Tracey McLaughlin

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. doi request reprint Use of a two-stage insulin infusion study to assess the relationship between insulin suppression of lipolysis and insulin-mediated glucose uptake in overweight/obese, nondiabetic women
    Tracey McLaughlin
    Stanford University School of Medicine, Division of Endocrinology, Stanford, CA 94305 5103, USA
    Metabolism 60:1741-7. 2011
  2. pmc Preferential fat deposition in subcutaneous versus visceral depots is associated with insulin sensitivity
    Tracey McLaughlin
    Division of Endocrinology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305 5103, USA
    J Clin Endocrinol Metab 96:E1756-60. 2011
  3. doi request reprint Pioglitazone increases the proportion of small cells in human abdominal subcutaneous adipose tissue
    Tracey M McLaughlin
    Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
    Obesity (Silver Spring) 18:926-31. 2010
  4. doi request reprint Inflammation in subcutaneous adipose tissue: relationship to adipose cell size
    T McLaughlin
    Division of Endocrinology, Stanford University School of Medicine, 300 Pasteur Drive, Rm S025, Stanford, CA 94305 5103, USA
    Diabetologia 53:369-77. 2010
  5. doi request reprint Reversible hyperinsulinemic hypoglycemia after gastric bypass: a consequence of altered nutrient delivery
    Tracey McLaughlin
    Stanford University School of Medicine, Department of Medicine, Division of Endocrinology, Stanford, California 94305 5103, USA
    J Clin Endocrinol Metab 95:1851-5. 2010
  6. ncbi request reprint Effects of moderate variations in macronutrient composition on weight loss and reduction in cardiovascular disease risk in obese, insulin-resistant adults
    Tracey McLaughlin
    Stanford University School of Medicine, Stanford, CA 94305, USA
    Am J Clin Nutr 84:813-21. 2006
  7. pmc Insulin resistance is associated with a modest increase in inflammation in subcutaneous adipose tissue of moderately obese women
    T McLaughlin
    Department of Medicine, Division of Endocrinology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5103, USA
    Diabetologia 51:2303-8. 2008
  8. ncbi request reprint Clinical efficacy of two hypocaloric diets that vary in overweight patients with type 2 diabetes: comparison of moderate fat versus carbohydrate reductions
    Tracey McLaughlin
    Department of Endocrinology, Stanford University, 300 Pasteur Dr, Stanford, CA 94305 5103, USA
    Diabetes Care 30:1877-9. 2007
  9. ncbi request reprint Enhanced proportion of small adipose cells in insulin-resistant vs insulin-sensitive obese individuals implicates impaired adipogenesis
    T McLaughlin
    Division of Endocrinology, Department of Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Diabetologia 50:1707-15. 2007
  10. doi request reprint Persistence of improvement in insulin sensitivity following a dietary weight loss programme
    T McLaughlin
    Department of Medicine, Division of Endocrinology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Diabetes Obes Metab 10:1186-94. 2008

Collaborators

Detail Information

Publications34

  1. doi request reprint Use of a two-stage insulin infusion study to assess the relationship between insulin suppression of lipolysis and insulin-mediated glucose uptake in overweight/obese, nondiabetic women
    Tracey McLaughlin
    Stanford University School of Medicine, Division of Endocrinology, Stanford, CA 94305 5103, USA
    Metabolism 60:1741-7. 2011
    ..Both can be quantified using a simple 2-stage insulin infusion study, with first-stage FFA concentrations and second-stage glucose concentrations being most informative...
  2. pmc Preferential fat deposition in subcutaneous versus visceral depots is associated with insulin sensitivity
    Tracey McLaughlin
    Division of Endocrinology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305 5103, USA
    J Clin Endocrinol Metab 96:E1756-60. 2011
    ..Studies on the relationship between regional fat and insulin resistance yield mixed results. Our objective was to determine whether regional fat distribution, independent of obesity, is associated with insulin resistance...
