Timothy Meyer

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. doi request reprint Uremic solutes from colon microbes
    Timothy W Meyer
    Department of Medicine, VA Palo Alto HCS and Stanford University, Palo Alto, California 94303, USA
    Kidney Int 81:949-54. 2012
  2. doi request reprint The removal of protein-bound solutes by dialysis
    Timothy W Meyer
    Department of Medicine Nephrology, VA Palo Alto HCS, Palo Alto, California 94303, USA
    J Ren Nutr 22:203-6. 2012
  3. ncbi request reprint Tubular injury in glomerular disease
    Timothy W Meyer
    VA Palo Alto Health Care System and Stanford University, Palo Alto, California 94304, USA
    Kidney Int 63:774-87. 2003
  4. ncbi request reprint Increasing the clearance of protein-bound solutes by addition of a sorbent to the dialysate
    Timothy W Meyer
    Department of Medicine, VA Palo Alto HCS, Palo Alto, CA 94303, USA
    J Am Soc Nephrol 18:868-74. 2007
  5. ncbi request reprint Increasing dialysate flow and dialyzer mass transfer area coefficient to increase the clearance of protein-bound solutes
    Timothy W Meyer
    the Departments of Medicine, VA Palo Alto HCS and Stanford University, Palo Alto, California 94303, USA
    J Am Soc Nephrol 15:1927-35. 2004
  6. ncbi request reprint The clearance of protein-bound solutes by hemofiltration and hemodiafiltration
    Timothy W Meyer
    Department of Medicine, VA Palo Alto Health Care Science, Palo Alto, California 94303, USA
    Kidney Int 68:867-77. 2005
  7. doi request reprint Coated carbon hemoperfusion provides limited clearance of protein-bound solutes
    Diana C Dinh
    Department of Medicine, VA Palo Alto HCS and Stanford University, Palo Alto, CA, USA
    Artif Organs 32:717-24. 2008
  8. doi request reprint New insights into uremic toxicity
    Amanda C Raff
    Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA
    Curr Opin Nephrol Hypertens 17:560-5. 2008
  9. doi request reprint Effect of increasing dialyzer mass transfer area coefficient and dialysate flow on clearance of protein-bound solutes: a pilot crossover trial
    Frank J G Luo
    Department of Medicine, VA Palo Alto HCS and Stanford University, Palo Alto, CA 94303, USA
    Am J Kidney Dis 53:1042-9. 2009
  10. pmc Removal of the protein-bound solutes indican and p-cresol sulfate by peritoneal dialysis
    Nhat M Pham
    Department of Medicine, VA Palo Alto Health Care System, and Stanford University, Palo Alto, California, USA
    Clin J Am Soc Nephrol 3:85-90. 2008

Research Grants

  1. Removal of Protein-Bound Solutes by Dialysis
    Timothy Meyer; Fiscal Year: 2007
  2. TRAINING PROGRAM IN ACADEMIC NEPHROLOGY
    Timothy Meyer; Fiscal Year: 2007
  3. Mechanisms Progression in Renal Insufficiency
    Timothy Meyer; Fiscal Year: 2006
  4. Donor Kidney Gene Expression and Delayed Graft Function
    Timothy Meyer; Fiscal Year: 2004
  5. Maximize RAS Blockade in Diabetic Nephropathy
    Timothy Meyer; Fiscal Year: 2003
  6. MECHANISMS OF PROGRESSION IN RENAL INSUFFICIENCY
    Timothy Meyer; Fiscal Year: 2000

