E Mignot

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Emerging therapies in narcolepsy-cataplexy
    Emmanuel Mignot
    Howard Hughes Medical Research Institute, Stanford University School of Medicine, Stanford, CA, USA
    Sleep 28:754-63. 2005
  2. pmc Polymorphisms within the canine MLPH gene are associated with dilute coat color in dogs
    Ute Philipp
    Institute of Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Bunteweg 17p, 30559 Hannover, Germany
    BMC Genet 6:34. 2005
  3. pmc Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups
    E Mignot
    Center for Narcolepsy, Stanford University, Department of Psychiatry and Behavioral Sciences, Palo Alto, CA 94304, USA
    Am J Hum Genet 68:686-99. 2001
  4. ncbi request reprint The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias
    Emmanuel Mignot
    Center for Narcolepsy, Stanford University, 701B Lower Welch Rd, Palo Alto, CA 94304 5742, USA
    Arch Neurol 59:1553-62. 2002
  5. ncbi request reprint Dopaminergic role in stimulant-induced wakefulness
    J P Wisor
    Sleep Disorders Research Center, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosci 21:1787-94. 2001
  6. ncbi request reprint Low cerebrospinal fluid hypocretin (Orexin) and altered energy homeostasis in human narcolepsy
    S Nishino
    Stanford University Center for Narcolepsy, Palo Alto, CA 94304, USA
    Ann Neurol 50:381-8. 2001
  7. ncbi request reprint Hypocretin/orexin, sleep and narcolepsy
    M Hungs
    Stanford Center for Narcolepsy, Department of Psychiatry Behavioral Sciences, Stanford University Medical Center, Palo Alto, CA 94305 5485, USA
    Bioessays 23:397-408. 2001
  8. ncbi request reprint Physical and radiation hybrid mapping of canine chromosome 12, in a region corresponding to human chromosome 6p12-q12
    R Li
    Room P 114, Stanford Center for Narcolepsy Research, 1201 Welch Road, Stanford, California 94305 5485, USA
    Genomics 73:299-315. 2001
  9. ncbi request reprint Polymorphisms in the vicinity of the hypocretin/orexin are not associated with human narcolepsy
    M Hungs
    Stanford Center for Narcolepsy, Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, CA 94305 5485, USA
    Neurology 57:1893-5. 2001
  10. ncbi request reprint Fluctuation of extracellular hypocretin-1 (orexin A) levels in the rat in relation to the light-dark cycle and sleep-wake activities
    Y Yoshida
    Stanford University Center for Narcolepsy, 701B Welch Rd, 1st Floor, Palo Alto, CA 94304, USA
    Eur J Neurosci 14:1075-81. 2001

Collaborators

Detail Information

Publications124 found, 100 shown here

  1. ncbi request reprint Emerging therapies in narcolepsy-cataplexy
    Emmanuel Mignot
    Howard Hughes Medical Research Institute, Stanford University School of Medicine, Stanford, CA, USA
    Sleep 28:754-63. 2005
    ..We also report on novel strategies designed to compensate for hypocretin deficiency and on the use of immunosupression at the time of narcolepsy onset...
  2. pmc Polymorphisms within the canine MLPH gene are associated with dilute coat color in dogs
    Ute Philipp
    Institute of Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Bunteweg 17p, 30559 Hannover, Germany
    BMC Genet 6:34. 2005
    ..In humans and mice a comparable pigmentation phenotype without any documented hair loss is caused by mutations within the melanophilin gene (MLPH)...
  3. pmc Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups
    E Mignot
    Center for Narcolepsy, Stanford University, Department of Psychiatry and Behavioral Sciences, Palo Alto, CA 94304, USA
    Am J Hum Genet 68:686-99. 2001
    ..Together with the recent hypocretin discoveries, these findings are consistent with an immunologically mediated destruction of hypocretin-containing cells in human narcolepsy-cataplexy...
  4. ncbi request reprint The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias
    Emmanuel Mignot
    Center for Narcolepsy, Stanford University, 701B Lower Welch Rd, Palo Alto, CA 94304 5742, USA
    Arch Neurol 59:1553-62. 2002
    ..Narcolepsy, a neurological disorder affecting 1 in 2000 individuals, is associated with HLA-DQB1*0602 and low cerebrospinal fluid (CSF) hypocretin (orexin) levels...
  5. ncbi request reprint Dopaminergic role in stimulant-induced wakefulness
    J P Wisor
    Sleep Disorders Research Center, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosci 21:1787-94. 2001
    ..Thus, dopamine transporters play an important role in sleep regulation and are necessary for the specific wake-promoting action of amphetamines and modafinil...
  6. ncbi request reprint Low cerebrospinal fluid hypocretin (Orexin) and altered energy homeostasis in human narcolepsy
    S Nishino
    Stanford University Center for Narcolepsy, Palo Alto, CA 94304, USA
    Ann Neurol 50:381-8. 2001
    ..Increased BMI and leptin indicate altered energy homeostasis. Sleep and energy metabolism are likely to be functionally connected through the hypocretin system...
  7. ncbi request reprint Hypocretin/orexin, sleep and narcolepsy
    M Hungs
    Stanford Center for Narcolepsy, Department of Psychiatry Behavioral Sciences, Stanford University Medical Center, Palo Alto, CA 94305 5485, USA
    Bioessays 23:397-408. 2001
    ..Other functions are suggested by pharmacological and neurochemical experiments. These include regulation of food intake, neuroendocrine function, autonomic nervous system activity and energy balance...