  3. doi request reprint Pioglitazone increases the proportion of small cells in human abdominal subcutaneous adipose tissue
    Tracey M McLaughlin
    Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
    Obesity (Silver Spring) 18:926-31. 2010
    ..These findings support the hypothesis that defects in subcutaneous fat storage may underlie obesity-associated insulin resistance...
  4. doi request reprint Inflammation in subcutaneous adipose tissue: relationship to adipose cell size
    T McLaughlin
    Division of Endocrinology, Stanford University School of Medicine, 300 Pasteur Drive, Rm S025, Stanford, CA 94305 5103, USA
    Diabetologia 53:369-77. 2010
    ..We sought to determine whether increased size of adipose cells is associated with localised inflammation in weight-stable, moderately obese humans...
  5. doi request reprint Reversible hyperinsulinemic hypoglycemia after gastric bypass: a consequence of altered nutrient delivery
    Tracey McLaughlin
    Stanford University School of Medicine, Department of Medicine, Division of Endocrinology, Stanford, California 94305 5103, USA
    J Clin Endocrinol Metab 95:1851-5. 2010
    ..Both pathophysiology and treatment of this disorder remain elusive, but it has been postulated that hyperplasia and/or hypertrophy of beta-cells due to morbid obesity and/or postsurgical nesidioblastosis may contribute...
  6. ncbi request reprint Effects of moderate variations in macronutrient composition on weight loss and reduction in cardiovascular disease risk in obese, insulin-resistant adults
    Tracey McLaughlin
    Stanford University School of Medicine, Stanford, CA 94305, USA
    Am J Clin Nutr 84:813-21. 2006
    ..Obese, insulin-resistant persons are at risk of cardiovascular disease. How best to achieve both weight loss and clinical benefit in these persons is controversial, and recent reports questioned the superiority of low-fat diets...
  7. pmc Insulin resistance is associated with a modest increase in inflammation in subcutaneous adipose tissue of moderately obese women
    T McLaughlin
    Department of Medicine, Division of Endocrinology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5103, USA
    Diabetologia 51:2303-8. 2008
    ..To determine whether other biological properties also differ between IR and IS obese individuals, we quantified markers of inflammatory activity in adipose tissue from overweight IR and IS individuals...
  8. ncbi request reprint Clinical efficacy of two hypocaloric diets that vary in overweight patients with type 2 diabetes: comparison of moderate fat versus carbohydrate reductions
    Tracey McLaughlin
    Department of Endocrinology, Stanford University, 300 Pasteur Dr, Stanford, CA 94305 5103, USA
    Diabetes Care 30:1877-9. 2007
  9. ncbi request reprint Enhanced proportion of small adipose cells in insulin-resistant vs insulin-sensitive obese individuals implicates impaired adipogenesis
    T McLaughlin
    Division of Endocrinology, Department of Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Diabetologia 50:1707-15. 2007
    ....
  10. doi request reprint Persistence of improvement in insulin sensitivity following a dietary weight loss programme
    T McLaughlin
    Department of Medicine, Division of Endocrinology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Diabetes Obes Metab 10:1186-94. 2008
    ..We sought to quantify the degree to which maintenance of weight loss after a short-term dietary intervention was associated with persistent metabolic benefits...
  11. ncbi request reprint Is there a simple way to identify insulin-resistant individuals at increased risk of cardiovascular disease?
    Tracey McLaughlin
    Stanford University School of Medicine, Stanford, California, USA
    Am J Cardiol 96:399-404. 2005
    ..5 provides a simple means of identifying insulin-resistant, dyslipidemic patients who are likely to be at increased risk of cardiovascular disease...
  12. ncbi request reprint Effect of rosiglitazone treatment on circulating vascular and inflammatory markers in insulin-resistant subjects
    James W Chu
    Department of Medicine, Stanford University School of Medicine, Stanford, California, 94305, USA
    Diab Vasc Dis Res 2:37-41. 2005
    ....
