Liqun Luo

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Rho GTPases in neuronal morphogenesis
    L Luo
    Department of Biological Sciences, Neurosciences Program, Stanford University, Stanford, California 94305, USA
    Nat Rev Neurosci 1:173-80. 2000
  2. pmc Fly MARCM and mouse MADM: genetic methods of labeling and manipulating single neurons
    Liqun Luo
    Department of Biological Sciences and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Brain Res Rev 55:220-7. 2007
  3. ncbi request reprint Actin cytoskeleton regulation in neuronal morphogenesis and structural plasticity
    Liqun Luo
    Department of Biological Sciences, Neurosciences Program, Stanford University, California 94305, USA
    Annu Rev Cell Dev Biol 18:601-35. 2002
  4. pmc Genghis Khan (Gek) as a putative effector for Drosophila Cdc42 and regulator of actin polymerization
    L Luo
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco 94143, USA
    Proc Natl Acad Sci U S A 94:12963-8. 1997
  5. ncbi request reprint Axon retraction and degeneration in development and disease
    Liqun Luo
    Department of Biological Sciences, Neurosciences Program, Stanford University, Stanford, CA 94305, USA
    Annu Rev Neurosci 28:127-56. 2005
  6. ncbi request reprint Development of continuous and discrete neural maps
    Liqun Luo
    Howard Hughes Medical Institute, Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Neuron 56:284-300. 2007
  7. pmc piggyBac-based mosaic screen identifies a postmitotic function for cohesin in regulating developmental axon pruning
    Oren Schuldiner
    Howard Hughes Medical Institute, Department of Biological Sciences and Neurosciences Program, Stanford University, Stanford, CA 94305, USA
    Dev Cell 14:227-38. 2008
  8. pmc Secreted semaphorins from degenerating larval ORN axons direct adult projection neuron dendrite targeting
    Lora B Sweeney
    Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Neuron 72:734-47. 2011
  9. ncbi request reprint Rho GTPases regulate axon growth through convergent and divergent signaling pathways
    Julian Ng
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Neuron 44:779-93. 2004
  10. ncbi request reprint Graded expression of semaphorin-1a cell-autonomously directs dendritic targeting of olfactory projection neurons
    Takaki Komiyama
    Department of Biological Sciences and Neurosciences Program, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Cell 128:399-410. 2007

Collaborators

Detail Information

Publications91

  1. ncbi request reprint Rho GTPases in neuronal morphogenesis
    L Luo
    Department of Biological Sciences, Neurosciences Program, Stanford University, Stanford, California 94305, USA
    Nat Rev Neurosci 1:173-80. 2000
    ..Mutations in these signalling pathways have been reported in human neurological diseases, which underscores their importance in the development and function of the nervous system...
  2. pmc Fly MARCM and mouse MADM: genetic methods of labeling and manipulating single neurons
    Liqun Luo
    Department of Biological Sciences and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Brain Res Rev 55:220-7. 2007
    ..In this assay I review recent progresses using genetic methods to recapitulate and extend the Golgi staining method. These methods enable new discoveries on organization and development of neuronal circuits in the fly and mouse brains...
  3. ncbi request reprint Actin cytoskeleton regulation in neuronal morphogenesis and structural plasticity
    Liqun Luo
    Department of Biological Sciences, Neurosciences Program, Stanford University, California 94305, USA
    Annu Rev Cell Dev Biol 18:601-35. 2002
    ..These studies support an emerging theme: Different aspects of neuronal morphogenesis may involve regulation of common core signaling pathways, in particular the Rho GTPases...
  4. pmc Genghis Khan (Gek) as a putative effector for Drosophila Cdc42 and regulator of actin polymerization
    L Luo
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco 94143, USA
    Proc Natl Acad Sci U S A 94:12963-8. 1997
    ..These phenotypes can be rescued by a wild-type gek transgene. Our results suggest that this multidomain protein kinase is an effector for the regulation of actin polymerization by Cdc42...
  5. ncbi request reprint Axon retraction and degeneration in development and disease
    Liqun Luo
    Department of Biological Sciences, Neurosciences Program, Stanford University, Stanford, CA 94305, USA
    Annu Rev Neurosci 28:127-56. 2005
    ..Here we review examples of these phenomena and consider potential cellular and molecular mechanisms that underlie axon retraction and degeneration and how they might relate to each other in development and disease...
  6. ncbi request reprint Development of continuous and discrete neural maps
    Liqun Luo
    Howard Hughes Medical Institute, Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Neuron 56:284-300. 2007
    ....