  8. ncbi request reprint Physical and radiation hybrid mapping of canine chromosome 12, in a region corresponding to human chromosome 6p12-q12
    R Li
    Room P 114, Stanford Center for Narcolepsy Research, 1201 Welch Road, Stanford, California 94305 5485, USA
    Genomics 73:299-315. 2001
    ..These data further establish the dog as a system for studying disease genes of interest to human populations and highlight feasible approaches for positional cloning of disease genes in organisms where genomic resources are limited...
  9. ncbi request reprint Polymorphisms in the vicinity of the hypocretin/orexin are not associated with human narcolepsy
    M Hungs
    Stanford Center for Narcolepsy, Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, CA 94305 5485, USA
    Neurology 57:1893-5. 2001
    ..None of the subjects carried -22T, a rare 5'UTR polymorphism previously reported to be associated with narcolepsy. The HCRT locus is not a major narcolepsy susceptibility locus...
  10. ncbi request reprint Fluctuation of extracellular hypocretin-1 (orexin A) levels in the rat in relation to the light-dark cycle and sleep-wake activities
    Y Yoshida
    Stanford University Center for Narcolepsy, 701B Welch Rd, 1st Floor, Palo Alto, CA 94304, USA
    Eur J Neurosci 14:1075-81. 2001
    ....
  11. ncbi request reprint DQB1*0602 and DQA1*0102 (DQ1) are better markers than DR2 for narcolepsy in Caucasian and black Americans
    E Mignot
    Stanford University, School of Medicine, Sleep Disorders Center, Palo Alto, California
    Sleep 17:S60-7. 1994
    ..These results demonstrate that DQB1*0602/DQA1*0102 is the best marker for narcolepsy across all ethnic groups...
  12. doi request reprint Effects of sleep on the cardiovascular and thermoregulatory systems: a possible role for hypocretins
    H Schwimmer
    Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, California, USA
    J Appl Physiol 109:1053-63. 2010
    ..Thus, while hypocretins are critical for the normal temporal structure of sleep and wakefulness, they also appear to be important in regulating baseline blood pressure and possibly in modulating the effects of sleep on blood pressure...
  13. ncbi request reprint Hypocretin levels in sporadic and familial cases of canine narcolepsy
    B Ripley
    Center for Narcolepsy, Stanford Sleep Center, Stanford University School of Medicine, Palo Alto, California 94304, USA
    Neurobiol Dis 8:525-34. 2001
    ..The presence of hypocretin peptides in Hcrtr 2-mutated animals suggests that neurotransmission through Hcrtr 1 may be intact, arguing for a preferential importance of Hcrtr 2-mediated function in narcolepsy...
  14. ncbi request reprint Narcolepsy and the HLA region
    L Lin
    Department of Psychiatry and Behavioral Sciences, Stanford Center for Narcolepsy, Stanford University Medical Center, 1201 Welch Road, P-114, Palo Alto, CA 94305-5485, USA
    J Neuroimmunol 117:9-20. 2001
    ..This data is consistent with an immune destruction of hypocretin-containing cells as the most common etiology for human narcolepsy...
  15. ncbi request reprint Narcoleptic canines display periodic leg movements during sleep
    M Okura
    Center for Narcolepsy, Sleep Research Center, Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, California, USA
    Psychiatry Clin Neurosci 55:243-4. 2001
    ..Our canines may therefore be an invaluable resource in PLMS research...
  16. ncbi request reprint Decreased brain histamine content in hypocretin/orexin receptor-2 mutated narcoleptic dogs
    S Nishino
    Stanford University Center for Narcolepsy, 701B, First Floor, Palo Alto, CA 94304, USA
    Neurosci Lett 313:125-8. 2001
    ..Considering the fact that histamine promotes wakefulness, decreases in histaminergic neurotransmission may also account for the sleep abnormalities in hypocretin-deficient narcolepsy...
  17. pmc The development of hypocretin (orexin) deficiency in hypocretin/ataxin-3 transgenic rats
    S Zhang
    Stanford University, 701 Welch Road, Room 145, Palo Alto, CA 94304 5742, USA
    Neuroscience 148:34-43. 2007
    ..The low output of these neurons is consistent with a widespread dysfunction of these neurons, and establishes this model as a tool to investigate the consequences of partial hypocretin deficiency...
  18. ncbi request reprint Identification and functional analysis of mutations in the hypocretin (orexin) genes of narcoleptic canines
    M Hungs
    Stanford Center for Narcolepsy, Stanford University Medical Center, Department of Psychiatry and Behavioral Sciences, Palo Alto, California 94304 5485, USA
    Genome Res 11:531-9. 2001
    ..These results are consistent with a loss of function for all three mutations. The absence of mutation in sporadic cases also indicates genetic heterogeneity in canine narcolepsy, as reported previously in humans...
  19. ncbi request reprint Neuropharmacology and neurochemistry of canine narcolepsy
    S Nishino
    Sleep Research Center, Stanford University School of Medicine, Palo Alto, California
    Sleep 17:S84-92. 1994
    ....
  20. pmc Sleep/wake fragmentation disrupts metabolism in a mouse model of narcolepsy
    Shengwen Zhang
    Psychiatry and Behavioural Sciences, Stanford University, Palo Alto, CA 94304 5742, USA
    J Physiol 581:649-63. 2007
    ..This investigation illustrates the need for coordinated study of multiple phenotypes in mouse models with altered sleep/wake patterns...
