E Mignot

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint A year in review--basic science, narcolepsy, and sleep in neurologic diseases
    Emmanuel Mignot
    Center for Narcolepsy, Stanford University School of Medicine, CA 94304, USA
    Sleep 27:1209-12. 2004
  2. pmc History of narcolepsy at Stanford University
    Emmanuel J M Mignot
    Stanford University Center for Sleep Sciences, 3165 Porter Drive, 2178, Palo Alto, CA, 94304, USA
    Immunol Res 58:315-39. 2014
  3. pmc Narcolepsy is strongly associated with the T-cell receptor alpha locus
    Joachim Hallmayer
    Center for Sleep Sciences, Stanford University School of Medicine, Palo Alto, California, USA
    Nat Genet 41:708-11. 2009
  4. pmc ImmunoChip study implicates antigen presentation to T cells in narcolepsy
    Juliette Faraco
    Center for Sleep Sciences and Medicine, Stanford University, Palo Alto, California, USA
    PLoS Genet 9:e1003270. 2013
  5. pmc Post-streptococcal antibodies are associated with metabolic syndrome in a population-based cohort
    Adi Aran
    Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, United States of America
    PLoS ONE 6:e25017. 2011
  6. pmc Common variants in P2RY11 are associated with narcolepsy
    Birgitte R Kornum
    Center for Sleep Sciences and Department of Psychiatry, Stanford University School of Medicine, Palo Alto, California, USA
    Nat Genet 43:66-71. 2011
  7. pmc Post-streptococcal auto-antibodies inhibit protein disulfide isomerase and are associated with insulin resistance
    Adi Aran
    Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, United States of America
    PLoS ONE 5:e12875. 2010
  8. pmc A practical guide to the therapy of narcolepsy and hypersomnia syndromes
    Emmanuel J M Mignot
    Stanford Center for Sleep Sciences and Medicine, Stanford University Medical School, Palo Alto, CA 94304, USA
    Neurotherapeutics 9:739-52. 2012
  9. pmc The type III neurofilament peripherin is expressed in the tuberomammillary neurons of the mouse
    Krister S Eriksson
    Psychiatry and Behavioural Sciences, Stanford University, Palo Alto, CA, USA
    BMC Neurosci 9:26. 2008
  10. pmc Reduced expression of TAC1, PENK and SOCS2 in Hcrtr-2 mutated narcoleptic dog brain
    Julia Lindberg
    Evolutionary Biology Centre, Department of Evolution, Genomics and Systematics, Uppsala University, Norbyvagen 18D, Uppsala, Sweden
    BMC Neurosci 8:34. 2007

Research Grants

  1. SLEEP HOMEOSTASIS AND STIMULANT DRUGS OF ABUSE
    Emmanuel Mignot; Fiscal Year: 2002
  2. CENTER FOR NARCOLEPSY AND RELATED DISORDERS
    Emmanuel Mignot; Fiscal Year: 2007
  3. Molecular Genetics of Kleine-Levin Syndrome
    Emmanuel Mignot; Fiscal Year: 2007
  4. Sleep promotion in zebrafish by hypocretin neuronal networks
    Emmanuel J Mignot; Fiscal Year: 2010
  5. SLEEP HOMEOSTASIS AND STIMULANT DRUGS OF ABUSE
    Emmanuel Mignot; Fiscal Year: 2000
  6. Sleep promotion in zebrafish by hypocretin neuronal networks
    Emmanuel Mignot; Fiscal Year: 2009
  7. Molecular Genetics of Kleine-Levin Syndrome
    Emmanuel Mignot; Fiscal Year: 2009
  8. Role of Hypocretin in Metabolic Effects of Sleep Loss
    Emmanuel Mignot; Fiscal Year: 2007
  9. SLEEP HOMEOSTASIS AND STIMULANT DRUGS OF ABUSE
    Emmanuel Mignot; Fiscal Year: 2001
  10. Sleep Disordered Breathing, APOE and Lipid Metabolism
    Emmanuel Mignot; Fiscal Year: 2002

Collaborators

Detail Information

Publications66

  1. ncbi request reprint A year in review--basic science, narcolepsy, and sleep in neurologic diseases
    Emmanuel Mignot
    Center for Narcolepsy, Stanford University School of Medicine, CA 94304, USA
    Sleep 27:1209-12. 2004
  2. pmc History of narcolepsy at Stanford University
    Emmanuel J M Mignot
    Stanford University Center for Sleep Sciences, 3165 Porter Drive, 2178, Palo Alto, CA, 94304, USA
    Immunol Res 58:315-39. 2014
    ....
