M MacIver

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Isoflurane depresses hippocampal CA1 glutamate nerve terminals without inhibiting fiber volleys
    Bruce D Winegar
    Neuroscience Program, Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305 5117, USA
    BMC Neurosci 7:5. 2006
  2. pmc Multiple synaptic and membrane sites of anesthetic action in the CA1 region of rat hippocampal slices
    Sky Pittson
    Department of Anesthesia, Stanford University School of Medicine, SUMC S288, Stanford, CA 94305 5117, USA
    BMC Neurosci 5:52. 2004
  3. pmc Slow GABA(A) mediated synaptic transmission in rat visual cortex
    Michael P Sceniak
    Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106, USA
    BMC Neurosci 9:8. 2008
  4. doi request reprint Human subthalamic neuron spiking exhibits subtle responses to sedatives
    M Bruce MacIver
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California, USA
    Anesthesiology 115:254-64. 2011
  5. pmc Abused inhalants enhance GABA-mediated synaptic inhibition
    M Bruce MacIver
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305 5117, USA
    Neuropsychopharmacology 34:2296-304. 2009
  6. ncbi request reprint Thiopental uncouples hippocampal and cortical synchronized electroencephalographic activity
    M B Maciver
    Department of Anesthesia, Stanford University School of Medicine, California 94305 5117, USA
    Anesthesiology 84:1411-24. 1996
  7. ncbi request reprint G-force induced alterations in rat EEG activity: a quantitative analysis
    H S Lukatch
    Stanford University Neuroscience Program, CA 94305 5117, USA
    Electroencephalogr Clin Neurophysiol 103:563-73. 1997
  8. ncbi request reprint Membrane and synaptic actions of halothane on rat hippocampal pyramidal neurons and inhibitory interneurons
    K Nishikawa
    Neuropharmacology Laboratory, Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305 5117, USA
    J Neurosci 20:5915-23. 2000
  9. ncbi request reprint General anaesthetic modification of synaptic facilitation and long-term potentiation in hippocampus
    M B Maciver
    Department of Anesthesia, Stanford University School of Medicine, CA94305 5117
    Br J Anaesth 62:301-10. 1989
  10. ncbi request reprint Excitatory synaptic transmission mediated by NMDA receptors is more sensitive to isoflurane than are non-NMDA receptor-mediated responses
    K Nishikawa
    Department of Anesthesia, Stanford University School of Medicine, California 94305 5117, USA
    Anesthesiology 92:228-36. 2000