  7. pmc piggyBac-based mosaic screen identifies a postmitotic function for cohesin in regulating developmental axon pruning
    Oren Schuldiner
    Howard Hughes Medical Institute, Department of Biological Sciences and Neurosciences Program, Stanford University, Stanford, CA 94305, USA
    Dev Cell 14:227-38. 2008
    ..We also demonstrate a postmitotic role for SMC1 in dendrite targeting of olfactory projection neurons. We suggest that cohesin regulates diverse aspects of neuronal morphogenesis...
  8. pmc Secreted semaphorins from degenerating larval ORN axons direct adult projection neuron dendrite targeting
    Lora B Sweeney
    Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Neuron 72:734-47. 2011
    ..Thus, a degenerating brain structure instructs the wiring of a developing circuit through the repulsive action of secreted semaphorins...
  9. ncbi request reprint Rho GTPases regulate axon growth through convergent and divergent signaling pathways
    Julian Ng
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Neuron 44:779-93. 2004
    ..These genetic analyses reveal convergent and divergent pathways from Rho GTPases to the cytoskeleton during axon growth in vivo and suggest that different developmental outcomes could be achieved by biases in pathway selection...
  10. ncbi request reprint Graded expression of semaphorin-1a cell-autonomously directs dendritic targeting of olfactory projection neurons
    Takaki Komiyama
    Department of Biological Sciences and Neurosciences Program, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Cell 128:399-410. 2007
    ..Thus, graded expression of Sema-1a contributes to connection specificity from ORNs to PNs and then to higher brain centers, ensuring proper representation of olfactory information in the brain...
  11. ncbi request reprint Temporal target restriction of olfactory receptor neurons by Semaphorin-1a/PlexinA-mediated axon-axon interactions
    Lora B Sweeney
    Howard Hughes Medical Institute, Department of Biological Sciences and Neurosciences Program, Stanford University, Stanford, CA 94305, USA
    Neuron 53:185-200. 2007
    ..We propose that Sema-1a/PlexinA-mediated repulsion provides a mechanism by which early-arriving ORN axons constrain the target choices of late-arriving axons...
  12. ncbi request reprint Developmentally programmed remodeling of the Drosophila olfactory circuit
    Elizabeth C Marin
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Development 132:725-37. 2005
    ..As with MB gamma neurons, PN pruning requires cell-autonomous reception of the nuclear hormone ecdysone. Thus, these synaptic partners are independently programmed to prune their dendrites and axons...
  13. ncbi request reprint Diverse functions of N-cadherin in dendritic and axonal terminal arborization of olfactory projection neurons
    Haitao Zhu
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Neuron 42:63-75. 2004
    ..Although the N-cadherin locus potentially encodes eight alternatively spliced isoforms, transgenic expression of one isoform is sufficient to rescue all phenotypes...
  14. pmc Genomic analysis of Drosophila neuronal remodeling: a role for the RNA-binding protein Boule as a negative regulator of axon pruning
    Eric D Hoopfer
    Department of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA
    J Neurosci 28:6092-103. 2008
    ..We propose a novel function for Boule in the CNS as a negative regulator of developmental axon pruning...
  15. ncbi request reprint Olfactory receptor neuron axon targeting: intrinsic transcriptional control and hierarchical interactions
    Takaki Komiyama
    Department of Biological Sciences and Neurosciences Program, Stanford University, Stanford, California 94305, USA
    Nat Neurosci 7:819-25. 2004
    ..We propose that the precision of ORN axon targeting derives from both intrinsic transcriptional control and extensive axon-axon interactions...
  16. pmc Leucine-rich repeat transmembrane proteins instruct discrete dendrite targeting in an olfactory map
    Weizhe Hong
    Howard Hughes Medical Institute and Department of Biology, Stanford University, Stanford, California, USA
    Nat Neurosci 12:1542-50. 2009
    ..The closely related protein Tartan was partially redundant with Caps. These LRR proteins are probably part of a combinatorial cell-surface code that instructs discrete olfactory map formation...
  17. pmc Comprehensive maps of Drosophila higher olfactory centers: spatially segregated fruit and pheromone representation
    Gregory S X E Jefferis
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Cell 128:1187-203. 2007
    ..Our results suggest that the LH is organized according to biological values of olfactory input...
  18. pmc A combinatorial semaphorin code instructs the initial steps of sensory circuit assembly in the Drosophila CNS
    Zhuhao Wu
    The Solomon H Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Howard Hughes Medical Institute, Baltimore, MD 21205, USA
    Neuron 70:281-98. 2011
    ..These results reveal that distinct semaphorin-mediated guidance functions converge at PlexB and are critical for functional neural circuit assembly...