  3. pmc Narcolepsy is strongly associated with the T-cell receptor alpha locus
    Joachim Hallmayer
    Center for Sleep Sciences, Stanford University School of Medicine, Palo Alto, California, USA
    Nat Genet 41:708-11. 2009
    ....
  4. pmc ImmunoChip study implicates antigen presentation to T cells in narcolepsy
    Juliette Faraco
    Center for Sleep Sciences and Medicine, Stanford University, Palo Alto, California, USA
    PLoS Genet 9:e1003270. 2013
    ..These findings underline the importance of antigen presentation by HLA Class II to T cells in the pathophysiology of this autoimmune disease...
  5. pmc Post-streptococcal antibodies are associated with metabolic syndrome in a population-based cohort
    Adi Aran
    Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, United States of America
    PLoS ONE 6:e25017. 2011
    ..This led us to evaluate associations between post-streptococcal antibodies and metabolic syndrome, as defined by the updated National Cholesterol Education Program definition, 2005...
  6. pmc Common variants in P2RY11 are associated with narcolepsy
    Birgitte R Kornum
    Center for Sleep Sciences and Department of Psychiatry, Stanford University School of Medicine, Palo Alto, California, USA
    Nat Genet 43:66-71. 2011
    ..0007) and natural killer cells (P = 0.001). These results identify P2RY11 as an important regulator of immune-cell survival, with possible implications in narcolepsy and other autoimmune diseases...
  7. pmc Post-streptococcal auto-antibodies inhibit protein disulfide isomerase and are associated with insulin resistance
    Adi Aran
    Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, United States of America
    PLoS ONE 5:e12875. 2010
    ..1 vs. 3.1, n = 1215, p = 0.004), in a population-based cohort. These results identify PDI as a major target of post-streptococcal autoimmunity, and establish a new link between infection, autoimmunity, and metabolic disturbances...
  8. pmc A practical guide to the therapy of narcolepsy and hypersomnia syndromes
    Emmanuel J M Mignot
    Stanford Center for Sleep Sciences and Medicine, Stanford University Medical School, Palo Alto, CA 94304, USA
    Neurotherapeutics 9:739-52. 2012
    ..Kleine-Levin Syndrome is usually best left untreated, although lithium can be considered in severe cases with frequent episodes. Guidelines are provided based on the literature and personal experience of the author...
  9. pmc The type III neurofilament peripherin is expressed in the tuberomammillary neurons of the mouse
    Krister S Eriksson
    Psychiatry and Behavioural Sciences, Stanford University, Palo Alto, CA, USA
    BMC Neurosci 9:26. 2008
    ..We noticed high peripherin expression in the posterior hypothalamus of mice, and decided to investigate further the exact location of expression and function of peripherin in the mouse posterior hypothalamus...
  10. pmc Reduced expression of TAC1, PENK and SOCS2 in Hcrtr-2 mutated narcoleptic dog brain
    Julia Lindberg
    Evolutionary Biology Centre, Department of Evolution, Genomics and Systematics, Uppsala University, Norbyvagen 18D, Uppsala, Sweden
    BMC Neurosci 8:34. 2007
    ..However, little is known about molecular alterations downstream of the hypocretin signals...
  11. pmc Association of narcolepsy-cataplexy with HLA-DRB1 and DQB1 in Mexican patients: a relationship between HLA and gender is suggested
    Carmen Alaez
    Department of Immunology and Immunogenetics, INDRE, Mexico City, Mexico
    BMC Med Genet 9:79. 2008
    ..The purpose of the present study was to investigate the association of HLA class II DRB1/DQB1 alleles with narcolepsy-cataplexy in Mexican Mestizo patients...
  12. ncbi request reprint Sleep, sleep disorders and hypocretin (orexin)
    Emmanuel Mignot
    Stanford University Center for Narcolepsy, Palo Alto, CA 94304 5742, USA
    Sleep Med 5:S2-8. 2004
    ..Abnormal Hcrt transmission is also found in neurologic disorders featuring excessive daytime sleepiness and/or hypothalamic abnormalities. Pharmacologic manipulations of Hcrts may have multiple therapeutic applications...
