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Genomes and Genes | Liqun LuoSummaryAffiliation: Stanford University Country: USA Publications
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Publications
Rho GTPases in neuronal morphogenesisL Luo
Department of Biological Sciences, Neurosciences Program, Stanford University, Stanford, California 94305, USA
Nat Rev Neurosci 1:173-80. 2000..Mutations in these signalling pathways have been reported in human neurological diseases, which underscores their importance in the development and function of the nervous system...- Axon retraction and degeneration in development and diseaseLiqun Luo
Department of Biological Sciences, Neurosciences Program, Stanford University, Stanford, CA 94305, USA
Annu Rev Neurosci 28:127-56. 2005..Here we review examples of these phenomena and consider potential cellular and molecular mechanisms that underlie axon retraction and degeneration and how they might relate to each other in development and disease... - Development of continuous and discrete neural mapsLiqun Luo
Howard Hughes Medical Institute, Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
Neuron 56:284-300. 2007.... - Actin cytoskeleton regulation in neuronal morphogenesis and structural plasticityLiqun Luo
Department of Biological Sciences, Neurosciences Program, Stanford University, California 94305, USA
Annu Rev Cell Dev Biol 18:601-35. 2002..These studies support an emerging theme: Different aspects of neuronal morphogenesis may involve regulation of common core signaling pathways, in particular the Rho GTPases... 
Genghis Khan (Gek) as a putative effector for Drosophila Cdc42 and regulator of actin polymerizationL Luo
Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco 94143, USA
Proc Natl Acad Sci U S A 94:12963-8. 1997..These phenotypes can be rescued by a wild-type gek transgene. Our results suggest that this multidomain protein kinase is an effector for the regulation of actin polymerization by Cdc42...- Fly MARCM and mouse MADM: genetic methods of labeling and manipulating single neuronsLiqun Luo
Department of Biological Sciences and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
Brain Res Rev 55:220-7. 2007..In this assay I review recent progresses using genetic methods to recapitulate and extend the Golgi staining method. These methods enable new discoveries on organization and development of neuronal circuits in the fly and mouse brains... - piggyBac-based mosaic screen identifies a postmitotic function for cohesin in regulating developmental axon pruningOren Schuldiner
Howard Hughes Medical Institute, Department of Biological Sciences and Neurosciences Program, Stanford University, Stanford, CA 94305, USA
Dev Cell 14:227-38. 2008..We also demonstrate a postmitotic role for SMC1 in dendrite targeting of olfactory projection neurons. We suggest that cohesin regulates diverse aspects of neuronal morphogenesis... - Rho GTPases regulate axon growth through convergent and divergent signaling pathwaysJulian Ng
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
Neuron 44:779-93. 2004..These genetic analyses reveal convergent and divergent pathways from Rho GTPases to the cytoskeleton during axon growth in vivo and suggest that different developmental outcomes could be achieved by biases in pathway selection... - Secreted semaphorins from degenerating larval ORN axons direct adult projection neuron dendrite targetingLora B Sweeney
Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
Neuron 72:734-47. 2011..Thus, a degenerating brain structure instructs the wiring of a developing circuit through the repulsive action of secreted semaphorins... - Graded expression of semaphorin-1a cell-autonomously directs dendritic targeting of olfactory projection neuronsTakaki Komiyama
Department of Biological Sciences and Neurosciences Program, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
Cell 128:399-410. 2007..Thus, graded expression of Sema-1a contributes to connection specificity from ORNs to PNs and then to higher brain centers, ensuring proper representation of olfactory information in the brain... - Temporal target restriction of olfactory receptor neurons by Semaphorin-1a/PlexinA-mediated axon-axon interactionsLora B Sweeney
Howard Hughes Medical Institute, Department of Biological Sciences and Neurosciences Program, Stanford University, Stanford, CA 94305, USA
Neuron 53:185-200. 2007..We propose that Sema-1a/PlexinA-mediated repulsion provides a mechanism by which early-arriving ORN axons constrain the target choices of late-arriving axons... - Genomic analysis of Drosophila neuronal remodeling: a role for the RNA-binding protein Boule as a negative regulator of axon pruningEric D Hoopfer
Department of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA
J Neurosci 28:6092-103. 2008..We propose a novel function for Boule in the CNS as a negative regulator of developmental axon pruning... - Diverse functions of N-cadherin in dendritic and axonal terminal arborization of olfactory projection neuronsHaitao Zhu
