Robert Malenka

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons
    Daniel Saal
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Neuron 37:577-82. 2003
  2. ncbi request reprint LTP and LTD: an embarrassment of riches
    Robert C Malenka
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Neuron 44:5-21. 2004
  3. doi request reprint Rapid release revealed: honoring the synapse
    Robert C Malenka
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford CA 94305, USA Electronic address
    Cell 154:1171-4. 2013
  4. ncbi request reprint Long-term potentiation--a decade of progress?
    R C Malenka
    Nancy Friend Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA
    Science 285:1870-4. 1999
  5. ncbi request reprint The long-term potential of LTP
    Robert C Malenka
    Nancy Friend Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, 1201 Welch Road, Room P105, Stanford Medical Center, Palo Alto, California 94304 5485, USA
    Nat Rev Neurosci 4:923-6. 2003
  6. ncbi request reprint Synaptic plasticity and AMPA receptor trafficking
    Robert C Malenka
    Nancy Friend Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California 94304 5485, USA
    Ann N Y Acad Sci 1003:1-11. 2003
  7. ncbi request reprint Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome
    Fabian Fernandez
    Department of Psychiatry and Behavioral Sciences, Nancy Pritzker Laboratory, Stanford University, Palo Alto, California 94304 5485, USA
    Nat Neurosci 10:411-3. 2007
  8. pmc Molecular dissociation of the role of PSD-95 in regulating synaptic strength and LTD
    Weifeng Xu
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Neuron 57:248-62. 2008
  9. ncbi request reprint Excitation-neurogenesis coupling in adult neural stem/progenitor cells
    Karl Deisseroth
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Neuron 42:535-52. 2004
  10. pmc A critical role for PSD-95/AKAP interactions in endocytosis of synaptic AMPA receptors
    Samarjit Bhattacharyya
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, 1050 Arastradero Road, Stanford University School of Medicine, Palo Alto, California 94304 5552, USA
    Nat Neurosci 12:172-81. 2009

Research Grants

Collaborators

Detail Information

Publications63

  1. ncbi request reprint Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons
    Daniel Saal
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Neuron 37:577-82. 2003
    ....
  2. ncbi request reprint LTP and LTD: an embarrassment of riches
    Robert C Malenka
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Neuron 44:5-21. 2004
    ..Here we review those forms of LTP and LTD for which mechanisms have been most firmly established. Examples are provided that show how these mechanisms can contribute to experience-dependent modifications of brain function...
  3. doi request reprint Rapid release revealed: honoring the synapse
    Robert C Malenka
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford CA 94305, USA Electronic address
    Cell 154:1171-4. 2013
    ..Their discoveries provided insight into the molecular basis of synaptic transmission and enhanced our understanding of how synaptic dysfunction may cause neuropsychiatric disorders. ..
  4. ncbi request reprint Long-term potentiation--a decade of progress?
    R C Malenka
    Nancy Friend Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA
    Science 285:1870-4. 1999
    ..This review presents a current understanding of the molecular mechanisms of this long-lasting increase in synaptic strength and describes a simple model that unifies much of the data that previously were viewed as contradictory...
  5. ncbi request reprint The long-term potential of LTP
    Robert C Malenka
    Nancy Friend Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, 1201 Welch Road, Room P105, Stanford Medical Center, Palo Alto, California 94304 5485, USA
    Nat Rev Neurosci 4:923-6. 2003
  6. ncbi request reprint Synaptic plasticity and AMPA receptor trafficking
    Robert C Malenka
    Nancy Friend Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California 94304 5485, USA
    Ann N Y Acad Sci 1003:1-11. 2003
    ..We also review recent work from our lab suggesting that synaptic plasticity in the mesolimbic dopamine system may contribute importantly to the neural adaptations elicited by drugs of abuse...
  7. ncbi request reprint Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome
    Fabian Fernandez
    Department of Psychiatry and Behavioral Sciences, Nancy Pritzker Laboratory, Stanford University, Palo Alto, California 94304 5485, USA
    Nat Neurosci 10:411-3. 2007
    ..These results suggest that over-inhibition contributes to intellectual disabilities associated with Down syndrome and that GABAA antagonists may be useful therapeutic agents for this disorder...