  13. ncbi request reprint Correlates of sleep-onset REM periods during the Multiple Sleep Latency Test in community adults
    Emmanuel Mignot
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA
    Brain 129:1609-23. 2006
    ..These results suggest a high prevalence of narcolepsy without cataplexy, as defined by the International Classification of Sleep Disorders, and/or a large number of false-positives for the MSLT...
  14. ncbi request reprint Sleeping with the hypothalamus: emerging therapeutic targets for sleep disorders
    Emmanuel Mignot
    Stanford University Center for Narcolepsy, 701 Welch Road B, Room 145, Palo Alto, California 94304 5742, USA
    Nat Neurosci 5:1071-5. 2002
    ..Here we highlight the role of the hypothalamus in sleep physiology and discuss neurotransmitter systems, such as adenosine, dopamine, GABA, histamine and hypocretin, that may have therapeutic applications for sleep disorders...
  15. ncbi request reprint A commentary on the neurobiology of the hypocretin/orexin system
    E Mignot
    Stanford Center for Narcolepsy, Department of Psychiatry and Behavioral Sciences, 1201 Welch Road, P 114, Palo Alto, CA 94305 5485, USA
    Neuropsychopharmacology 25:S5-13. 2001
    ..The potential role of this system in regulating the sleep cycle, modulating wakefulness at selected circadian times and in mediating the deleterious effects of sleep deprivation is discussed...
  16. pmc A circadian sleep disorder reveals a complex clock
    Emmanuel Mignot
    Howard Hughes Medical Institute, Stanford University School of Medicine, 701 B Welch Road, Stanford, CA 94304, USA
    Cell 128:22-3. 2007
    ..Their results reveal that PER2 phosphorylation, by CK1delta and other kinases, is surprisingly complex and has opposite effects on PER2 levels and period length...
  17. pmc Why we sleep: the temporal organization of recovery
    Emmanuel Mignot
    Howard Hughes Medical Institute and Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, United States of America
    PLoS Biol 6:e106. 2008
  18. doi request reprint Resting our cortices by going DOWN to sleep
    Emmanuel Mignot
    Stanford University Center for Narcolepsy, Palo Alto, CA 94304 5742, USA
    Neuron 63:719-21. 2009
    ..Sleep debt may be integrated at the level of individual cortical neurons, providing support for the synaptic homeostasis theory...
  19. ncbi request reprint Dopaminergic role in stimulant-induced wakefulness
    J P Wisor
    Sleep Disorders Research Center, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosci 21:1787-94. 2001
    ..Thus, dopamine transporters play an important role in sleep regulation and are necessary for the specific wake-promoting action of amphetamines and modafinil...
  20. ncbi request reprint Fluctuation of extracellular hypocretin-1 (orexin A) levels in the rat in relation to the light-dark cycle and sleep-wake activities
    Y Yoshida
    Stanford University Center for Narcolepsy, 701B Welch Rd, 1st Floor, Palo Alto, CA 94304, USA
    Eur J Neurosci 14:1075-81. 2001
    ....
  21. ncbi request reprint Low cerebrospinal fluid hypocretin (Orexin) and altered energy homeostasis in human narcolepsy
    S Nishino
    Stanford University Center for Narcolepsy, Palo Alto, CA 94304, USA
    Ann Neurol 50:381-8. 2001
    ..Increased BMI and leptin indicate altered energy homeostasis. Sleep and energy metabolism are likely to be functionally connected through the hypocretin system...
  22. ncbi request reprint Polymorphisms in the vicinity of the hypocretin/orexin are not associated with human narcolepsy
    M Hungs
    Stanford Center for Narcolepsy, Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, CA 94305 5485, USA
    Neurology 57:1893-5. 2001
    ..None of the subjects carried -22T, a rare 5'UTR polymorphism previously reported to be associated with narcolepsy. The HCRT locus is not a major narcolepsy susceptibility locus...
  23. ncbi request reprint Physical and radiation hybrid mapping of canine chromosome 12, in a region corresponding to human chromosome 6p12-q12
    R Li
    Room P 114, Stanford Center for Narcolepsy Research, 1201 Welch Road, Stanford, California 94305 5485, USA
    Genomics 73:299-315. 2001
    ..These data further establish the dog as a system for studying disease genes of interest to human populations and highlight feasible approaches for positional cloning of disease genes in organisms where genomic resources are limited...
