Dirk Mayer

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Application of hyperpolarized [1-¹³C]lactate for the in vivo investigation of cardiac metabolism
    Dirk Mayer
    SRI International, Neuroscience Program, 333 Ravenswood Ave, Menlo Park, CA 94025, USA
    NMR Biomed 25:1119-24. 2012
  2. pmc Dynamic and high-resolution metabolic imaging of hyperpolarized [1-13C]-pyruvate in the rat brain using a high-performance gradient insert
    Dirk Mayer
    SRI International, Neuroscience Program, Menlo Park, California 94025, USA
    Magn Reson Med 65:1228-33. 2011
  3. pmc In vivo application of sub-second spiral chemical shift imaging (CSI) to hyperpolarized 13C metabolic imaging: comparison with phase-encoded CSI
    Dirk Mayer
    Stanford University, Department of Radiology, Richard M Lucas Center for Imaging, 1201 Welch Rd, Stanford, CA 94305, USA
    J Magn Reson 204:340-5. 2010
  4. pmc Application of subsecond spiral chemical shift imaging to real-time multislice metabolic imaging of the rat in vivo after injection of hyperpolarized 13C1-pyruvate
    Dirk Mayer
    Department of Radiology, Stanford University, Richard M Lucas Center for Imaging, Stanford, California 94305 5488, USA
    Magn Reson Med 62:557-64. 2009
  5. doi request reprint Fast parallel spiral chemical shift imaging at 3T using iterative SENSE reconstruction
    Dirk Mayer
    Stanford University, Richard M Lucas Center for Magnetic Resonance Spectroscopy and Imaging, Department of Radiology, Stanford, California 94305 5488, USA
    Magn Reson Med 59:891-7. 2008
  6. ncbi request reprint RF refocused echoes of J-coupled spin systems: effects on RARE-based spectroscopic imaging
    Dirk Mayer
    Lucas MRS Imaging Center, Department of Radiology, Stanford University, Stanford, California 94305 5488, USA
    Magn Reson Med 57:967-71. 2007
  7. pmc In vivo metabolite differences between the basal ganglia and cerebellum of the rat brain detected with proton MRS at 3T
    Dirk Mayer
    Radiology Department Lucas MRS I Center Stanford University, 1201 Welch Road, P 273, Stanford, California 94305 5488, USA
    Psychiatry Res 154:267-73. 2007
  8. ncbi request reprint Fast CT-PRESS-based spiral chemical shift imaging at 3 Tesla
    Dirk Mayer
    Richard M Lucas Center for Magnetic Resonance Spectroscopy and Imaging, Department of Radiology, Stanford University, Stanford, California 94305 5488, USA
    Magn Reson Med 55:974-8. 2006
  9. ncbi request reprint Fast metabolic imaging of systems with sparse spectra: application for hyperpolarized 13C imaging
    Dirk Mayer
    Richard M Lucas Center for Magnetic Resonance Spectroscopy and Imaging, Department of Radiology, Stanford University, Stanford, California 94305 5488, USA
    Magn Reson Med 56:932-7. 2006
  10. ncbi request reprint Detection of glutamate in the human brain at 3 T using optimized constant time point resolved spectroscopy
    Dirk Mayer
    Stanford University, Lucas MRS Imaging Center, Department of Radiology, Stanford, California 94305 5488, USA
    Magn Reson Med 54:439-42. 2005

Detail Information

Publications43

  1. pmc Application of hyperpolarized [1-¹³C]lactate for the in vivo investigation of cardiac metabolism
    Dirk Mayer
    SRI International, Neuroscience Program, 333 Ravenswood Ave, Menlo Park, CA 94025, USA
    NMR Biomed 25:1119-24. 2012
    ..5-fold increase in bicarbonate-to-substrate ratio was found after administration of DCA, similar to the effect when using [1-(13) C]pyruvate as the substrate...
  2. pmc Dynamic and high-resolution metabolic imaging of hyperpolarized [1-13C]-pyruvate in the rat brain using a high-performance gradient insert
    Dirk Mayer
    SRI International, Neuroscience Program, Menlo Park, California 94025, USA
    Magn Reson Med 65:1228-33. 2011
    ....
