David Lyons

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Separation induced changes in squirrel monkey hypothalamic-pituitary-adrenal physiology resemble aspects of hypercortisolism in humans
    D M Lyons
    Department of Psychiatry and Behavioral Science, Stanford University School of Medicine, CA 94305 5485, USA
    Psychoneuroendocrinology 24:131-42. 1999
  2. pmc Stress coping stimulates hippocampal neurogenesis in adult monkeys
    David M Lyons
    Departments of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 107:14823-7. 2010
  3. pmc Animal models of early life stress: Implications for understanding resilience
    David M Lyons
    Department of Psychiatry and Behavioral Sciences, Stanford University, 1201 Welch Rd, MSLS P104, Stanford, CA 94305, USA
    Dev Psychobiol 52:402-10. 2010
  4. ncbi request reprint Stress inoculation-induced indications of resilience in monkeys
    David M Lyons
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, CA 94305 5485, USA
    J Trauma Stress 20:423-33. 2007
  5. pmc Preliminary evidence that hippocampal volumes in monkeys predict stress levels of adrenocorticotropic hormone
    David M Lyons
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, California 94305 5485, USA
    Biol Psychiatry 62:1171-4. 2007
  6. doi request reprint Animal models of early life stress: implications for understanding resilience
    David M Lyons
    Department of Psychiatry and Behavioral Sciences, Stanford University, CA 94305, USA
    Dev Psychobiol 52:616-24. 2010
  7. ncbi request reprint Cognitive correlates of white matter growth and stress hormones in female squirrel monkey adults
    David M Lyons
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5485, USA
    J Neurosci 24:3655-62. 2004
  8. ncbi request reprint Early maternal availability and prefrontal correlates of reward-related memory
    David M Lyons
    Department of Psychiatry and Behavioral Science, Stanford University Medical School, Stanford, CA 94305 5485, USA
    Neurobiol Learn Mem 80:97-104. 2003
  9. ncbi request reprint Early life stress and inherited variation in monkey hippocampal volumes
    D M Lyons
    Department of Psychiatry and Behavioral Science, 1201 Welch Rd, Medical School Laboratory Surge Bldg, Room P104 Mail Code 5485, Stanford University School of Medicine, Stanford, CA 94305 5485, USA
    Arch Gen Psychiatry 58:1145-51. 2001
  10. ncbi request reprint Postnatal experiences and genetic effects on squirrel monkey social affinities and emotional distress
    D M Lyons
    Department of Psychiatry and Behavioral Science, Stanford University School of Medicine, Stanford, California 94305 5485, USA
    Horm Behav 36:266-75. 1999

Research Grants

  1. Neurobiology of Stress Inoculation
    David M Lyons; Fiscal Year: 2010
  2. Early Chronic Stress and Prefrontal Development
    David Lyons; Fiscal Year: 2005
  3. Neurobiology of Stress Inoculation
    David Lyons; Fiscal Year: 2007

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Separation induced changes in squirrel monkey hypothalamic-pituitary-adrenal physiology resemble aspects of hypercortisolism in humans
    D M Lyons
    Department of Psychiatry and Behavioral Science, Stanford University School of Medicine, CA 94305 5485, USA
    Psychoneuroendocrinology 24:131-42. 1999
    ..Similar findings in humans have been reported in clinical studies of hypercortisolism and major depression...
  2. pmc Stress coping stimulates hippocampal neurogenesis in adult monkeys
    David M Lyons
    Departments of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 107:14823-7. 2010
    ..These findings support recent indications that stress coping stimulates hippocampal neurogenesis in adult rodents. Psychotherapies designed to promote stress coping potentially have similar effects in humans with major depression...
  3. pmc Animal models of early life stress: Implications for understanding resilience
    David M Lyons
    Department of Psychiatry and Behavioral Sciences, Stanford University, 1201 Welch Rd, MSLS P104, Stanford, CA 94305, USA
    Dev Psychobiol 52:402-10. 2010
    ..Implications for programs designed to enhance resilience in human development are discussed...