  24. ncbi request reprint Hypocretin/orexin, sleep and narcolepsy
    M Hungs
    Stanford Center for Narcolepsy, Department of Psychiatry Behavioral Sciences, Stanford University Medical Center, Palo Alto, CA 94305 5485, USA
    Bioessays 23:397-408. 2001
    ..Other functions are suggested by pharmacological and neurochemical experiments. These include regulation of food intake, neuroendocrine function, autonomic nervous system activity and energy balance...
  25. pmc The development of hypocretin (orexin) deficiency in hypocretin/ataxin-3 transgenic rats
    S Zhang
    Stanford University, 701 Welch Road, Room 145, Palo Alto, CA 94304 5742, USA
    Neuroscience 148:34-43. 2007
    ..The low output of these neurons is consistent with a widespread dysfunction of these neurons, and establishes this model as a tool to investigate the consequences of partial hypocretin deficiency...
  26. ncbi request reprint DQB1*0602 and DQA1*0102 (DQ1) are better markers than DR2 for narcolepsy in Caucasian and black Americans
    E Mignot
    Stanford University, School of Medicine, Sleep Disorders Center, Palo Alto, California
    Sleep 17:S60-7. 1994
    ..These results demonstrate that DQB1*0602/DQA1*0102 is the best marker for narcolepsy across all ethnic groups...
  27. doi request reprint Effects of sleep on the cardiovascular and thermoregulatory systems: a possible role for hypocretins
    H Schwimmer
    Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, California, USA
    J Appl Physiol (1985) 109:1053-63. 2010
    ..Thus, while hypocretins are critical for the normal temporal structure of sleep and wakefulness, they also appear to be important in regulating baseline blood pressure and possibly in modulating the effects of sleep on blood pressure...
  28. ncbi request reprint Hypocretin levels in sporadic and familial cases of canine narcolepsy
    B Ripley
    Center for Narcolepsy, Stanford Sleep Center, Stanford University School of Medicine, Palo Alto, California 94304, USA
    Neurobiol Dis 8:525-34. 2001
    ..The presence of hypocretin peptides in Hcrtr 2-mutated animals suggests that neurotransmission through Hcrtr 1 may be intact, arguing for a preferential importance of Hcrtr 2-mediated function in narcolepsy...
  29. ncbi request reprint Narcoleptic canines display periodic leg movements during sleep
    M Okura
    Center for Narcolepsy, Sleep Research Center, Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, California, USA
    Psychiatry Clin Neurosci 55:243-4. 2001
    ..Our canines may therefore be an invaluable resource in PLMS research...
  30. ncbi request reprint Narcolepsy and the HLA region
    L Lin
    Department of Psychiatry and Behavioral Sciences, Stanford Center for Narcolepsy, Stanford University Medical Center, 1201 Welch Road, P-114, Palo Alto, CA 94305-5485, USA
    J Neuroimmunol 117:9-20. 2001
    ..This data is consistent with an immune destruction of hypocretin-containing cells as the most common etiology for human narcolepsy...
  31. pmc Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups
    E Mignot
    Center for Narcolepsy, Stanford University, Department of Psychiatry and Behavioral Sciences, Palo Alto, CA 94304, USA
    Am J Hum Genet 68:686-99. 2001
    ..Together with the recent hypocretin discoveries, these findings are consistent with an immunologically mediated destruction of hypocretin-containing cells in human narcolepsy-cataplexy...
  32. ncbi request reprint A polymorphism in the human timeless gene is not associated with diurnal preferences in normal adults
    M Pedrazzoli
    Center for Narcolepsy, Department of Psychiatry, Stanford University, California, USA
    Sleep Res Online 3:73-6. 2000
    ..Our results indicate that Q831R Timeless has no influence on morningness- eveningness tendencies in humans...
  33. ncbi request reprint A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
    C Peyron
    Center for Narcolepsy, Stanford University Medical School 1201 Welch Road, Stanford, California 94305 5485, USA
    Nat Med 6:991-7. 2000
    ..Although hypocretin loci do not contribute significantly to genetic predisposition, most cases of human narcolepsy are associated with a deficient hypocretin system...
  34. ncbi request reprint Neuropharmacology and neurochemistry of canine narcolepsy
    S Nishino
    Sleep Research Center, Stanford University School of Medicine, Palo Alto, California
    Sleep 17:S84-92. 1994
    ....