Detail Information

Publications23

  1. doi request reprint Uremic solutes from colon microbes
    Timothy W Meyer
    Department of Medicine, VA Palo Alto HCS and Stanford University, Palo Alto, California 94303, USA
    Kidney Int 81:949-54. 2012
    ..To the extent that they are toxic, suppressing their production could improve the health of renal failure patients without the need for more intensive or prolonged dialysis...
  2. doi request reprint The removal of protein-bound solutes by dialysis
    Timothy W Meyer
    Department of Medicine Nephrology, VA Palo Alto HCS, Palo Alto, California 94303, USA
    J Ren Nutr 22:203-6. 2012
    ..A trial testing whether reducing bound solute levels clinically benefits dialysis patients is required to determine whether these measures should be adopted in routine clinical practice...
  3. ncbi request reprint Tubular injury in glomerular disease
    Timothy W Meyer
    VA Palo Alto Health Care System and Stanford University, Palo Alto, California 94304, USA
    Kidney Int 63:774-87. 2003
  4. ncbi request reprint Increasing the clearance of protein-bound solutes by addition of a sorbent to the dialysate
    Timothy W Meyer
    Department of Medicine, VA Palo Alto HCS, Palo Alto, CA 94303, USA
    J Am Soc Nephrol 18:868-74. 2007
    ..These results suggest that as an adjunct to conventional hemodialysis, addition of sorbents to the dialysate could increase the clearance of protein-bound solutes without greatly altering the clearance of unbound solutes...
  5. ncbi request reprint Increasing dialysate flow and dialyzer mass transfer area coefficient to increase the clearance of protein-bound solutes
    Timothy W Meyer
    the Departments of Medicine, VA Palo Alto HCS and Stanford University, Palo Alto, California 94303, USA
    J Am Soc Nephrol 15:1927-35. 2004
    ..The model accurately predicts the pattern of measured results and shows further that ClPR can be made to approach Qp only by very large increases in both KoAPR and Qd...
  6. ncbi request reprint The clearance of protein-bound solutes by hemofiltration and hemodiafiltration
    Timothy W Meyer
    Department of Medicine, VA Palo Alto Health Care Science, Palo Alto, California 94303, USA
    Kidney Int 68:867-77. 2005
    ..Compared to hemodialysis, hemofiltration provides high clearances for large solutes but its effect on protein-bound solutes has been largely ignored...
  7. doi request reprint Coated carbon hemoperfusion provides limited clearance of protein-bound solutes
    Diana C Dinh
    Department of Medicine, VA Palo Alto HCS and Stanford University, Palo Alto, CA, USA
    Artif Organs 32:717-24. 2008
    ..These results indicate that hemoperfusion over coated granular carbon provides limited clearance of protein-bound solutes...
  8. doi request reprint New insights into uremic toxicity
    Amanda C Raff
    Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA
    Curr Opin Nephrol Hypertens 17:560-5. 2008
    ..New insights into the accumulation of uremic toxins and the loss of function of hormones and enzymes provide important information on the etiology of uremia...
  9. doi request reprint Effect of increasing dialyzer mass transfer area coefficient and dialysate flow on clearance of protein-bound solutes: a pilot crossover trial
    Frank J G Luo
    Department of Medicine, VA Palo Alto HCS and Stanford University, Palo Alto, CA 94303, USA
    Am J Kidney Dis 53:1042-9. 2009
    ....
  10. pmc Removal of the protein-bound solutes indican and p-cresol sulfate by peritoneal dialysis
    Nhat M Pham
    Department of Medicine, VA Palo Alto Health Care System, and Stanford University, Palo Alto, California, USA
    Clin J Am Soc Nephrol 3:85-90. 2008
    ..Protein-bound solutes are poorly cleared by peritoneal dialysis. We examined the hypothesis that plasma concentrations of bound solutes would therefore rise as residual renal function is lost...
  11. ncbi request reprint Uremia
    Timothy W Meyer
    Stanford University School of Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA
    N Engl J Med 357:1316-25. 2007
  12. pmc Relationship of impaired olfactory function in ESRD to malnutrition and retained uremic molecules
    Amanda C Raff
    Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA
    Am J Kidney Dis 52:102-10. 2008
    ..This study examines the relationship of impaired olfactory function to malnutrition and levels of the retained uremic solutes monomethylamine, ethylamine, indoxyl sulfate, and P-cresol sulfate...
  13. ncbi request reprint Removal of P-cresol sulfate by hemodialysis
    Andres W Martinez
    Department of Medicine, Veterans Association, Palo Alto, California, USA
    J Am Soc Nephrol 16:3430-6. 2005
    ..PCS is poorly removed by hemodialysis because its clearance is limited by protein binding and the ratio of its volume of distribution to its clearance is high...
  14. pmc Cardiovascular disease among hispanics and non-hispanics in the chronic renal insufficiency cohort (CRIC) study
    Ana C Ricardo
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
    Clin J Am Soc Nephrol 6:2121-31. 2011
    ..Hispanics are the largest minority group in the United States. The leading cause of death in patients with chronic kidney disease (CKD) is cardiovascular disease (CVD), yet little is known about its prevalence among Hispanics with CKD...
  15. pmc Sociodemographic factors contribute to the depressive affect among African Americans with chronic kidney disease
    Michael J Fischer
    Department of Medicine, Jesse Brown VA Medical Center and University of Illinois Medical Center, Chicago, Illinois, USA
    Kidney Int 77:1010-9. 2010
    ..Sociodemographic factors have especially strong associations with this increased depressive affect. Because this study was conducted in an African-American cohort, its findings may not be generalized to other ethnic groups...
  16. pmc Methylamine clearance by haemodialysis is low
    Manish P Ponda
    Division of Nephrology, Department of Medicine, Albert Einstein College of Medicine, Room 615, Ullmann Building, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Nephrol Dial Transplant 25:1608-13. 2010
    ..However, urea is relatively non-toxic and has properties distinct from large classes of other retained solutes. In particular, intracellularly sequestered solutes are likely to behave differently than urea...
  17. pmc Colonic contribution to uremic solutes
    Pavel A Aronov
    Vincent Coates Foundation Mass Spectrometry Laboratory, Stanford University, Stanford, California, USA
    J Am Soc Nephrol 22:1769-76. 2011
    ..These results suggest that colonic microbes may produce an important portion of uremic solutes, most of which remain unidentified...
  18. pmc Contribution of residual function to removal of protein-bound solutes in hemodialysis
    Ilian O Marquez
    Department of Medicine, VA Palo Alto HCS and Stanford University, 3801 Miranda Avenue, Palo Alto, CA 94303, USA
    Clin J Am Soc Nephrol 6:290-6. 2011
    ..This study evaluated the contribution of residual function to the removal of solutes for which protein binding limits clearance by hemdialysis...
  19. ncbi request reprint Effects of antihypertensive therapy on intrarenal angiotensin and bradykinin levels in experimental renal insufficiency
    Fiona E Mackie
    Division of Nephrology, VA Palo Alto Health Care System and Stanford University, Palo Alto, California, USA
    Kidney Int 61:555-63. 2002
    ..This study examined whether these different means of blood pressure reduction have different effects on renal levels of angiotensin (Ang) and bradykinin peptides...
  20. ncbi request reprint Genome-wide gene-expression patterns of donor kidney biopsies distinguish primary allograft function
    Peter Hauser
    Department of Nephrology, University of Vienna, Austria
    Lab Invest 84:353-61. 2004
    ..Thus, suppression of inflammation in the cadaveric donor might be a cheap and promising intervention for postischemic acute renal failure...
  21. ncbi request reprint Alterations in gene expression in cadaveric vs. live donor kidneys suggest impaired tubular counterbalance of oxidative stress at implantation
    Alexander Kainz
    Department of Nephrology, University of Vienna, Vienna, Austria
    Am J Transplant 4:1595-604. 2004
    ..These data suggest that CAD kidneys exhibit a distinctly different set of transcripts in the TI compartment but not in the G compartment when compared with LIV kidneys...
  22. ncbi request reprint More work to do on renin-angiotensin system blockade
    Yiming Z Lit
    Clin J Am Soc Nephrol 1:611-3. 2006
  23. ncbi request reprint Renal structural abnormalities following recovery from acute puromycin nephrosis
    Ruth Rasch
    Department of Cell Biology, Stereological Research and Electron Microscopy Laboratory, University of Aarhus, Aarhus, Denmark
    Kidney Int 62:496-506. 2002
    ..The current study sought to identify structural changes present in the recovery phase that could precipitate progressive renal disease...

