relly Brandman
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 282:4113-23. 2007
    ....
  12. pmc Activation of aldehyde dehydrogenase 2 (ALDH2) confers cardioprotection in protein kinase C epsilon (PKCvarepsilon) knockout mice
    Grant R Budas
    Department of Chemical and Systems Biology, Stanford University School of Medicine, CCSR, Rm 3145A, 269 Campus Drive, Stanford, CA 94305 5174, USA
    J Mol Cell Cardiol 48:757-64. 2010
    ..Taken together, our findings suggest that direct activation of ALDH2 may represent a method of harnessing the cardioprotective effect of ethanol without the side effects associated with alcohol consumption...
  13. pmc Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart
    Che Hong Chen
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305 5174, USA
    Science 321:1493-5. 2008
    ..Thus, pharmacologic enhancement of ALDH2 activity may be useful for patients with wild-type or mutant ALDH2 who are subjected to cardiac ischemia, such as during coronary bypass surgery...
  14. pmc Identification of εPKC targets during cardiac ischemic injury
    Grant Budas
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA
    Circ J 76:1476-85. 2012
    ..Whether these εPKC-mediated alterations were because of differences in protein expression or phosphorylation was not determined...
  15. pmc PKCβII inhibition attenuates myocardial infarction induced heart failure and is associated with a reduction of fibrosis and pro-inflammatory responses
    Suresh Selvaraj Palaniyandi
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA
    J Cell Mol Med 15:1769-77. 2011
    ..Therefore, sustained selective inhibition of PKCβII in a post-MI HF rat model improves cardiac function and is associated with inhibition of pathological myocardial remodelling...
  16. pmc Pharmacological inhibition of epsilon-protein kinase C attenuates cardiac fibrosis and dysfunction in hypertension-induced heart failure
    Koichi Inagaki
    Department of Chemical and Systems Biology, Stanford University School of Medicine, CCSR, Room 3145A, 269 Campus Dr, Stanford, CA 94305 5174, USA
    Hypertension 51:1565-9. 2008
    ..These data suggest that an epsilonPKC-selective inhibitor such as epsilonV1-2 may have a potential in augmenting current therapeutic strategies for the treatment of heart failure in humans...
  17. pmc Impaired perfusion after myocardial infarction is due to reperfusion-induced deltaPKC-mediated myocardial damage
    Fumiaki Ikeno
    Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305 5174, United States
    Cardiovasc Res 73:699-709. 2007
    ....
  18. pmc DeltaPKC mediates microcerebrovascular dysfunction in acute ischemia and in chronic hypertensive stress in vivo
    Rachel Bright
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305 5174, USA
    Brain Res 1144:146-55. 2007
    ..Together, these findings demonstrate that deltaPKC is an important therapeutic target for protection of microvascular structure and function under both acute and chronic conditions of cerebrovascular stress...
  19. doi request reprint Sustained inhibition of epsilon protein kinase C inhibits vascular restenosis after balloon injury and stenting
    Tobias Deuse
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    Circulation 122:S170-8. 2010
    ..protein kinase C (εPKC) is involved in vascular smooth muscle cell (VSMC) activation, but little is known about its function in vascular pathology. We aimed at assessing the role of εPKC in the development of restenosis...
  20. ncbi request reprint Suppression of deltaPKC activation after focal cerebral ischemia contributes to the protective effect of hypothermia
    Takayoshi Shimohata
    Department of Neurosurgery, Stanford University, Stanford, California 94305 5327, USA
    J Cereb Blood Flow Metab 27:1463-75. 2007
    ..Both cytochrome c release and deltaPKC translocation were blocked by hypothermia. In conclusion, hypothermia protects against ischemic damage in part by suppressing deltaPKC activation after stroke...
  21. doi request reprint Non-volume-loaded heart provides a more relevant heterotopic transplantation model
    Karis R Tang-Quan
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, USA
    Transpl Immunol 23:65-70. 2010
    ..Non-volume-loaded (NL) and volume-loaded (VL) models were tested for their physiologic and immunologic properties to assess their suitability for transplant studies...