  35. ncbi request reprint Decreased brain histamine content in hypocretin/orexin receptor-2 mutated narcoleptic dogs
    S Nishino
    Stanford University Center for Narcolepsy, 701B, First Floor, Palo Alto, CA 94304, USA
    Neurosci Lett 313:125-8. 2001
    ..Considering the fact that histamine promotes wakefulness, decreases in histaminergic neurotransmission may also account for the sleep abnormalities in hypocretin-deficient narcolepsy...
  36. ncbi request reprint The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene
    L Lin
    Center for Narcolepsy, Department of Psychiatry, Stanford University School of Medicine, California 94305 5485, USA
    Cell 98:365-76. 1999
    ..This result identifies hypocretins as major sleep-modulating neurotransmitters and opens novel potential therapeutic approaches for narcoleptic patients...
  37. ncbi request reprint Identification and functional analysis of mutations in the hypocretin (orexin) genes of narcoleptic canines
    M Hungs
    Stanford Center for Narcolepsy, Stanford University Medical Center, Department of Psychiatry and Behavioral Sciences, Palo Alto, California 94304 5485, USA
    Genome Res 11:531-9. 2001
    ..These results are consistent with a loss of function for all three mutations. The absence of mutation in sporadic cases also indicates genetic heterogeneity in canine narcolepsy, as reported previously in humans...
  38. ncbi request reprint CSF hypocretin/orexin levels in narcolepsy and other neurological conditions
    B Ripley
    Stanford University Center for Narcolepsy, Palo Alto, CA 94304, USA
    Neurology 57:2253-8. 2001
    ..Future research in this area is needed to establish functional significance...
  39. ncbi request reprint Changes in CSF hypocretin-1 (orexin A) levels in rats across 24 hours and in response to food deprivation
    N Fujiki
    Stanford University Center for Narcolepsy, Palo Alto, CA 94304 USA
    Neuroreport 12:993-7. 2001
    ..These results indicate an important link between circadian control of sleep and energy homeostasis via the hypocretin system...
  40. ncbi request reprint An immunoglobulin switchlike sequence is linked with canine narcolepsy
    E Mignot
    Stanford University, School of Medicine, Sleep Disorders Center, Palo Alto, California
    Sleep 17:S68-76. 1994
    ..We are now using chromosome walking and Yeast Artificial Chromosome Cloning techniques, together with corresponding studies in humans to identify the pathological gene...
  41. ncbi request reprint Comparative effects of modafinil and amphetamine on daytime sleepiness and cataplexy of narcoleptic dogs
    J Shelton
    Sleep Research Center, Stanford University School of Medicine, Palo Alto, California 94304, USA
    Sleep 18:817-26. 1995
    ..This finding is consistent with the data collected in human narcolepsy and validates the use of this canine model for the screening of stimulant compounds...
  42. ncbi request reprint HLA DQB1*0602 is associated with cataplexy in 509 narcoleptic patients
    E Mignot
    Stanford Center for Narcolepsy, Palo Alto, CA 94301, USA
    Sleep 20:1012-20. 1997
    ..These results could be explained by increased disease heterogeneity in the noncataplexy group or by a direct effect of the HLA DQB1*0602 genotype on the clinical expression of narcolepsy...
  43. ncbi request reprint Mesopontine organization of cholinergic and catecholaminergic cell groups in the normal and narcoleptic dog
    M Tafti
    Center for Narcolepsy Research, Stanford University, Palo Alto, California 94304, USA
    J Comp Neurol 379:185-97. 1997
    ..In conclusion, the present results do not support the hypothesis that the neurochemical imbalance in narcolepsy could result from abnormal organization, numbers, or ratio of the corresponding neuronal populations...
  44. ncbi request reprint DQB1-0602 (DQw1) is not present in most nonDR2 Caucasian narcoleptics
    E Mignot
    Stanford University, School of Medicine, Sleep Disorders Center, Palo Alto, California 94304
    Sleep 15:415-22. 1992
    ..Further studies with more patients are warranted to exclude the possibility that a few caucasian patients carry rare haplotypes with DQB1-0602 independently of DR2...