  21. ncbi request reprint The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene
    L Lin
    Center for Narcolepsy, Department of Psychiatry, Stanford University School of Medicine, California 94305 5485, USA
    Cell 98:365-76. 1999
    ..This result identifies hypocretins as major sleep-modulating neurotransmitters and opens novel potential therapeutic approaches for narcoleptic patients...
  22. ncbi request reprint CSF hypocretin/orexin levels in narcolepsy and other neurological conditions
    B Ripley
    Stanford University Center for Narcolepsy, Palo Alto, CA 94304, USA
    Neurology 57:2253-8. 2001
    ..Future research in this area is needed to establish functional significance...
  23. ncbi request reprint Comparative effects of modafinil and amphetamine on daytime sleepiness and cataplexy of narcoleptic dogs
    J Shelton
    Sleep Research Center, Stanford University School of Medicine, Palo Alto, California 94304, USA
    Sleep 18:817-26. 1995
    ..This finding is consistent with the data collected in human narcolepsy and validates the use of this canine model for the screening of stimulant compounds...
  24. ncbi request reprint An immunoglobulin switchlike sequence is linked with canine narcolepsy
    E Mignot
    Stanford University, School of Medicine, Sleep Disorders Center, Palo Alto, California
    Sleep 17:S68-76. 1994
    ..We are now using chromosome walking and Yeast Artificial Chromosome Cloning techniques, together with corresponding studies in humans to identify the pathological gene...
  25. ncbi request reprint Circadian and homeostatic regulation of hypocretin in a primate model: implications for the consolidation of wakefulness
    Jamie M Zeitzer
    Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, California 94304, USA
    J Neurosci 23:3555-60. 2003
    ..In the squirrel monkey, hypocretin-1 works in opposition to the accumulating sleep drive during the day to maintain a constant level of wake...
  26. ncbi request reprint HLA DQB1*0602 is associated with cataplexy in 509 narcoleptic patients
    E Mignot
    Stanford Center for Narcolepsy, Palo Alto, CA 94301, USA
    Sleep 20:1012-20. 1997
    ..These results could be explained by increased disease heterogeneity in the noncataplexy group or by a direct effect of the HLA DQB1*0602 genotype on the clinical expression of narcolepsy...
  27. ncbi request reprint A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
    C Peyron
    Center for Narcolepsy, Stanford University Medical School 1201 Welch Road, Stanford, California 94305 5485, USA
    Nat Med 6:991-7. 2000
    ..Although hypocretin loci do not contribute significantly to genetic predisposition, most cases of human narcolepsy are associated with a deficient hypocretin system...
  28. ncbi request reprint A commentary on the neurobiology of the hypocretin/orexin system
    E Mignot
    Stanford Center for Narcolepsy, Department of Psychiatry and Behavioral Sciences, 1201 Welch Road, P 114, Palo Alto, CA 94305 5485, USA
    Neuropsychopharmacology 25:S5-13. 2001
    ..The potential role of this system in regulating the sleep cycle, modulating wakefulness at selected circadian times and in mediating the deleterious effects of sleep deprivation is discussed...
  29. ncbi request reprint DQB1-0602 (DQw1) is not present in most nonDR2 Caucasian narcoleptics
    E Mignot
    Stanford University, School of Medicine, Sleep Disorders Center, Palo Alto, California 94304
    Sleep 15:415-22. 1992
    ..Further studies with more patients are warranted to exclude the possibility that a few caucasian patients carry rare haplotypes with DQB1-0602 independently of DR2...
  30. ncbi request reprint A polymorphism in the human timeless gene is not associated with diurnal preferences in normal adults
    M Pedrazzoli
    Center for Narcolepsy, Department of Psychiatry, Stanford University, California, USA
    Sleep Res Online 3:73-6. 2000
    ..Our results indicate that Q831R Timeless has no influence on morningness- eveningness tendencies in humans...
  31. ncbi request reprint Mesopontine organization of cholinergic and catecholaminergic cell groups in the normal and narcoleptic dog
    M Tafti
    Center for Narcolepsy Research, Stanford University, Palo Alto, California 94304, USA
    J Comp Neurol 379:185-97. 1997
    ..In conclusion, the present results do not support the hypothesis that the neurochemical imbalance in narcolepsy could result from abnormal organization, numbers, or ratio of the corresponding neuronal populations...
  32. ncbi request reprint Measurement of hypocretin/orexin content in the mouse brain using an enzyme immunoassay: the effect of circadian time, age and genetic background
    L Lin
    Department of Psychiatry and Behavior Sciences, Center for Narcolepsy and Sleep Disorder, Stanford University, Palo Alto, CA 94304 5742, USA
    Peptides 23:2203-11. 2002
    ..Compared to controls, only histamine receptor knockouts had lower hypocretin levels. This was most pronounced in H1 receptor knockouts suggesting the existence of a positive feedback loop between hypocretin and histaminergic neurons...
  33. ncbi request reprint Nocturnal sleep and daytime sleepiness in normal subjects with HLA-DQB1*0602
    E Mignot
    Stanford University, Department of Psychiatry and Behavioral Sciences, CA 94305-5485, USA
    Sleep 22:347-52. 1999
    ..These results support the hypothesis that polymorphisms at the level of HLA DQ modulates sleep tendencies in humans...
  34. ncbi request reprint CSF versus serum leptin in narcolepsy: is there an effect of hypocretin deficiency?
    Isabelle Arnulf
    Center for Narcolepsy, Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA
    Sleep 29:1017-24. 2006
    ..To determine if hypocretin deficiency is associated with abnormally low serum leptin levels, a putative cause of increased body mass index in narcoleptics...