  13. doi request reprint Pioglitazone administration decreases cardiovascular disease risk factors in insulin-resistant smokers
    Fahim Abbasi
    Stanford University School of Medicine, CA 94305, USA
    Metabolism 57:1108-14. 2008
    ....
  14. ncbi request reprint Differentiation between obesity and insulin resistance in the association with C-reactive protein
    Tracey McLaughlin
    Stanford University School of Medicine, Stanford, Calif, USA
    Circulation 106:2908-12. 2002
    ..Plasma C-reactive protein (CRP) concentrations are increased in obese and/or hyperinsulinemic individuals. The goal of this study was to determine if the relation between insulin resistance and CRP was independent of obesity...
  15. ncbi request reprint Plasma adiponectin concentrations do not increase in association with moderate weight loss in insulin-resistant, obese women
    Fahim Abbasi
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Metabolism 53:280-3. 2004
    ..Adiponectin concentrations did not change with weight loss in either group. Thus, neither weight loss, per se, nor enhanced insulin sensitivity resulted in a change in plasma adiponectin concentrations...
  16. ncbi request reprint Use of metabolic markers to identify overweight individuals who are insulin resistant
    Tracey McLaughlin
    Stanford University School of Medicine, Stanford, California 94305, USA
    Ann Intern Med 139:802-9. 2003
    ....
  17. pmc Differential adipogenic and inflammatory properties of small adipocytes in Zucker Obese and Lean rats
    Alice Liu
    Division of Endocrinology, Department of Medicine, Stanford University Medical Center, CA 94305, USA
    Diab Vasc Dis Res 7:311-8. 2010
    ....
  18. pmc Differential intra-abdominal adipose tissue profiling in obese, insulin-resistant women
    Alice Liu
    Division of Endocrinology, Department of Medicine, Stanford University Medical Center, 300 Pasteur Drive Rm S 025, Stanford, CA 94305, USA
    Obes Surg 19:1564-73. 2009
    ..We compared cell size distribution and genetic markers in SAT and VAT of IR individuals undergoing bariatric surgery...
  19. ncbi request reprint Effect of metformin treatment on multiple cardiovascular disease risk factors in patients with type 2 diabetes mellitus
    Fahim Abbasi
    Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Metabolism 53:159-64. 2004
    ..Administration of metformin, either as monotherapy or in combination with a sulfonylurea drug, improved glycemic control and led to a decrease in several CVD risk factors in patients with type 2 diabetes...
  20. ncbi request reprint The relationship between plasma adiponectin concentration and insulin resistance is altered in smokers
    Fahim Abbasi
    Department of Medicien, Stanford University School of Medicine, CA 94305, USA
    J Clin Endocrinol Metab 91:5002-7. 2006
    ..Low plasma adiponectin concentrations in smokers may contribute to the adverse consequences that occur in these individuals...
  21. ncbi request reprint Prevalence of insulin resistance and associated cardiovascular disease risk factors among normal weight, overweight, and obese individuals
    Tracey McLaughlin
    Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Metabolism 53:495-9. 2004
    ..These results show that while BMI and insulin resistance are related, they are not synonymous, and that they make independent and different contributions to increasing CVD risk...
  22. ncbi request reprint Comparative effects of rosuvastatin and gemfibrozil on glucose, insulin, and lipid metabolism in insulin-resistant, nondiabetic patients with combined dyslipidemia
    Cindy Lamendola
    Department of Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Am J Cardiol 95:189-93. 2005
    ..05) in rosuvastatin-treated patients, and this difference in the relative effectiveness of the drugs was also true of the decrease in non-high-density lipoprotein cholesterol concentrations...
  23. doi request reprint Glucose-stimulated insulin secretion in gastric bypass patients with hypoglycemic syndrome: no evidence for inappropriate pancreatic beta-cell function
    Sun H Kim
    Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Obes Surg 20:1110-6. 2010
    ..The syndrome is believed to occur due to insulin hypersecretion from either pancreatic beta-cell hyperplasia or hyperfunction...
