Affiliation: Stanford University
- Approaches to uremiaTimothy W Meyer
Department of Medicine, Veterans Affairs Palo Alto Healthcare System, Palo Alto, California Department of Medicine, Stanford University, Palo Alto, California and
J Am Soc Nephrol 25:2151-8. 2014..This review summarizes our current knowledge of toxic solutes and highlights methods being explored to identify additional toxic solutes and to enhance the clearance of these solutes to improve patient outcomes. ..
- Uremic solutes from colon microbesTimothy W Meyer
Department of Medicine, VA Palo Alto HCS and Stanford University, Palo Alto, California 94303, USA
Kidney Int 81:949-54. 2012..To the extent that they are toxic, suppressing their production could improve the health of renal failure patients without the need for more intensive or prolonged dialysis...
- The removal of protein-bound solutes by dialysisTimothy W Meyer
Department of Medicine Nephrology, VA Palo Alto HCS, Palo Alto, California 94303, USA
J Ren Nutr 22:203-6. 2012..A trial testing whether reducing bound solute levels clinically benefits dialysis patients is required to determine whether these measures should be adopted in routine clinical practice...
- Increasing the clearance of protein-bound solutes by addition of a sorbent to the dialysateTimothy W Meyer
Department of Medicine, VA Palo Alto HCS, Palo Alto, CA 94303, USA
J Am Soc Nephrol 18:868-74. 2007..These results suggest that as an adjunct to conventional hemodialysis, addition of sorbents to the dialysate could increase the clearance of protein-bound solutes without greatly altering the clearance of unbound solutes...
- The clearance of protein-bound solutes by hemofiltration and hemodiafiltrationTimothy W Meyer
Department of Medicine, VA Palo Alto Health Care Science, Palo Alto, California 94303, USA
Kidney Int 68:867-77. 2005..Compared to hemodialysis, hemofiltration provides high clearances for large solutes but its effect on protein-bound solutes has been largely ignored...
- Increasing dialysate flow and dialyzer mass transfer area coefficient to increase the clearance of protein-bound solutesTimothy W Meyer
the Departments of Medicine, VA Palo Alto HCS and Stanford University, Palo Alto, California 94303, USA
J Am Soc Nephrol 15:1927-35. 2004..The model accurately predicts the pattern of measured results and shows further that ClPR can be made to approach Qp only by very large increases in both KoAPR and Qd...
- Tubular injury in glomerular diseaseTimothy W Meyer
VA Palo Alto Health Care System and Stanford University, Palo Alto, California 94304, USA
Kidney Int 63:774-87. 2003
- Coated carbon hemoperfusion provides limited clearance of protein-bound solutesDiana C Dinh
Department of Medicine, VA Palo Alto HCS and Stanford University, Palo Alto, CA, USA
Artif Organs 32:717-24. 2008..These results indicate that hemoperfusion over coated granular carbon provides limited clearance of protein-bound solutes...
- Effect of increasing dialyzer mass transfer area coefficient and dialysate flow on clearance of protein-bound solutes: a pilot crossover trialFrank J G Luo
Department of Medicine, VA Palo Alto HCS and Stanford University, Palo Alto, CA 94303, USA
Am J Kidney Dis 53:1042-9. 2009....
- New insights into uremic toxicityAmanda C Raff
Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA
Curr Opin Nephrol Hypertens 17:560-5. 2008..New insights into the accumulation of uremic toxins and the loss of function of hormones and enzymes provide important information on the etiology of uremia...
- Removal of the protein-bound solutes indican and p-cresol sulfate by peritoneal dialysisNhat M Pham
Department of Medicine, VA Palo Alto Health Care System, and Stanford University, Palo Alto, California, USA
Clin J Am Soc Nephrol 3:85-90. 2008..Protein-bound solutes are poorly cleared by peritoneal dialysis. We examined the hypothesis that plasma concentrations of bound solutes would therefore rise as residual renal function is lost...
- Relationship of impaired olfactory function in ESRD to malnutrition and retained uremic moleculesAmanda C Raff
Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA
Am J Kidney Dis 52:102-10. 2008..This study examines the relationship of impaired olfactory function to malnutrition and levels of the retained uremic solutes monomethylamine, ethylamine, indoxyl sulfate, and P-cresol sulfate...
- UremiaTimothy W Meyer
Stanford University School of Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA
N Engl J Med 357:1316-25. 2007
- Removal of P-cresol sulfate by hemodialysisAndres W Martinez
Department of Medicine, Veterans Association, Palo Alto, California, USA
J Am Soc Nephrol 16:3430-6. 2005..PCS is poorly removed by hemodialysis because its clearance is limited by protein binding and the ratio of its volume of distribution to its clearance is high...