  4. ncbi request reprint Stress inoculation-induced indications of resilience in monkeys
    David M Lyons
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, CA 94305 5485, USA
    J Trauma Stress 20:423-33. 2007
    ....
  5. pmc Preliminary evidence that hippocampal volumes in monkeys predict stress levels of adrenocorticotropic hormone
    David M Lyons
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, California 94305 5485, USA
    Biol Psychiatry 62:1171-4. 2007
    ..Hippocampal volumes previously determined in monkeys by magnetic resonance imaging are used to test the hypothesis that small hippocampi predict increased stress levels of adrenocorticotropic hormone (ACTH)...
  6. doi request reprint Animal models of early life stress: implications for understanding resilience
    David M Lyons
    Department of Psychiatry and Behavioral Sciences, Stanford University, CA 94305, USA
    Dev Psychobiol 52:616-24. 2010
    ..Implications for programs designed to enhance resilience in human development are discussed...
  7. ncbi request reprint Cognitive correlates of white matter growth and stress hormones in female squirrel monkey adults
    David M Lyons
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5485, USA
    J Neurosci 24:3655-62. 2004
    ....
  8. ncbi request reprint Early maternal availability and prefrontal correlates of reward-related memory
    David M Lyons
    Department of Psychiatry and Behavioral Science, Stanford University Medical School, Stanford, CA 94305 5485, USA
    Neurobiol Learn Mem 80:97-104. 2003
    ..Differences in performance were also discerned after each spatial reversal. These findings indicate that maternal availability alters developing ventral medial prefrontal brain regions involved in reward-related memory...
  9. ncbi request reprint Early life stress and inherited variation in monkey hippocampal volumes
    D M Lyons
    Department of Psychiatry and Behavioral Science, 1201 Welch Rd, Medical School Laboratory Surge Bldg, Room P104 Mail Code 5485, Stanford University School of Medicine, Stanford, CA 94305 5485, USA
    Arch Gen Psychiatry 58:1145-51. 2001
    ..Therefore, this longitudinal study investigated early life stress and inherited variation in monkey hippocampal volumes...
  10. ncbi request reprint Postnatal experiences and genetic effects on squirrel monkey social affinities and emotional distress
    D M Lyons
    Department of Psychiatry and Behavioral Science, Stanford University School of Medicine, Stanford, California 94305 5485, USA
    Horm Behav 36:266-75. 1999
    ..These findings concur with human twin studies that suggest genetic and experiential factors contribute to individual differences in vulnerability to emotional distress...
  11. ncbi request reprint Stress, depression, and inherited variation in primate hippocampal and prefrontal brain development
    David M Lyons
    Department of Psychiatry and Behavioral Sciences, 1201 Welch Road, MSLS Room P104, Mail Code 5485, Stanford University Medical School, Stanford, CA 94305 5485, USA
    Psychopharmacol Bull 36:27-43. 2002
    ..Here, we illustrate this preclinical approach with a series of studies on early life stress and inherited variation in squirrel monkey hippocampal and prefrontal volumes determined in vivo with magnetic resonance imaging...
  12. ncbi request reprint Early environmental regulation of glucocorticoid feedback sensitivity in young adult monkeys
    D M Lyons
    Department of Psychiatry and Behavioral Science, Stanford University School of Medicine, Stanford, CA 94305 5485, USA
    J Neuroendocrinol 12:723-8. 2000
    ....
  13. ncbi request reprint Stress-level cortisol treatment impairs inhibitory control of behavior in monkeys
    D M Lyons
    Department of Psychiatry and Behavioral Science, Stanford University School of Medicine, Stanford, California 94305 5485, USA
    J Neurosci 20:7816-21. 2000
    ....
