Research Topics
| Harden McConnellSummaryAffiliation: Stanford University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Understanding membranesHarden M McConnell
Department of Chemistry, Stanford University, Stanford, California 94305, USA
ACS Chem Biol 3:265-7. 2008..Remarkably, the intensity fluctuations in the membrane blebs are found to be the same as those expected for the theoretical 2D Ising ferromagnet!..- Single molecule diffusion in critical lipid bilayersHarden McConnell
Department of Chemistry, Stanford University, Stanford, California 94305, USA
J Chem Phys 137:215104. 2012..This biphasic diffusion should be readily detectable experimentally... 
Theory of the deuterium NMR of sterol-phospholipid membranesHarden McConnell
Department of Chemistry, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 103:1184-9. 2006..There is a corresponding jump in the calculated heat capacity as well as in the temperature derivative of the deuterium NMR first moment...- Contrast inversion in the epifluorescence of cholesterol-phospholipid monolayersT M Okonogi
Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
Biophys J 86:880-90. 2004..The data show that binary dihydrocholesterol-phospholipid mixtures can form three distinct liquids, one of which is interpreted as a phase rich in condensed complex... 
Condensed complexes of cholesterol and phospholipidsHarden M McConnell
Department of Chemistry, Stanford University, Stanford, CA 94305, USA
Biochim Biophys Acta 1610:159-73. 2003..Here we give an overview of the model, its relation to other models, and to modern views of the properties of animal cell membranes...- Liquid-liquid immiscibility in membranesHarden M McConnell
Department of Chemistry, Biophysics Program, Stanford University, Stanford, California 94305 5080, USA
Annu Rev Biophys Biomol Struct 32:469-92. 2003..The properties of defined cholesterol-phospholipid mixtures provide a conceptual foundation for the exploration of a number of aspects of the biophysics and biochemistry of animal cell membranes... - Nuclear relaxation and critical fluctuations in membranes containing cholesterolHarden McConnell
Department of Chemistry, Stanford University, Stanford, California 94305, USA
J Chem Phys 130:165103. 2009..The calculated rates at the critical temperature are close to the experimental rates. The rate maxima involve relatively rapid tracer diffusion in a static composition gradient over distances of up to 10-100 nm... - Adventures in physical chemistryHarden McConnell
Department of Chemistry, Stanford University, Stanford, California 94305, USA
Annu Rev Biophys 39:1-21. 2010..In the area of immunology, it was shown that antigenic peptides bind to reconstituted class II MHC molecules in membranes and trigger specific T-helper cells... - Composition fluctuations, correlated response, and protein solvation in membranesHarden McConnell
Department of Chemistry, Stanford University, Stanford, California 94305, USA
J Chem Phys 132:205102. 2010.... - Communication: Critical dynamics and nuclear relaxation in lipid bilayersHarden McConnell
Department of Chemistry, Stanford University, Stanford, California 94305, USA
J Chem Phys 134:011102. 2011..We calculate the effects of these dynamics on transverse deuterium nuclear relaxation in the 0.1(o)-10(o) range above the critical temperature... - Complexes in ternary cholesterol-phospholipid mixturesHarden McConnell
Department of Chemistry, Stanford University, Stanford, California 94305, USA
Biophys J 88:L23-5. 2005..The model also accounts for significant qualitative features of the deuterium NMR spectra of these mixtures in bilayers... - Translational diffusion of individual class II MHC membrane proteins in cellsMarija Vrljic
Biophysics Program, Stanford University, Stanford, CA 94305-5080, USA
Biophys J 83:2681-92. 2002..Both analyses show that motion is predominantly Brownian. This study finds no strong evidence for significant confinement of either GPI-linked or native I-E(k) in the plasma membrane of CHO cells... - Cholesterol depletion induces solid-like regions in the plasma membraneStefanie Y Nishimura
Department of Chemistry, Molecular and Cellular Physiology, and Biophysics Program, Stanford University, Stanford, California 94305 5080, USA
Biophys J 90:927-38. 2006..Cytoskeletal effects appear to be minimal. These results are consistent with a previously described model of solid-like domain formation in the plasma membrane... - Cholesterol depletion suppresses the translational diffusion of class II major histocompatibility complex proteins in the plasma membraneMarija Vrljic
Biophysics Program, Stanford University, Stanford, California 94305 5080, USA
Biophys J 88:334-47. 2005..That is, cholesterol extraction destroys liquid cholesterol-phospholipid complexes, leaving solid-like high melting phospholipid domains that inhibit the lateral diffusion of membrane components... - A thermodynamic model for extended complexes of cholesterol and phospholipidThomas G Anderson
Department of Chemistry, Stanford University, California 94305-5080, USA
Biophys J 83:2039-52. 2002..The average number of molecules in a large complex shows a pronounced dependence on the composition of the reaction mixture. Large complexes have properties of a separate thermodynamic phase... - Critical points in charged membranes containing cholesterolArun Radhakrishnan
Department of Chemistry, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 99:13391-6. 2002..The miscibility critical pressures depend on subphase pH and ionic strength. Changes in critical pressures due to changes in subphase composition are closely related to changes in membrane electrostatic pressure and surface ionization... - Two fatty acids can replace one phospholipid in condensed complexes with cholesterolTamara M Okonogi
Department of Chemistry, Stanford University, CA 94305, USA
Biochim Biophys Acta 1564:1-4. 2002..The condensed complex stoichiometry is thus largely determined by the C14 fatty acid acyl chains, in this case about 4-4.6 per DChol molecule... - Structural factors contributing to DM susceptibility of MHC class II/peptide complexesMichael P Belmares
Department of Chemistry, Stanford University, CA 94305, USA
J Immunol 169:5109-17. 2002..Thus, the peptide repertoire displayed to CD4(+) T cells is the result of a mechanistically complicated editing process and cannot be simply predicted from the intrinsic stability of the complexes in the absence of DM... - Relationship between kinetic stability and immunogenicity of HLA-DR4/peptide complexesFrances C Hall
Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
Eur J Immunol 32:662-70. 2002..These data indicate that kinetic stability of peptide/MHC complexes in vivo is a key determinant of immunogenicity... - Formation of two peptide/MHC II isomers is catalyzed differentially by HLA-DMMichael P Belmares
Departments of Chemistry and Pediatrics, Stanford University, Stanford, California 94305, USA
Biochemistry 42:838-47. 2003..Intramolecular isomer interconversion does not appear to be involved. The behavior of these complexes may provide a model for peptide editing by DM in endosomes...