  8. pmc Molecular dissociation of the role of PSD-95 in regulating synaptic strength and LTD
    Weifeng Xu
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Neuron 57:248-62. 2008
    ..Thus, the C-terminal portion of PSD-95 serves a dual function. It is required to localize PSD-95 at synapses and as a scaffold for signaling proteins that are required for LTD...
  9. ncbi request reprint Excitation-neurogenesis coupling in adult neural stem/progenitor cells
    Karl Deisseroth
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Neuron 42:535-52. 2004
    ....
  10. pmc A critical role for PSD-95/AKAP interactions in endocytosis of synaptic AMPA receptors
    Samarjit Bhattacharyya
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, 1050 Arastradero Road, Stanford University School of Medicine, Palo Alto, California 94304 5552, USA
    Nat Neurosci 12:172-81. 2009
    ..Our results suggest that PSD-95's interaction with AKAP150 is critical for NMDAR-triggered AMPAR endocytosis and LTD, possibly because these scaffolds position calcineurin in the appropriate subsynaptic domain...
  11. pmc Differential roles for NSF and GRIP/ABP in AMPA receptor cycling
    Steven P Braithwaite
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304 5485, USA
    Proc Natl Acad Sci U S A 99:7096-101. 2002
    ..These results provide further evidence for distinct functional roles of GluR2-interacting proteins in AMPAR trafficking...
  12. ncbi request reprint Differential regulation of AMPA receptor and GABA receptor trafficking by tumor necrosis factor-alpha
    David Stellwagen
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford Medical School, Palo Alto, California 94305, USA
    J Neurosci 25:3219-28. 2005
    ..These results suggest that TNFalpha can regulate neuronal circuit homeostasis in a manner that may exacerbate excitotoxic damage resulting from neuronal insults...
  13. ncbi request reprint Multiple roles for the active zone protein RIM1alpha in late stages of neurotransmitter release
    Nicole Calakos
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Neuron 42:889-96. 2004
    ..These results suggest that RIM1alpha modulates sequential steps in synaptic vesicle exocytosis through serial protein-protein interactions and that this modulation is the basis for RIM1alpha's role in synaptic plasticity...
  14. ncbi request reprint Control of synaptic strength by glial TNFalpha
    Eric C Beattie
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Science 295:2282-5. 2002
    ..Through its effects on AMPA receptor trafficking, TNFalpha may play roles in synaptic plasticity and modulating responses to neural injury...
  15. pmc N-methyl-D-aspartate receptor- and metabotropic glutamate receptor-dependent long-term depression are differentially regulated by the ubiquitin-proteasome system
    Ami Citri
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304 5552, USA
    Eur J Neurosci 30:1443-50. 2009
    ..These results suggest that, although NMDAR-dependent LTD may utilize ubiquitin as a signal for AMPAR endocytosis, mGluR-induced signaling and LTD are limited by a feedback mechanism that involves the ubiquitin-proteasome system...
  16. ncbi request reprint Synaptic scaling mediated by glial TNF-alpha
    David Stellwagen
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California 94304 5485, USA
    Nature 440:1054-9. 2006
    ..We suggest that by modulating TNF-alpha levels, glia actively participate in the homeostatic activity-dependent regulation of synaptic connectivity...
  17. ncbi request reprint Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression
    Wade Morishita
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304 5485, USA
    Neuropharmacology 52:71-6. 2007
    ..These results demonstrate that activation of NR2B-containing NMDARs is not an absolute requirement for the induction of LTD in the hippocampus...
  18. pmc Molecular and magnetic resonance imaging of human embryonic stem cell-derived neural stem cell grafts in ischemic rat brain
    Marcel M Daadi
    Department of Neurosurgery, Stanford Stroke Center, Stanford University School of Medicine, California 94305 5487, USA
    Mol Ther 17:1282-91. 2009
    ..Our data suggest that the combination of BLI and MRI modalities provides reliable real-time monitoring of cell fate...