Research Grants17

  1. Removal of Protein-Bound Solutes by Dialysis
    Timothy Meyer; Fiscal Year: 2007
    ..The proposed ancillary study to the FHN will provide a unique opportunity to relate protein-bound solute levels to other chemical parameters and indices of well-being in a large group of hemodialysis patients. ..
  2. TRAINING PROGRAM IN ACADEMIC NEPHROLOGY
    Timothy Meyer; Fiscal Year: 2007
    ..At the Veterans Affairs Palo Alto Health Care System there are well-equipped research laboratories in the Medical Service that have been assigned to the Nephrology Division. ..
  3. Mechanisms Progression in Renal Insufficiency
    Timothy Meyer; Fiscal Year: 2006
    ..These studies, like those of endocytosis, will employ knockout mice to assess the importance of potential mediators of injury which are not yet subject to pharmacologic manipulation. ..
  4. Donor Kidney Gene Expression and Delayed Graft Function
    Timothy Meyer; Fiscal Year: 2004
    ..Ultimately, better understanding of these mechanisms should provide a basis for treatment to prevent cadaver kidney injury and improve graft function. ..
  5. Maximize RAS Blockade in Diabetic Nephropathy
    Timothy Meyer; Fiscal Year: 2003
    ..But the number of such trials which can be performed is limited. Short term trials, such as those described in this proposal, are urgently required to help identify treatment regimens which merit further, longer term study. ..
  6. MECHANISMS OF PROGRESSION IN RENAL INSUFFICIENCY
    Timothy Meyer; Fiscal Year: 2000
    ..It is anticipated that with a better understanding of when and how AII contributes to the progression of renal disease, it will be feasible to more rationally prescribe AII antagonist therapy. ..