  3. pmc In vivo application of sub-second spiral chemical shift imaging (CSI) to hyperpolarized 13C metabolic imaging: comparison with phase-encoded CSI
    Dirk Mayer
    Stanford University, Department of Radiology, Richard M Lucas Center for Imaging, 1201 Welch Rd, Stanford, CA 94305, USA
    J Magn Reson 204:340-5. 2010
    ..The presented results demonstrate that dramatic reductions in scan time are feasible in hyperpolarized (13)C metabolic imaging without a penalty in SNR or spatial resolution...
  4. pmc Application of subsecond spiral chemical shift imaging to real-time multislice metabolic imaging of the rat in vivo after injection of hyperpolarized 13C1-pyruvate
    Dirk Mayer
    Department of Radiology, Stanford University, Richard M Lucas Center for Imaging, Stanford, California 94305 5488, USA
    Magn Reson Med 62:557-64. 2009
    ..These results demonstrate the feasibility of real-time, hyperpolarized metabolic imaging and highlight its potential in assessing organ-specific kinetic parameters...
  5. doi request reprint Fast parallel spiral chemical shift imaging at 3T using iterative SENSE reconstruction
    Dirk Mayer
    Stanford University, Richard M Lucas Center for Magnetic Resonance Spectroscopy and Imaging, Department of Radiology, Stanford, California 94305 5488, USA
    Magn Reson Med 59:891-7. 2008
    ....
  6. ncbi request reprint RF refocused echoes of J-coupled spin systems: effects on RARE-based spectroscopic imaging
    Dirk Mayer
    Lucas MRS Imaging Center, Department of Radiology, Stanford University, Stanford, California 94305 5488, USA
    Magn Reson Med 57:967-71. 2007
    ..When the pulse interval falls short of the fast pulse rate regime, spectroscopic U-FLARE provides an improved spatial impulse response in the phase-encoding (PE) direction compared to spectroscopic RARE...
  7. pmc In vivo metabolite differences between the basal ganglia and cerebellum of the rat brain detected with proton MRS at 3T
    Dirk Mayer
    Radiology Department Lucas MRS I Center Stanford University, 1201 Welch Road, P 273, Stanford, California 94305 5488, USA
    Psychiatry Res 154:267-73. 2007
    ....
  8. ncbi request reprint Fast CT-PRESS-based spiral chemical shift imaging at 3 Tesla
    Dirk Mayer
    Richard M Lucas Center for Magnetic Resonance Spectroscopy and Imaging, Department of Radiology, Stanford University, Stanford, California 94305 5488, USA
    Magn Reson Med 55:974-8. 2006
    ..Signals from N-acetyl-aspartate, total creatine, choline-containing compounds (Cho), Glu, and mI were detected in a healthy volunteer with no or only minor baseline distortions within 14 min on a 3 T MR scanner...
  9. ncbi request reprint Fast metabolic imaging of systems with sparse spectra: application for hyperpolarized 13C imaging
    Dirk Mayer
    Richard M Lucas Center for Magnetic Resonance Spectroscopy and Imaging, Department of Radiology, Stanford University, Stanford, California 94305 5488, USA
    Magn Reson Med 56:932-7. 2006
    ..The metabolic maps of Ala and Lac for single-shot spCSI contain minor artifacts due to signal overlap of aliased resonances...
  10. ncbi request reprint Detection of glutamate in the human brain at 3 T using optimized constant time point resolved spectroscopy
    Dirk Mayer
    Stanford University, Lucas MRS Imaging Center, Department of Radiology, Stanford, California 94305 5488, USA
    Magn Reson Med 54:439-42. 2005
    ..However, glutamine resonances could not be resolved due to severe signal overlap from glutamate and N-acetyl aspartate...
  11. pmc Brain injury and recovery following binge ethanol: evidence from in vivo magnetic resonance spectroscopy
    Natalie M Zahr
    Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    Biol Psychiatry 67:846-54. 2010
    ..The current in vivo magnetic resonance (MR) imaging and spectroscopy study was conducted to test the hypothesis that binge EtOH exposure would injure but not cause the death of neurons as previously ascertained postmortem...
  12. pmc Quantification of glutamate and glutamine using constant-time point-resolved spectroscopy at 3 T
    Meng Gu
    Department of Radiology, Stanford University, Stanford, CA 94305, USA
    NMR Biomed 26:164-72. 2013
    ....