  14. ncbi request reprint Experience-dependent asymmetric variation in primate prefrontal morphology
    David M Lyons
    Department of Psychiatry and Behavioral Science, Psychiatry Neuroscience, Stanford University Medical School, 1201 Welch Road, MSLS Room P104, Mail Code 5485, CA 94305 5485, USA
    Behav Brain Res 136:51-9. 2002
    ..Follow-up studies now need to determine whether maternal availability directly affects or interacts with subsequent experiences to alter prefrontal substrates of emotional processing and sensitivity to stress...
  15. ncbi request reprint Frustrative nonreward and pituitary-adrenal activity in squirrel monkeys
    D M Lyons
    Department of Psychiatry and Behavioral Science, Stanford University School of Medicine, MSLS Room P111, Stanford, CA 94305 5485, USA
    Physiol Behav 71:559-63. 2000
    ..In keeping with comparable findings in rats, our observations indicate that frustrative nonreward elicits ACTH-stimulated secretion of cortisol in primates...
  16. ncbi request reprint Circadian and homeostatic regulation of hypocretin in a primate model: implications for the consolidation of wakefulness
    Jamie M Zeitzer
    Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, California 94304, USA
    J Neurosci 23:3555-60. 2003
    ..In the squirrel monkey, hypocretin-1 works in opposition to the accumulating sleep drive during the day to maintain a constant level of wake...
  17. ncbi request reprint Increasing length of wakefulness and modulation of hypocretin-1 in the wake-consolidated squirrel monkey
    Jamie M Zeitzer
    Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1736-42. 2007
    ..Concomitants of wakefulness that affect hypocretin-1 in polyphasic species, such as locomotion, food intake, and food deprivation, likely have a more minor role in monophasic species, such as humans...
  18. pmc Prefrontal plasticity and stress inoculation-induced resilience
    Maor Katz
    Department of Psychiatry, Stanford University, Stanford, Calif, USA
    Dev Neurosci 31:293-9. 2009
    ..These findings suggest that the process of coping with early life stress increases prefrontal myelination and expands a region of cortex that broadly controls arousal regulation and resilience...
  19. pmc Modafinil and γ-hydroxybutyrate have sleep state-specific pharmacological actions on hypocretin-1 physiology in a primate model of human sleep
    Jamie M Zeitzer
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, USA
    Behav Pharmacol 20:643-52. 2009
    ..Furthermore, hypocretin neurons do not seem to respond to an 'effort' to remain awake, but rather keep track of time spent awake as a wake-promoting counterbalance to extended wakefulness...
  20. pmc Early life stress and novelty seeking behavior in adolescent monkeys
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 1201 Welch Road, MSLS Room P104, Mail Code 5485, Stanford, CA 94305 5485, USA
    Psychoneuroendocrinology 32:785-92. 2007
    ..These trait-like differences in novelty seeking appear to reflect mild early stress-induced adaptations that enhance curiosity and resilience...
  21. ncbi request reprint Neuroendocrine aspects of hypercortisolism in major depression
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, 1201 Welch Road, MSLS Room P104, Mail Code 5485, Stanford, CA 94305 5485, USA
    Horm Behav 43:60-6. 2003
    ..In considering the evidence for hypercortisolism in humans, studies of nonhuman primates are presented and their utility and limitations as comparative models of human depression are discussed...
  22. ncbi request reprint Social stress-related behavior affects hippocampal cell proliferation in mice
    Rupshi Mitra
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5020, USA
    Physiol Behav 89:123-7. 2006
    ....
  23. pmc Locomotor-dependent and -independent components to hypocretin-1 (orexin A) regulation in sleep-wake consolidating monkeys
    Jamie M Zeitzer
    Department of Psychiatry and Behavioural Sciences, Stanford University, Palo Alto, CA 94304, USA
    J Physiol 557:1045-53. 2004
    ..In this wake-consolidating animal, locomotion is not necessary for CSF hypocretin-1 to increase throughout the daytime, but high levels of locomotion are likely to provide a small positive feedback onto the hypocretin system...
