Holden T Maecker

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc The Stanford Data Miner: a novel approach for integrating and exploring heterogeneous immunological data
    Janet C Siebert
    CytoAnalytics, Denver, CO, USA
    J Transl Med 10:62. 2012
  2. pmc A model for harmonizing flow cytometry in clinical trials
    Holden T Maecker
    Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA
    Nat Immunol 11:975-8. 2010
  3. pmc Standardizing immunophenotyping for the Human Immunology Project
    Holden T Maecker
    Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Rev Immunol 12:191-200. 2012
  4. pmc Cytomegalovirus infection enhances the immune response to influenza
    David Furman
    Department of Microbiology and Immunology, School of Medicine, Stanford University, Stanford, CA 94305, USA
    Sci Transl Med 7:281ra43. 2015
  5. pmc New tools for classification and monitoring of autoimmune diseases
    Holden T Maecker
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Nat Rev Rheumatol 8:317-28. 2012
  6. pmc Variation in the human immune system is largely driven by non-heritable influences
    Petter Brodin
    Science for Life Laboratory, Department of Medicine, Solna, Karolinska Institutet, 17121 Solna, Sweden Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94304, USA Institute of Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94304, USA
    Cell 160:37-47. 2015
  7. pmc Daily cytokine fluctuations, driven by leptin, are associated with fatigue severity in chronic fatigue syndrome: evidence of inflammatory pathology
    Elizabeth Ann Stringer
    Department of Anesthesiology, Stanford University School of Medicine, Stanford, CA 94304, USA
    J Transl Med 11:93. 2013
  8. pmc flowCL: ontology-based cell population labelling in flow cytometry
    Melanie Courtot
    Molecular Biology and Biochemistry Department, Simon Fraser University, Burnaby, BC V5A 1S6, Canada, Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC V5Z 1L3, Canada, Department of Neurology, University at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY 14203, USA, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA, Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA, Center for Human Immunology, Autoimmunity and Inflammation, National Institutes of Health, Bethesda, MD 20892, USA, School of Dental Medicine, University at Buffalo, NY 14214 8006, USA, J Craig Venter Institute, La Jolla, CA 92037, USA, Department of Pathology, University of California, San Diego, CA 92093, USA
    Bioinformatics 31:1337-9. 2015
  9. pmc Algorithmic Tools for Mining High-Dimensional Cytometry Data
    Cariad Chester
    The Human Immune Monitoring Center, Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA 94305 and Division of Oncology, Department of Medicine, Stanford University, Stanford, CA 94305
    J Immunol 195:773-9. 2015
  10. pmc Barcoding of live human peripheral blood mononuclear cells for multiplexed mass cytometry
    Henrik E Mei
    Human Immune Monitoring Center, Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94305 and
    J Immunol 194:2022-31. 2015