  22. ncbi request reprint State-specific monoclonal antibodies identify an intermediate state in epsilon protein kinase C activation
    Miriam C Souroujon
    Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 279:17617-24. 2004
    ..Further, monoclonal antibody 14E6 should be a powerful tool to study the pathways that control rapid translocation of epsilonPKC from cytosolic to membrane localization on activation...
  23. ncbi request reprint Exaggerated nociceptive responses on morphine withdrawal: roles of protein kinase C epsilon and gamma
    Sarah M Sweitzer
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
    Pain 110:281-9. 2004
    ....
  24. pmc Aldehyde dehydrogenase 2 in cardiac protection: a new therapeutic target?
    Grant R Budas
    Department of Chemical and Systems Biology, Stanford University School of Medicine, CA 94305 5174, USA
    Trends Cardiovasc Med 19:158-64. 2009
    ..In this review, we discuss evidence that ALDH2 is a key mediator of endogenous survival signaling in the heart, suggest possible cardioprotective mechanisms mediated by ALDH2 and discuss potential clinical implications of these findings...
  25. ncbi request reprint Ethanol withdrawal-associated allodynia and hyperalgesia: age-dependent regulation by protein kinase C epsilon and gamma isoenzymes
    Jennifer A Shumilla
    Department of Anesthesiology, Stanford University School of Medicine, Stanford, CA, USA
    J Pain 6:535-49. 2005
    ..These studies demonstrate developmental differences in neonatal nociceptive responses after withdrawal from acute EtOH and implicate a role for specific PKC isozymes in EtOH withdrawal-associated allodynia and hyperalgesia...
  26. pmc deltaPKC participates in the endoplasmic reticulum stress-induced response in cultured cardiac myocytes and ischemic heart
    Xin Qi
    Department of Chemical and Systems Biology, Stanford University School of Medicine, CCSR, Room 3145A, 269 Campus Dr, Stanford, CA 94305, USA
    J Mol Cell Cardiol 43:420-8. 2007
    ..Taken together, our data show for the first time that deltaPKC activation plays a critical role in the ER stress-mediated response and the resultant cell death...
  27. doi request reprint Selective activation of protein kinase C∊ in mitochondria is neuroprotective in vitro and reduces focal ischemic brain injury in mice
    Xiaoyun Sun
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosci Res 91:799-807. 2013
    ....
  28. pmc Rational design of a selective antagonist of epsilon protein kinase C derived from the selective allosteric agonist, pseudo-RACK peptide
    Tamar Liron
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305 5332, USA
    J Mol Cell Cardiol 42:835-41. 2007
    ..These data support our hypothesis regarding the mechanism by which pseudo-RACK peptide activates PKC in heart cells and suggest that this approach is applicable to other signaling proteins with inducible protein-protein interactions...
  29. ncbi request reprint Cardioprotective mechanisms of PKC isozyme-selective activators and inhibitors in the treatment of ischemia-reperfusion injury
    Grant R Budas
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305 5174, USA
    Pharmacol Res 55:523-36. 2007
    ....
  30. pmc Ischaemic preconditioning improves proteasomal activity and increases the degradation of deltaPKC during reperfusion
    Eric N Churchill
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305 5174, USA
    Cardiovasc Res 85:385-94. 2010
    ..Here, we determined the spatial and temporal relationships between these two isozymes in the context of ischaemia/reperfusion (I/R) and ischaemic preconditioning (IPC) to better understand their roles in cardioprotection...
  31. pmc Mitochondrial aldehyde dehydrogenase and cardiac diseases
    Che Hong Chen
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305 5174, USA
    Cardiovasc Res 88:51-7. 2010
    ....
  32. ncbi request reprint Protein kinase C delta (deltaPKC)-annexin V interaction: a required step in deltaPKC translocation and function
    Viktoria Kheifets
    Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 281:23218-26. 2006
    ..We show that following cell activation, deltaPKC-annexin V binding is a transient and an essential step in the function of deltaPKC, thus identifying a new role for annexin V in PKC signaling and a new step in PKC activation...
  33. pmc ALDH2 activator inhibits increased myocardial infarction injury by nitroglycerin tolerance
    Lihan Sun
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305 5174, USA
    Sci Transl Med 3:107ra111. 2011
    ....