  19. pmc Spike timing-dependent long-term potentiation in ventral tegmental area dopamine cells requires PKC
    Percy Luu
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94304 5485, USA
    J Neurophysiol 100:533-8. 2008
    ..These results suggest that NMDAR-mediated activation of PKC, but not CaMKII, is a critical trigger for LTP in VTA DA cells...
  20. ncbi request reprint CREB modulates excitability of nucleus accumbens neurons
    Yan Dong
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, California 94304, USA
    Nat Neurosci 9:475-7. 2006
    ....
  21. doi request reprint Functional engraftment of the medial ganglionic eminence cells in experimental stroke model
    Marcel M Daadi
    Department of Neurosurgery and Stanford Stroke Center, Stanford University School of Medicine, Stanford, CA 94305 5487, USA
    Cell Transplant 18:815-26. 2009
    ....
  22. ncbi request reprint Transsynaptic signaling by postsynaptic synapse-associated protein 97
    Maria Paz Regalado
    Department of Psychiatry and Behavioral Sciences, Nancy Pritzker Laboratory, Stanford University, Palo Alto, California 94304 5485, USA
    J Neurosci 26:2343-57. 2006
    ....
  23. ncbi request reprint Distinct triggering and expression mechanisms underlie LTD of AMPA and NMDA synaptic responses
    Wade Morishita
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 1201 Welch Rd, Palo Alto, California 94304, USA
    Nat Neurosci 8:1043-50. 2005
    ..These results suggest that the same pattern of afferent activity elicits depression of AMPAR- and NMDAR-mediated synaptic responses by means of distinct triggering and expression mechanisms...
  24. ncbi request reprint Enhanced inhibition of synaptic transmission by dopamine in the nucleus accumbens during behavioral sensitization to cocaine
    Corinne Beurrier
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California 94304, USA
    J Neurosci 22:5817-22. 2002
    ..We hypothesize that the enhanced inhibitory effects of DA on synaptic transmission in the NAc are one of a number of adaptations that contribute to a decrease in excitatory drive to NAc after exposure to drugs of abuse...
  25. ncbi request reprint Beta-catenin is critical for dendritic morphogenesis
    Xiang Yu
    Nancy Friend Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California 94304, USA
    Nat Neurosci 6:1169-77. 2003
    ....
  26. ncbi request reprint Activity-dependent regulation of dendritic synthesis and trafficking of AMPA receptors
    William Ju
    Nancy Friend Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, 1201 Welch Road, Stanford University School of Medicine, Palo Alto, California 94304, USA
    Nat Neurosci 7:244-53. 2004
    ....
  27. ncbi request reprint Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome
    Alexander M Kleschevnikov
    Department of Neurology and Neurological Sciences, and the Institute for Neuroscience, Stanford University Medical School, Stanford University, Stanford, California 94305 5489, USA
    J Neurosci 24:8153-60. 2004
    ..These findings raise the possibility that similar changes contribute to abnormalities in learning and memory in people with DS and, perhaps, in other developmental disorders with cognitive failure...
  28. ncbi request reprint Multiple functions for the cadherin/catenin complex during neuronal development
    Xiang Yu
    Nancy Friend Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5485, USA
    Neuropharmacology 47:779-86. 2004
    ..These results demonstrate that the cadherin/catenin complex plays multiple roles in the development of neuronal morphology and that these roles change as neurons mature...
  29. ncbi request reprint Synaptic plasticity: multiple forms, functions, and mechanisms
    Ami Citri
    Department of Psychiatry and Behavioral Sciences, Nancy Pritzker Laboratory, Stanford University School of Medicine, Palo Alto, CA 94304 5485, USA
    Neuropsychopharmacology 33:18-41. 2008
    ..We also provide examples of the possible developmental and behavioral functions of synaptic plasticity and how maladaptive synaptic plasticity may contribute to neuropsychiatric disorders...
