Research Topics
| Dirk MayerSummaryAffiliation: Stanford University Country: USA Publications
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Detail Information
Publications
Application of hyperpolarized [1-¹³C]lactate for the in vivo investigation of cardiac metabolismDirk Mayer
SRI International, Neuroscience Program, 333 Ravenswood Ave, Menlo Park, CA 94025, USA
NMR Biomed 25:1119-24. 2012..5-fold increase in bicarbonate-to-substrate ratio was found after administration of DCA, similar to the effect when using [1-(13) C]pyruvate as the substrate...- Dynamic and high-resolution metabolic imaging of hyperpolarized [1-13C]-pyruvate in the rat brain using a high-performance gradient insertDirk Mayer
SRI International, Neuroscience Program, Menlo Park, California 94025, USA
Magn Reson Med 65:1228-33. 2011.... 
RF refocused echoes of J-coupled spin systems: effects on RARE-based spectroscopic imagingDirk Mayer
Lucas MRS Imaging Center, Department of Radiology, Stanford University, Stanford, California 94305 5488, USA
Magn Reson Med 57:967-71. 2007..When the pulse interval falls short of the fast pulse rate regime, spectroscopic U-FLARE provides an improved spatial impulse response in the phase-encoding (PE) direction compared to spectroscopic RARE...- In vivo metabolite differences between the basal ganglia and cerebellum of the rat brain detected with proton MRS at 3TDirk Mayer
Radiology Department Lucas MRS I Center Stanford University, 1201 Welch Road, P 273, Stanford, California 94305 5488, USA
Psychiatry Res 154:267-73. 2007.... 
Fast parallel spiral chemical shift imaging at 3T using iterative SENSE reconstructionDirk Mayer
Stanford University, Richard M Lucas Center for Magnetic Resonance Spectroscopy and Imaging, Department of Radiology, Stanford, California 94305 5488, USA
Magn Reson Med 59:891-7. 2008....- Fast metabolic imaging of systems with sparse spectra: application for hyperpolarized 13C imagingDirk Mayer
Richard M Lucas Center for Magnetic Resonance Spectroscopy and Imaging, Department of Radiology, Stanford University, Stanford, California 94305 5488, USA
Magn Reson Med 56:932-7. 2006..The metabolic maps of Ala and Lac for single-shot spCSI contain minor artifacts due to signal overlap of aliased resonances... - Application of subsecond spiral chemical shift imaging to real-time multislice metabolic imaging of the rat in vivo after injection of hyperpolarized 13C1-pyruvateDirk Mayer
Department of Radiology, Stanford University, Richard M Lucas Center for Imaging, Stanford, California 94305 5488, USA
Magn Reson Med 62:557-64. 2009..These results demonstrate the feasibility of real-time, hyperpolarized metabolic imaging and highlight its potential in assessing organ-specific kinetic parameters... - Fast CT-PRESS-based spiral chemical shift imaging at 3 TeslaDirk Mayer
Richard M Lucas Center for Magnetic Resonance Spectroscopy and Imaging, Department of Radiology, Stanford University, Stanford, California 94305 5488, USA
Magn Reson Med 55:974-8. 2006..Signals from N-acetyl-aspartate, total creatine, choline-containing compounds (Cho), Glu, and mI were detected in a healthy volunteer with no or only minor baseline distortions within 14 min on a 3 T MR scanner... - In vivo application of sub-second spiral chemical shift imaging (CSI) to hyperpolarized 13C metabolic imaging: comparison with phase-encoded CSIDirk Mayer
Stanford University, Department of Radiology, Richard M Lucas Center for Imaging, 1201 Welch Rd, Stanford, CA 94305, USA
J Magn Reson 204:340-5. 2010..The presented results demonstrate that dramatic reductions in scan time are feasible in hyperpolarized (13)C metabolic imaging without a penalty in SNR or spatial resolution... - Detection of glutamate in the human brain at 3 T using optimized constant time point resolved spectroscopyDirk Mayer
Stanford University, Lucas MRS Imaging Center, Department of Radiology, Stanford, California 94305 5488, USA