  35. ncbi request reprint Effects of IV and ICV hypocretin-1 (orexin A) in hypocretin receptor-2 gene mutated narcoleptic dogs and IV hypocretin-1 replacement therapy in a hypocretin-ligand-deficient narcoleptic dog
    Nobuhiro Fujiki
    Center for Narcolepsy, Stanford University School of Medicine, Palo Alto, CA 94304 5485, USA
    Sleep 26:953-9. 2003
    ..Using two different canine models of narcolepsy, we evaluated the therapeutic effects of hypocretin-1 on cataplexy and sleep...
  36. pmc Hypocretin receptor expression in canine and murine narcolepsy models and in hypocretin-ligand deficient human narcolepsy
    Kazuo Mishima
    Department of Psychiatry, Stanford University, Center for Narcolepsy, Palo Alto, CA, USA
    Sleep 31:1119-26. 2008
    ..To determine whether hypocretin receptor gene (hcrtR1 and hcrtR2) expression is affected after long-term hypocretin ligand loss in humans and animal models of narcolepsy...
  37. ncbi request reprint Circadian distribution of rest/activity in narcoleptic and control dogs: assessment with ambulatory activity monitoring
    S Nishino
    Sleep Disorders Center, Stanford University School of Medicine, CA, USA
    J Sleep Res 6:120-7. 1997
    ..Ambulatory activity monitoring may be a useful non-invasive method for future pharmacological and development studies in the narcoleptic canine model...
  38. ncbi request reprint Is narcolepsy a REM sleep disorder? Analysis of sleep abnormalities in narcoleptic Dobermans
    S Nishino
    Center for Narcolepsy, Stanford Sleep Center, Stanford University School of Medicine, 1201 Welch Road, MSLS Building Room P113, Palo Alto, CA 94304 5485, USA
    Neurosci Res 38:437-46. 2000
    ..Cataplexy and a dysfunction in the maintenance of vigilance states, but not abnormal REM sleep generation, may therefore be central to narcolepsy...
  39. ncbi request reprint Cholinergic regulation of cataplexy in canine narcolepsy in the pontine reticular formation is mediated by M2 muscarinic receptors
    M S Reid
    Stanford University, Sleep Disorders Research Center, Palo Alto, California 94304
    Sleep 17:424-35. 1994
    ..The effects of muscimol indicate that the stimulation of cataplexy might be elicited by local neuronal inhibition...
  40. ncbi request reprint Narcolepsy research: past, present, and future perspectives
    S Fromherz
    Stanford University Center for Narcolepsy Research, Palo Alto, CA 94305, USA
    Arch Ital Biol 142:479-86. 2004
    ..It was not until the early 1970s when the exciting animal and human research first started to unravel the mysteries of the genetics and physiology of narcolepsy. This research will be discussed below...
  41. pmc Locomotor-dependent and -independent components to hypocretin-1 (orexin A) regulation in sleep-wake consolidating monkeys
    Jamie M Zeitzer
    Department of Psychiatry and Behavioural Sciences, Stanford University, Palo Alto, CA 94304, USA
    J Physiol 557:1045-53. 2004
    ..In this wake-consolidating animal, locomotion is not necessary for CSF hypocretin-1 to increase throughout the daytime, but high levels of locomotion are likely to provide a small positive feedback onto the hypocretin system...
  42. pmc Characterization of sleep in zebrafish and insomnia in hypocretin receptor mutants
    Tohei Yokogawa
    Howard Hughes Medical Institute, Stanford University, Palo Alto, California, USA
    PLoS Biol 5:e277. 2007
    ..Our study validates the use of zebrafish for the study of sleep and indicates molecular diversity in sleep regulatory networks across vertebrates...
  43. ncbi request reprint Desmethyl metabolites of serotonergic uptake inhibitors are more potent for suppressing canine cataplexy than their parent compounds
    S Nishino
    Sleep Research Center, Stanford University School of Medicine, Palo Alto, California 94304
    Sleep 16:706-12. 1993
    ..Our results also suggest that the anticataplectic effect of "selective" serotonergic uptake inhibitors in human narcolepsy might be mediated by their less selective active metabolites...
  44. ncbi request reprint Hypocretin stimulates [(35)S]GTP gamma S binding in Hcrtr 2-transfected cell lines and in brain homogenate
    T Shiba
    Center for Narcolepsy, Stanford University, 701B Welch Rd, Palo Alto, CA 94304, USA
    Biochem Biophys Res Commun 294:615-20. 2002
    ..Hypocretin-stimulated [(35)S]GTP gamma S binding, may thus be a useful functional assay for hypocretin receptors in both cell lines and brain tissue homogenates...
  45. ncbi request reprint Association between apolipoprotein E epsilon4 and sleep-disordered breathing in adults
    H Kadotani
    Center for Narcolepsy, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5485, USA
    JAMA 285:2888-90. 2001
    ..Sleep-disordered breathing occurs in Alzheimer disease patients and increases risks for cardiovascular disease. Complex interactions among sleep, brain pathology, and cardiovascular disease may occur in ApoE epsilon4 carriers...
  46. ncbi request reprint Clinical aspects of narcolepsy-cataplexy across ethnic groups
    Michele L Okun
    Center for Narcolepsy, Stanford University, Department of Psychiatry and Behavioral Sciences, Palo Alto, CA 94304 5742, USA
    Sleep 25:27-35. 2002
    ..A large sample of narcoleptic patients was also used to further describe symptomatology and natural history for this sleep disorder...