  30. ncbi request reprint Mechanisms underlying dedepression of synaptic NMDA receptors in the hippocampus
    Wade Morishita
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA
    J Neurophysiol 99:254-63. 2008
    ..These results provide further evidence that synaptic NMDARs can be bidirectionally modified by activity but by mechanisms distinct from those responsible for the activity-dependent, bidirectional modulation of synaptic AMPARs...
  31. pmc Long-term monitoring of transplanted human neural stem cells in developmental and pathological contexts with MRI
    Raphael Guzman
    Department of Neurosurgery, Stanford University School of Medicine, 300 Pasteur Drive R200, Stanford, CA 94305 5327, USA
    Proc Natl Acad Sci U S A 104:10211-6. 2007
    ..Knowledge of migration patterns and implementation of noninvasive stem cell tracking might help to improve the design of future clinical neural stem cell transplantation...
  32. ncbi request reprint Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models
    Anatol C Kreitzer
    Department of Psychiatry and Behavioral Sciences, Nancy Pritzker Laboratory, Stanford University Medical School, Palo Alto, California 94305, USA
    Nature 445:643-7. 2007
    ..These findings have implications for understanding the normal functions of the basal ganglia, and also suggest approaches for the development of therapeutic drugs for the treatment of striatal-based brain disorders...
  33. pmc Understanding synapses: past, present, and future
    Thomas C Sudhof
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 1050 Arastradero Road, Palo Alto, CA 94304 USA
    Neuron 60:469-76. 2008
    ..In the present perspective, we provide a short description of our personal view of these advances, suggest a series of important future questions about synapses, and discuss ideas about how best to achieve further progress in the field...
  34. ncbi request reprint A novel anterograde trafficking signal present in the N-terminal extracellular domain of ionotropic glutamate receptors
    Houhui Xia
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California 94304, USA
    J Biol Chem 277:47765-9. 2002
    ..These results suggest a specific function of a short sequence present in the N-terminal domain in controlling anterograde trafficking of ionotropic glutamate receptors...
  35. ncbi request reprint Alternative N-terminal domains of PSD-95 and SAP97 govern activity-dependent regulation of synaptic AMPA receptor function
    Oliver M Schlüter
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California 94304, USA
    Neuron 51:99-111. 2006
    ..These results demonstrate that the different N termini of the predominant endogenous forms of PSD-95 (alpha-isoform) and SAP97 (beta-isoform) govern their role in regulating synaptic function...
  36. ncbi request reprint Dopamine modulation of state-dependent endocannabinoid release and long-term depression in the striatum
    Anatol C Kreitzer
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, Palo Alto, California 94305, USA
    J Neurosci 25:10537-45. 2005
    ..However, this gating of plasticity by dopamine is accomplished via an unexpected mechanism involving the regulation of mGluR-dependent endocannabinoid release...
  37. ncbi request reprint A developmental switch in the signaling cascades for LTP induction
    Hiroki Yasuda
    Department of Psychiatry and Behavioral Sciences, Nancy Pritzker Laboratory, Stanford University School of Medicine, Stanford, California 94304, USA
    Nat Neurosci 6:15-6. 2003
    ....
  38. pmc Endocytosis and recycling of AMPA receptors lacking GluR2/3
    Virginie Biou
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Proc Natl Acad Sci U S A 105:1038-43. 2008
    ....
  39. ncbi request reprint RIM1alpha is required for presynaptic long-term potentiation
    Pablo E Castillo
    Nancy Friend Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94304, USA
    Nature 415:327-30. 2002
    ....
  40. ncbi request reprint Mechanisms for synapse specificity during striatal long-term depression
    Sheela Singla
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California 94304, USA
    J Neurosci 27:5260-4. 2007
    ..This dual requirement for CB1 activation and presynaptic activity is a mechanism by which eCB-LTD may be made synapse specific...
  41. pmc A calcineurin/AKAP complex is required for NMDA receptor-dependent long-term depression
    Sandra Jurado
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California, USA
    Nat Neurosci 13:1053-5. 2010
    ..Using a viral-mediated molecular replacement strategy in rat hippocampal slices, we found that AKAP is required for NMDA receptor-dependent long-term depression solely because of its interaction with calcineurin...