  45. ncbi request reprint Nocturnal sleep and daytime sleepiness in normal subjects with HLA-DQB1*0602
    E Mignot
    Stanford University, Department of Psychiatry and Behavioral Sciences, CA 94305-5485, USA
    Sleep 22:347-52. 1999
    ..These results support the hypothesis that polymorphisms at the level of HLA DQ modulates sleep tendencies in humans...
  46. ncbi request reprint Cholinergic regulation of cataplexy in canine narcolepsy in the pontine reticular formation is mediated by M2 muscarinic receptors
    M S Reid
    Stanford University, Sleep Disorders Research Center, Palo Alto, California 94304
    Sleep 17:424-35. 1994
    ..The effects of muscimol indicate that the stimulation of cataplexy might be elicited by local neuronal inhibition...
  47. ncbi request reprint Measurement of hypocretin/orexin content in the mouse brain using an enzyme immunoassay: the effect of circadian time, age and genetic background
    L Lin
    Department of Psychiatry and Behavior Sciences, Center for Narcolepsy and Sleep Disorder, Stanford University, Palo Alto, CA 94304 5742, USA
    Peptides 23:2203-11. 2002
    ..Compared to controls, only histamine receptor knockouts had lower hypocretin levels. This was most pronounced in H1 receptor knockouts suggesting the existence of a positive feedback loop between hypocretin and histaminergic neurons...
  48. ncbi request reprint Circadian distribution of rest/activity in narcoleptic and control dogs: assessment with ambulatory activity monitoring
    S Nishino
    Sleep Disorders Center, Stanford University School of Medicine, CA, USA
    J Sleep Res 6:120-7. 1997
    ..Ambulatory activity monitoring may be a useful non-invasive method for future pharmacological and development studies in the narcoleptic canine model...
  49. ncbi request reprint Narcolepsy research: past, present, and future perspectives
    S Fromherz
    Stanford University Center for Narcolepsy Research, Palo Alto, CA 94305, USA
    Arch Ital Biol 142:479-86. 2004
    ..It was not until the early 1970s when the exciting animal and human research first started to unravel the mysteries of the genetics and physiology of narcolepsy. This research will be discussed below...
  50. ncbi request reprint Is narcolepsy a REM sleep disorder? Analysis of sleep abnormalities in narcoleptic Dobermans
    S Nishino
    Center for Narcolepsy, Stanford Sleep Center, Stanford University School of Medicine, 1201 Welch Road, MSLS Building Room P113, Palo Alto, CA 94304 5485, USA
    Neurosci Res 38:437-46. 2000
    ..Cataplexy and a dysfunction in the maintenance of vigilance states, but not abnormal REM sleep generation, may therefore be central to narcolepsy...
  51. ncbi request reprint Desmethyl metabolites of serotonergic uptake inhibitors are more potent for suppressing canine cataplexy than their parent compounds
    S Nishino
    Sleep Research Center, Stanford University School of Medicine, Palo Alto, California 94304
    Sleep 16:706-12. 1993
    ..Our results also suggest that the anticataplectic effect of "selective" serotonergic uptake inhibitors in human narcolepsy might be mediated by their less selective active metabolites...
  52. ncbi request reprint Hypocretin stimulates [(35)S]GTP gamma S binding in Hcrtr 2-transfected cell lines and in brain homogenate
    T Shiba
    Center for Narcolepsy, Stanford University, 701B Welch Rd, Palo Alto, CA 94304, USA
    Biochem Biophys Res Commun 294:615-20. 2002
    ..Hypocretin-stimulated [(35)S]GTP gamma S binding, may thus be a useful functional assay for hypocretin receptors in both cell lines and brain tissue homogenates...
  53. ncbi request reprint CSF hypocretin levels in Guillain-Barré syndrome and other inflammatory neuropathies
    S Nishino
    Stanford University Center for Narcolepsy, Palo Alto, CA 94304, USA
    Neurology 61:823-5. 2003
    ..Hypocretin-1 levels were moderately reduced in an additional 11 GBS, 5 Miller-Fisher syndrome, and 1 CIDP subject. Low levels in GBS occurred early in the disease and were associated with upper CNS level abnormalities...
  54. ncbi request reprint Association between apolipoprotein E epsilon4 and sleep-disordered breathing in adults
    H Kadotani
    Center for Narcolepsy, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5485, USA
    JAMA 285:2888-90. 2001
    ..Sleep-disordered breathing occurs in Alzheimer disease patients and increases risks for cardiovascular disease. Complex interactions among sleep, brain pathology, and cardiovascular disease may occur in ApoE epsilon4 carriers...