  47. pmc Sleep-wake regulation and hypocretin-melatonin interaction in zebrafish
    Lior Appelbaum
    Center for Narcolepsy, Department of Psychiatry and Behavioral Sciences, Howard Hughes Medical Institute, Stanford University, Palo Alto, CA 94305, USA
    Proc Natl Acad Sci U S A 106:21942-7. 2009
    ..These results demonstrate the existence of a functional HCRT neurons-pineal gland circuit able to modulate melatonin production and sleep consolidation...
  48. pmc Circadian and homeostatic regulation of structural synaptic plasticity in hypocretin neurons
    Lior Appelbaum
    Center for Narcolepsy, Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, California 94305, USA
    Neuron 68:87-98. 2010
    ..This behavioral effect is consistent with NPTX2b-mediated increased activity of HCRT circuitry. These data provide real-time in vivo evidence of circadian and homeostatic regulation of structural synaptic plasticity...
  49. ncbi request reprint Controversies in the diagnosis of narcolepsy
    C Guilleminault
    Sleep Disorders Clinic, School of Medicine, Stanford University, Palo Alto, California
    Sleep 17:S1-6. 1994
    ..History of daytime sleepiness and presence of more than one SOREMP during MSLT, however, is a poorer discriminant of narcolepsy than history of cataplexy, particularly in an aging population...
  50. ncbi request reprint CSF hypocretin levels in Guillain-Barré syndrome and other inflammatory neuropathies
    S Nishino
    Stanford University Center for Narcolepsy, Palo Alto, CA 94304, USA
    Neurology 61:823-5. 2003
    ..Hypocretin-1 levels were moderately reduced in an additional 11 GBS, 5 Miller-Fisher syndrome, and 1 CIDP subject. Low levels in GBS occurred early in the disease and were associated with upper CNS level abnormalities...
  51. ncbi request reprint A new DRB1*1202 allele (DRB1*12022) found in association with DQA1*0102 and DQB1*0602 in two black narcoleptic subjects
    E Behar
    Stanford University Blood Center, Palo Alto, CA 94304
    Immunogenetics 41:52. 1995
  52. ncbi request reprint In Alzheimer disease, increased wake fragmentation found in those with lower hypocretin-1
    L F Friedman
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA
    Neurology 68:793-4. 2007
  53. pmc Decreased CSF histamine in narcolepsy with and without low CSF hypocretin-1 in comparison to healthy controls
    Seiji Nishino
    Sleep and Circadian Neurobiology Laboratory, Center for Narcolepsy, Stanford Sleep Research Center, Stanford University, MSLS Bldg Room P213, 1201 Welch Road, Palo Alto CA 94305, USA
    Sleep 32:175-80. 2009
    ..To examine whether cerebrospinal fluid (CSF) histamine contents are altered in human narcolepsy and whether these alterations are specific to hypocretin deficiency, as defined by low CSF hypocretin-1...
  54. ncbi request reprint Lesions of the suprachiasmatic nucleus eliminate the daily rhythm of hypocretin-1 release
    Shengwen Zhang
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA
    Sleep 27:619-27. 2004
    ..The effect of lesions of the suprachiasmatic nucleus (SCN) on hypocretin-1 in the cerebrospinal fluid (CSF) was examined...
  55. ncbi request reprint Sleep, sleep disorders and hypocretin (orexin)
    Emmanuel Mignot
    Stanford University Center for Narcolepsy, Palo Alto, CA 94304 5742, USA
    Sleep Med 5:S2-8. 2004
    ..Abnormal Hcrt transmission is also found in neurologic disorders featuring excessive daytime sleepiness and/or hypothalamic abnormalities. Pharmacologic manipulations of Hcrts may have multiple therapeutic applications...
  56. pmc Why we sleep: the temporal organization of recovery
    Emmanuel Mignot
    Howard Hughes Medical Institute and Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, United States of America
    PLoS Biol 6:e106. 2008
  57. pmc The type III neurofilament peripherin is expressed in the tuberomammillary neurons of the mouse
    Krister S Eriksson
    Psychiatry and Behavioural Sciences, Stanford University, Palo Alto, CA, USA
    BMC Neurosci 9:26. 2008
    ..We noticed high peripherin expression in the posterior hypothalamus of mice, and decided to investigate further the exact location of expression and function of peripherin in the mouse posterior hypothalamus...
  58. pmc Modafinil and γ-hydroxybutyrate have sleep state-specific pharmacological actions on hypocretin-1 physiology in a primate model of human sleep
    Jamie M Zeitzer
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, USA
    Behav Pharmacol 20:643-52. 2009
    ..Furthermore, hypocretin neurons do not seem to respond to an 'effort' to remain awake, but rather keep track of time spent awake as a wake-promoting counterbalance to extended wakefulness...
  59. ncbi request reprint Increasing length of wakefulness and modulation of hypocretin-1 in the wake-consolidated squirrel monkey
    Jamie M Zeitzer
    Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1736-42. 2007
    ..Concomitants of wakefulness that affect hypocretin-1 in polyphasic species, such as locomotion, food intake, and food deprivation, likely have a more minor role in monophasic species, such as humans...
  60. pmc T-box 3 is expressed in the adult mouse hypothalamus and medulla
    Krister S Eriksson
    Center for Narcolepsy, Stanford University, Palo Alto, CA 94304 5742, USA
    Brain Res 1302:233-9. 2009
    ....