  34. pmc epsilonPKC confers acute tolerance to cerebral ischemic reperfusion injury
    Rachel Bright
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305 5174, USA
    Neurosci Lett 441:120-4. 2008
    ..Here we demonstrate the role of acute and transient epsilonPKC in early cerebral tolerance in vivo and suggest that extra-parenchymal mechanisms, such as vasoconstriction, may contribute to the conferred protection...
  35. ncbi request reprint A critical intramolecular interaction for protein kinase Cepsilon translocation
    Deborah Schechtman
    Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 279:15831-40. 2004
    ..Together our data suggest that intramolecular interaction between the psiepsilonRACK site and RACK-binding site within epsilonPKC is critical and rate limiting in the process of PKC translocation...
  36. pmc Activating deltaPKC antagonizes the protective effect of ERK1/2 inhibition against stroke in rats
    Dora Castaneda
    Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA
    Brain Res 1251:256-61. 2009
    ..In conclusion, we find that inhibiting both the MEK/ERK and the deltaPKC pathways offers greater protection than either alone, indicating they likely act independently...
  37. pmc Therapeutic potential for protein kinase C inhibitor in vascular restenosis
    Richard Qinxue Ding
    Division of Vascular and Endovascular Surgery, Department of Surgery, Stanford University, Stanford, CA 94350, USA
    J Cardiovasc Pharmacol Ther 16:160-7. 2011
    ..The delivery strategy, efficacy, and safety of such PKC regulators will also be discussed...
  38. pmc Matrix metalloproteinases modulated by protein kinase Cε mediate resistin-induced migration of human coronary artery smooth muscle cells
    Qinxue Ding
    Division of Vascular and Endovascular Surgery, Department of Surgery, Stanford University, Stanford, CA 94304, USA
    J Vasc Surg 53:1044-51. 2011
    ..Given that matrix metalloproteinases (MMPs) also regulate cell migration, we hypothesized that MMPs may mediate resistin-induced VSMC migration...
  39. pmc Time-dependent and ethanol-induced cardiac protection from ischemia mediated by mitochondrial translocation of varepsilonPKC and activation of aldehyde dehydrogenase 2
    Eric N Churchill
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, 94305 5174, USA
    J Mol Cell Cardiol 46:278-84. 2009
    ..Together, this work provides an insight into the mitochondrial-dependent basis of ethanol-induced and varepsilonPKC-mediated protection from cardiac ischemia, in vivo...
  40. ncbi request reprint Protein kinase C epsilon and gamma: involvement in formalin-induced nociception in neonatal rats
    Sarah M Sweitzer
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California, USA
    J Pharmacol Exp Ther 309:616-25. 2004
    ..Identifying the molecular mechanisms responsible for age-specific patterns of nociception is necessary for the rational development of novel therapeutic strategies for treating pediatric pain...
  41. pmc Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) phosphorylation by protein kinase Cδ (PKCδ) inhibits mitochondria elimination by lysosomal-like structures following ischemia and reoxygenation-induced injury
    Gouri Yogalingam
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California 94305 5174, USA
    J Biol Chem 288:18947-60. 2013
    ..Taken together, we identified a GAPDH/PKCδ signaling switch, which is activated during oxidative stress to regulate the balance between cell survival by mitophagy and cell death due to accumulation of damaged mitochondria. ..
  42. ncbi request reprint Protein kinase C delta mediates cerebral reperfusion injury in vivo
    Rachel Bright
    Department of Molecular Pharmacology, Stanford Stroke Center, Stanford University School of Medicine, Stanford, California 94305 5174, USA
    J Neurosci 24:6880-8. 2004
    ..These data support a deleterious role for deltaPKC during reperfusion and suggest that deltaV1-1 delivery, even hours after commencement of reperfusion, may provide a therapeutic advantage after cerebral ischemia...
  43. ncbi request reprint The role of protein kinase C in cerebral ischemic and reperfusion injury
    Rachel Bright
    Stanford University School of Medicine, Stanford, CA 94305 5174, USA
    Stroke 36:2781-90. 2005
    ..However, because of conflicting reports, it remains unclear whether PKC is involved in cell survival signaling, or mediates detrimental processes...