  13. pmc Fast volumetric imaging of ethanol metabolism in rat liver with hyperpolarized [1-(13) C]pyruvate
    Sonal Josan
    SRI International, Neuroscience Program, Menlo Park, CA 94025, USA
    NMR Biomed 25:993-9. 2012
    ..A significant increase in the pyruvate to lactate conversion was observed in the liver as a result of the greater availability of NADH (nicotinamide adenine dinucleotide, reduced form) from ethanol metabolism...
  14. pmc Metabolic response of glioma to dichloroacetate measured in vivo by hyperpolarized (13)C magnetic resonance spectroscopic imaging
    Jae Mo Park
    Stanford University, Department of Radiology, The Lucas Center for Imaging, 1201 Welch Road, Stanford, CA, 94305, USA
    Neuro Oncol 15:433-41. 2013
    ..The aim of this study is to improve the detection of (13)C-labeled metabolites, in particular bicarbonate, in glioma and normal brain in vivo and to measure the metabolic response to dichloroacetate, which upregulates PDH activity...
  15. pmc In vivo glutamate decline associated with kainic acid-induced status epilepticus
    Natalie M Zahr
    Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Rd, Stanford, CA 94305, USA
    Brain Res 1300:65-78. 2009
    ..Taken together, these results support the conclusion that seizure activity following KA infusion causes loss of glutamatergic neurons...
  16. pmc In vivo evidence for alcohol-induced neurochemical changes in rat brain without protracted withdrawal, pronounced thiamine deficiency, or severe liver damage
    Natalie M Zahr
    Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5723, USA
    Neuropsychopharmacology 34:1427-42. 2009
    ..Thus, we provide novel in vivo evidence for alcohol exposure as causing changes in brain chemistry in the absence of protracted withdrawal, pronounced thiamine deficiency, or severe liver damage...
  17. pmc Quantification of in vivo metabolic kinetics of hyperpolarized pyruvate in rat kidneys using dynamic 13C MRSI
    Tao Xu
    Department of Electrical Engineering, Stanford University, Stanford, CA, USA
    NMR Biomed 24:997-1005. 2011
    ....
  18. pmc A mechanism of rapidly reversible cerebral ventricular enlargement independent of tissue atrophy
    Natalie M Zahr
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA
    Neuropsychopharmacology 38:1121-9. 2013
    ..Together, these data support a model of fluid redistribution during acute EtOH intoxication and recovery to account for rapid ventricular volume changes...
  19. pmc In vivo measurement of aldehyde dehydrogenase-2 activity in rat liver ethanol model using dynamic MRSI of hyperpolarized [1-(13) C]pyruvate
    Sonal Josan
    SRI International, Neuroscience Program, Menlo Park, CA, USA
    NMR Biomed 26:607-12. 2013
    ..Results from a rat liver ethanol model (n = 9) show that changes in (13) C-lactate labeling following the bolus injection of hyperpolarized pyruvate are highly correlated with changes in ALDH2 activity (R(2) = 0.76)...
  20. pmc Metabolite kinetics in C6 rat glioma model using magnetic resonance spectroscopic imaging of hyperpolarized [1-(13)C]pyruvate
    Jae Mo Park
    Department of Electrical Engineering, Stanford University, Stanford, California, USA
    Magn Reson Med 68:1886-93. 2012
    ..12 ± 0.02 for glioma, normal brain, and vasculature, respectively. The data suggest that the apparent conversion rate better differentiate glioma from normal brain (P = 0.001, n = 6) than the lactate-to-pyruvate ratio (P = 0.02)...
  21. pmc In vivo measurement of ethanol metabolism in the rat liver using magnetic resonance spectroscopy of hyperpolarized [1-13C]pyruvate
    Daniel M Spielman
    Stanford University Department of Radiology, Lucas Center for Medical Imaging, Stanford, CA 94305, USA
    Magn Reson Med 62:307-13. 2009
    ....
  22. doi request reprint Use of in vivo bioluminescence and MRI to determine hyperthermia-induced changes in luciferase activity under the control of an hsp70 promoter
    Walter Hundt
    Department of Radiology, Lucas MRS Research Center, Stanford School of Medicine, Stanford, CA, USA
    NMR Biomed 25:1378-91. 2012
    ..The major finding of the present study was that heat-related biochemical changes in tumor tissue can be determined by MRI...