  61. ncbi request reprint The neurobiology of hypocretins (orexins), narcolepsy and related therapeutic interventions
    Jamie M Zeitzer
    Department of Psychiatry, Stanford University, 701 B Welch Road, Palo Alto, CA 94304, USA
    Trends Pharmacol Sci 27:368-74. 2006
    ..Hypocretin receptor agonists are likely to be ideal therapeutic options for hypocretin-deficient narcolepsy but such compounds are still not available in humans...
  62. doi request reprint Resting our cortices by going DOWN to sleep
    Emmanuel Mignot
    Stanford University Center for Narcolepsy, Palo Alto, CA 94304 5742, USA
    Neuron 63:719-21. 2009
    ..Sleep debt may be integrated at the level of individual cortical neurons, providing support for the synaptic homeostasis theory...
  63. pmc A circadian sleep disorder reveals a complex clock
    Emmanuel Mignot
    Howard Hughes Medical Institute, Stanford University School of Medicine, 701 B Welch Road, Stanford, CA 94304, USA
    Cell 128:22-3. 2007
    ..Their results reveal that PER2 phosphorylation, by CK1delta and other kinases, is surprisingly complex and has opposite effects on PER2 levels and period length...
  64. ncbi request reprint Correlates of sleep-onset REM periods during the Multiple Sleep Latency Test in community adults
    Emmanuel Mignot
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA
    Brain 129:1609-23. 2006
    ..These results suggest a high prevalence of narcolepsy without cataplexy, as defined by the International Classification of Sleep Disorders, and/or a large number of false-positives for the MSLT...
  65. ncbi request reprint A year in review--basic science, narcolepsy, and sleep in neurologic diseases
    Emmanuel Mignot
    Center for Narcolepsy, Stanford University School of Medicine, CA 94304, USA
    Sleep 27:1209-12. 2004
  66. ncbi request reprint CSF hypocretin-1 levels in schizophrenics and controls: relationship to sleep architecture
    Seiji Nishino
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94305, USA
    Psychiatry Res 110:1-7. 2002
    ..Further studies of whether CNS hypocretin neurotransmission is involved in sleep and neuroendocrine abnormalities seen in patients with schizophrenia and other psychiatric conditions are warranted...
  67. ncbi request reprint The role of hypocretins (orexins) in sleep regulation and narcolepsy
    Shahrad Taheri
    Stanford University Center for Narcolepsy, 701 Welch Road B, Basement, Palo Alto, California 94304 5742, USA
    Annu Rev Neurosci 25:283-313. 2002
    ..The aim of this review is to describe and discuss the current knowledge regarding the hypocretin neurotransmitter system in narcolepsy and normal sleep...
  68. ncbi request reprint Sleeping with the hypothalamus: emerging therapeutic targets for sleep disorders
    Emmanuel Mignot
    Stanford University Center for Narcolepsy, 701 Welch Road B, Room 145, Palo Alto, California 94304 5742, USA
    Nat Neurosci 5:1071-5. 2002
    ..Here we highlight the role of the hypothalamus in sleep physiology and discuss neurotransmitter systems, such as adenosine, dopamine, GABA, histamine and hypocretin, that may have therapeutic applications for sleep disorders...
  69. ncbi request reprint Report of a case of immunosuppression with prednisone in an 8-year-old boy with an acute onset of hypocretin-deficiency narcolepsy
    Marketa Hecht
    Center for Narcolepsy, Department of Pediatrics, Stanford University School of Medicine, Stanford, Calif, USA
    Sleep 26:809-10. 2003
    ..To explore whether acute destruction of hypocretin cells in a patient with narcolepsy could be detected and if the course of the disease could be reversed or altered by the use of prednisone for immunosuppression...
  70. ncbi request reprint Cerebrospinal fluid prostaglandins and corticotropin releasing factor in schizophrenics and controls: relationship to sleep architecture
    S Nishino
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94305, USA
    Psychiatry Res 78:141-50. 1998
    ..These results do not favor the hypothesis of a role for CRF or PGs in the pathophysiology of sleep disturbances in schizophrenia...
  71. ncbi request reprint Stability of cataplexy over several months--information for the design of therapeutic trials
    M Gelb
    Center for Narcolepsy, Stanford University Sleep Research Center, Palo Alto, California 94304
    Sleep 17:265-73. 1994
    ..The finding of a long-lasting "precataplectic" feeling or "aura" pointed to the need to carefully clarify the symptom prior to beginning a therapeutic trial...
  72. ncbi request reprint Validation of a cataplexy questionnaire in 983 sleep-disorders patients
    S Anic-Labat
    Stanford University, Center for Narcolepsy, Department of Psychiatry and Behavioral Sciences, CA 94305, USA
    Sleep 22:77-87. 1999
    ..7%) and low-(0.6%) risk groups for cataplexy. This questionnaire will be used to increase diagnostic consistency across clinical centers, thus providing more homogenous subject pools for clinical and basic research studies...
  73. ncbi request reprint Drug treatment of patients with insomnia and excessive daytime sleepiness: pharmacokinetic considerations
    S Nishino
    Stanford Center for Narcolepsy, Stanford University, School of Medicine, Palo Alto, California 94304, USA
    Clin Pharmacokinet 37:305-30. 1999
    ..In this review, we will introduce recently obtained knowledge of the pharmacokinetics of hypnosedatives and CNS stimulants and their applications for patients affected with insomnia and EDS...
  74. doi request reprint Kleine-Levin syndrome: a systematic study of 108 patients
    Isabelle Arnulf
    Stanford Center for Narcolepsy and Howard Hughes Medical Institute, Stanford University, Palo Alto, CA, USA
    Ann Neurol 63:482-93. 2008
    ..Kleine-Levin syndrome is a rare disorder characterized by relapsing-remitting episodes of hypersomnia, cognitive disturbances, and behavioral disturbances, such as hyperphagia and hypersexuality...