  19. pmc Histone deacetylase Rpd3 regulates olfactory projection neuron dendrite targeting via the transcription factor Prospero
    Joy S Tea
    Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, California 94305, USA
    J Neurosci 30:9939-46. 2010
    ..Our study suggests a specific function for the general chromatin remodeling factor Rpd3 in regulating dendrite targeting in neurons, largely through the postmitotic action of the Pros transcription factor...
  20. pmc Lola regulates Drosophila olfactory projection neuron identity and targeting specificity
    Maria Lynn Spletter
    Howard Hughes Medical Institute, Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
    Neural Dev 2:14. 2007
    ..These decisions are likely specified by a PN-intrinsic transcriptional code that regulates the expression of cell-surface molecules to instruct wiring specificity...
  21. ncbi request reprint Development of wiring specificity of the Drosophila olfactory system
    Gregory S X E Jefferis
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Chem Senses 30:i94. 2005
  22. pmc Diversity and wiring variability of olfactory local interneurons in the Drosophila antennal lobe
    Ya Hui Chou
    Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, California, USA
    Nat Neurosci 13:439-49. 2010
    ..Our results reveal an unexpected degree of complexity and individual variation in an invertebrate neural circuit, a result that creates challenges for solving the Drosophila connectome...
  23. pmc The chromatin remodeling factor Bap55 functions through the TIP60 complex to regulate olfactory projection neuron dendrite targeting
    Joy S Tea
    Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, CA 94305, USA
    Neural Dev 6:5. 2011
    ..These wiring decisions are likely determined through a transcriptional program...
  24. pmc Trans-synaptic Teneurin signalling in neuromuscular synapse organization and target choice
    Timothy J Mosca
    Department of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA
    Nature 484:237-41. 2012
    ..Our study identifies the Teneurins as a key bi-directional trans-synaptic signal involved in general synapse organization, and demonstrates that proteins such as these can also regulate target selection...
  25. ncbi request reprint Developmental origin of wiring specificity in the olfactory system of Drosophila
    Gregory S X E Jefferis
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Development 131:117-30. 2004
    ..We propose instead that this prototypic map might originate from both patterning information external to the developing antennal lobe and interactions among PN dendrites...
  26. ncbi request reprint Dendritic patterning by Dscam and synaptic partner matching in the Drosophila antennal lobe
    Haitao Zhu
    Howard Hughes Medical Institute and Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
    Nat Neurosci 9:349-55. 2006
    ..This observation provides evidence for a pre- and postsynaptic matching mechanism independent of precise glomerular positioning...
  27. ncbi request reprint Wiring stability of the adult Drosophila olfactory circuit after lesion
    Daniela Berdnik
    Howard Hughes Medical Institute, Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
    J Neurosci 26:3367-76. 2006
    ..We conclude that, although adult olfactory neurons can undergo plastic changes in response to the loss of competition, the olfactory circuit overall is extremely stable in preserving segregated information channels in this discrete map...
  28. pmc Plum, an immunoglobulin superfamily protein, regulates axon pruning by facilitating TGF-β signaling
    Xiaomeng M Yu
    Department of Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94303, USA
    Neuron 78:456-68. 2013
    ....
  29. ncbi request reprint Wlds protection distinguishes axon degeneration following injury from naturally occurring developmental pruning
    Eric D Hoopfer
    Howard Hughes Medical Institute, Department of Biological Sciences and Neurosciences Program, Stanford University, 385 Serra Mall, Stanford, California 94305, USA
    Neuron 50:883-95. 2006
    ..Thus, mechanistically, naturally occurring developmental axon pruning by degeneration and injury-induced axon degeneration differ significantly in early steps, but may converge onto a common execution pathway...
  30. pmc MicroRNA processing pathway regulates olfactory neuron morphogenesis
    Daniela Berdnik
    Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, CA 94305, USA
    Curr Biol 18:1754-9. 2008
    ..However, Argonaute-1 and Argonaute-2 are dispensable for PN morphogenesis. Our findings suggest a role for the miRNA processing pathway in establishing wiring specificity in the nervous system...
  31. pmc Linking cell fate, trajectory choice, and target selection: genetic analysis of Sema-2b in olfactory axon targeting
    WILLIAM J JOO
    Howard Hughes Medical Institute and Department of Biology, Stanford University, Stanford, CA 94305, USA
    Neuron 78:673-86. 2013
    ....
  32. pmc Site-specific integrase-mediated transgenesis in mice via pronuclear injection
    Bosiljka Tasic
    The Howard Hughes Medical Institute and Department of Biology, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 108:7902-7. 2011
    ..The technique presented here will greatly facilitate murine transgenesis and precise structure/function dissection of mammalian gene function and regulation in vivo...