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
Neuron 42:63-75. 2004..Although the N-cadherin locus potentially encodes eight alternatively spliced isoforms, transgenic expression of one isoform is sufficient to rescue all phenotypes... - Developmentally programmed remodeling of the Drosophila olfactory circuitElizabeth C Marin
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
Development 132:725-37. 2005..As with MB gamma neurons, PN pruning requires cell-autonomous reception of the nuclear hormone ecdysone. Thus, these synaptic partners are independently programmed to prune their dendrites and axons... - Leucine-rich repeat transmembrane proteins instruct discrete dendrite targeting in an olfactory mapWeizhe Hong
Howard Hughes Medical Institute and Department of Biology, Stanford University, Stanford, California, USA
Nat Neurosci 12:1542-50. 2009..The closely related protein Tartan was partially redundant with Caps. These LRR proteins are probably part of a combinatorial cell-surface code that instructs discrete olfactory map formation... - Comprehensive maps of Drosophila higher olfactory centers: spatially segregated fruit and pheromone representationGregory S X E Jefferis
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
Cell 128:1187-203. 2007..Our results suggest that the LH is organized according to biological values of olfactory input... - Olfactory receptor neuron axon targeting: intrinsic transcriptional control and hierarchical interactionsTakaki Komiyama
Department of Biological Sciences and Neurosciences Program, Stanford University, Stanford, California 94305, USA
Nat Neurosci 7:819-25. 2004..We propose that the precision of ORN axon targeting derives from both intrinsic transcriptional control and extensive axon-axon interactions... - Histone deacetylase Rpd3 regulates olfactory projection neuron dendrite targeting via the transcription factor ProsperoJoy S Tea
Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, California 94305, USA
J Neurosci 30:9939-46. 2010..Our study suggests a specific function for the general chromatin remodeling factor Rpd3 in regulating dendrite targeting in neurons, largely through the postmitotic action of the Pros transcription factor... - Lola regulates Drosophila olfactory projection neuron identity and targeting specificityMaria Lynn Spletter
Howard Hughes Medical Institute, Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
Neural Dev 2:14. 2007..These decisions are likely specified by a PN-intrinsic transcriptional code that regulates the expression of cell-surface molecules to instruct wiring specificity... - Development of wiring specificity of the Drosophila olfactory systemGregory S X E Jefferis
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
Chem Senses 30:i94. 2005 - Diversity and wiring variability of olfactory local interneurons in the Drosophila antennal lobeYa Hui Chou
Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, California, USA
Nat Neurosci 13:439-49. 2010..Our results reveal an unexpected degree of complexity and individual variation in an invertebrate neural circuit, a result that creates challenges for solving the Drosophila connectome... - Trans-synaptic Teneurin signalling in neuromuscular synapse organization and target choiceTimothy J Mosca
Department of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA
Nature 484:237-41. 2012..Our study identifies the Teneurins as a key bi-directional trans-synaptic signal involved in general synapse organization, and demonstrates that proteins such as these can also regulate target selection... - The chromatin remodeling factor Bap55 functions through the TIP60 complex to regulate olfactory projection neuron dendrite targetingJoy S Tea
Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, CA 94305, USA
Neural Dev 6:5. 2011..These wiring decisions are likely determined through a transcriptional program... - Wiring stability of the adult Drosophila olfactory circuit after lesionDaniela Berdnik
Howard Hughes Medical Institute, Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
J Neurosci 26:3367-76. 2006..We conclude that, although adult olfactory neurons can undergo plastic changes in response to the loss of competition, the olfactory circuit overall is extremely stable in preserving segregated information channels in this discrete map... - Dendritic patterning by Dscam and synaptic partner matching in the Drosophila antennal lobeHaitao Zhu
Howard Hughes Medical Institute and Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
Nat Neurosci 9:349-55. 2006..This observation provides evidence for a pre- and postsynaptic matching mechanism independent of precise glomerular positioning... - Developmental origin of wiring specificity in the olfactory system of DrosophilaGregory S X E Jefferis
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