  75. pmc Elevated anti-streptococcal antibodies in patients with recent narcolepsy onset
    Adi Aran
    Center for Sleep Sciences and Department of Psychiatry, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Sleep 32:979-83. 2009
    ..This study evaluated whether Streptococcus pyogenes and Helicobacter pylori infections are triggers for narcolepsy...
  76. doi request reprint Sleep and EEG features in genetic models of Down syndrome
    Damien Colas
    Center for Narcolepsy, Department of Psychiatry and Behavioral Sciences, Stanford, CA 94305, USA
    Neurobiol Dis 30:1-7. 2008
    ..These results demonstrate abnormalities in sleep and EEG in Ts65Dn mice and underscore a possible correlation between App overexpression and hippocampal theta oscillations...
  77. pmc Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index
    Shahrad Taheri
    Howard Hughes Medical Institute, Stanford University, Palo Alto, California, USA
    PLoS Med 1:e62. 2004
    ..An association between short habitual sleep time and increased body mass index (BMI) has been reported in large population samples. The potential role of metabolic hormones in this association is unknown...
  78. ncbi request reprint Genomic and functional conservation of sedative-hypnotic targets in the zebrafish
    Corinne Renier
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California, USA
    Pharmacogenet Genomics 17:237-53. 2007
    ..We investigated the effects of sedative hypnotics commonly used in humans on zebrafish locomotor activity and identified the corresponding genomic and receptor binding targets...
  79. doi request reprint CSF hypocretin-1 assessment in sleep and neurological disorders
    Patrice Bourgin
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA
    Lancet Neurol 7:649-62. 2008
    ..Although hypocretin-1 deficiency in narcolepsy might have therapeutic relevance, additional research is needed in this area...
  80. ncbi request reprint Comparative expression of p2x receptors and ecto-nucleoside triphosphate diphosphohydrolase 3 in hypocretin and sensory neurons in zebrafish
    Lior Appelbaum
    Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA 94305, USA
    Brain Res 1174:66-75. 2007
    ..The conservation of expression of these genes in HCRT cells and sensory neurons across vertebrates suggests an important role for ATP mediated transmission in the regulation of sleep and the processing of sensory inputs...
  81. pmc Characterization of two melanin-concentrating hormone genes in zebrafish reveals evolutionary and physiological links with the mammalian MCH system
    Jennifer R Berman
    Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, California 94304, USA
    J Comp Neurol 517:695-710. 2009
    ..These findings demonstrate that zebrafish MCH2 is the putative structural and functional ortholog of mammalian MCH and help elucidate the nature of MCH evolution among vertebrates...
  82. pmc Narcolepsy is strongly associated with the T-cell receptor alpha locus
    Joachim Hallmayer
    Center for Sleep Sciences, Stanford University School of Medicine, Palo Alto, California, USA
    Nat Genet 41:708-11. 2009
    ....
  83. pmc Anti-Tribbles homolog 2 (TRIB2) autoantibodies in narcolepsy are associated with recent onset of cataplexy
    Minae Kawashima
    Center for Narcolepsy, Stanford University School of Medicine, 701 B Welch Road, Palo Alto, CA 94304, USA
    Sleep 33:869-74. 2010
    ..Recent studies have found increased autoantibodies against Tribbles homolog 2 (anti-TRIB2) and anti-streptolysin O (ASO) in narcolepsy. In this study, we replicated this finding with a primary focus on recent onset cases...
  84. ncbi request reprint Kleine-Levin syndrome: a systematic review of 186 cases in the literature
    I Arnulf
    Stanford University Center for Narcolepsy, Palo Alto, CA, USA
    Brain 128:2763-76. 2005
    ..In conclusion, KLS is a unique disease which may be more severe in female and secondary cases...
  85. ncbi request reprint Construction and characterization of an eightfold redundant dog genomic bacterial artificial chromosome library
    R Li
    Stanford Center for Narcolepsy Research, 1201 Welch Road, Room P 112, Stanford, California 94305 5485, USA
    Genomics 58:9-17. 1999
    ..The library was hybridized with dog PCR products representing eight genes (ADA, TNFA, GCA, MYB, HOXA, GUSB, THY1, and TOP1). The resulting positive clones were characterized and shown to be compatible with an eightfold redundant library...
  86. ncbi request reprint A CLOCK polymorphism associated with human diurnal preference
    D Katzenberg
    Department of Psychiatry and Behavioral Sciences, Stanford University Sleep Disorders Center, Palo Alto, Calif, USA
    Sleep 21:569-76. 1998
    ..We suggest that the identified polymorphism or another tightly linked polymorphism within the CLOCK gene or its regulatory elements may be responsible for the finding...
  87. ncbi request reprint The roles of midbrain and diencephalic dopamine cell groups in the regulation of cataplexy in narcoleptic Dobermans
    Mutsumi Okura
    Center for Narcolepsy, Stanford Sleep Center, Stanford University School of Medicine, Palo Alto, CA 94304 5485, USA
    Neurobiol Dis 16:274-82. 2004
    ..e., autoreceptors) for the regulation of cataplexy. Because the A11 cell group projects to the spinal ventral horn, the A11 D(2/3) receptive mechanisms may directly modulate the activity of spinal motoneurons and modulate cataplexy...