  33. pmc The Q system: a repressible binary system for transgene expression, lineage tracing, and mosaic analysis
    Christopher J Potter
    Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Cell 141:536-48. 2010
    ..The Q system can be expanded to other uses in Drosophila and to any organism conducive to transgenesis...
  34. pmc Teneurins instruct synaptic partner matching in an olfactory map
    Weizhe Hong
    Department of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA
    Nature 484:201-7. 2012
    ..We propose that Teneurins instruct matching specificity between synaptic partners through homophilic attraction...
  35. ncbi request reprint Glia engulf degenerating axons during developmental axon pruning
    Ryan J Watts
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 USA
    Curr Biol 14:678-84. 2004
    ..Our study reveals a key role for glia in the removal of axon fragments during developmental axon pruning...
  36. ncbi request reprint Intrinsic control of precise dendritic targeting by an ensemble of transcription factors
    Takaki Komiyama
    Howard Hughes Medical Institute, Department of Biological Sciences, Neurosciences Program, Stanford University, Stanford, California 94305, USA
    Curr Biol 17:278-85. 2007
    ..These results begin to provide insights into the global strategy of how an ensemble of TFs regulates wiring specificity of a large number of neurons constituting a neural circuit...
  37. pmc Permanent Genetic Access to Transiently Active Neurons via TRAP: Targeted Recombination in Active Populations
    Casey J Guenthner
    Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA Department of Biology, Stanford University, Stanford, CA 94305, USA Neurosciences Program, Stanford University, Stanford, CA 94305, USA
    Neuron 78:773-84. 2013
    ..When combined with tools for labeling, tracing, recording, and manipulating neurons, TRAP offers a powerful approach for understanding how the brain processes information and generates behavior...
  38. ncbi request reprint A global double-fluorescent Cre reporter mouse
    Mandar Deepak Muzumdar
    Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA
    Genesis 45:593-605. 2007
    ..In addition to serving as a global Cre reporter, the mT/mG mouse may also be used as a tool for lineage tracing, transplantation studies, and analysis of cell morphology in vivo...
  39. pmc Modeling sporadic loss of heterozygosity in mice by using mosaic analysis with double markers (MADM)
    Mandar Deepak Muzumdar
    Howard Hughes Medical Institute and Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 104:4495-500. 2007
    ..These studies establish MADM as a high-resolution method for modeling sporadic loss of heterozygosity in mice, providing insights into TSG function...
  40. ncbi request reprint Small GTPase Cdc42 is required for multiple aspects of dendritic morphogenesis
    Ethan K Scott
    Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
    J Neurosci 23:3118-23. 2003
    ..Remarkably, Cdc42 mutant neurons also show a 50% reduction in dendritic spine density. These results demonstrate that Cdc42 is a regulator for multiple aspects of dendritic development...
  41. ncbi request reprint Axon pruning during Drosophila metamorphosis: evidence for local degeneration and requirement of the ubiquitin-proteasome system
    Ryan J Watts
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Neuron 38:871-85. 2003
    ..Our findings suggest that some forms of axon pruning during development may share similarities with degeneration of axons in response to injury...
  42. pmc The SUMO protease Verloren regulates dendrite and axon targeting in olfactory projection neurons
    Daniela Berdnik
    Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, California 94305, USA
    J Neurosci 32:8331-40. 2012
    ..Our study provides the first in vivo evidence for a specific role of a SUMO protease during neuronal target selection that can be dissociated from its functions in neuronal proliferation and survival...
  43. pmc Patterning axon targeting of olfactory receptor neurons by coupled hedgehog signaling at two distinct steps
    Ya Hui Chou
    Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Cell 142:954-66. 2010
    ..Such coupled two-step signaling may be more generally used to coordinate other spatially and temporally segregated developmental events...
  44. pmc Dendritic development of Drosophila high order visual system neurons is independent of sensory experience
    Ethan K Scott
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    BMC Neurosci 4:14. 2003
    ..In this study, we make use of the highly complex Vertical System (VS) of motion sensing neurons in the lobula plate of the Drosophila visual system to gauge the importance of visual input and synaptic activity to dendritic development...
  45. doi request reprint Role of leucine-rich repeat proteins in the development and function of neural circuits
    Joris De Wit
    Neurobiology Section, Division of Biology, University of California, San Diego, La Jolla, California 92093 0366, USA
    Annu Rev Cell Dev Biol 27:697-729. 2011
    ..Here, we focus on a few exquisite examples of secreted or membrane-associated LRR proteins in Drosophila and mammals and review the mechanisms by which they regulate diverse aspects of nervous system development and function...