Development 131:117-30. 2004..We propose instead that this prototypic map might originate from both patterning information external to the developing antennal lobe and interactions among PN dendrites... - Wlds protection distinguishes axon degeneration following injury from naturally occurring developmental pruningEric D Hoopfer
Howard Hughes Medical Institute, Department of Biological Sciences and Neurosciences Program, Stanford University, 385 Serra Mall, Stanford, California 94305, USA
Neuron 50:883-95. 2006..Thus, mechanistically, naturally occurring developmental axon pruning by degeneration and injury-induced axon degeneration differ significantly in early steps, but may converge onto a common execution pathway... - MicroRNA processing pathway regulates olfactory neuron morphogenesisDaniela Berdnik
Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, CA 94305, USA
Curr Biol 18:1754-9. 2008..However, Argonaute-1 and Argonaute-2 are dispensable for PN morphogenesis. Our findings suggest a role for the miRNA processing pathway in establishing wiring specificity in the nervous system... - The Q system: a repressible binary system for transgene expression, lineage tracing, and mosaic analysisChristopher J Potter
Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
Cell 141:536-48. 2010..The Q system can be expanded to other uses in Drosophila and to any organism conducive to transgenesis... - Teneurins instruct synaptic partner matching in an olfactory mapWeizhe Hong
Department of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA
Nature 484:201-7. 2012..We propose that Teneurins instruct matching specificity between synaptic partners through homophilic attraction... - Intrinsic control of precise dendritic targeting by an ensemble of transcription factorsTakaki Komiyama
Howard Hughes Medical Institute, Department of Biological Sciences, Neurosciences Program, Stanford University, Stanford, California 94305, USA
Curr Biol 17:278-85. 2007..These results begin to provide insights into the global strategy of how an ensemble of TFs regulates wiring specificity of a large number of neurons constituting a neural circuit... - Glia engulf degenerating axons during developmental axon pruningRyan J Watts
Department of Biological Sciences, Stanford University, Stanford, CA 94305 USA
Curr Biol 14:678-84. 2004..Our study reveals a key role for glia in the removal of axon fragments during developmental axon pruning... - A combinatorial semaphorin code instructs the initial steps of sensory circuit assembly in the Drosophila CNSZhuhao Wu
The Solomon H Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Howard Hughes Medical Institute, Baltimore, MD 21205, USA
Neuron 70:281-98. 2011..These results reveal that distinct semaphorin-mediated guidance functions converge at PlexB and are critical for functional neural circuit assembly... - Site-specific integrase-mediated transgenesis in mice via pronuclear injectionBosiljka Tasic
The Howard Hughes Medical Institute and Department of Biology, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 108:7902-7. 2011..The technique presented here will greatly facilitate murine transgenesis and precise structure/function dissection of mammalian gene function and regulation in vivo... - Modeling sporadic loss of heterozygosity in mice by using mosaic analysis with double markers (MADM)Mandar Deepak Muzumdar
Howard Hughes Medical Institute and Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 104:4495-500. 2007..These studies establish MADM as a high-resolution method for modeling sporadic loss of heterozygosity in mice, providing insights into TSG function... - Small GTPase Cdc42 is required for multiple aspects of dendritic morphogenesisEthan K Scott
Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
J Neurosci 23:3118-23. 2003..Remarkably, Cdc42 mutant neurons also show a 50% reduction in dendritic spine density. These results demonstrate that Cdc42 is a regulator for multiple aspects of dendritic development... - Axon pruning during Drosophila metamorphosis: evidence for local degeneration and requirement of the ubiquitin-proteasome systemRyan J Watts
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
Neuron 38:871-85. 2003..Our findings suggest that some forms of axon pruning during development may share similarities with degeneration of axons in response to injury... - A global double-fluorescent Cre reporter mouseMandar Deepak Muzumdar
Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA
Genesis 45:593-605. 2007..In addition to serving as a global Cre reporter, the mT/mG mouse may also be used as a tool for lineage tracing, transplantation studies, and analysis of cell morphology in vivo... - Patterning axon targeting of olfactory receptor neurons by coupled hedgehog signaling at two distinct stepsYa Hui Chou
Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
Cell 142:954-66. 2010..Such coupled two-step signaling may be more generally used to coordinate other spatially and temporally segregated developmental events... 
