M P Lutolf
Affiliation: Stanford University
- Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineeringM P Lutolf
Integrative Biosciences Institute, Ecole Polytechnique Federale de Lausanne EPFL, Building AA B 039, CH 1015 Lausanne, Switzerland
Nat Biotechnol 23:47-55. 2005....
- Mechanisms of 3-D migration and matrix remodeling of fibroblasts within artificial ECMsG P Raeber
Institute of Bioengineering and Institute of Chemical Sciences and Engineering, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
Acta Biomater 3:615-29. 2007....
- Molecularly engineered PEG hydrogels: a novel model system for proteolytically mediated cell migrationG P Raeber
Integrative Biosciences Institute and Institute for Chemical Science and Engineering, Ecole Polytechnique Federale de Lausanne EPFL, Switzerland
Biophys J 89:1374-88. 2005....
- The selective modulation of endothelial cell mobility on RGD peptide containing surfaces by YIGSR peptidesM H Fittkau
Cardiovascular Research Unit, Christian Barnard Department of Cardiothoracic Surgery, Cape Heart Centre, University of Cape Town, Anzio Road, 7925 Observatory, Cape Town, South Africa
Biomaterials 26:167-74. 2005..05). No corresponding effect was observed for HVSMC. This suggests that the desired response of specific cell types to tissue engineering scaffolds could be optimized through a combinatory approach to the use of biomimetic peptides...
- MMP-2 sensitive, VEGF-bearing bioactive hydrogels for promotion of vascular healingD Seliktar
Institute for Biomedical Engineering, Swiss Federal Institute of Technology and University of Zurich, Moussonstrasse 18, CH 8044 Zurich, Switzerland
J Biomed Mater Res A 68:704-16. 2004..Functionalized PEG-peptide hydrogels could help restore the native vessel wall and improve the performance of angioplasty procedures...
- Synthesis and physicochemical characterization of end-linked poly(ethylene glycol)-co-peptide hydrogels formed by Michael-type additionM P Lutolf
Department of Materials and Institute for Biomedical Engineering, ETH Zurich, Zurich, Switzerland
Biomacromolecules 4:713-22. 2003..Hydrogels were also prepared with varying macromer structures, and their properties were shown to respond to both macromer functionality and molecular weight...
- Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: engineering cell-invasion characteristicsM P Lutolf
Department of Materials and Institute for Biomedical Engineering, Swiss Federal Institute of Technology and University of Zurich, CH 8044 Zurich, Switzerland
Proc Natl Acad Sci U S A 100:5413-8. 2003..These hydrogels may be useful in tissue engineering and cell biology as alternatives for naturally occurring extracellular matrix-derived materials such as fibrin or collagen...
- Poly(ethylene glycol) block copolymersN Tirelli
Institute for Biomedical Engineering and Department of Materials, Swiss Federal Institute of Technology and University of Zurich
J Biotechnol 90:3-15. 2002....
- Systematic modulation of Michael-type reactivity of thiols through the use of charged amino acidsM P Lutolf
Department of Materials and Institute for Biomedical Engineering, ETH Zurich and the University of Zurich, Zurich, Switzerland
Bioconjug Chem 12:1051-6. 2001..These results provide a basis for the rational design of peptides, where the kinetics and thus selectivity of protein/peptide conjugation with polymeric structures via Michael-type addition reactions can be controlled...
- Protein delivery from materials formed by self-selective conjugate addition reactionsD L Elbert
Institute for Biomedical Engineering and Department of Materials, Swiss Federal Institute of Technology and University of Zurich, Moussonstrasse 18, CH-8044, Zurich, Switzerland
J Control Release 76:11-25. 2001..Utilizing the Flory-Rehner and Peppas-Merrill equations, a framework for modeling the protein release from the gels is described...