  46. pmc Visualizing the distribution of synapses from individual neurons in the mouse brain
    Ling Li
    Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, California, United States of America
    PLoS ONE 5:e11503. 2010
    ..To understand how complex neural circuits function, it is crucial to precisely describe neuronal connectivity and the distributions of synapses to and from individual neurons...
  47. pmc Cortical representations of olfactory input by trans-synaptic tracing
    Kazunari Miyamichi
    HHMI Department of Biology, Stanford University, Stanford, California 94305, USA
    Nature 472:191-6. 2011
    ..The trans-synaptic labelling method described here should be widely applicable to mapping connections throughout the mouse nervous system...
  48. pmc Uncoupling dendrite growth and patterning: single-cell knockout analysis of NMDA receptor 2B
    J Sebastian Espinosa
    Department of Biology, Stanford University, Stanford, CA 94305, USA
    Neuron 62:205-17. 2009
    ..Our study also indicates that molecular mechanisms that regulate activity-dependent dendrite patterning can be separated from those that control general dendrite growth and branching...
  49. ncbi request reprint From lineage to wiring specificity. POU domain transcription factors control precise connections of Drosophila olfactory projection neurons
    Takaki Komiyama
    Department of Biological Sciences, Neurosciences Program, Stanford University, Stanford, CA 94305, USA
    Cell 112:157-67. 2003
    ..Acj6 also controls stereotypical axon terminal arborization of PNs in a central target, suggesting that the connectivity of PN axons and dendrites in different brain centers is coordinately regulated...
  50. ncbi request reprint A mosaic genetic screen for genes necessary for Drosophila mushroom body neuronal morphogenesis
    John E Reuter
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Development 130:1203-13. 2003
    ..Our results suggest that most genes involved in neuronal morphogenesis play multiple roles in different aspects of neural development, rather than performing a dedicated function limited to a specific process...
  51. pmc Genetic mosaic dissection of Lis1 and Ndel1 in neuronal migration
    Simon Hippenmeyer
    Howard Hughes Medical Institute and Department of Biology, Stanford University, Stanford, CA 94305, USA
    Neuron 68:695-709. 2010
    ..Comparisons with previous genetic perturbations of Lis1 and Ndel1 also suggest a surprising degree of cell-nonautonomous function for these proteins in regulating neuronal migration...
  52. ncbi request reprint Development of wiring specificity in the olfactory system
    Takaki Komiyama
    Howard Hughes Medical Institute, Department of Biological Sciences and Neurosciences Program, Stanford University, Stanford, CA, 94305, USA
    Curr Opin Neurobiol 16:67-73. 2006
    ....
  53. ncbi request reprint Representation of the glomerular olfactory map in the Drosophila brain
    Elizabeth C Marin
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Cell 109:243-55. 2002
    ..This map is characterized by spatial convergence and divergence of PN axons, allowing integration of olfactory information...
  54. ncbi request reprint Neuroscience. Calcium and CREST for healthy dendrites
    Gregory S X E Jefferis
    Department of Biological Sciences and Neurosciences Program, Stanford University, Stanford, CA 94305, USA
    Science 303:179-81. 2004
  55. ncbi request reprint A protocol for mosaic analysis with a repressible cell marker (MARCM) in Drosophila
    Joy S Wu
    Howard Hughes Medical Institute, Department of Biological Sciences, Neurosciences Program, Stanford University, Stanford, California 94305 5020, USA
    Nat Protoc 1:2583-9. 2006
    ..In both the PDF and HTML versions, "mutant" was omitted from the label on the right, which should read "Labeled homozygous mutant daughter cell". The figure has been corrected in all versions of the article...
  56. ncbi request reprint Mosaic analysis with double markers in mice
    Hui Zong
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Cell 121:479-92. 2005
    ..To illustrate the utility of MADM, we show that cerebellar granule cell progenitors are fated at an early stage to produce granule cells with axonal projections limited to specific sublayers of the cerebellar cortex...
  57. pmc Anterograde or retrograde transsynaptic labeling of CNS neurons with vesicular stomatitis virus vectors
    KEVIN T BEIER
    Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:15414-9. 2011
    ..In vivo infections of several areas in the mouse brain led to the predicted patterns of spread for anterograde or retrograde tracers...
  58. ncbi request reprint Cytoplasmic and mitochondrial protein translation in axonal and dendritic terminal arborization
    Takahiro Chihara
    Howard Hughes Medical Institute, Department of Biological Sciences, 385 Serra Mall, Stanford University, Stanford, California 94305, USA
    Nat Neurosci 10:828-37. 2007
    ..Our study highlights different demands of protein translation for the development and maintenance of axons and dendrites...