Magn Reson Med 54:439-42. 2005..However, glutamine resonances could not be resolved due to severe signal overlap from glutamate and N-acetyl aspartate... - Brain injury and recovery following binge ethanol: evidence from in vivo magnetic resonance spectroscopyNatalie M Zahr
Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
Biol Psychiatry 67:846-54. 2010..The current in vivo magnetic resonance (MR) imaging and spectroscopy study was conducted to test the hypothesis that binge EtOH exposure would injure but not cause the death of neurons as previously ascertained postmortem... - Fast volumetric imaging of ethanol metabolism in rat liver with hyperpolarized [1-(13) C]pyruvateSonal Josan
SRI International, Neuroscience Program, Menlo Park, CA 94025, USA
NMR Biomed 25:993-9. 2012..A significant increase in the pyruvate to lactate conversion was observed in the liver as a result of the greater availability of NADH (nicotinamide adenine dinucleotide, reduced form) from ethanol metabolism... - Quantification of in vivo metabolic kinetics of hyperpolarized pyruvate in rat kidneys using dynamic 13C MRSITao Xu
Department of Electrical Engineering, Stanford University, Stanford, CA, USA
NMR Biomed 24:997-1005. 2011.... - In vivo evidence for alcohol-induced neurochemical changes in rat brain without protracted withdrawal, pronounced thiamine deficiency, or severe liver damageNatalie M Zahr
Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5723, USA
Neuropsychopharmacology 34:1427-42. 2009..Thus, we provide novel in vivo evidence for alcohol exposure as causing changes in brain chemistry in the absence of protracted withdrawal, pronounced thiamine deficiency, or severe liver damage... - In vivo measurement of ethanol metabolism in the rat liver using magnetic resonance spectroscopy of hyperpolarized [1-13C]pyruvateDaniel M Spielman
Stanford University Department of Radiology, Lucas Center for Medical Imaging, Stanford, CA 94305, USA
Magn Reson Med 62:307-13. 2009.... - In vivo glutamate decline associated with kainic acid-induced status epilepticusNatalie M Zahr
Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Rd, Stanford, CA 94305, USA
Brain Res 1300:65-78. 2009..Taken together, these results support the conclusion that seizure activity following KA infusion causes loss of glutamatergic neurons... - Detection of inflammatory arthritis by using hyperpolarized 13C-pyruvate with MR imaging and spectroscopyJohn D MacKenzie
Department of Radiology, Stanford University, Stanford, Calif, USA
Radiology 259:414-20. 2011..To examine the feasibility of using magnetic resonance (MR) spectroscopy with hyperpolarized carbon 13 ((13)C)-labeled pyruvate to detect inflammation... - Longitudinal brain magnetic resonance imaging study of the alcohol-preferring rat. Part II: effects of voluntary chronic alcohol consumptionAdolf Pfefferbaum
Neuroscience Program, SRI International, Menlo Park, California, USA
Alcohol Clin Exp Res 30:1248-61. 2006..CONCLUSION: The P rats showed an age-alcohol interaction different from humans, in that normal growth in selective brain regions that continues in adult rats was retarded... - In vivo MRSI of hyperpolarized [1-(13)C]pyruvate metabolism in rat hepatocellular carcinomaMoses M Darpolor
Department of Radiology, Stanford University, Stanford, CA 94305 5488, USA
NMR Biomed 24:506-13. 2011.... - Cerebral dynamics and metabolism of hyperpolarized [1-(13)C]pyruvate using time-resolved MR spectroscopic imagingRalph E Hurd
Global Applied Science Laboratory, GE Healthcare, Menlo Park, California 94025, USA
J Cereb Blood Flow Metab 30:1734-41. 2010..A model for brain [1-(13)C]lactate, based on blood-brain transport kinetics, CBV, and the observed pyruvate dynamics is described... - Ventricular expansion in wild-type Wistar rats after alcohol exposure by vapor chamberAdolf Pfefferbaum