  44. pmc βIIPKC and εPKC isozymes as potential pharmacological targets in cardiac hypertrophy and heart failure
    Julio Cesar Batista Ferreira
    Department of Chemical and Systems Biology, Stanford University School of Medicine, CCSR, Rm 3145A, 269 Campus Drive, Stanford, CA 94305 5174, USA
    J Mol Cell Cardiol 51:479-84. 2011
    ..In this review, we describe the role of PKC isozymes that is involved in cardiac hypertrophy and heart failure. This article is part of a special issue entitled "Key Signaling Molecules in Hypertrophy and Heart Failure"...
  45. ncbi request reprint RBCK1, a protein kinase CbetaI (PKCbetaI)-interacting protein, regulates PKCbeta-dependent function
    Alice Vallentin
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 282:1650-7. 2007
    ..Our results suggest that RBCK1 binds PKCbetaI and is a key regulator of PKCbetaI function in cells and that, together with PKCbetaII, the three proteins are essential for developmental hypertrophy of cardiac myocytes...
  46. ncbi request reprint Pharmacological inhibition of epsilon PKC suppresses chronic inflammation in murine cardiac transplantation model
    Tomoyoshi Koyanagi
    Department of Chemical and Systems Biology, Stanford University School of Medicine CCSR, Rm 3145A, 269 Campus Drive Stanford, CA 94305 5174, USA
    J Mol Cell Cardiol 43:517-22. 2007
    ....
  47. pmc Mitigation of radiation-induced dermatitis by activation of aldehyde dehydrogenase 2 using topical alda-1 in mice
    Shoucheng Ning
    Department of Radiation Oncology, Stanford University Medical Center, Stanford, California 94305, USA
    Radiat Res 178:69-74. 2012
    ..Our findings suggest that ALDH2 represents a novel target for the treatment of radiation dermatitis without reducing the benefit of radiotherapy...
  48. pmc Insight into intra- and inter-molecular interactions of PKC: design of specific modulators of kinase function
    Viktoria Kheifets
    Department of Chemical and Systems Biology, Stanford University School of Medicine, CCSR, Rm 3145A, 269 Campus Drive, Stanford, CA 94305 5174, USA
    Pharmacol Res 55:467-76. 2007
    ..This chapter focuses on mapping the sites for many of these inter- and intra-molecular interactions and how this information may be used to generate selective inhibitors and activators of PKC signaling...
  49. pmc Ethanol for cardiac ischemia: the role of protein kinase c
    Eric N Churchill
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA
    Ther Adv Cardiovasc Dis 2:469-83. 2008
    ..This review focuses on the different modalities of chronic vs. acute ethanol consumption and discusses recent evidence for a protective effect of acute ethanol exposure and the possible use of ethanol as a therapeutic agent...
  50. ncbi request reprint Sequential activation of individual PKC isozymes in integrin-mediated muscle cell spreading: a role for MARCKS in an integrin signaling pathway
    Marie Helene Disatnik
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, CA 94305, USA
    J Cell Sci 115:2151-63. 2002
    ..The mechanism of PKC-mediated cell spreading may be via the phosphorylation of signaling proteins, such as MARCKS, that are involved in the reorganization of the actin cytoskeleton...
  51. pmc Rationally designed peptide regulators of protein kinase C
    Eric N Churchill
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Trends Endocrinol Metab 20:25-33. 2009
    ..Here, we discuss the methodologies and applications for identifying selective regulators of PKC...
  52. pmc Sustained pharmacological inhibition of deltaPKC protects against hypertensive encephalopathy through prevention of blood-brain barrier breakdown in rats
    Xin Qi
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Clin Invest 118:173-82. 2008
    ..Together, these results suggest that deltaPKC plays a role in the development of hypertension-induced encephalopathy and may be a therapeutic target for the prevention of BBB disruption...
  53. ncbi request reprint Opposing roles of delta and epsilonPKC in cardiac ischemia and reperfusion: targeting the apoptotic machinery
    Christopher L Murriel
    Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, CA 94305 5174, USA
    Arch Biochem Biophys 420:246-54. 2003
    ..We also discuss the role of apoptosis and necrosis in cardiac damage, the means to protect the heart from damage by ischemia and reperfusion, and the role of protein kinase C in these processes...