  42. pmc A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spines
    Wendou Yu
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Hum Mol Genet 21:1384-90. 2012
    ..Our results reveal a critical role for PAR-1/MARK kinases in AD pathogenesis and suggest PAR-1/MARK inhibitors as potential therapeutics for AD and possibly other tauopathies where aberrant tau hyperphosphorylation is involved...
  43. ncbi request reprint Generation of silent synapses by acute in vivo expression of CaMKIV and CREB
    Helene Marie
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Neuron 45:741-52. 2005
    ....
  44. pmc LRRTM2 functions as a neurexin ligand in promoting excitatory synapse formation
    Jaewon Ko
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 1050 Arastradero Road, Palo Alto, CA 94304 5543, USA
    Neuron 64:791-8. 2009
    ..Thus, our data suggest that two unrelated postsynaptic cell-adhesion molecules, LRRTMs and neuroligins, unexpectedly bind to neurexins as the same presynaptic receptor, but that their binding is subject to distinct regulatory mechanisms...
  45. ncbi request reprint Substrate localization creates specificity in calcium/calmodulin-dependent protein kinase II signaling at synapses
    Jennifer Tsui
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, California 94304 5485, USA
    J Biol Chem 281:13794-804. 2006
    ..Phosphatase activity limited phosphorylation of Stargazin but not NR2B and GluR1. These results suggest that the unique molecular architecture of the PSD results in highly selective substrate discrimination by CaMKII...
  46. ncbi request reprint GABA excitation in the adult brain: a mechanism for excitation- neurogenesis coupling
    Karl Deisseroth
    Department of Bioengineering and Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California 94304, USA
    Neuron 47:775-7. 2005
    ....
  47. pmc RIM1alpha phosphorylation at serine-413 by protein kinase A is not required for presynaptic long-term plasticity or learning
    Pascal S Kaeser
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 105:14680-5. 2008
    ....
  48. pmc Mechanism and time course of cocaine-induced long-term potentiation in the ventral tegmental area
    Emanuela Argilli
    Department of Neurology, Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 28:9092-100. 2008
    ....
  49. doi request reprint Interactions between drebrin and Ras regulate dendritic spine plasticity
    Virginie Biou
    Friedrich Miescher Institute, Basel, Switzerland
    Eur J Neurosci 27:2847-59. 2008
    ..Together these data demonstrate a novel mechanism in which the balance between stability and plasticity in dendritic spines depends on binding of drebrin to actin filaments in a manner that is regulated by Ras...
  50. pmc Synaptic plasticity in the mesolimbic dopamine system
    Mark J Thomas
    Departments of Neuroscience and Psychology, and Institute of Human Genetics, University of Minnesota, Minneapolis, MN 55455, USA
    Philos Trans R Soc Lond B Biol Sci 358:815-9. 2003
    ....
  51. pmc Neuronal pentraxins mediate synaptic refinement in the developing visual system
    Lisa Bjartmar
    Department of Neurosciences, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Neurosci 26:6269-81. 2006
    ..We speculate that NPs exert their effects through mechanisms that parallel the known role of short pentraxins outside the CNS...
  52. ncbi request reprint Acute and chronic cocaine-induced potentiation of synaptic strength in the ventral tegmental area: electrophysiological and behavioral correlates in individual rats
    Stephanie L Borgland
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 24:7482-90. 2004
    ..Furthermore, chronic cocaine exposure disrupts the normal, presumably adaptive relationship between synaptic enhancement in the VTA and behavior...
  53. ncbi request reprint LTP: AMPA receptors trading places
    Julie A Kauer
    Nat Neurosci 9:593-4. 2006
  54. ncbi request reprint Neural mechanisms of addiction: the role of reward-related learning and memory
    Steven E Hyman
    Office of the Provost, Harvard University, Cambridge, Massachusetts 02138, USA
    Annu Rev Neurosci 29:565-98. 2006
    ..Here we review progress in identifying candidate mechanisms of addiction...