  23. pmc In vivo glutamate measured with magnetic resonance spectroscopy: behavioral correlates in aging
    Natalie M Zahr
    Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA
    Neurobiol Aging 34:1265-76. 2013
    ..These findings suggest that low brain glutamate levels are related to high blood pressure and that changes in brain glutamate levels might mediate the behavioral changes noted in normal aging...
  24. pmc In vivo MRSI of hyperpolarized [1-(13)C]pyruvate metabolism in rat hepatocellular carcinoma
    Moses M Darpolor
    Department of Radiology, Stanford University, Stanford, CA 94305 5488, USA
    NMR Biomed 24:506-13. 2011
    ....
  25. pmc Cerebral dynamics and metabolism of hyperpolarized [1-(13)C]pyruvate using time-resolved MR spectroscopic imaging
    Ralph E Hurd
    Global Applied Science Laboratory, GE Healthcare, Menlo Park, California 94025, USA
    J Cereb Blood Flow Metab 30:1734-41. 2010
    ..A model for brain [1-(13)C]lactate, based on blood-brain transport kinetics, CBV, and the observed pyruvate dynamics is described...
  26. ncbi request reprint Longitudinal brain magnetic resonance imaging study of the alcohol-preferring rat. Part II: effects of voluntary chronic alcohol consumption
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, Menlo Park, California, USA
    Alcohol Clin Exp Res 30:1248-61. 2006
    ....
  27. pmc Detection of inflammatory arthritis by using hyperpolarized 13C-pyruvate with MR imaging and spectroscopy
    John D MacKenzie
    Department of Radiology, Stanford University, Stanford, Calif, USA
    Radiology 259:414-20. 2011
    ..To examine the feasibility of using magnetic resonance (MR) spectroscopy with hyperpolarized carbon 13 ((13)C)-labeled pyruvate to detect inflammation...
  28. doi request reprint Rat strain differences in brain structure and neurochemistry in response to binge alcohol
    Natalie M Zahr
    Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Rd, Stanford, CA, 94305, USA
    Psychopharmacology (Berl) 231:429-45. 2014
    ..g., N-acetylaspartate (NAA) and choline-containing compounds (Cho))...
  29. pmc Metabolic imaging in the anesthetized rat brain using hyperpolarized [1-13C] pyruvate and [1-13C] ethyl pyruvate
    Ralph E Hurd
    Global Applied Science Laboratory, GE Healthcare, Menlo Park, California 94025, USA
    Magn Reson Med 63:1137-43. 2010
    ..Hyperpolarized [1-(13)C]-ethyl pyruvate and [1-(13)C]-pyruvate metabolic imaging in normal brain is demonstrated and quantified in this feasibility and range-finding study...
  30. pmc Ventricular expansion in wild-type Wistar rats after alcohol exposure by vapor chamber
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, Menlo Park, California, USA
    Alcohol Clin Exp Res 32:1459-67. 2008
    ....
  31. pmc In vivo fiber tracking in the rat brain on a clinical 3T MRI system using a high strength insert gradient coil
    Dirk Mayer
    Department of Radiology, Stanford University School of Medicine, Stanford, CA, USA
    Neuroimage 35:1077-85. 2007
    ..An additional benefit of scanning at lower field strength, such as 3 T, is the reduction of artifacts due to main field inhomogeneity relative to higher field animal systems...
  32. pmc Low striatal glutamate levels underlie cognitive decline in the elderly: evidence from in vivo molecular spectroscopy
    Natalie M Zahr
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305 5723, USA
    Cereb Cortex 18:2241-50. 2008
    ..The selective relations between performance and striatal Glu provide initial and novel, human in vivo support for age-related modification of Glu levels as contributing to cognitive decline in normal aging...
  33. pmc Application of double spin echo spiral chemical shift imaging to rapid metabolic mapping of hyperpolarized [1-¹³C]-pyruvate
    Sonal Josan
    SRI International, Neuroscience Program, Menlo Park, CA 94025, USA
    J Magn Reson 209:332-6. 2011
    ..Care must be taken for dynamic imaging to ensure that the spins remain within the B₁-homogeneous sensitive volume of the RF coil...
  34. pmc In vivo investigation of cardiac metabolism in the rat using MRS of hyperpolarized [1-13C] and [2-13C]pyruvate
    Sonal Josan
    SRI International, Neuroscience Program, Menlo Park, CA, USA Stanford University, Department of Radiology, Lucas MRI Center, Stanford, CA, USA
    NMR Biomed 26:1680-7. 2013
    ..Using a high dose of pyruvate may provide an improved ability to observe changes in glutamate...