Collaborators

Detail Information

Publications14

  1. pmc Isoflurane depresses hippocampal CA1 glutamate nerve terminals without inhibiting fiber volleys
    Bruce D Winegar
    Neuroscience Program, Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305 5117, USA
    BMC Neurosci 7:5. 2006
    ..EPSPs were recorded from CA1 neurons in rat hippocampal brain slices in response to Schaffer-collateral fiber stimulation...
  2. pmc Multiple synaptic and membrane sites of anesthetic action in the CA1 region of rat hippocampal slices
    Sky Pittson
    Department of Anesthesia, Stanford University School of Medicine, SUMC S288, Stanford, CA 94305 5117, USA
    BMC Neurosci 5:52. 2004
    ..The present study compared and contrasted effects produced by five general anesthetics on synaptic circuitry in the CA1 region of hippocampal slices...
  3. pmc Slow GABA(A) mediated synaptic transmission in rat visual cortex
    Michael P Sceniak
    Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106, USA
    BMC Neurosci 9:8. 2008
    ..Spontaneous slow GABA(A) IPSCs were recorded from both pyramidal and inhibitory neurons in rat visual cortex...
  4. doi request reprint Human subthalamic neuron spiking exhibits subtle responses to sedatives
    M Bruce MacIver
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California, USA
    Anesthesiology 115:254-64. 2011
    ..The effects produced by propofol or remifentanil on discharge activity of subthalamic neurons were studied intraoperatively to determine whether they alter neuronal activity...
  5. pmc Abused inhalants enhance GABA-mediated synaptic inhibition
    M Bruce MacIver
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305 5117, USA
    Neuropsychopharmacology 34:2296-304. 2009
    ....
  6. ncbi request reprint Thiopental uncouples hippocampal and cortical synchronized electroencephalographic activity
    M B Maciver
    Department of Anesthesia, Stanford University School of Medicine, California 94305 5117, USA
    Anesthesiology 84:1411-24. 1996
    ..The current study investigated thiopental actions on cortical EEG and hippocampal electrical activity, to determine whether similar effects occur on both structures and to compare synchronized activity between these structures...
  7. ncbi request reprint G-force induced alterations in rat EEG activity: a quantitative analysis
    H S Lukatch
    Stanford University Neuroscience Program, CA 94305 5117, USA
    Electroencephalogr Clin Neurophysiol 103:563-73. 1997
    ..Additionally, several EEG measures were identified which correlated with acceleration level at specific post-acceleration onset times...
  8. ncbi request reprint Membrane and synaptic actions of halothane on rat hippocampal pyramidal neurons and inhibitory interneurons
    K Nishikawa
    Neuropharmacology Laboratory, Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305 5117, USA
    J Neurosci 20:5915-23. 2000
    ....
  9. ncbi request reprint General anaesthetic modification of synaptic facilitation and long-term potentiation in hippocampus
    M B Maciver
    Department of Anesthesia, Stanford University School of Medicine, CA94305 5117
    Br J Anaesth 62:301-10. 1989
    ..92); methoxyflurane did not block LTP. The results suggest that these agents affect cortical excitability by multiple actions, the distribution of actions being specific to each agent...
  10. ncbi request reprint Excitatory synaptic transmission mediated by NMDA receptors is more sensitive to isoflurane than are non-NMDA receptor-mediated responses
    K Nishikawa
    Department of Anesthesia, Stanford University School of Medicine, California 94305 5117, USA
    Anesthesiology 92:228-36. 2000
    ..The authors compared effects produced by halothane and isoflurane on electrophysiologic properties of NMDA and non-NMDA receptor-mediated synaptic responses in slices from the rat hippocampus...
  11. ncbi request reprint Cellular actions of urethane on rat visual cortical neurons in vitro
    Michael P Sceniak
    Department of Anesthesia, Stanford University School of Medicine, Room S288, Stanford, California 94305 5117, USA
    J Neurophysiol 95:3865-74. 2006
    ..These results are consistent with observations seen in vivo during urethane anesthesia where urethane produced minimal disruption of signal transmission in the neocortex...
  12. ncbi request reprint Major role for tonic GABAA conductances in anesthetic suppression of intrinsic neuronal excitability
    Mark C Bieda
    Neuroscience Program and Department of Anesthesia, Stanford University, SUMC 288 MC5117, Stanford, CA 94305, USA
    J Neurophysiol 92:1658-67. 2004
    ....
  13. ncbi request reprint Anesthetic-induced burst suppression EEG activity requires glutamate-mediated excitatory synaptic transmission
    Heath S Lukatch
    Stanford Neuroscience Program and Neuropharmacology Laboratory, Stanford University School of Medicine, Stanford, CA 94305 5117, USA
    Cereb Cortex 15:1322-31. 2005
    ..A GABA(A) agonist produced a similar EEG effect to the anesthetics. It appears that anesthetic effects at both glutamate and GABA synapses contribute to EEG patterns seen during anesthesia...
  14. ncbi request reprint Anesthesia in silico
    Michael P Sceniak
    Anesthesiology 104:400-2. 2006

Research Grants13

  1. Abused Inhalant Actions at GABA and Glutamate Synapses
    M MacIver; Fiscal Year: 2007
    ..Taken together, the results will allow a quantitative comparison of drug effects on glutamate and GABA-mediated transmission for commonly abused solvents including: toluene, 1,1,1-trichloroethane and trichloroethylene. ..
  2. ANESTHETIC ACTIONS AT GABA AND GLUTAMATE SYNAPSES
    M MacIver; Fiscal Year: 2004
    ..abstract_text> ..
  3. ANESTHETIC ACTIONS AT GABA AND GLUTAMATE SYNAPSES
    M MacIver; Fiscal Year: 2000
    ..Parallel studies will determine the extent to which an anesthetic-induced depression of CA 1 neuron discharge can be reversed by blocking GABA receptor/Cl- channels. ..