  59. ncbi request reprint Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion
    L Luo
    Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco 94143
    Genes Dev 8:1787-802. 1994
    ..Expressions of analogous mutant Dcdc42 proteins cause qualitatively distinct morphological defects, suggesting that similar GTPases in the same subfamily have unique roles in morphogenesis...
  60. pmc Function and regulation of Tumbleweed (RacGAP50C) in neuroblast proliferation and neuronal morphogenesis
    Ann Y N Goldstein
    Department of Biological Sciences and Neurosciences Program, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 102:3834-9. 2005
    ..Taken together with previous studies of RacGAP50C in regulating cytokinesis, we propose that Tum serves as a scaffolding protein in regulating cell division but acts as a GAP to limit axon growth in postmitotic neurons...
  61. pmc Timing neurogenesis and differentiation: insights from quantitative clonal analyses of cerebellar granule cells
    J Sebastian Espinosa
    Howard Hughes Medical Institute and Department of Biology, Neurosciences Program, Stanford University, Stanford, California 94305, USA
    J Neurosci 28:2301-12. 2008
    ..These properties produce GC clones that are distinct, each having a restricted axonal projection, but that are on average similar in cell number. We discuss possible developmental mechanisms and functional implications of these findings...
  62. ncbi request reprint Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton
    C G Winter
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Cell 105:81-91. 2001
    ..Drosophila myosin VIIA, the homolog of the human Usher Syndrome 1B gene, also functions in conjunction with this newly defined portion of the Fz/Dsh signaling pathway to regulate the actin cytoskeleton...
  63. doi request reprint Controlling gene expression with the Q repressible binary expression system in Caenorhabditis elegans
    Xing Wei
    Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, California, USA
    Nat Methods 9:391-5. 2012
    ..Each domain showed negligible transcriptional activity when expressed alone, but expression of both reconstituted QF activity, providing additional combinatorial power to control gene expression...
  64. ncbi request reprint Rac GTPases control axon growth, guidance and branching
    Julian Ng
    Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
    Nature 416:442-7. 2002
    ..These results demonstrate the central role of Rac GTPases in multiple aspects of axon development in vivo, and suggest that axon growth, guidance and branching could be controlled by differential activation of Rac signalling pathways...
  65. doi request reprint The olfactory circuit of the fruit fly Drosophila melanogaster
    Liang Liang
    Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, CA 94305, USA
    Sci China Life Sci 53:472-84. 2010
    ..We discuss here the organizational principles of the olfactory circuit that make it an attractive model for experimental manipulations, the lessons that have been learned, and future challenges...
  66. ncbi request reprint Drosophila Lis1 is required for neuroblast proliferation, dendritic elaboration and axonal transport
    Z Liu
    Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
    Nat Cell Biol 2:776-83. 2000
    ..These results implicate Lis1 as a regulator of the microtubule cytoskeleton and show that it is important for diverse physiological functions in the nervous system...
  67. ncbi request reprint Trio quartet in D. (melanogaster)
    L Luo
    Department of Biological Sciences, Stanford University, California 94305, USA
    Neuron 26:1-2. 2000
  68. ncbi request reprint enok encodes a Drosophila putative histone acetyltransferase required for mushroom body neuroblast proliferation
    E K Scott
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Curr Biol 11:99-104. 2001
    ..Our results provide in vivo evidence for essential functions of a histone acetyltransferase in the construction of the Drosophila brain...
  69. ncbi request reprint Structure of the vertical and horizontal system neurons of the lobula plate in Drosophila
    Ethan K Scott
    Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
    J Comp Neurol 454:470-81. 2002
    ..Access to these cells in Drosophila should allow for the use of genetic tools in future studies of horizontal and vertical system function...
  70. ncbi request reprint Development of neuronal connectivity in Drosophila antennal lobes and mushroom bodies
    Gregory S X E Jefferis
    Neurosciences Program, Stanford University, Stanford, California 94305 5020, USA
    Curr Opin Neurobiol 12:80-6. 2002
    ..This same theme of sequential generation has been observed in the generation of the three major types of mushroom body neurons...
  71. doi request reprint Octopamine fuels fighting flies
    Christopher J Potter
    Department of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA
    Nat Neurosci 11:989-90. 2008
    ..The neural basis of aggression is poorly understood. A study in this issue used genetic scalpels to dissect the circuitry of the fly brain and identified a small cluster of octopaminergic neurons that can make a fly fighting mad...
  72. ncbi request reprint Rho family GTP-binding proteins in growth cone signalling
    L Luo
    Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco, California 94143, USA
    Curr Opin Neurobiol 7:81-6. 1997
    ..Recent evidence suggests that they may also be important components of the signalling pathways that link the reception of extracellular cues to the regulation of the cytoskeleton in neuronal growth cones...