  35. doi request reprint In vivo monitoring of antiangiogenic therapy by magnetic resonance and bioluminescence imaging in an M21 tumor model through activation of an hsp70 promoter-luciferase reporter construct
    Walter Hundt
    Department of Radiology, Lucas MRS Research Center, Stanford School of Medicine, Stanford, CA 94305, USA
    Contrast Media Mol Imaging 7:450-9. 2012
    ..Moreover, MRI showed a significant reduction of the contrast medium uptake parameters and an increase in the diffusion coefficient of the tumors...
  36. pmc Measuring mitochondrial metabolism in rat brain in vivo using MR Spectroscopy of hyperpolarized [2-¹³C]pyruvate
    Jae Mo Park
    Department of Electrical Engineering, Stanford University, Stanford, CA, USA Department of Radiology, Stanford University, Stanford, CA, USA
    NMR Biomed 26:1197-203. 2013
    ..This study demonstrates, for the first time, that hyperpolarized [2-(13) C]Pyr can be used for the in vivo investigation of mitochondrial function and tricarboxylic acid cycle metabolism in brain...
  37. pmc Reproducibility study of whole-brain 1H spectroscopic imaging with automated quantification
    Meng Gu
    Department of Electrical Engineering, Stanford University, Stanford, California 94305 5488, USA
    Magn Reson Med 60:542-7. 2008
    ..The results demonstrate that reproducible whole-brain (1)H-MRSI data can be robustly obtained with the proposed methods...
  38. doi request reprint Modulation of luciferase activity using high intensity focused ultrasound in combination with bioluminescence imaging, magnetic resonance imaging and histological analysis in muscle tissue
    Walter Hundt
    Department of Radiology, Lucas MRS Research Center, Stanford School of Medicine, Stanford, CA 94305, USA
    Ultrasonics 49:549-57. 2009
    ..9 W/cm2 and 802.0 W/cm2 14.1 +/- 3.6 x 10(6) photon/s (6.1 +/- 1.5-fold), respectively, 5.1 +/- 4.7 x 10(6) photon/s (6.5 +/- 2.0-fold). HIFU can enhance the luciferase activity controlled by a CMV-promoter...
  39. ncbi request reprint Longitudinal brain magnetic resonance imaging study of the alcohol-preferring rat. Part I: adult brain growth
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA
    Alcohol Clin Exp Res 30:1234-47. 2006
    ....
  40. ncbi request reprint Quantitative evaluation of the relaxivity effects of iodine on GD-DTPA enhanced MR arthrography
    Arundhuti Ganguly
    Lucas MRS Center, Department of Radiology, Stanford University, 1201 Welch Road, Stanford, CA 94305, USA
    J Magn Reson Imaging 25:1219-25. 2007
    ..To quantify the effect of iodine on the gadolinium (Gd) contrast-enhanced signal in MR arthrography...
  41. pmc Visualizing implanted tumors in mice with magnetic resonance imaging using magnetotactic bacteria
    Michael R Benoit
    Department of Microbiology and Immunology, Stanford University, Stanford, California 94305 5124, USA
    Clin Cancer Res 15:5170-7. 2009
    ..To determine if magnetotactic bacteria can target tumors in mice and provide positive contrast for visualization using magnetic resonance imaging...
  42. ncbi request reprint Fast U-FLARE-based correlation-peak imaging with complete effective homonuclear decoupling
    Dirk Mayer
    Fachbereich 2 Chemie, Universitat Bremen, Bremen, Germany
    Magn Reson Med 49:810-6. 2003
    ..The in vivo application of this method on healthy rat brain demonstrates its improved spectral resolution, as cross-peak signals from both Ins and Tau can be separated clearly...
  43. ncbi request reprint In vivo quantification of ethanol kinetics in rat brain
    Elfar Adalsteinsson
    Harvard MIT Division of Health Sciences and Technology, MIT, Cambridge, MA, USA
    Neuropsychopharmacology 31:2683-91. 2006
    ..Serial proton spectroscopy measurements provide a valid in vivo method for quantifying brain alcohol uptake and elimination kinetics in real time...