  24. ncbi request reprint Prospective investigation of stress inoculation in young monkeys
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, Stanford, Calif 94305 5485, USA
    Arch Gen Psychiatry 61:933-41. 2004
    ..Retrospective studies in humans have identified characteristics that promote stress resistance, including childhood exposure to moderately stressful events (ie, stress inoculation)...
  25. ncbi request reprint Mild early life stress enhances prefrontal-dependent response inhibition in monkeys
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, Stanford, California 94305 5485, USA
    Biol Psychiatry 57:848-55. 2005
    ..e., stress inoculation) strengthens emotional and neuroendocrine resistance to subsequent stressors. Herein we extend this research to examine the effects of mild early life stress on cognition...
  26. ncbi request reprint Intranasal oxytocin administration attenuates the ACTH stress response in monkeys
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, CA 94305 5485, USA
    Psychoneuroendocrinology 30:924-9. 2005
    ..This primate model offers critical opportunities to improve our understanding of the anti-stress effects of OT and may lead to novel pharmacological treatments for stress-related psychiatric disorders...
  27. pmc Maternal mediation, stress inoculation, and the development of neuroendocrine stress resistance in primates
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, Stanford University, 1201 Welch Road, MSLS P104, Stanford, CA 94305 5485, USA
    Proc Natl Acad Sci U S A 103:3000-5. 2006
    ..Results from both experiments demonstrate that stress inoculation, rather than high levels of maternal care, promotes the development of primate stress resistance...
  28. ncbi request reprint Mutations in squirrel monkey glucocorticoid receptor impair nuclear translocation
    Song Her
    Department of Psychiatry, Stanford University Medical Center, Stanford, CA 94305 5485, USA
    J Steroid Biochem Mol Biol 94:319-26. 2005
    ..Three back-mutations of gsmGR to hGR (Thr551Ser, Ala616Ser, and Ser618Ala) in the LBD confirmed that these amino acids play a role in diminished translocation...
  29. pmc Somatic and neuroendocrine responses to standard and biologically salient acoustic startle stimuli in monkeys
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA
    Psychoneuroendocrinology 36:547-56. 2011
    ..The development of monkey startle methodology may further enhance the utility of this paradigm in translational studies of human stress-related psychiatric disorders...
  30. ncbi request reprint Application of microarray technology in primate behavioral neuroscience research
    Adriaan M Karssen
    Department of Psychiatry and Behavioral Sciences, Stanford University, USA
    Methods 38:227-34. 2006
    ....
  31. pmc Stress-induced changes in corticosteroid receptor expression in primate hippocampus and prefrontal cortex
    Paresh D Patel
    Department of Psychiatry, Molecular and Behavioral Neuroscience Institute, University of Michigan Medical Center, 5053 Biomedical Sciences Research Building, 109 Zina Pitcher Place, Ann Arbor, MI 48109 2200, USA
    Psychoneuroendocrinology 33:360-7. 2008
    ..053). These results provide new information on regional differences and the long-term effects of stress on MR and GR distributions in corticolimbic regions that control cognitive and neuroendocrine functions...
  32. ncbi request reprint Effects of emotion on oxytocin, prolactin, and ACTH in women
    Rebecca A Turner
    California School of Professional Psychology, Alliant International University, San Francisco 94109, USA
    Stress 5:269-76. 2002
    ..Overall, the degree of change in circulating hormones in response to happy and sad emotions was very small and possibly not functionally significant...

Research Grants7

  1. Neurobiology of Stress Inoculation
    David M Lyons; Fiscal Year: 2010
    ..These issues are important because of concerns that re-experiencing stressors may exacerbate psychiatric symptoms and impede recovery instead of fostering the development of resilience. ..
  2. Early Chronic Stress and Prefrontal Development
    David Lyons; Fiscal Year: 2005
    ..abstract_text> ..
  3. Neurobiology of Stress Inoculation
    David Lyons; Fiscal Year: 2007
    ..These issues are important because of concerns that re-experiencing stressors may exacerbate psychiatric symptoms and impede recovery instead of fostering the development of resilience. ..