Research Topics
| Tracey McLaughlinSummaryAffiliation: Stanford University Country: USA Publications
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Publications
Use of a two-stage insulin infusion study to assess the relationship between insulin suppression of lipolysis and insulin-mediated glucose uptake in overweight/obese, nondiabetic womenTracey McLaughlin
Stanford University School of Medicine, Division of Endocrinology, Stanford, CA 94305 5103, USA
Metabolism 60:1741-7. 2011..Both can be quantified using a simple 2-stage insulin infusion study, with first-stage FFA concentrations and second-stage glucose concentrations being most informative...
Preferential fat deposition in subcutaneous versus visceral depots is associated with insulin sensitivityTracey McLaughlin
Division of Endocrinology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305 5103, USA
J Clin Endocrinol Metab 96:E1756-60. 2011..Studies on the relationship between regional fat and insulin resistance yield mixed results. Our objective was to determine whether regional fat distribution, independent of obesity, is associated with insulin resistance...- Pioglitazone increases the proportion of small cells in human abdominal subcutaneous adipose tissueTracey M McLaughlin
Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
Obesity (Silver Spring) 18:926-31. 2010..These findings support the hypothesis that defects in subcutaneous fat storage may underlie obesity-associated insulin resistance... - Inflammation in subcutaneous adipose tissue: relationship to adipose cell sizeT McLaughlin
Division of Endocrinology, Stanford University School of Medicine, 300 Pasteur Drive, Rm S025, Stanford, CA 94305 5103, USA
Diabetologia 53:369-77. 2010..We sought to determine whether increased size of adipose cells is associated with localised inflammation in weight-stable, moderately obese humans... - Reversible hyperinsulinemic hypoglycemia after gastric bypass: a consequence of altered nutrient deliveryTracey McLaughlin
Stanford University School of Medicine, Department of Medicine, Division of Endocrinology, Stanford, California 94305 5103, USA
J Clin Endocrinol Metab 95:1851-5. 2010..Both pathophysiology and treatment of this disorder remain elusive, but it has been postulated that hyperplasia and/or hypertrophy of beta-cells due to morbid obesity and/or postsurgical nesidioblastosis may contribute... 
Effects of moderate variations in macronutrient composition on weight loss and reduction in cardiovascular disease risk in obese, insulin-resistant adultsTracey McLaughlin
Stanford University School of Medicine, Stanford, CA 94305, USA
Am J Clin Nutr 84:813-21. 2006..Obese, insulin-resistant persons are at risk of cardiovascular disease. How best to achieve both weight loss and clinical benefit in these persons is controversial, and recent reports questioned the superiority of low-fat diets...- Insulin resistance is associated with a modest increase in inflammation in subcutaneous adipose tissue of moderately obese womenT McLaughlin
Department of Medicine, Division of Endocrinology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5103, USA
Diabetologia 51:2303-8. 2008..To determine whether other biological properties also differ between IR and IS obese individuals, we quantified markers of inflammatory activity in adipose tissue from overweight IR and IS individuals... - Clinical efficacy of two hypocaloric diets that vary in overweight patients with type 2 diabetes: comparison of moderate fat versus carbohydrate reductionsTracey McLaughlin
Department of Endocrinology, Stanford University, 300 Pasteur Dr, Stanford, CA 94305-5103, USA
Diabetes Care 30:1877-9. 2007 - Enhanced proportion of small adipose cells in insulin-resistant vs insulin-sensitive obese individuals implicates impaired adipogenesisT McLaughlin
Division of Endocrinology, Department of Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
Diabetologia 50:1707-15. 2007.... - Persistence of improvement in insulin sensitivity following a dietary weight loss programmeT McLaughlin
Department of Medicine, Division of Endocrinology, Stanford University School of Medicine, Stanford, CA 94305, USA
