MERRITT C MADUKE

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Cysteine accessibility in ClC-0 supports conservation of the ClC intracellular vestibule
    Anita M Engh
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, CA 94305, USA
    J Gen Physiol 125:601-17. 2005
  2. pmc The mechanism of fast-gate opening in ClC-0
    Anita M Engh
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Gen Physiol 130:335-49. 2007
  3. pmc The role of a conserved lysine in chloride- and voltage-dependent ClC-0 fast gating
    Anita M Engh
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Gen Physiol 130:351-63. 2007
  4. pmc The ClC-0 chloride channel is a 'broken' Cl-/H+ antiporter
    Jirí Lísal
    Stanford University, Department of Molecular and Cellular Physiology, 279 Campus Drive, Stanford, California 94305, USA
    Nat Struct Mol Biol 15:805-10. 2008
  5. pmc A cytoplasmic domain mutation in ClC-Kb affects long-distance communication across the membrane
    Gilbert Q Martinez
    Department of Molecular and Cellular Physiology and Program in Biophysics, Stanford University Stanford, California, United States of America
    PLoS ONE 3:e2746. 2008
  6. pmc Dynamic response of model lipid membranes to ultrasonic radiation force
    Martin Loynaz Prieto
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 8:e77115. 2013
  7. ncbi request reprint Biochemistry to the rescue: a ClC-2 auxiliary subunit provides a tangible link to leukodystrophy
    MERRITT C MADUKE
    Department of Molecular and Cellular Physiology, Stanford University, 279 Campus Drive West, Stanford, CA 94305, USA
    Neuron 73:855-7. 2012
  8. pmc A designed inhibitor of a CLC antiporter blocks function through a unique binding mode
    Andrew E Howery
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA
    Chem Biol 19:1460-70. 2012

Research Grants

  1. Mechanisms of CIC Chloride Transport Proteins
    Merritt Maduke; Fiscal Year: 2005
  2. Mechanisms of CIC Chloride Transport Proteins
    Merritt Maduke; Fiscal Year: 2006
  3. Mechanisms of CIC Chloride Transport Proteins
    Merritt Maduke; Fiscal Year: 2007
  4. Mechanisms of CIC Chloride Transport Proteins
    Merritt Maduke; Fiscal Year: 2009
  5. Mechanisms of CIC Chloride Transport Proteins
    Merritt Maduke; Fiscal Year: 2009

Collaborators

  • Jonas Almqvist
  • Ulrich Zachariae
  • Kee Hyun Choi
  • Anita M Engh
  • Martin Loynaz Prieto
  • Andrew E Howery
  • Gilbert Q Martinez
  • Jirí Lísal
  • José D Faraldo-Gómez
  • Omer Ömer
  • Butrus T Khuri-Yakub
  • Sherwin J Abraham
  • Kimberly Matulef
  • SHELLEY ELVINGTON
  • Kevin Tran
  • Sierra Dworschak-Simpson
  • Christopher M Ryan
  • R Lea Sanford
  • Olaf S Andersen
  • Julian Whitelegge
  • Thomas A Chew
  • Sabrina Phillips
  • JUSTIN DU BOIS

Detail Information

Publications8

  1. pmc Cysteine accessibility in ClC-0 supports conservation of the ClC intracellular vestibule
    Anita M Engh
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, CA 94305, USA
    J Gen Physiol 125:601-17. 2005
    ..2004). These results support the hypothesis that both secondary and tertiary structures in the intracellular vestibule are conserved among ClC family members, even in regions of very low sequence similarity...
  2. pmc The mechanism of fast-gate opening in ClC-0
    Anita M Engh
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Gen Physiol 130:335-49. 2007
    ....
  3. pmc The role of a conserved lysine in chloride- and voltage-dependent ClC-0 fast gating
    Anita M Engh
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Gen Physiol 130:351-63. 2007
    ..The analysis of gating kinetics in combination with the available structural information suggests some of the structural changes likely to underpin fast-gate opening...
  4. pmc The ClC-0 chloride channel is a 'broken' Cl-/H+ antiporter
    Jirí Lísal
    Stanford University, Department of Molecular and Cellular Physiology, 279 Campus Drive, Stanford, California 94305, USA
    Nat Struct Mol Biol 15:805-10. 2008
    ..This finding clarifies the evolutionary relationship between the channels and transporters and conveys that similar mechanisms and analogous protein movements are used by both...
  5. pmc A cytoplasmic domain mutation in ClC-Kb affects long-distance communication across the membrane
    Gilbert Q Martinez
    Department of Molecular and Cellular Physiology and Program in Biophysics, Stanford University Stanford, California, United States of America
    PLoS ONE 3:e2746. 2008
    ..A point mutation in ClC-Kb, R538P, linked to Bartter's Syndrome and located in the C-terminal cytoplasmic domain was hypothesized to alter electrophysiological properties due to its proximity to an important membrane-embedded helix...
  6. pmc Dynamic response of model lipid membranes to ultrasonic radiation force
    Martin Loynaz Prieto
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 8:e77115. 2013
    ..Based on these results, we conclude that synthetic lipid bilayers can be used to study the effects of ultrasound on cell membranes and membrane proteins. ..
  7. ncbi request reprint Biochemistry to the rescue: a ClC-2 auxiliary subunit provides a tangible link to leukodystrophy
    MERRITT C MADUKE
    Department of Molecular and Cellular Physiology, Stanford University, 279 Campus Drive West, Stanford, CA 94305, USA
    Neuron 73:855-7. 2012
    ..In this issue of Neuron, Jeworutzki et al. (2012) use a biochemical approach to identify GlialCAM, a protein with a defined link to leukodystrophy, as a ClC-2 auxiliary subunit...
  8. pmc A designed inhibitor of a CLC antiporter blocks function through a unique binding mode
    Andrew E Howery
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA
    Chem Biol 19:1460-70. 2012
    ..This compound will empower research to elucidate differences between antiporter and channel mechanisms and to develop treatments for CLC-mediated disorders...

Research Grants6

  1. Mechanisms of CIC Chloride Transport Proteins
    Merritt Maduke; Fiscal Year: 2005
    ..Together, these studies will offer new insights into the functional relationships between channels and transporters. ..
  2. Mechanisms of CIC Chloride Transport Proteins
    Merritt Maduke; Fiscal Year: 2006
    ..Together, these studies will offer new insights into the functional relationships between channels and transporters. ..
  3. Mechanisms of CIC Chloride Transport Proteins
    Merritt Maduke; Fiscal Year: 2007
    ..Together, these studies will offer new insights into the functional relationships between channels and transporters. ..
  4. Mechanisms of CIC Chloride Transport Proteins
    Merritt Maduke; Fiscal Year: 2009
    ..Together, these studies will offer new insights into the functional relationships between channels and transporters. ..
  5. Mechanisms of CIC Chloride Transport Proteins
    Merritt Maduke; Fiscal Year: 2009
    ..Together, these studies will offer new insights into the functional relationships between channels and transporters. ..