  73. ncbi request reprint Essential roles of Drosophila RhoA in the regulation of neuroblast proliferation and dendritic but not axonal morphogenesis
    T Lee
    Department of Biological Sciences, Stanford University, California 94305, USA
    Neuron 25:307-16. 2000
    ..Thus, RhoA is an important regulator of dendritic morphogenesis, while distinct mechanisms are used for axonal morphogenesis...
  74. ncbi request reprint Intracellular signaling pathways that regulate dendritic spine morphogenesis
    A Y Nakayama
    Department of Biological Sciences, Stanford University, California 94305 5020, USA
    Hippocampus 10:582-6. 2000
    ..Thus, the Rac signal transduction pathway may provide links between extracellular ligands or synaptic activity and the regulation of the actin cytoskeleton in spine morphogenesis...
  75. ncbi request reprint A protocol for dissecting Drosophila melanogaster brains for live imaging or immunostaining
    Joy S Wu
    Howard Hughes Medical Institute, Department of Biological Sciences, Neurosciences Program, Stanford University, Stanford, California 94305 5020, USA
    Nat Protoc 1:2110-5. 2006
    ..Advantages of fluorescence immunostaining include compatibility with multicolor labeling and confocal or multiphoton imaging. This brain dissection and immunofluorescence staining protocol requires approximately 2 to 6 d to complete...
  76. pmc Genetic dissection of neural circuits
    Liqun Luo
    Department of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Neuron 57:634-60. 2008
    ..Here we review progress in the genetic analysis of neural circuits and discuss directions for future research and development...
  77. doi request reprint A new family of odorant receptors in Drosophila
    Maria L Spletter
    Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Cell 136:23-5. 2009
    ..Benton et al. (2009) now present evidence that a family of proteins related to ionotropic glutamate receptors is a previously unrecognized class of odorant receptors...
  78. ncbi request reprint Cell-autonomous requirement of the USP/EcR-B ecdysone receptor for mushroom body neuronal remodeling in Drosophila
    T Lee
    Department of Biological Sciences, Stanford University, Stanford, CA 94305
    Neuron 28:807-18. 2000
    ..Surprisingly, most identified primary EcR/USP targets are dispensable for MB neuronal remodeling. Our study demonstrates cell-autonomous roles for EcR/USP in controlling neuronal remodeling, potentially through novel downstream targets...
  79. ncbi request reprint split ends encodes large nuclear proteins that regulate neuronal cell fate and axon extension in the Drosophila embryo
    B Kuang
    Howard Hughes Medical Institute, Department of Cell Biology, Vanderbilt University Medical Center, Nashville TN 37232 0295, USA
    Development 127:1517-29. 2000
    ..We propose that Spen proteins regulate the expression of key effectors of signaling pathways required to specify neuronal cell fate and morphology...
  80. ncbi request reprint Like poles repel; molecular mechanisms of dendritic tiling
    Takahiro Chihara
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Cell 119:148-9. 2004
    ..In this issue of Cell, provide first insight into the molecular mechanisms of dendritic tiling...
  81. ncbi request reprint Regulating axon branch stability: the role of p190 RhoGAP in repressing a retraction signaling pathway
    P Billuart
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Cell 107:195-207. 2001
    ..Local regulation of p190 could control the structural plasticity of neurons. Indeed, genetic evidence supports negative regulation of p190 by integrin and Src, both implicated in neural plasticity...
  82. ncbi request reprint Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis
    T Lee
    Department of Biological Sciences, Stanford University, California 94305, USA
    Neuron 22:451-61. 1999
    ..As an example, we show that the short stop gene is required in mushroom body neurons for the extension and guidance of their axons...
  83. ncbi request reprint Target neuron prespecification in the olfactory map of Drosophila
    G S Jefferis
    Neurosciences Program, Department of Biological Sciences, Stanford University, CA 94305, USA
    Nature 414:204-8. 2001
    ..These studies also imply a previously unanticipated role for precise dendritic targeting by postsynaptic neurons in determining connection specificity...
  84. ncbi request reprint How do dendrites take their shape?
    E K Scott
    Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
    Nat Neurosci 4:359-65. 2001
    ..In this review, we describe recent advances in our understanding of the molecular mechanisms underlying dendritic morphogenesis, and discuss their cell-biological implications...
  85. ncbi request reprint Development of the Drosophila mushroom bodies: sequential generation of three distinct types of neurons from a neuroblast
    T Lee
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Development 126:4065-76. 1999
    ..This study illustrates the cellular organization of mushroom bodies and the development of different MB neurons at the single cell level. It allows for future studies on the molecular mechanisms of mushroom body development...