Neuroscience Program, SRI International, Menlo Park, California, USA
Alcohol Clin Exp Res 32:1459-67. 2008.... - Metabolic imaging in the anesthetized rat brain using hyperpolarized [1-13C] pyruvate and [1-13C] ethyl pyruvateRalph E Hurd
Global Applied Science Laboratory, GE Healthcare, Menlo Park, California 94025, USA
Magn Reson Med 63:1137-43. 2010..Hyperpolarized [1-(13)C]-ethyl pyruvate and [1-(13)C]-pyruvate metabolic imaging in normal brain is demonstrated and quantified in this feasibility and range-finding study... - Metabolic response of glioma to dichloroacetate measured in vivo by hyperpolarized (13)C magnetic resonance spectroscopic imagingJae Mo Park
Stanford University, Department of Radiology, The Lucas Center for Imaging, 1201 Welch Road, Stanford, CA, 94305, USA
Neuro Oncol 15:433-41. 2013..The aim of this study is to improve the detection of (13)C-labeled metabolites, in particular bicarbonate, in glioma and normal brain in vivo and to measure the metabolic response to dichloroacetate, which upregulates PDH activity... - In vivo fiber tracking in the rat brain on a clinical 3T MRI system using a high strength insert gradient coilDirk Mayer
Department of Radiology, Stanford University School of Medicine, Stanford, CA, USA
Neuroimage 35:1077-85. 2007..An additional benefit of scanning at lower field strength, such as 3 T, is the reduction of artifacts due to main field inhomogeneity relative to higher field animal systems... - Application of double spin echo spiral chemical shift imaging to rapid metabolic mapping of hyperpolarized [1-¹³C]-pyruvateSonal Josan
SRI International, Neuroscience Program, Menlo Park, CA 94025, USA
J Magn Reson 209:332-6. 2011..Care must be taken for dynamic imaging to ensure that the spins remain within the B₁-homogeneous sensitive volume of the RF coil... - Low striatal glutamate levels underlie cognitive decline in the elderly: evidence from in vivo molecular spectroscopyNatalie M Zahr
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305 5723, USA
Cereb Cortex 18:2241-50. 2008..The selective relations between performance and striatal Glu provide initial and novel, human in vivo support for age-related modification of Glu levels as contributing to cognitive decline in normal aging... - In vivo measurement of aldehyde dehydrogenase-2 activity in rat liver ethanol model using dynamic MRSI of hyperpolarized [1-(13) C]pyruvateSonal Josan
SRI International, Neuroscience Program, Menlo Park, CA, USA Stanford University, Department of Radiology, Lucas MRI Center, Stanford, CA, USA
NMR Biomed 26:607-12. 2013..76). Copyright © 2012 John Wiley & Sons, Ltd... - A mechanism of rapidly reversible cerebral ventricular enlargement independent of tissue atrophyNatalie M Zahr
1 Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA 2 Neuroscience Program, SRI International, Menlo Park, CA, USA
Neuropsychopharmacology 38:1121-9. 2013..Together, these data support a model of fluid redistribution during acute EtOH intoxication and recovery to account for rapid ventricular volume changes... - In vivo monitoring of antiangiogenic therapy by magnetic resonance and bioluminescence imaging in an M21 tumor model through activation of an hsp70 promoter-luciferase reporter constructWalter Hundt
Department of Radiology, Lucas MRS Research Center, Stanford School of Medicine, Stanford, CA 94305, USA
Contrast Media Mol Imaging 7:450-9. 2012..Moreover, MRI showed a significant reduction of the contrast medium uptake parameters and an increase in the diffusion coefficient of the tumors... - In vivo glutamate measured with magnetic resonance spectroscopy: behavioral correlates in agingNatalie M Zahr
Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA Neuroscience Program, SRI International, Menlo Park, CA, USA