  54. pmc Nitroglycerin use in myocardial infarction patients
    Julio C B Ferreira
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305 5174, USA
    Circ J 76:15-21. 2012
    ..In this review, we describe the molecular mechanisms associated with the benefits and risks of GTN administration in MI...
  55. pmc Acute inhibition of excessive mitochondrial fission after myocardial infarction prevents long-term cardiac dysfunction
    Marie Helene Disatnik
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, 94305, CA
    J Am Heart Assoc 2:e000461. 2013
    ..We determined whether acute inhibition of excessive mitochondrial fission at the onset of reperfusion improves mitochondrial dysfunction and cardiac contractility postmyocardial infarction in rats...
  56. pmc Regulation of cardiac excitability by protein kinase C isozymes
    Julio Cesar Batista Ferreira
    Stanford University, School of Medicine, Stanford, CA, USA
    Front Biosci (Schol Ed) 4:532-46. 2012
    ..Selective and effective pharmacological interventions to normalize cardiac electrical activities and correct cardiac arrhythmias will be of great clinical benefit...
  57. pmc β2-adrenergic receptors mediate cardioprotection through crosstalk with mitochondrial cell death pathways
    Giovanni Fajardo
    Department of Pediatrics Cardiology, Stanford University, Stanford, CA, USA
    J Mol Cell Cardiol 51:781-9. 2011
    ....
  58. ncbi request reprint Methods for detecting binding proteins: an introduction
    Gerda Endemann
    Department of Molecular Pharmacology, Stanford University School of Medicine, CA, USA
    Methods Mol Biol 233:307-25. 2003
  59. ncbi request reprint Opposing effects of delta- and zeta-protein kinase C isozymes on cardiac fibroblast proliferation: use of isozyme-selective inhibitors
    Martin Ulrich Braun
    Department of Molecular Pharmacology, Stanford University School of Medicine, 269 Campus Drive, CCSR 3145, Stanford, CA 94305 5332, USA
    J Mol Cell Cardiol 35:895-903. 2003
    ..Taken together, our data provide evidence that delta-PKC inhibits and zeta-PKC stimulates proliferation of neonatal rat cardiac fibroblasts...
  60. ncbi request reprint Inhibition of delta-protein kinase C protects against reperfusion injury of the ischemic heart in vivo
    Koichi Inagaki
    Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, Calif 94305 5174, USA
    Circulation 108:2304-7. 2003
    ..We focus here on the role for deltaPKC during reperfusion only, using an in vivo porcine model of AMI...
  61. pmc Mast cells and epsilonPKC: a role in cardiac remodeling in hypertension-induced heart failure
    Suresh Selvaraj Palaniyandi
    Department of Chemical and Systems Biology, Stanford University School of Medicine, CCSR, Stanford, CA 94305 5174, USA
    J Mol Cell Cardiol 45:779-86. 2008
    ..Together, our data suggest that epsilonPKC inhibition attenuates pathological remodeling in hypertension-induced HF, at least in part, by preventing cardiac MC degranulation...
  62. ncbi request reprint PKC isozymes in chronic cardiac disease: possible therapeutic targets?
    Eric Churchill
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305 5174, USA
    Annu Rev Pharmacol Toxicol 48:569-99. 2008
    ..The review focuses on the roles of specific PKC isozymes in atherosclerosis, fibrosis, and cardiac hypertrophy, and examines principles of pharmacology as they pertain to regulators of signaling cascades associated with these diseases...
  63. ncbi request reprint Cell-specific role for epsilon- and betaI-protein kinase C isozymes in protecting cortical neurons and astrocytes from ischemia-like injury
    Jian Wang
    Department of Anesthesia, School of Medicine, Stanford University, Stanford, CA 94305 5117, USA
    Neuropharmacology 47:136-45. 2004
    ..Our data demonstrate protection of neurons by selective activation of epsilonPKC but enhanced astrocyte cell death with selective inhibition of betaIPKC. Thus PKC isozymes exhibit cell type-specific effects on ischemia-like injury...