  24. ncbi request reprint Whole-body glycolysis measured by the deuterated-glucose disposal test correlates highly with insulin resistance in vivo
    Carine Beysen
    KineMed, Inc, Emeryville, California, USA
    Diabetes Care 30:1143-9. 2007
    ....
  25. ncbi request reprint Plasma asymmetric dimethylarginine concentrations are elevated in obese insulin-resistant women and fall with weight loss
    Tracey McLaughlin
    Division of Endocrinology, Stanford University School of Medicine, Stanford, California 94305 5103, USA
    J Clin Endocrinol Metab 91:1896-900. 2006
    ..Plasma asymmetric dimethylarginine (ADMA) concentrations are higher in apparently healthy, insulin-resistant (IR) individuals and decrease in response to thiazolidenedione treatment...
  26. ncbi request reprint Heterogeneity in the prevalence of risk factors for cardiovascular disease and type 2 diabetes mellitus in obese individuals: effect of differences in insulin sensitivity
    Tracey McLaughlin
    Division of Endocrinology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Arch Intern Med 167:642-8. 2007
    ..We tested the hypothesis that risk factors for type 2 diabetes mellitus and cardiovascular disease vary dramatically in moderately obese individuals as a function of differences in a specific measure of insulin sensitivity...
  27. ncbi request reprint Usefulness of plasma glucose and insulin concentrations in identifying patients with insulin resistance
    Cheng Yang Tuan
    Stanford University School of Medicine, Stanford, California 94305, USA
    Am J Cardiol 92:606-10. 2003
    ..We then made standard measurements of plasma glucose and insulin concentrations to see how useful they would be as surrogate markers of insulin resistance...
  28. ncbi request reprint Discrimination between obesity and insulin resistance in the relationship with adiponectin
    Fahim Abbasi
    Divisions of Cardiovascular Medicine and Endocrinology and Metabolism, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
    Diabetes 53:585-90. 2004
    ..These results suggest that adiponectin concentrations are more closely related to differences in insulin-mediated glucose disposal than obesity...
  29. ncbi request reprint Obesity, insulin resistance, and cardiovascular disease
    Gerald Reaven
    School of Medicine, Stanford University, Stanford, California 94305, USA
    Recent Prog Horm Res 59:207-23. 2004
    ....
  30. ncbi request reprint Relationship between obesity, insulin resistance, and coronary heart disease risk
    Fahim Abbasi
    Department of Medicine, Stanford, California, USA
    J Am Coll Cardiol 40:937-43. 2002
    ....
  31. ncbi request reprint Plasma ghrelin concentrations are decreased in insulin-resistant obese adults relative to equally obese insulin-sensitive controls
    Tracey McLaughlin
    Division of Endocrinology, University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    J Clin Endocrinol Metab 89:1630-5. 2004
    ..Thus, insulin resistance or related metabolic abnormalities may constitute part of a feedback mechanism by which body weight is regulated in humans...
  32. ncbi request reprint Comparison in patients with type 2 diabetes of fibric acid versus hepatic hydroxymethyl glutaryl-coenzyme a reductase inhibitor treatment of combined dyslipidemia
    Tracey McLaughlin
    Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Metabolism 51:1355-9. 2002
    ..As such, the clinical utility of statin monotherapy in the treatment of combined dyslipidemia may have been underestimated...
  33. pmc B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies
    Daniel A Winer
    Department of Pathology, Stanford University, Palo Alto, California, USA
    Nat Med 17:610-7. 2011
    ..These results establish the importance of B cells and adaptive immunity in insulin resistance and suggest new diagnostic and therapeutic modalities for managing the disease...
  34. pmc Using pre-existing microarray datasets to increase experimental power: application to insulin resistance
    Bernie J Daigle
    Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Comput Biol 6:e1000718. 2010
    ..We envision SAGAT as a means to maximize the potential for biological discovery from subtle transcriptional responses, and we provide it as a freely available software package that is immediately applicable to any human microarray study...