Diabetes Obes Metab 10:1186-94. 2008..We sought to quantify the degree to which maintenance of weight loss after a short-term dietary intervention was associated with persistent metabolic benefits... - Is there a simple way to identify insulin-resistant individuals at increased risk of cardiovascular disease?Tracey McLaughlin
Stanford University School of Medicine, Stanford, California, USA
Am J Cardiol 96:399-404. 2005..5 provides a simple means of identifying insulin-resistant, dyslipidemic patients who are likely to be at increased risk of cardiovascular disease... - Effect of rosiglitazone treatment on circulating vascular and inflammatory markers in insulin-resistant subjectsJames W Chu
Department of Medicine, Stanford University School of Medicine, Stanford, California, 94305, USA
Diab Vasc Dis Res 2:37-41. 2005.... - Pioglitazone administration decreases cardiovascular disease risk factors in insulin-resistant smokersFahim Abbasi
Stanford University School of Medicine, CA 94305, USA
Metabolism 57:1108-14. 2008.... - Differentiation between obesity and insulin resistance in the association with C-reactive proteinTracey McLaughlin
Stanford University School of Medicine, Stanford, Calif, USA
Circulation 106:2908-12. 2002..The relation between CRP concentrations and insulin resistance is independent of obesity... - Plasma adiponectin concentrations do not increase in association with moderate weight loss in insulin-resistant, obese womenFahim Abbasi
Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Metabolism 53:280-3. 2004..Adiponectin concentrations did not change with weight loss in either group. Thus, neither weight loss, per se, nor enhanced insulin sensitivity resulted in a change in plasma adiponectin concentrations... - Use of metabolic markers to identify overweight individuals who are insulin resistantTracey McLaughlin
Stanford University School of Medicine, Stanford, California 94305, USA
Ann Intern Med 139:802-9. 2003.... - Differential adipogenic and inflammatory properties of small adipocytes in Zucker Obese and Lean ratsAlice Liu
Division of Endocrinology, Department of Medicine, Stanford University Medical Center, CA 94305, USA
Diab Vasc Dis Res 7:311-8. 2010.... - Differential intra-abdominal adipose tissue profiling in obese, insulin-resistant womenAlice Liu
Division of Endocrinology, Department of Medicine, Stanford University Medical Center, 300 Pasteur Drive Rm S 025, Stanford, CA 94305, USA
Obes Surg 19:1564-73. 2009..We compared cell size distribution and genetic markers in SAT and VAT of IR individuals undergoing bariatric surgery... - Effect of metformin treatment on multiple cardiovascular disease risk factors in patients with type 2 diabetes mellitusFahim Abbasi
Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
Metabolism 53:159-64. 2004..Administration of metformin, either as monotherapy or in combination with a sulfonylurea drug, improved glycemic control and led to a decrease in several CVD risk factors in patients with type 2 diabetes... - The relationship between plasma adiponectin concentration and insulin resistance is altered in smokersFahim Abbasi
Department of Medicien, Stanford University School of Medicine, CA 94305, USA
J Clin Endocrinol Metab 91:5002-7. 2006..These findings suggest that low levels of adiponectin in smokers may be independent of both insulin resistance and a generalized inflammatory response... - Prevalence of insulin resistance and associated cardiovascular disease risk factors among normal weight, overweight, and obese individualsTracey McLaughlin
Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
Metabolism 53:495-9. 2004..These results show that while BMI and insulin resistance are related, they are not synonymous, and that they make independent and different contributions to increasing CVD risk... - Comparative effects of rosuvastatin and gemfibrozil on glucose, insulin, and lipid metabolism in insulin-resistant, nondiabetic patients with combined dyslipidemiaCindy Lamendola
Department of Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
Am J Cardiol 95:189-93. 2005..05) in rosuvastatin-treated patients, and this difference in the relative effectiveness of the drugs was also true of the decrease in non-high-density lipoprotein cholesterol concentrations... - Glucose-stimulated insulin secretion in gastric bypass patients with hypoglycemic syndrome: no evidence for inappropriate pancreatic beta-cell functionSun H Kim
Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
