Bingwei Lu

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint RNA interference technologies for understanding and treating neurodegenerative diseases
    Bingwei Lu
    Department of Pathology, and GRECC Program VAPAHCS, Stanford University School of Medicine, Stanford, CA 94304, USA
    Neuromolecular Med 6:1-12. 2004
  2. pmc Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin
    Yufeng Yang
    Department of Pathology and Geriatric Research, Education and Clinical Center Veterans Affairs Palo Alto Health Care System, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Proc Natl Acad Sci U S A 103:10793-8. 2006
  3. pmc Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery
    Yufeng Yang
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 105:7070-5. 2008
  4. pmc Synapses and dendritic spines as pathogenic targets in Alzheimer's disease
    Wendou Yu
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Neural Plast 2012:247150. 2012
  5. pmc dp53 Restrains ectopic neural stem cell formation in the Drosophila brain in a non-apoptotic mechanism involving Archipelago and cyclin E
    Yingshi Ouyang
    Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 6:e28098. 2011
  6. pmc Reduction of protein translation and activation of autophagy protect against PINK1 pathogenesis in Drosophila melanogaster
    Song Liu
    Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Genet 6:e1001237. 2010
  7. pmc Recent advances in using Drosophila to model neurodegenerative diseases
    Bingwei Lu
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Apoptosis 14:1008-20. 2009
  8. pmc Mitochondrial dynamics and neurodegeneration
    Bingwei Lu
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Lane 235, Stanford, CA 94305, USA
    Curr Neurol Neurosci Rep 9:212-9. 2009
  9. pmc Drosophila models of neurodegenerative diseases
    Bingwei Lu
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Annu Rev Pathol 4:315-42. 2009
  10. pmc Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression
    Stephan Gehrke
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 466:637-41. 2010