  55. ncbi request reprint Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family
    Angela Ho
    Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 26:13089-101. 2006
    ..Our studies thus indicate that Mints are important regulators of presynaptic neurotransmitter release that are essential for mouse survival...
  56. pmc Tumor necrosis factor-alpha mediates one component of competitive, experience-dependent plasticity in developing visual cortex
    Megumi Kaneko
    Department of Physiology and W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA 94143 0444, USA
    Neuron 58:673-80. 2008
    ....
  57. ncbi request reprint Synaptic plasticity and addiction
    Julie A Kauer
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island 02912, USA
    Nat Rev Neurosci 8:844-58. 2007
    ..Reversing or preventing these drug-induced synaptic modifications may prove beneficial in the treatment of one of society's most intractable health problems...
  58. pmc CREB modulates the functional output of nucleus accumbens neurons: a critical role of N-methyl-D-aspartate glutamate receptor (NMDAR) receptors
    Yanhua H Huang
    Program in Neuroscience, Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, Wegner 205, Pullman, WA 99164, USA
    J Biol Chem 283:2751-60. 2008
    ..Green, T., Saal, D., Marie, H., Neve, R., Nestler, E. J., and Malenka, R. C. (2006) Nat. Neurosci. 9, 475-477), may counteract drug-induced maladaptations in the NAc and thus ameliorate the addictive state...
  59. ncbi request reprint AMPA receptor trafficking and synaptic plasticity
    Roberto Malinow
    Cold Spring Harbor Laboratory, New York 11724, USA
    Annu Rev Neurosci 25:103-26. 2002
    ..While much work remains to understand the molecular basis for synaptic plasticity, recent results on AMPA receptor trafficking provide a clear conceptual framework for future studies...
  60. pmc A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission
    Angela Ho
    Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
    Proc Natl Acad Sci U S A 100:1409-14. 2003
    ..Our data indicate that Mints 1 and 2 perform redundant synaptic functions that become apparent in Mint 1-deficient mice in inhibitory interneurons because these neurons selectively express higher levels of Mint 1 than Mint 2...
  61. ncbi request reprint The addicted brain
    Eric J Nestler
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, USA
    Sci Am 290:78-85. 2004
  62. ncbi request reprint RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone
    Susanne Schoch
    The Center for Basic Neuroscience and Department of Molecular Genetics, Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    Nature 415:321-6. 2002
    ..These data indicate that RIM1alpha has a central function in integrating active zone proteins and synaptic vesicles into a molecular scaffold that controls neurotransmitter release...
  63. ncbi request reprint Cocaine-induced plasticity of intrinsic membrane properties in prefrontal cortex pyramidal neurons: adaptations in potassium currents
    Yan Dong
    Department of Neuroscience, The Chicago Medical School, North Chicago, Illinois 60064, USA
    J Neurosci 25:936-40. 2005
    ..This long-lasting, cocaine-induced plasticity of membrane excitability in PFC pyramidal neurons may contribute to the impaired decision making and drug craving that characterize cocaine withdrawal...

Research Grants16

  1. Conference on Excitatory Amino Acids & Brain Function
    Robert Malenka; Fiscal Year: 2007
    ..The conference should be of interest to the missions of several institutes at NIH including NIMH, NINDS, NICHD, NIA, NIDA and NIAAA. ..
  2. DRUGS OF ABUSE & SYNAPTIC PROCESSES IN DOPAMINE SYSTEMS
    Robert Malenka; Fiscal Year: 2003
    ..Such information is critical for a detailed understanding of the neural mechanism which contribute to the development of drug addiction as well as the development of severe mental illness such as schizophrenia. ..
  3. DRUGS OF ABUSE & SYNAPTIC PROCESSES IN DOPAMINE SYSTEMS
    Robert Malenka; Fiscal Year: 2009
    ..Such information is critical for a detailed understanding of the neural mechanisms that lead to drug addiction as well as the development of severe mental illnesses such as schizophrenia. ..