Neurobiol Aging 34:1265-76. 2013..These findings suggest that low brain glutamate levels are related to high blood pressure and that changes in brain glutamate levels might mediate the behavioral changes noted in normal aging... - Quantification of glutamate and glutamine using constant-time point-resolved spectroscopy at 3 TMeng Gu
Department of Radiology, Stanford University, Stanford, CA 94305, USA
NMR Biomed 26:164-72. 2013.... - Metabolite kinetics in C6 rat glioma model using magnetic resonance spectroscopic imaging of hyperpolarized [1-(13)C]pyruvateJae Mo Park
Department of Electrical Engineering, Stanford University, Stanford, California, USA
Magn Reson Med 68:1886-93. 2012..12 ± 0.02 for glioma, normal brain, and vasculature, respectively. The data suggest that the apparent conversion rate better differentiate glioma from normal brain (P = 0.001, n = 6) than the lactate-to-pyruvate ratio (P = 0.02)... - Use of in vivo bioluminescence and MRI to determine hyperthermia-induced changes in luciferase activity under the control of an hsp70 promoterWalter Hundt
Department of Radiology, Lucas MRS Research Center, Stanford School of Medicine, Stanford, CA, USA Department of Radiology, Philipps University, Marburg, Germany
NMR Biomed 25:1378-91. 2012..The major finding of the present study was that heat-related biochemical changes in tumor tissue can be determined by MRI. Copyright © 2012 John Wiley & Sons, Ltd... - Reproducibility study of whole-brain 1H spectroscopic imaging with automated quantificationMeng Gu
Department of Electrical Engineering, Stanford University, Stanford, California 94305 5488, USA
Magn Reson Med 60:542-7. 2008..The results demonstrate that reproducible whole-brain (1)H-MRSI data can be robustly obtained with the proposed methods... - Modulation of luciferase activity using high intensity focused ultrasound in combination with bioluminescence imaging, magnetic resonance imaging and histological analysis in muscle tissueWalter Hundt
Department of Radiology, Lucas MRS Research Center, Stanford School of Medicine, Stanford, CA 94305, USA
Ultrasonics 49:549-57. 2009..9 W/cm2 and 802.0 W/cm2 14.1 +/- 3.6 x 10(6) photon/s (6.1 +/- 1.5-fold), respectively, 5.1 +/- 4.7 x 10(6) photon/s (6.5 +/- 2.0-fold). HIFU can enhance the luciferase activity controlled by a CMV-promoter... - Quantitative evaluation of the relaxivity effects of iodine on GD-DTPA enhanced MR arthrographyArundhuti Ganguly
Lucas MRS Center, Department of Radiology, Stanford University, 1201 Welch Road, Stanford, CA 94305, USA
J Magn Reson Imaging 25:1219-25. 2007..To quantify the effect of iodine on the gadolinium (Gd) contrast-enhanced signal in MR arthrography... - Longitudinal brain magnetic resonance imaging study of the alcohol-preferring rat. Part I: adult brain growthEdith V Sullivan
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA
Alcohol Clin Exp Res 30:1234-47. 2006.... - Visualizing implanted tumors in mice with magnetic resonance imaging using magnetotactic bacteriaMichael R Benoit
Department of Microbiology and Immunology, Stanford University, Stanford, California 94305 5124, USA
Clin Cancer Res 15:5170-7. 2009..To determine if magnetotactic bacteria can target tumors in mice and provide positive contrast for visualization using magnetic resonance imaging... - Fast U-FLARE-based correlation-peak imaging with complete effective homonuclear decouplingDirk Mayer
Fachbereich 2 (Chemie, , Bremen, Germany
Magn Reson Med 49:810-6. 2003..The in vivo application of this method on healthy rat brain demonstrates its improved spectral resolution, as cross-peak signals from both Ins and Tau can be separated clearly... - In vivo quantification of ethanol kinetics in rat brainElfar Adalsteinsson
Harvard-MIT Division of Health Sciences and Technology, MIT, Cambridge, MA, USA
Neuropsychopharmacology 31:2683-91. 2006..Serial proton spectroscopy measurements provide a valid in vivo method for quantifying brain alcohol uptake and elimination kinetics in real time...