Collaborators

Detail Information

Publications30

  1. ncbi request reprint RNA interference technologies for understanding and treating neurodegenerative diseases
    Bingwei Lu
    Department of Pathology, and GRECC Program VAPAHCS, Stanford University School of Medicine, Stanford, CA 94304, USA
    Neuromolecular Med 6:1-12. 2004
    ..The prospects of the application of RNAi in clinical setting to treat these devastating diseases will also be presented...
  2. pmc Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin
    Yufeng Yang
    Department of Pathology and Geriatric Research, Education and Clinical Center Veterans Affairs Palo Alto Health Care System, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Proc Natl Acad Sci U S A 103:10793-8. 2006
    ..Together, these results implicate Pink1 and Parkin in a common pathway that regulates mitochondrial physiology and cell survival in Drosophila...
  3. pmc Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery
    Yufeng Yang
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 105:7070-5. 2008
    ..These results reveal a cell biological role for Pink1 and establish mitochondrial fission/fusion as a paradigm for PD research. Compounds that modulate mitochondrial fission/fusion could have therapeutic value in PD intervention...
  4. pmc Synapses and dendritic spines as pathogenic targets in Alzheimer's disease
    Wendou Yu
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Neural Plast 2012:247150. 2012
    ..Synaptic and dendritic spine pathology is also observed in other neurodegenerative disease. It is possible that some common pathogenic mechanisms may underlie the synaptic and dendritic spine pathology in neurodegenerative diseases...
  5. pmc dp53 Restrains ectopic neural stem cell formation in the Drosophila brain in a non-apoptotic mechanism involving Archipelago and cyclin E
    Yingshi Ouyang
    Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 6:e28098. 2011
    ..This has important clinical implications...
  6. pmc Reduction of protein translation and activation of autophagy protect against PINK1 pathogenesis in Drosophila melanogaster
    Song Liu
    Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Genet 6:e1001237. 2010
    ..Our results reveal complex cellular responses to PINK1 inactivation and suggest novel therapeutic strategies through manipulation of the compensatory responses...
  7. pmc Recent advances in using Drosophila to model neurodegenerative diseases
    Bingwei Lu
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Apoptosis 14:1008-20. 2009
    ..It is anticipated that Drosophila models will further our understanding of mechanisms of neurodegeneration and facilitate the development of novel and rational treatments for these debilitating neurodegenerative diseases...
  8. pmc Mitochondrial dynamics and neurodegeneration
    Bingwei Lu
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Lane 235, Stanford, CA 94305, USA
    Curr Neurol Neurosci Rep 9:212-9. 2009
    ..These studies establish mitochondrial dynamics as a new paradigm for neurodegenerative disease research. Compounds that modulate mitochondrial fission/fusion could have therapeutic value in disease intervention...
  9. pmc Drosophila models of neurodegenerative diseases
    Bingwei Lu
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Annu Rev Pathol 4:315-42. 2009
    ..We anticipate that further exploration of the animal models will further our understanding of mechanisms of neurodegeneration as well as facilitate the development of rational treatments for debilitating degenerative diseases...
  10. pmc Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression
    Stephan Gehrke
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 466:637-41. 2010
    ..Our results implicate deregulated synthesis of E2F1/DP caused by the miRNA pathway impairment as a key event in LRRK2 pathogenesis and suggest novel miRNA-based therapeutic strategies...
  11. ncbi request reprint Activation of PAR-1 kinase and stimulation of tau phosphorylation by diverse signals require the tumor suppressor protein LKB1
    Ji Wu Wang
    Department of Pathology, Stanford University School of Medicine, and Geriatric Research, Education, and Clinical Center Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
    J Neurosci 27:574-81. 2007
    ..These results reveal a new function for the tumor suppressor protein LKB1 in a signaling cascade through which the phosphorylation and function of tau is regulated by diverse signals under physiological and pathological conditions...
  12. ncbi request reprint Phospho-dependent ubiquitination and degradation of PAR-1 regulates synaptic morphology and tau-mediated Aβ toxicity in Drosophila
    Seongsoo Lee
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Commun 3:1312. 2012
    ..Our results provide new insights into the regulation of PAR-1 in various physiological processes and offer new therapeutic strategies for diseases involving PAR-1/MARK deregulation...
  13. ncbi request reprint The synaptic function of LRRK2
    Seongsoo Lee
    Department of Pathology, Stanford University School of Medicine, R270 Edwards Building, Stanford, CA 94305, U S A
    Biochem Soc Trans 40:1047-51. 2012
    ....
  14. pmc Neuroprotective effects of compounds with antioxidant and anti-inflammatory properties in a Drosophila model of Parkinson's disease
    Katharina Faust
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    BMC Neurosci 10:109. 2009
    ....
  15. pmc Interaction of Notch signaling modulator Numb with α-Adaptin regulates endocytosis of Notch pathway components and cell fate determination of neural stem cells
    Yan Song
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 287:17716-28. 2012
    ..These findings are likely to have important implications for cancer biology...
  16. pmc Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb-induced ectopic neuroblast formation in Drosophila
    Yingshi Ouyang
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Development 138:2185-96. 2011
    ..Reduction of Dronc activity facilitates ENF induced by phospho-Numb. Our findings uncover a molecular mechanism that regulates Numb activity and suggest a novel role for Dronc caspase in regulating neural stem cell homeostasis...
  17. pmc LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction
    Seongsoo Lee
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosci 30:16959-69. 2010
    ..These results implicate synaptic dysfunction caused by deregulated protein synthesis and aberrant MT dynamics in LRRK2 pathogenesis and offer a new paradigm for understanding and ultimately treating PD...
  18. pmc Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway
    Kyu Sun Lee
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 27:2642-7. 2013
    ..Our results emphasize the importance of mitochondria to N and NSC biology, with important implications for diseases associated with aberrant N signaling. ..
  19. pmc Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria
    Song Liu
    Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Genet 8:e1002537. 2012
    ..Moreover, the different effects of loss of PINK1 function on Miro protein level in Drosophila and mouse cells may offer one explanation of the distinct phenotypic manifestations of PINK1 mutants in these two species...
  20. pmc The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons
    Wendou Yu
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Hum Mol Genet 20:3227-40. 2011
    ..These results, together with previous findings in Drosophila dopaminergic neurons, indicate that the PINK1/Parkin pathway plays conserved roles in regulating neuronal mitochondrial dynamics and function...
  21. pmc PAR-1 kinase phosphorylates Dlg and regulates its postsynaptic targeting at the Drosophila neuromuscular junction
    Yali Zhang
    Department of Pathology, Stanford University School of Medicine, GRECC VAPAHCS, Palo Alto, CA 94304, USA
    Neuron 53:201-15. 2007
    ..Control of Dlg synaptic targeting by PAR-1-mediated phosphorylation thus constitutes a critical event in synaptogenesis...
  22. pmc A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spines
    Wendou Yu
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Hum Mol Genet 21:1384-90. 2012
    ..Our results reveal a critical role for PAR-1/MARK kinases in AD pathogenesis and suggest PAR-1/MARK inhibitors as potential therapeutics for AD and possibly other tauopathies where aberrant tau hyperphosphorylation is involved...
  23. pmc Regulation of cell growth by Notch signaling and its differential requirement in normal vs. tumor-forming stem cells in Drosophila
    Yan Song
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 25:2644-58. 2011
    ..Our findings highlight the importance of Notch-regulated cell growth in stem cell maintenance and reveal a stronger dependence on eIF4E function and cell growth by CSCs, which might be exploited therapeutically...
  24. pmc Tricornered/NDR kinase signaling mediates PINK1-directed mitochondrial quality control and tissue maintenance
    Zhihao Wu
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 27:157-62. 2013
    ..Genetically, mTORC2 and Trc act upstream of Parkin. Thus, multiplex kinase signaling is acting between PINK1 and Parkin to regulate MQC, a process highly conserved in mammals...
  25. pmc Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling
    Yufeng Yang
    Department of Pathology, Stanford University School of Medicine, and Geriatric Research, Education and Clinical Center Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Proc Natl Acad Sci U S A 102:13670-5. 2005
    ..Manipulation of PI3K/Akt signaling may therefore offer therapeutic benefits for the treatment of PD...
  26. pmc Mitochondrial morphogenesis, distribution, and Parkinson disease: insights from PINK1
    Yufeng Yang
    Department of Pathology, Stanford University School of Medicine, Stanford Geriatric Research Education and Clinical Center, Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA
    J Neuropathol Exp Neurol 68:953-63. 2009
    ....
  27. ncbi request reprint HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites
    Chad A Dickey
    Mayo Clinic Jacksonville, College of Medicine, Jacksonville, Florida, USA
    FASEB J 20:753-5. 2006
    ....
  28. pmc Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon
    Hongyan Wang
    Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore, Singapore 117604
    Nature 449:96-100. 2007
    ..Our results reveal a biochemical link between the cell cycle and the asymmetric protein localization machinery, and indicate that Polo can inhibit progenitor self-renewal by regulating the localization and function of Numb...
  29. pmc Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
    Yuzuru Imai
    Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    EMBO J 27:2432-43. 2008
    ..Our results suggest that chronic inactivation of 4E-BP by LRRK2 with pathogenic mutations deregulates protein translation, eventually resulting in age-dependent loss of DA neurons...
  30. ncbi request reprint Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila
    Yufeng Yang
    Laboratory of Developmental Neurobiology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuron 37:911-24. 2003
    ..Our study implicates Parkin as a central player in the molecular pathway of Parkinson's disease (PD) and suggests that manipulating Parkin expression may provide a novel avenue of PD therapy...