Role of leucine-rich repeat proteins in the development and function of neural circuitsJoris De Wit
Neurobiology Section, Division of Biology, University of California, San Diego, La Jolla, California 92093 0366, USA
Annu Rev Cell Dev Biol 27:697-729. 2011..Here, we focus on a few exquisite examples of secreted or membrane-associated LRR proteins in Drosophila and mammals and review the mechanisms by which they regulate diverse aspects of nervous system development and function...- Dendritic development of Drosophila high order visual system neurons is independent of sensory experienceEthan K Scott
Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
BMC Neurosci 4:14. 2003..In this study, we make use of the highly complex Vertical System (VS) of motion sensing neurons in the lobula plate of the Drosophila visual system to gauge the importance of visual input and synaptic activity to dendritic development... - Cortical representations of olfactory input by trans-synaptic tracingKazunari Miyamichi
HHMI Department of Biology, Stanford University, Stanford, California 94305, USA
Nature 472:191-6. 2011..The trans-synaptic labelling method described here should be widely applicable to mapping connections throughout the mouse nervous system... - Genetic mosaic dissection of Lis1 and Ndel1 in neuronal migrationSimon Hippenmeyer
Howard Hughes Medical Institute and Department of Biology, Stanford University, Stanford, CA 94305, USA
Neuron 68:695-709. 2010..Comparisons with previous genetic perturbations of Lis1 and Ndel1 also suggest a surprising degree of cell-nonautonomous function for these proteins in regulating neuronal migration... - A mosaic genetic screen for genes necessary for Drosophila mushroom body neuronal morphogenesisJohn E Reuter
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
Development 130:1203-13. 2003..Our results suggest that most genes involved in neuronal morphogenesis play multiple roles in different aspects of neural development, rather than performing a dedicated function limited to a specific process... - Visualizing the distribution of synapses from individual neurons in the mouse brainLing Li
Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, California, United States of America
PLoS ONE 5:e11503. 2010..To understand how complex neural circuits function, it is crucial to precisely describe neuronal connectivity and the distributions of synapses to and from individual neurons... - Development of wiring specificity in the olfactory systemTakaki Komiyama
Howard Hughes Medical Institute, Department of Biological Sciences and Neurosciences Program, Stanford University, Stanford, CA, 94305, USA
Curr Opin Neurobiol 16:67-73. 2006.... - From lineage to wiring specificity. POU domain transcription factors control precise connections of Drosophila olfactory projection neuronsTakaki Komiyama
Department of Biological Sciences, Neurosciences Program, Stanford University, Stanford, CA 94305, USA
Cell 112:157-67. 2003..Acj6 also controls stereotypical axon terminal arborization of PNs in a central target, suggesting that the connectivity of PN axons and dendrites in different brain centers is coordinately regulated... - Uncoupling dendrite growth and patterning: single-cell knockout analysis of NMDA receptor 2BJ Sebastian Espinosa
Department of Biology, Stanford University, Stanford, CA 94305, USA
Neuron 62:205-17. 2009..Our study also indicates that molecular mechanisms that regulate activity-dependent dendrite patterning can be separated from those that control general dendrite growth and branching... - The SUMO protease Verloren regulates dendrite and axon targeting in olfactory projection neuronsDaniela Berdnik
Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, California 94305, USA
J Neurosci 32:8331-40. 2012..Our study provides the first in vivo evidence for a specific role of a SUMO protease during neuronal target selection that can be dissociated from its functions in neuronal proliferation and survival... - Representation of the glomerular olfactory map in the Drosophila brainElizabeth C Marin
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
Cell 109:243-55. 2002..This map is characterized by spatial convergence and divergence of PN axons, allowing integration of olfactory information... - Mosaic analysis with double markers in miceHui Zong
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
Cell 121:479-92. 2005..To illustrate the utility of MADM, we show that cerebellar granule cell progenitors are fated at an early stage to produce granule cells with axonal projections limited to specific sublayers of the cerebellar cortex... - Cytoplasmic and mitochondrial protein translation in axonal and dendritic terminal arborizationTakahiro Chihara
Howard Hughes Medical Institute, Department of Biological Sciences, 385 Serra Mall, Stanford University, Stanford, California 94305, USA
Nat Neurosci 10:828-37. 2007..Our study highlights different demands of protein translation for the development and maintenance of axons and dendrites... - Anterograde or retrograde transsynaptic labeling of CNS neurons with vesicular stomatitis virus vectorsKEVIN T BEIER
Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 108:15414-9. 2011..In vivo infections of several areas in the mouse brain led to the predicted patterns of spread for anterograde or retrograde tracers... - A protocol for mosaic analysis with a repressible cell marker (MARCM) in DrosophilaJoy S Wu
Howard Hughes Medical Institute, Department of Biological Sciences, Neurosciences Program, Stanford University, Stanford, California 94305-5020, USA
Nat Protoc 1:2583-9. 2006..In both the PDF and HTML versions, "mutant" was omitted from the label on the right, which should read "Labeled homozygous mutant daughter cell". The figure has been corrected in all versions of the article... - Neuroscience. Calcium and CREST for healthy dendritesGregory S X E Jefferis
Department of Biological Sciences and Neurosciences Program, Stanford University, Stanford, CA 94305, USA
Science 303:179-81. 2004 - Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusionL Luo
Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco 94143
Genes Dev 8:1787-802. 1994..Expressions of analogous mutant Dcdc42 proteins cause qualitatively distinct morphological defects, suggesting that similar GTPases in the same subfamily have unique roles in morphogenesis... - Timing neurogenesis and differentiation: insights from quantitative clonal analyses of cerebellar granule cellsJ Sebastian Espinosa
Howard Hughes Medical Institute and Department of Biology, Neurosciences Program, Stanford University, Stanford, California 94305, USA
J Neurosci 28:2301-12. 2008..These properties produce GC clones that are distinct, each having a restricted axonal projection, but that are on average similar in cell number. We discuss possible developmental mechanisms and functional implications of these findings... - Function and regulation of Tumbleweed (RacGAP50C) in neuroblast proliferation and neuronal morphogenesisAnn Y N Goldstein
Department of Biological Sciences and Neurosciences Program, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 102:3834-9. 2005..Taken together with previous studies of RacGAP50C in regulating cytokinesis, we propose that Tum serves as a scaffolding protein in regulating cell division but acts as a GAP to limit axon growth in postmitotic neurons... - Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeletonC G Winter
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
Cell 105:81-91. 2001..Drosophila myosin VIIA, the homolog of the human Usher Syndrome 1B gene, also functions in conjunction with this newly defined portion of the Fz/Dsh signaling pathway to regulate the actin cytoskeleton... - Controlling gene expression with the Q repressible binary expression system in Caenorhabditis elegansXing Wei
Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, California, USA
Nat Methods 9:391-5. 2012..Each domain showed negligible transcriptional activity when expressed alone, but expression of both reconstituted QF activity, providing additional combinatorial power to control gene expression... - Rac GTPases control axon growth, guidance and branchingJulian Ng
Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
Nature 416:442-7. 2002..These results demonstrate the central role of Rac GTPases in multiple aspects of axon development in vivo, and suggest that axon growth, guidance and branching could be controlled by differential activation of Rac signalling pathways... - The olfactory circuit of the fruit fly Drosophila melanogasterLiang Liang
Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, CA 94305, USA
Sci China Life Sci 53:472-84. 2010..We discuss here the organizational principles of the olfactory circuit that make it an attractive model for experimental manipulations, the lessons that have been learned, and future challenges... - Drosophila Lis1 is required for neuroblast proliferation, dendritic elaboration and axonal transportZ Liu
Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
Nat Cell Biol 2:776-83. 2000..These results implicate Lis1 as a regulator of the microtubule cytoskeleton and show that it is important for diverse physiological functions in the nervous system... - Trio quartet in D. (melanogaster)L Luo
Department of Biological Sciences, Stanford University, California 94305, USA
Neuron 26:1-2. 2000 - enok encodes a Drosophila putative histone acetyltransferase required for mushroom body neuroblast proliferationE K Scott
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
Curr Biol 11:99-104. 2001..Our results provide in vivo evidence for essential functions of a histone acetyltransferase in the construction of the Drosophila brain... - Structure of the vertical and horizontal system neurons of the lobula plate in DrosophilaEthan K Scott
Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
J Comp Neurol 454:470-81. 2002..Access to these cells in Drosophila should allow for the use of genetic tools in future studies of horizontal and vertical system function... - Development of neuronal connectivity in Drosophila antennal lobes and mushroom bodiesGregory S X E Jefferis