- Cardiovascular disease among hispanics and non-hispanics in the chronic renal insufficiency cohort (CRIC) studyAna C Ricardo
Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
Clin J Am Soc Nephrol 6:2121-31. 2011..Hispanics are the largest minority group in the United States. The leading cause of death in patients with chronic kidney disease (CKD) is cardiovascular disease (CVD), yet little is known about its prevalence among Hispanics with CKD...
- Sociodemographic factors contribute to the depressive affect among African Americans with chronic kidney diseaseMichael J Fischer
Department of Medicine, Jesse Brown VA Medical Center and University of Illinois Medical Center, Chicago, Illinois, USA
Kidney Int 77:1010-9. 2010..Sociodemographic factors have especially strong associations with this increased depressive affect. Because this study was conducted in an African-American cohort, its findings may not be generalized to other ethnic groups...
- Methylamine clearance by haemodialysis is lowManish P Ponda
Division of Nephrology, Department of Medicine, Albert Einstein College of Medicine, Room 615, Ullmann Building, 1300 Morris Park Ave, Bronx, NY 10461, USA
Nephrol Dial Transplant 25:1608-13. 2010..However, urea is relatively non-toxic and has properties distinct from large classes of other retained solutes. In particular, intracellularly sequestered solutes are likely to behave differently than urea...
- Colonic contribution to uremic solutesPavel A Aronov
Vincent Coates Foundation Mass Spectrometry Laboratory, Stanford University, Stanford, California, USA
J Am Soc Nephrol 22:1769-76. 2011..These results suggest that colonic microbes may produce an important portion of uremic solutes, most of which remain unidentified...
- Contribution of residual function to removal of protein-bound solutes in hemodialysisIlian O Marquez
Department of Medicine, VA Palo Alto HCS and Stanford University, 3801 Miranda Avenue, Palo Alto, CA 94303, USA
Clin J Am Soc Nephrol 6:290-6. 2011..This study evaluated the contribution of residual function to the removal of solutes for which protein binding limits clearance by hemdialysis...
- Effects of antihypertensive therapy on intrarenal angiotensin and bradykinin levels in experimental renal insufficiencyFiona E Mackie
Division of Nephrology, VA Palo Alto Health Care System and Stanford University, Palo Alto, California, USA
Kidney Int 61:555-63. 2002..This study examined whether these different means of blood pressure reduction have different effects on renal levels of angiotensin (Ang) and bradykinin peptides...
- Alterations in gene expression in cadaveric vs. live donor kidneys suggest impaired tubular counterbalance of oxidative stress at implantationAlexander Kainz
Department of Nephrology, University of Vienna, Vienna, Austria
Am J Transplant 4:1595-604. 2004..These data suggest that CAD kidneys exhibit a distinctly different set of transcripts in the TI compartment but not in the G compartment when compared with LIV kidneys...
- More work to do on renin-angiotensin system blockadeYiming Z Lit
Clin J Am Soc Nephrol 1:611-3. 2006
- Genome-wide gene-expression patterns of donor kidney biopsies distinguish primary allograft functionPeter Hauser
Department of Nephrology, University of Vienna, Austria
Lab Invest 84:353-61. 2004..Thus, suppression of inflammation in the cadaveric donor might be a cheap and promising intervention for postischemic acute renal failure...
- Renal structural abnormalities following recovery from acute puromycin nephrosisRuth Rasch
Department of Cell Biology, Stereological Research and Electron Microscopy Laboratory, University of Aarhus, Aarhus, Denmark
Kidney Int 62:496-506. 2002..The current study sought to identify structural changes present in the recovery phase that could precipitate progressive renal disease...
- Maximize RAS Blockade in Diabetic NephropathyTimothy Meyer; Fiscal Year: 2003..But the number of such trials which can be performed is limited. Short term trials, such as those described in this proposal, are urgently required to help identify treatment regimens which merit further, longer term study. ..
- Donor Kidney Gene Expression and Delayed Graft FunctionTimothy Meyer; Fiscal Year: 2004..Ultimately, better understanding of these mechanisms should provide a basis for treatment to prevent cadaver kidney injury and improve graft function. ..
- Mechanisms Progression in Renal InsufficiencyTimothy Meyer; Fiscal Year: 2006..These studies, like those of endocytosis, will employ knockout mice to assess the importance of potential mediators of injury which are not yet subject to pharmacologic manipulation. ..
- Removal of Protein-Bound Solutes by DialysisTimothy Meyer; Fiscal Year: 2007..The proposed ancillary study to the FHN will provide a unique opportunity to relate protein-bound solute levels to other chemical parameters and indices of well-being in a large group of hemodialysis patients. ..