  88. ncbi request reprint Regulation of hypocretin (orexin) expression in embryonic zebrafish
    Juliette H Faraco
    Stanford University Center for Narcolepsy, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California 94305, USA
    J Biol Chem 281:29753-61. 2006
    ..A critical region of 250 base pairs was identified containing a core 13-base pair element essential for hypocretin expression...
  89. ncbi request reprint The genetics of sleep disorders
    Shahrad Taheri
    Stanford University Center for Narcolepsy, Palo Alto, CA 94304 5742, USA
    Lancet Neurol 1:242-50. 2002
    ..The aim of this review is to discuss the current knowledge on the role of genetic factors in sleep disorders, in particular circadian disorders, narcolepsy, restless-legs syndrome, and OSAS...
  90. ncbi request reprint Analysis of onset location, laterality and propagation of cataplexy in canine narcolepsy
    Nobuhiro Fujiki
    Center for Narcolepsy, Stanford University School of Medicine, Palo Alto 94304, United States of America
    Psychiatry Clin Neurosci 56:275-6. 2002
    ..Involvement of abnormal inactivation of bilateral pathways to the spinal motoneurones due to a deficiency in hypocretin neurotransmission is suggested in the occurrence of cataplexy...
  91. ncbi request reprint REM behavior disorder (RBD) can be one of the first symptoms of childhood narcolepsy
    Sona Nevsimalova
    Department of Neurology, 1st Medical Faculty, Charles University, Prague, Czech Republic
    Sleep Med 8:784-6. 2007
    ..Both girls were human leukocyte antigen (HLA)-DQB1 *0602 positive, and their cerebrospinal fluid (CSF) hypocretin level (Hcrt-1) was extremely low...
  92. ncbi request reprint Transient total sleep loss in cerebral Whipple's disease: a longitudinal study
    Ulrich Voderholzer
    Department of Psychiatry and Psychotherapy, University of Freiburg, Freiburg, Germany
    J Sleep Res 11:321-9. 2002
    ..The extent of sleep disruption in this case of organic insomnia was similar to cases of familial fatal insomnia, but was at least partially reversible with treatment...
  93. ncbi request reprint The association of angiotensin converting enzyme (ACE) polymorphisms with sleep apnea and hypertension
    Sanjay R Patel
    Division of Pulmonary, Critical Care and Sleep Medicine, University Hospital and Case Western Reserve University, Cleveland, OH, USA
    Sleep 30:531-3. 2007
    ..To identify the role of polymorphisms in the angiotensin-converting enzyme (ACE) gene in modulating susceptibility to hypertension in sleep apnea...
  94. ncbi request reprint HLA and hypocretin studies in Korean patients with narcolepsy
    Seung Chul Hong
    Department of Neuropsychiatry, St Vincent s Hospital, Catholic University of Korea, Suwon
    Sleep 25:440-4. 2002
    ..Very few studies have evaluated narcolepsy in Asian countries, outside of Japan. Our goal was to study narcolepsy at the genetic, clinical and pathophysiological level in Korea...
  95. pmc Association of narcolepsy-cataplexy with HLA-DRB1 and DQB1 in Mexican patients: a relationship between HLA and gender is suggested
    Carmen Alaez
    Department of Immunology and Immunogenetics, INDRE, Mexico City, Mexico
    BMC Med Genet 9:79. 2008
    ..The purpose of the present study was to investigate the association of HLA class II DRB1/DQB1 alleles with narcolepsy-cataplexy in Mexican Mestizo patients...
  96. doi request reprint Excessive daytime sleepiness: population and etiology versus nosology
    Emmanuel Mignot
    Sleep Med Rev 12:87-94. 2008
  97. ncbi request reprint Normal CSF hypocretin-1 (orexin A) levels in dementia with Lewy bodies associated with excessive daytime sleepiness
    Christian R Baumann
    Neurology Department, University Hospital, Zurich, Switzerland
    Eur Neurol 52:73-6. 2004
    ..In DLB, excessive daytime sleepiness, hallucinations and REM sleep behavior may occur in the absence of a detectable hypocretin deficiency...
  98. ncbi request reprint Analysis of extended HLA haplotypes in multiple sclerosis and narcolepsy families confirms a predisposing effect for the class I region in Tasmanian MS patients
    Justin P Rubio
    The Neurogenetics Laboratory, The Howard Florey Institute, University of Melbourne, Melbourne, Victoria, Australia
    Immunogenetics 59:177-86. 2007
    ..0006; OR 2.83 [1.54-5.19]). Together, these data confirm that an alternate MS risk locus exists in the extended class I region in Tasmanian MS patients independent of DRB1*15...
  99. ncbi request reprint Normal cerebrospinal fluid levels of hypocretin-1 (orexin A) in patients with fibromyalgia syndrome
    Oludare B Taiwo
    University of Minnesota, Department of Veterinary and Biomedical Sciences, Rm 295, Animal Science Veterinary Medicine Building, 1988 Fitch Avenue, St Paul, MN 55113, USA
    Sleep Med 8:260-5. 2007
    ..Cerebrospinal fluid (CSF) hypocretin-1 (Hcrt-1) concentrations are low in patients with narcolepsy-cataplexy, a sleep disorder characterized by hypersomnolence and rapid eye movement (REM) sleep abnormalities...
  100. ncbi request reprint Sodium oxybate for excessive daytime sleepiness in narcolepsy-cataplexy
    Isabelle Arnulf
    Sleep 27:1242-3. 2004
  101. ncbi request reprint Effect of the prion 129 polymorphism on nocturnal sleep and insomnia complaints: a population-based study
    Mario Pedrazzoli
    J Sleep Res 11:357-8. 2002