  86. ncbi request reprint Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons
    R J McEvilly
    Howard Hughes Medical Institute, University of California, San Diego, USA
    Nature 384:574-7. 1996
    ..Deletion of Brn-3.0 also alters either differentiation, migration or survival of specific central neuronal populations...
  87. ncbi request reprint Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development
    L Erkman
    Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla 92093, USA
    Nature 381:603-6. 1996
    ..Mutation of Brn-3.1 results in complete deafness, owing to a failure of hair cells to appear in the inner ear, with subsequent loss of cochlear and vestibular ganglia...
  88. ncbi request reprint Rac function and regulation during Drosophila development
    Satoko Hakeda-Suzuki
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nature 416:438-42. 2002
    ..Different Rac activators thus act in different developmental processes. The specific cellular response to Rac activation may be determined more by the upstream activator than the specific Rac protein involved...
  89. ncbi request reprint Involvement of the ubiquitin-proteasome system in the early stages of wallerian degeneration
    Qiwei Zhai
    Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuron 39:217-25. 2003
    ..Our findings suggest a possibility that inhibiting UPS activity may serve to retard axon degeneration in pathological conditions...
  90. ncbi request reprint Glomerular maps without cellular redundancy at successive levels of the Drosophila larval olfactory circuit
    Ariane Ramaekers
    Department of Biology, University of Fribourg, Chemin du Musee 10, CH 1700 Fribourg, Switzerland
    Curr Biol 15:982-92. 2005
    ..Does this suggest that the larval olfactory system is built according to a different design than its adult counterpart, or is it just a miniature version thereof?..
  91. ncbi request reprint Developmental neuroscience: two gradients are better than one
    Liqun Luo
    Nature 439:23-4. 2006

Research Grants30

  1. Assembly of the Central Olfactory Networks in Drosophila
    Liqun Luo; Fiscal Year: 2007
    ..Our studies will also provide insight into how olfactory information is transferred and transformed along the central pathways in the brain. ..
  2. Mosaic Analysis with Double Markers in Mice
    Liqun Luo; Fiscal Year: 2007
    ..This method can also be used to create mouse models for human diseases such as loss of heterozygosity in cancer and neurological diseases. ..
  3. MECHANISMS OF NEURONAL REORGANIZATION
    Liqun Luo; Fiscal Year: 2007
    ..Thus, we believe these studies will contribute to our understanding of axon degeneration in diseases ..
  4. Assembly of the Central Olfactory Networks in Drosophila
    Liqun Luo; Fiscal Year: 2009
    ..In addition, knowledge of insect olfactory system organization and development can be used to help design strategies to combat malaria, transmitted by mosquitos that utilize primarily olfaction to find their mates and human host. ..
  5. Mosaic Analysis with Double Markers in Mice
    Liqun Luo; Fiscal Year: 2009
    ..These studies will have direct implications to our understanding of the pathogenesis of lissencephaly and Smith-Magenis Syndrome. ..
  6. Mosaic Analysis with Double Markers in Mice
    Liqun Luo; Fiscal Year: 2010
    ..These studies will have direct implications to our understanding of the pathogenesis of lissencephaly and Smith-Magenis Syndrome. ..
  7. 2004 Molecular & Cellular Neurobiology Gordon Conference
    Liqun Luo; Fiscal Year: 2004
    ..Majority of which be used to support conference fees and/or travel of students and postdocs from US, especially minority and women participants to increase their number. ..
  8. MECHANISMS OF NEURONAL REORGANIZATION
    Liqun Luo; Fiscal Year: 2004
    ..These mechanisms may also be used for experience-dependent reshaping of neuronal connections, and may be misregulated during aging and neurodegenerative diseases to cause degeneration of neuronal processes. ..
  9. MOLECULAR MECHANISMS OF NEURONAL MORPHOGENESIS
    Liqun Luo; Fiscal Year: 2000
    ..Thus understanding the biological function C17 may shed light on the molecular pathogenesis of myotonic dystrophy, the most common adult form of muscular dystrophy. ..
  10. MOLECULAR MECHANISMS OF NEURONAL MORPHOGENESIS
    Liqun Luo; Fiscal Year: 2004
    ....
  11. Assembly of the Central Olfactory Networks in Drosophila
    Liqun Luo; Fiscal Year: 2010
    ..In addition, knowledge of insect olfactory system organization and development can be used to help design strategies to combat malaria, transmitted by mosquitos that utilize primarily olfaction to find their mates and human host. ..