Neurosciences Program, Stanford University, Stanford, California 94305 5020, USA
Curr Opin Neurobiol 12:80-6. 2002..This same theme of sequential generation has been observed in the generation of the three major types of mushroom body neurons... - Octopamine fuels fighting fliesChristopher J Potter
Department of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA
Nat Neurosci 11:989-90. 2008..The neural basis of aggression is poorly understood. A study in this issue used genetic scalpels to dissect the circuitry of the fly brain and identified a small cluster of octopaminergic neurons that can make a fly fighting mad... - Rho family GTP-binding proteins in growth cone signallingL Luo
Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco, California 94143, USA
Curr Opin Neurobiol 7:81-6. 1997..Recent evidence suggests that they may also be important components of the signalling pathways that link the reception of extracellular cues to the regulation of the cytoskeleton in neuronal growth cones... - Essential roles of Drosophila RhoA in the regulation of neuroblast proliferation and dendritic but not axonal morphogenesisT Lee
Department of Biological Sciences, Stanford University, California 94305, USA
Neuron 25:307-16. 2000..Thus, RhoA is an important regulator of dendritic morphogenesis, while distinct mechanisms are used for axonal morphogenesis... - Intracellular signaling pathways that regulate dendritic spine morphogenesisA Y Nakayama
Department of Biological Sciences, Stanford University, California 94305 5020, USA
Hippocampus 10:582-6. 2000..Thus, the Rac signal transduction pathway may provide links between extracellular ligands or synaptic activity and the regulation of the actin cytoskeleton in spine morphogenesis... - Genetic dissection of neural circuitsLiqun Luo
Department of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
Neuron 57:634-60. 2008..Here we review progress in the genetic analysis of neural circuits and discuss directions for future research and development... - A new family of odorant receptors in DrosophilaMaria L Spletter
Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
Cell 136:23-5. 2009..Benton et al. (2009) now present evidence that a family of proteins related to ionotropic glutamate receptors is a previously unrecognized class of odorant receptors... - A protocol for dissecting Drosophila melanogaster brains for live imaging or immunostainingJoy S Wu
Howard Hughes Medical Institute, Department of Biological Sciences, Neurosciences Program, Stanford University, Stanford, California 94305-5020, USA
Nat Protoc 1:2110-5. 2006..Advantages of fluorescence immunostaining include compatibility with multicolor labeling and confocal or multiphoton imaging. This brain dissection and immunofluorescence staining protocol requires approximately 2 to 6 d to complete... - Cell-autonomous requirement of the USP/EcR-B ecdysone receptor for mushroom body neuronal remodeling in DrosophilaT Lee
Department of Biological Sciences, Stanford University, Stanford, CA 94305
Neuron 28:807-18. 2000..Surprisingly, most identified primary EcR/USP targets are dispensable for MB neuronal remodeling. Our study demonstrates cell-autonomous roles for EcR/USP in controlling neuronal remodeling, potentially through novel downstream targets... - split ends encodes large nuclear proteins that regulate neuronal cell fate and axon extension in the Drosophila embryoB Kuang
Howard Hughes Medical Institute, Department of Cell Biology, Vanderbilt University Medical Center, Nashville TN 37232 0295, USA
Development 127:1517-29. 2000..We propose that Spen proteins regulate the expression of key effectors of signaling pathways required to specify neuronal cell fate and morphology... - Like poles repel; molecular mechanisms of dendritic tilingTakahiro Chihara
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
Cell 119:148-9. 2004..In this issue of Cell, provide first insight into the molecular mechanisms of dendritic tiling... - Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesisT Lee
Department of Biological Sciences, Stanford University, California 94305, USA
Neuron 22:451-61. 1999..As an example, we show that the short stop gene is required in mushroom body neurons for the extension and guidance of their axons... - Regulating axon branch stability: the role of p190 RhoGAP in repressing a retraction signaling pathwayP Billuart
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
Cell 107:195-207. 2001..Local regulation of p190 could control the structural plasticity of neurons. Indeed, genetic evidence supports negative regulation of p190 by integrin and Src, both implicated in neural plasticity... - Target neuron prespecification in the olfactory map of DrosophilaG S Jefferis
Neurosciences Program, Department of Biological Sciences, Stanford University, CA 94305, USA
Nature 414:204-8. 2001..These studies also imply a previously unanticipated role for precise dendritic targeting by postsynaptic neurons in determining connection specificity... - How do dendrites take their shape?E K Scott
Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