Collaborators

Detail Information

Publications14

  1. pmc The Stanford Data Miner: a novel approach for integrating and exploring heterogeneous immunological data
    Janet C Siebert
    CytoAnalytics, Denver, CO, USA
    J Transl Med 10:62. 2012
    ..g., mean cytokine levels by age and gender)...
  2. pmc A model for harmonizing flow cytometry in clinical trials
    Holden T Maecker
    Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA
    Nat Immunol 11:975-8. 2010
    ..The novel use of a central laboratory may help mitigate these issues...
  3. pmc Standardizing immunophenotyping for the Human Immunology Project
    Holden T Maecker
    Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Rev Immunol 12:191-200. 2012
    ..In this Review, we outline the current state of standardization of flow cytometry assays and summarize the steps that are required to enable the Human Immunology Project...
  4. pmc Cytomegalovirus infection enhances the immune response to influenza
    David Furman
    Department of Microbiology and Immunology, School of Medicine, Stanford University, Stanford, CA 94305, USA
    Sci Transl Med 7:281ra43. 2015
    ..These data show that CMV and its murine equivalent can have a beneficial effect on the immune response of young, healthy individuals, which may explain the ubiquity of CMV infection in humans and many other species. ..
  5. pmc New tools for classification and monitoring of autoimmune diseases
    Holden T Maecker
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Nat Rev Rheumatol 8:317-28. 2012
    ..These analyses are revealing a more comprehensive and interconnected view of the immune system than ever before and should have an important role in directing future treatment approaches for autoimmune diseases...
  6. pmc Variation in the human immune system is largely driven by non-heritable influences
    Petter Brodin
    Science for Life Laboratory, Department of Medicine, Solna, Karolinska Institutet, 17121 Solna, Sweden Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94304, USA Institute of Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94304, USA
    Cell 160:37-47. 2015
    ..Lastly, in MZ twins discordant for cytomegalovirus infection, more than half of all parameters are affected. These results highlight the largely reactive and adaptive nature of the immune system in healthy individuals. ..
  7. pmc Daily cytokine fluctuations, driven by leptin, are associated with fatigue severity in chronic fatigue syndrome: evidence of inflammatory pathology
    Elizabeth Ann Stringer
    Department of Anesthesiology, Stanford University School of Medicine, Stanford, CA 94304, USA
    J Transl Med 11:93. 2013
    ..Single time-point approaches potentially overlook important features of CFS, such as fluctuations in fatigue severity. We have observed that individuals with CFS demonstrate significant day-to-day variability in their fatigue severity...
  8. pmc flowCL: ontology-based cell population labelling in flow cytometry
    Melanie Courtot
    Molecular Biology and Biochemistry Department, Simon Fraser University, Burnaby, BC V5A 1S6, Canada, Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC V5Z 1L3, Canada, Department of Neurology, University at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY 14203, USA, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA, Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA, Center for Human Immunology, Autoimmunity and Inflammation, National Institutes of Health, Bethesda, MD 20892, USA, School of Dental Medicine, University at Buffalo, NY 14214 8006, USA, J Craig Venter Institute, La Jolla, CA 92037, USA, Department of Pathology, University of California, San Diego, CA 92093, USA
    Bioinformatics 31:1337-9. 2015
    ..However, labelling of cell populations is not well defined, making it difficult to integrate the output of algorithms to external knowledge sources...
  9. pmc Algorithmic Tools for Mining High-Dimensional Cytometry Data
    Cariad Chester
    The Human Immune Monitoring Center, Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA 94305 and Division of Oncology, Department of Medicine, Stanford University, Stanford, CA 94305
    J Immunol 195:773-9. 2015
    ..This review will help immunologists to identify suitable algorithmic tools for their particular projects. ..
  10. pmc Barcoding of live human peripheral blood mononuclear cells for multiplexed mass cytometry
    Henrik E Mei
    Human Immune Monitoring Center, Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94305 and
    J Immunol 194:2022-31. 2015
    ..Hence, CD45 barcoding facilitates accuracy of mass cytometric immunophenotyping studies, thus supporting biomarker discovery efforts, and it should be applicable to fluorescence flow cytometry as well. ..
  11. pmc The Split Virus Influenza Vaccine rapidly activates immune cells through Fcγ receptors
    William E O'Gorman
    The Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, United States
    Vaccine 32:5989-97. 2014
    ....
  12. pmc Apoptosis and other immune biomarkers predict influenza vaccine responsiveness
    David Furman
    Department of Microbiology and Immunology, School of Medicine, Stanford University, Palo Alto, CA 94305, USA
    Mol Syst Biol 9:659. 2013
    ..The identification of these biomarkers provides new insights into what immune features may be most important for immune health...
  13. pmc Experimental pain and opioid analgesia in volunteers at high risk for obstructive sleep apnea
    Anthony G Doufas
    Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA
    PLoS ONE 8:e54807. 2013
    ..Using accepted experimental pain models, we characterized pain processing and opioid analgesia in male volunteers recruited based on their risk for OSA...
  14. pmc New technologies for autoimmune disease monitoring
    Holden T Maecker
    Institute for Immunity, Transplantation, and Infection Operations, USA
    Curr Opin Endocrinol Diabetes Obes 17:322-8. 2010
    ..This article will review new technologies used to characterize the immune phenotype of cells and serum for potential use in studies of autoimmunity...