  55. ncbi request reprint In Alzheimer disease, increased wake fragmentation found in those with lower hypocretin-1
    L F Friedman
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA
    Neurology 68:793-4. 2007
  56. ncbi request reprint Controversies in the diagnosis of narcolepsy
    C Guilleminault
    Sleep Disorders Clinic, School of Medicine, Stanford University, Palo Alto, California
    Sleep 17:S1-6. 1994
    ..History of daytime sleepiness and presence of more than one SOREMP during MSLT, however, is a poorer discriminant of narcolepsy than history of cataplexy, particularly in an aging population...
  57. ncbi request reprint Kleine-Levin syndrome: a systematic review of 186 cases in the literature
    I Arnulf
    Stanford University Center for Narcolepsy, Palo Alto, CA, USA
    Brain 128:2763-76. 2005
    ..In conclusion, KLS is a unique disease which may be more severe in female and secondary cases...
  58. ncbi request reprint Stability of cataplexy over several months--information for the design of therapeutic trials
    M Gelb
    Center for Narcolepsy, Stanford University Sleep Research Center, Palo Alto, California 94304
    Sleep 17:265-73. 1994
    ..The finding of a long-lasting "precataplectic" feeling or "aura" pointed to the need to carefully clarify the symptom prior to beginning a therapeutic trial...
  59. ncbi request reprint Cerebrospinal fluid prostaglandins and corticotropin releasing factor in schizophrenics and controls: relationship to sleep architecture
    S Nishino
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94305, USA
    Psychiatry Res 78:141-50. 1998
    ..These results do not favor the hypothesis of a role for CRF or PGs in the pathophysiology of sleep disturbances in schizophrenia...
  60. ncbi request reprint Validation of a cataplexy questionnaire in 983 sleep-disorders patients
    S Anic-Labat
    Stanford University, Center for Narcolepsy, Department of Psychiatry and Behavioral Sciences, CA 94305, USA
    Sleep 22:77-87. 1999
    ..7%) and low-(0.6%) risk groups for cataplexy. This questionnaire will be used to increase diagnostic consistency across clinical centers, thus providing more homogenous subject pools for clinical and basic research studies...
  61. ncbi request reprint Construction and characterization of an eightfold redundant dog genomic bacterial artificial chromosome library
    R Li
    Stanford Center for Narcolepsy Research, 1201 Welch Road, Room P 112, Stanford, California 94305 5485, USA
    Genomics 58:9-17. 1999
    ..The library was hybridized with dog PCR products representing eight genes (ADA, TNFA, GCA, MYB, HOXA, GUSB, THY1, and TOP1). The resulting positive clones were characterized and shown to be compatible with an eightfold redundant library...
  62. ncbi request reprint Drug treatment of patients with insomnia and excessive daytime sleepiness: pharmacokinetic considerations
    S Nishino
    Stanford Center for Narcolepsy, Stanford University, School of Medicine, Palo Alto, California 94304, USA
    Clin Pharmacokinet 37:305-30. 1999
    ..In this review, we will introduce recently obtained knowledge of the pharmacokinetics of hypnosedatives and CNS stimulants and their applications for patients affected with insomnia and EDS...
  63. ncbi request reprint A CLOCK polymorphism associated with human diurnal preference
    D Katzenberg
    Department of Psychiatry and Behavioral Sciences, Stanford University Sleep Disorders Center, Palo Alto, Calif, USA
    Sleep 21:569-76. 1998
    ..We suggest that the identified polymorphism or another tightly linked polymorphism within the CLOCK gene or its regulatory elements may be responsible for the finding...
  64. ncbi request reprint A new DRB1*1202 allele (DRB1*12022) found in association with DQA1*0102 and DQB1*0602 in two black narcoleptic subjects
    E Behar
    Stanford University Blood Center, Palo Alto, CA 94304
    Immunogenetics 41:52. 1995
  65. ncbi request reprint The month-of-birth pattern in narcolepsy is moderated by cataplexy severity and may be independent of HLA-DQB1*0602
    Dante Picchioni
    University of Southern Mississippi, Hattiesburg, USA
    Sleep 27:1471-5. 2004
    ..The objectives of the present study were to determine whether the month-of-birth pattern would (a) vary with the presence and severity of cataplexy and (b) differ for patients positive and negative for HLA-DQB1*0602...