  64. pmc PKCδ activation mediates angiogenesis via NADPH oxidase activity in PC-3 prostate cancer cells
    Jeewon Kim
    Department of Chemical and Systems Biology, Stanford University, School of Medicine, Stanford, California 94305 5174, USA
    Prostate 71:946-54. 2011
    ..PKCδ is generally known as a pro-apoptotic and anti-proliferative enzyme in human prostate cancer cells...
  65. pmc Protein kinase Cgamma mediates ethanol withdrawal hyper-responsiveness of NMDA receptor currents in spinal cord motor neurons
    Hui Fang Li
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, U S A
    Br J Pharmacol 144:301-7. 2005
    ..The results show that PKCgamma mediates ethanol withdrawal hyper-responsiveness in spinal motor neurons; the results may be relevant to some symptoms of ethanol withdrawal in vivo...
  66. ncbi request reprint Glutathione S-transferase pull-down assay
    Deborah Schechtman
    Department of Molecular Pharmacology, Stanford University School of Medicine, CA, USA
    Methods Mol Biol 233:345-50. 2003
  67. pmc Protein kinase C in heart failure: a therapeutic target?
    Suresh Selvaraj Palaniyandi
    Department of Chemical and Systems Biology, Stanford University School of Medicine, CCSR, Rm 3145A, 269 Campus Drive, Stanford, CA 94305 5174, USA
    Cardiovasc Res 82:229-39. 2009
    ..In this review, we describe the PKC isozymes that play critical roles in specific aspects of cardiac remodelling and dysfunction in HF...

Research Grants38

  1. Protein Kinase C Isozymes in Stroke-Therapeutic Target?
    Daria Mochly Rosen; Fiscal Year: 2006
    ..Should the treatment be found efficacious and safe, these peptide regulators of PKC activity may be useful for the treatment of stroke and brain ischemia in humans. ..
  2. PROTEIN KINASE C ISOZYMES IN HEART
    Daria Mochly Rosen; Fiscal Year: 2006
    ..Together, these studies will identify the PKC isozymes and the molecular pathways that should be targeted for the development of new therapeutics for human cardiac ischemia and heart failure. ..
  3. Hypertrophy, Heart Failure and PKC
    Daria Mochly Rosen; Fiscal Year: 2007
    ..Together, these studies will identify the PKC isozyme(s) that should be targeted for the development of new therapeutics for human heart failure, especially if PKC-based pharmacotherapy is considered ..
  4. MECHANISMS OF ETHANOL-INDUCED CARDIAC PROTECTION
    Daria Mochly Rosen; Fiscal Year: 2007
    ..Together, our studies will assess the molecular basis and potential use of ethanol as an agent to protect the heart from ischemic damage. ..
  5. MECHANISMS OF ETHANOL-INDUCED CARDIAC PROTECTION
    Daria Mochly Rosen; Fiscal Year: 2009
    ..This study may eventually provide new means to induce cytoprotection in humans subjected to ischemic insult. ..
  6. Protein Kinase C Isozymes in Ischemic Heart
    Daria Mochly Rosen; Fiscal Year: 2009
    ....
  7. MECHANISMS OF ETHANOL-INDUCED CARDIAC PROTECTION
    Daria Mochly Rosen; Fiscal Year: 2009
    ..Our studies will also provide new tools and test their application as treatment for cardiac ischemia using animal models. ..
  8. MECHANISMS OF ETHANOL INDUCED CARDIAC MYOCYTE PROTECTION
    Daria Mochly Rosen; Fiscal Year: 1999
    ..Together, these studies will help elucidating the molecular basis for cardio- protection by ethanol. ..
  9. PROTEIN KINASE C ISOZYMES IN HEART
    Daria Mochly Rosen; Fiscal Year: 2002
    ....
  10. MECHANISMS OF ETHANOL-INDUCED CARDIAC PROTECTION
    Daria Mochly Rosen; Fiscal Year: 2003
    ..Together, these studies will help determine the time and dosage of ethanol exposure that provide cardioprotection and help elucidate the molecular basis for cardioprotection by ethanol. ..
  11. Protein Kinase C Isozymes in Ischemic Heart
    Daria Mochly Rosen; Fiscal Year: 2010
    ....