Harden McConnell

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. doi request reprint Understanding membranes
    Harden M McConnell
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    ACS Chem Biol 3:265-7. 2008
  2. doi request reprint Single molecule diffusion in critical lipid bilayers
    Harden McConnell
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    J Chem Phys 137:215104. 2012
  3. pmc Theory of the deuterium NMR of sterol-phospholipid membranes
    Harden McConnell
    Department of Chemistry, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 103:1184-9. 2006
  4. pmc Contrast inversion in the epifluorescence of cholesterol-phospholipid monolayers
    T M Okonogi
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Biophys J 86:880-90. 2004
  5. ncbi request reprint Condensed complexes of cholesterol and phospholipids
    Harden M McConnell
    Department of Chemistry, Stanford University, Stanford, CA 94305, USA
    Biochim Biophys Acta 1610:159-73. 2003
  6. ncbi request reprint Liquid-liquid immiscibility in membranes
    Harden M McConnell
    Department of Chemistry, Biophysics Program, Stanford University, Stanford, California 94305 5080, USA
    Annu Rev Biophys Biomol Struct 32:469-92. 2003
  7. doi request reprint Nuclear relaxation and critical fluctuations in membranes containing cholesterol
    Harden McConnell
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    J Chem Phys 130:165103. 2009
  8. doi request reprint Adventures in physical chemistry
    Harden McConnell
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    Annu Rev Biophys 39:1-21. 2010
  9. doi request reprint Composition fluctuations, correlated response, and protein solvation in membranes
    Harden McConnell
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    J Chem Phys 132:205102. 2010
  10. doi request reprint Communication: Critical dynamics and nuclear relaxation in lipid bilayers
    Harden McConnell
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    J Chem Phys 134:011102. 2011