  66. pmc Anomalous hypothalamic responses to humor in cataplexy
    Allan L Reiss
    Center for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 3:e2225. 2008
    ..The objective of this study was to examine the neural systems underlying humor processing in individuals with cataplexy...

Research Grants24

  1. SLEEP HOMEOSTASIS AND STIMULANT DRUGS OF ABUSE
    Emmanuel Mignot; Fiscal Year: 2002
    ....
  2. CENTER FOR NARCOLEPSY AND RELATED DISORDERS
    Emmanuel Mignot; Fiscal Year: 2007
    ..A weekly research meeting is held to facilitate communication among the investigators and between the research staff and research administration staff. ..
  3. Molecular Genetics of Kleine-Levin Syndrome
    Emmanuel Mignot; Fiscal Year: 2007
    ..This may also lead to novel insights in the control of sleep, appetite and other instinctual behaviors, with potential applications in other periodic neuropsychiatric disorders. ..
  4. Sleep promotion in zebrafish by hypocretin neuronal networks
    Emmanuel J Mignot; Fiscal Year: 2010
    ....
  5. SLEEP HOMEOSTASIS AND STIMULANT DRUGS OF ABUSE
    Emmanuel Mignot; Fiscal Year: 2000
    ....
  6. Sleep promotion in zebrafish by hypocretin neuronal networks
    Emmanuel Mignot; Fiscal Year: 2009
    ....
  7. Molecular Genetics of Kleine-Levin Syndrome
    Emmanuel Mignot; Fiscal Year: 2009
    ..This may also lead to novel insights in the control of sleep, appetite and other instinctual behaviors, with potential applications in other periodic neuropsychiatric disorders. ..
  8. Role of Hypocretin in Metabolic Effects of Sleep Loss
    Emmanuel Mignot; Fiscal Year: 2007
    ..These studies will be critical to extend our understanding of the association between chronic sleep loss, metabolism and body weight regulation. ..
  9. SLEEP HOMEOSTASIS AND STIMULANT DRUGS OF ABUSE
    Emmanuel Mignot; Fiscal Year: 2001
    ....
  10. Sleep Disordered Breathing, APOE and Lipid Metabolism
    Emmanuel Mignot; Fiscal Year: 2002
    ..With lipid metabolism being critical to cardiovascular risk, this application will also trigger further studies focusing on cardiovascular impact with adequate control of SDB. ..
  11. Sleep Disordered Breathing, APOE and Lipid Metabolism
    Emmanuel Mignot; Fiscal Year: 2003
    ..With lipid metabolism being critical to cardiovascular risk, this application will also trigger further studies focusing on cardiovascular impact with adequate control of SDB. ..
  12. Sleep Disordered Breathing, APOE and Lipid Metabolism
    Emmanuel Mignot; Fiscal Year: 2004
    ..With lipid metabolism being critical to cardiovascular risk, this application will also trigger further studies focusing on cardiovascular impact with adequate control of SDB. ..
  13. Role of Hypocretin in Metabolic Effects of Sleep Loss
    Emmanuel Mignot; Fiscal Year: 2004
    ..These studies will be critical to extend our understanding of the association between chronic sleep loss, metabolism and body weight regulation. ..
  14. Role of Hypocretin in Metabolic Effects of Sleep Loss
    Emmanuel Mignot; Fiscal Year: 2005
    ..These studies will be critical to extend our understanding of the association between chronic sleep loss, metabolism and body weight regulation. ..
  15. Sleep Disordered Breathing, APOE and Lipid Metabolism
    Emmanuel Mignot; Fiscal Year: 2005
    ..With lipid metabolism being critical to cardiovascular risk, this application will also trigger further studies focusing on cardiovascular impact with adequate control of SDB. ..
  16. Role of Hypocretin in Metabolic Effects of Sleep Loss
    Emmanuel Mignot; Fiscal Year: 2006
    ..These studies will be critical to extend our understanding of the association between chronic sleep loss, metabolism and body weight regulation. ..
  17. Molecular Genetics of Kleine-Levin Syndrome
    Emmanuel J Mignot; Fiscal Year: 2010
    ..This may also lead to novel insights in the control of sleep, appetite and other instinctual behaviors, with potential applications in other periodic neuropsychiatric disorders. ..