Obes Surg 20:1110-6. 2010..The syndrome is believed to occur due to insulin hypersecretion from either pancreatic beta-cell hyperplasia or hyperfunction... - Whole-body glycolysis measured by the deuterated-glucose disposal test correlates highly with insulin resistance in vivoCarine Beysen
KineMed, Inc, Emeryville, California, USA
Diabetes Care 30:1143-9. 2007.... - Plasma asymmetric dimethylarginine concentrations are elevated in obese insulin-resistant women and fall with weight lossTracey McLaughlin
Division of Endocrinology, Stanford University School of Medicine, Stanford, California 94305-5103, USA
J Clin Endocrinol Metab 91:1896-900. 2006..CONCLUSION: Plasma ADMA levels are higher in obese, IR women than in equally obese, IS women and decrease in response to weight loss when associated with enhancement of insulin sensitivity... - Heterogeneity in the prevalence of risk factors for cardiovascular disease and type 2 diabetes mellitus in obese individuals: effect of differences in insulin sensitivityTracey McLaughlin
Division of Endocrinology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
Arch Intern Med 167:642-8. 2007..We tested the hypothesis that risk factors for type 2 diabetes mellitus and cardiovascular disease vary dramatically in moderately obese individuals as a function of differences in a specific measure of insulin sensitivity... - Usefulness of plasma glucose and insulin concentrations in identifying patients with insulin resistanceCheng-Yang Tuan
Stanford University School of Medicine, Stanford, California 94305, USA
Am J Cardiol 92:606-10. 2003..We then made standard measurements of plasma glucose and insulin concentrations to see how useful they would be as surrogate markers of insulin resistance... - Discrimination between obesity and insulin resistance in the relationship with adiponectinFahim Abbasi
Divisions of Cardiovascular Medicine and Endocrinology and Metabolism, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
Diabetes 53:585-90. 2004..These results suggest that adiponectin concentrations are more closely related to differences in insulin-mediated glucose disposal than obesity... - Obesity, insulin resistance, and cardiovascular diseaseGerald Reaven
School of Medicine, Stanford University, Stanford, California 94305, USA
Recent Prog Horm Res 59:207-23. 2004.... - Relationship between obesity, insulin resistance, and coronary heart disease riskFahim Abbasi
Department of Medicine, Stanford, California, USA
J Am Coll Cardiol 40:937-43. 2002..CONCLUSIONS: Obesity and insulin resistance are both powerful predictors of CHD risk, and insulin resistance at any given degree of obesity accentuates the risk of CHD and type 2 diabetes... - Plasma ghrelin concentrations are decreased in insulin-resistant obese adults relative to equally obese insulin-sensitive controlsTracey McLaughlin
Division of Endocrinology, University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
J Clin Endocrinol Metab 89:1630-5. 2004..Thus, insulin resistance or related metabolic abnormalities may constitute part of a feedback mechanism by which body weight is regulated in humans... - Comparison in patients with type 2 diabetes of fibric acid versus hepatic hydroxymethyl glutaryl-coenzyme a reductase inhibitor treatment of combined dyslipidemiaTracey McLaughlin
Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
Metabolism 51:1355-9. 2002..As such, the clinical utility of statin monotherapy in the treatment of combined dyslipidemia may have been underestimated... - B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodiesDaniel A Winer
Department of Pathology, Stanford University, Palo Alto, California, USA
Nat Med 17:610-7. 2011..These results establish the importance of B cells and adaptive immunity in insulin resistance and suggest new diagnostic and therapeutic modalities for managing the disease... - Using pre-existing microarray datasets to increase experimental power: application to insulin resistanceBernie J Daigle
Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America
PLoS Comput Biol 6:e1000718. 2010..We envision SAGAT as a means to maximize the potential for biological discovery from subtle transcriptional responses, and we provide it as a freely available software package that is immediately applicable to any human microarray study...