Nat Neurosci 4:359-65. 2001..In this review, we describe recent advances in our understanding of the molecular mechanisms underlying dendritic morphogenesis, and discuss their cell-biological implications... - Development of the Drosophila mushroom bodies: sequential generation of three distinct types of neurons from a neuroblastT Lee
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
Development 126:4065-76. 1999..This study illustrates the cellular organization of mushroom bodies and the development of different MB neurons at the single cell level. It allows for future studies on the molecular mechanisms of mushroom body development... - Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system developmentL Erkman
Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla 92093, USA
Nature 381:603-6. 1996..Mutation of Brn-3.1 results in complete deafness, owing to a failure of hair cells to appear in the inner ear, with subsequent loss of cochlear and vestibular ganglia... - Requirement for Brn-3.0 in differentiation and survival of sensory and motor neuronsR J McEvilly
Howard Hughes Medical Institute, University of California, San Diego, USA
Nature 384:574-7. 1996..Deletion of Brn-3.0 also alters either differentiation, migration or survival of specific central neuronal populations... - Involvement of the ubiquitin-proteasome system in the early stages of wallerian degenerationQiwei Zhai
Division of Neuroscience, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA
Neuron 39:217-25. 2003..Our findings suggest a possibility that inhibiting UPS activity may serve to retard axon degeneration in pathological conditions... - Rac function and regulation during Drosophila developmentSatoko Hakeda-Suzuki
Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
Nature 416:438-42. 2002..Different Rac activators thus act in different developmental processes. The specific cellular response to Rac activation may be determined more by the upstream activator than the specific Rac protein involved... - Glomerular maps without cellular redundancy at successive levels of the Drosophila larval olfactory circuitAriane Ramaekers
Department of Biology, University of Fribourg, Chemin du Musee 10, CH 1700 Fribourg, Switzerland
Curr Biol 15:982-92. 2005..Does this suggest that the larval olfactory system is built according to a different design than its adult counterpart, or is it just a miniature version thereof?.. - Developmental neuroscience: two gradients are better than oneLiqun Luo
Nature 439:23-4. 2006
Research Grants
- Assembly of the Central Olfactory Networks in DrosophilaLiqun Luo; Fiscal Year: 2007..Our studies will also provide insight into how olfactory information is transferred and transformed along the central pathways in the brain. ..
- Mosaic Analysis with Double Markers in MiceLiqun Luo; Fiscal Year: 2007..This method can also be used to create mouse models for human diseases such as loss of heterozygosity in cancer and neurological diseases. ..
- MECHANISMS OF NEURONAL REORGANIZATIONLiqun Luo; Fiscal Year: 2007..Thus, we believe these studies will contribute to our understanding of axon degeneration in diseases ..
- Assembly of the Central Olfactory Networks in DrosophilaLiqun Luo; Fiscal Year: 2009..In addition, knowledge of insect olfactory system organization and development can be used to help design strategies to combat malaria, transmitted by mosquitos that utilize primarily olfaction to find their mates and human host. ..
- Mosaic Analysis with Double Markers in MiceLiqun Luo; Fiscal Year: 2009..These studies will have direct implications to our understanding of the pathogenesis of lissencephaly and Smith-Magenis Syndrome. ..
- Mosaic Analysis with Double Markers in MiceLiqun Luo; Fiscal Year: 2010..These studies will have direct implications to our understanding of the pathogenesis of lissencephaly and Smith-Magenis Syndrome. ..
- 2004 Molecular & Cellular Neurobiology Gordon ConferenceLiqun Luo; Fiscal Year: 2004..Majority of which be used to support conference fees and/or travel of students and postdocs from US, especially minority and women participants to increase their number. ..
- MECHANISMS OF NEURONAL REORGANIZATIONLiqun Luo; Fiscal Year: 2004..These mechanisms may also be used for experience-dependent reshaping of neuronal connections, and may be misregulated during aging and neurodegenerative diseases to cause degeneration of neuronal processes. ..
- MOLECULAR MECHANISMS OF NEURONAL MORPHOGENESISLiqun Luo; Fiscal Year: 2000..Thus understanding the biological function C17 may shed light on the molecular pathogenesis of myotonic dystrophy, the most common adult form of muscular dystrophy. ..
- MOLECULAR MECHANISMS OF NEURONAL MORPHOGENESISLiqun Luo; Fiscal Year: 2004....
- Assembly of the Central Olfactory Networks in DrosophilaLiqun Luo; Fiscal Year: 2010..In addition, knowledge of insect olfactory system organization and development can be used to help design strategies to combat malaria, transmitted by mosquitos that utilize primarily olfaction to find their mates and human host. ..