Collaborators

Detail Information

Publications20

  1. doi request reprint Understanding membranes
    Harden M McConnell
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    ACS Chem Biol 3:265-7. 2008
    ..Remarkably, the intensity fluctuations in the membrane blebs are found to be the same as those expected for the theoretical 2D Ising ferromagnet!..
  2. doi request reprint Single molecule diffusion in critical lipid bilayers
    Harden McConnell
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    J Chem Phys 137:215104. 2012
    ..This biphasic diffusion should be readily detectable experimentally...
  3. pmc Theory of the deuterium NMR of sterol-phospholipid membranes
    Harden McConnell
    Department of Chemistry, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 103:1184-9. 2006
    ..There is a corresponding jump in the calculated heat capacity as well as in the temperature derivative of the deuterium NMR first moment...
  4. pmc Contrast inversion in the epifluorescence of cholesterol-phospholipid monolayers
    T M Okonogi
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Biophys J 86:880-90. 2004
    ..The data show that binary dihydrocholesterol-phospholipid mixtures can form three distinct liquids, one of which is interpreted as a phase rich in condensed complex...
  5. ncbi request reprint Condensed complexes of cholesterol and phospholipids
    Harden M McConnell
    Department of Chemistry, Stanford University, Stanford, CA 94305, USA
    Biochim Biophys Acta 1610:159-73. 2003
    ..Here we give an overview of the model, its relation to other models, and to modern views of the properties of animal cell membranes...
  6. ncbi request reprint Liquid-liquid immiscibility in membranes
    Harden M McConnell
    Department of Chemistry, Biophysics Program, Stanford University, Stanford, California 94305 5080, USA
    Annu Rev Biophys Biomol Struct 32:469-92. 2003
    ..The properties of defined cholesterol-phospholipid mixtures provide a conceptual foundation for the exploration of a number of aspects of the biophysics and biochemistry of animal cell membranes...
  7. doi request reprint Nuclear relaxation and critical fluctuations in membranes containing cholesterol
    Harden McConnell
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    J Chem Phys 130:165103. 2009
    ..The calculated rates at the critical temperature are close to the experimental rates. The rate maxima involve relatively rapid tracer diffusion in a static composition gradient over distances of up to 10-100 nm...
  8. doi request reprint Adventures in physical chemistry
    Harden McConnell
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    Annu Rev Biophys 39:1-21. 2010
    ..In the area of immunology, it was shown that antigenic peptides bind to reconstituted class II MHC molecules in membranes and trigger specific T-helper cells...
  9. doi request reprint Composition fluctuations, correlated response, and protein solvation in membranes
    Harden McConnell
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    J Chem Phys 132:205102. 2010
    ....
  10. doi request reprint Communication: Critical dynamics and nuclear relaxation in lipid bilayers
    Harden McConnell
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    J Chem Phys 134:011102. 2011
    ..We calculate the effects of these dynamics on transverse deuterium nuclear relaxation in the 0.1(o)-10(o) range above the critical temperature...
  11. pmc Complexes in ternary cholesterol-phospholipid mixtures
    Harden McConnell
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    Biophys J 88:L23-5. 2005
    ..The model also accounts for significant qualitative features of the deuterium NMR spectra of these mixtures in bilayers...
  12. pmc Translational diffusion of individual class II MHC membrane proteins in cells
    Marija Vrljic
    Biophysics Program, Stanford University, Stanford, CA 94305 5080, USA
    Biophys J 83:2681-92. 2002
    ..Both analyses show that motion is predominantly Brownian. This study finds no strong evidence for significant confinement of either GPI-linked or native I-E(k) in the plasma membrane of CHO cells...
  13. pmc Cholesterol depletion induces solid-like regions in the plasma membrane
    Stefanie Y Nishimura
    Department of Chemistry, Molecular and Cellular Physiology, and Biophysics Program, Stanford University, Stanford, California 94305 5080, USA
    Biophys J 90:927-38. 2006
    ..Cytoskeletal effects appear to be minimal. These results are consistent with a previously described model of solid-like domain formation in the plasma membrane...
  14. pmc Cholesterol depletion suppresses the translational diffusion of class II major histocompatibility complex proteins in the plasma membrane
    Marija Vrljic
    Biophysics Program, Stanford University, Stanford, California 94305 5080, USA
    Biophys J 88:334-47. 2005
    ..That is, cholesterol extraction destroys liquid cholesterol-phospholipid complexes, leaving solid-like high melting phospholipid domains that inhibit the lateral diffusion of membrane components...
  15. pmc A thermodynamic model for extended complexes of cholesterol and phospholipid
    Thomas G Anderson
    Department of Chemistry, Stanford University, California 94305 5080, USA
    Biophys J 83:2039-52. 2002
    ..The average number of molecules in a large complex shows a pronounced dependence on the composition of the reaction mixture. Large complexes have properties of a separate thermodynamic phase...
  16. pmc Critical points in charged membranes containing cholesterol
    Arun Radhakrishnan
    Department of Chemistry, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 99:13391-6. 2002
    ..The miscibility critical pressures depend on subphase pH and ionic strength. Changes in critical pressures due to changes in subphase composition are closely related to changes in membrane electrostatic pressure and surface ionization...
  17. ncbi request reprint Two fatty acids can replace one phospholipid in condensed complexes with cholesterol
    Tamara M Okonogi
    Department of Chemistry, Stanford University, CA 94305, USA
    Biochim Biophys Acta 1564:1-4. 2002
    ..The condensed complex stoichiometry is thus largely determined by the C14 fatty acid acyl chains, in this case about 4-4.6 per DChol molecule...
  18. ncbi request reprint Structural factors contributing to DM susceptibility of MHC class II/peptide complexes
    Michael P Belmares
    Department of Chemistry, Stanford University, CA 94305, USA
    J Immunol 169:5109-17. 2002
    ..Thus, the peptide repertoire displayed to CD4(+) T cells is the result of a mechanistically complicated editing process and cannot be simply predicted from the intrinsic stability of the complexes in the absence of DM...
  19. ncbi request reprint Relationship between kinetic stability and immunogenicity of HLA-DR4/peptide complexes
    Frances C Hall
    Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
    Eur J Immunol 32:662-70. 2002
    ..These data indicate that kinetic stability of peptide/MHC complexes in vivo is a key determinant of immunogenicity...
  20. ncbi request reprint Formation of two peptide/MHC II isomers is catalyzed differentially by HLA-DM
    Michael P Belmares
    Departments of Chemistry and Pediatrics, Stanford University, Stanford, California 94305, USA
    Biochemistry 42:838-47. 2003
    ..Intramolecular isomer interconversion does not appear to be involved. The behavior of these complexes may provide a model for peptide editing by DM in endosomes...