Research Grants15

  1. Interaction Between DJ-1 and TSC1-TSC2/TOR Signaling in Cell Survival
    Bingwei Lu; Fiscal Year: 2007
    ..Further studies could lead to the identification of new therapeutic targets and ultimately help develop mechanism-based treatment strategies that target TSC brain lesions which cause the most devastating symptoms of the disease. ..
  2. Control of Asymmetric Neural Stem Cell Division
    Bingwei Lu; Fiscal Year: 2007
    ..We believe that knowledge gained from our study will influence mammalian NSC research and contribute to the understanding and treatment of neurological diseases in humans. ..
  3. Role of PAR-1 Kinase in Synaptogenesis
    Bingwei Lu; Fiscal Year: 2010
    ....
  4. Control of Asymmetric Neural Stem Cell Division
    Bingwei Lu; Fiscal Year: 2010
    ..Accomplishment of the proposed aims will ultimately help understand and treat a number of neurological disorders originated from aberrant neural stem cells, such as neurodegenerative diseases and brain tumors. ..
  5. Control of Asymmetric Neural Stem Cell Division
    Bingwei Lu; Fiscal Year: 2004
    ..We believe that knowledge gained from our study will influence mammalian NSC research and contribute to the understanding and treatment of neurological diseases in humans. ..
  6. Control of Asymmetric Neural Stem Cell Division
    Bingwei Lu; Fiscal Year: 2009
    ..Accomplishment of the proposed aims will ultimately help understand and treat a number of neurological disorders originated from aberrant neural stem cells, such as neurodegenerative diseases and brain tumors. ..
  7. Control of Asymmetric Neural Stem Cell Division
    Bingwei Lu; Fiscal Year: 2003
    ..We believe that knowledge gained from our study will influence mammalian NSC research and contribute to the understanding and treatment of neurological diseases in humans. ..
  8. Genetic Dissection of Mitochondria and Muscle Maintenance
    Bingwei Lu; Fiscal Year: 2010
    ..Since Pink1 is also involved in Parkinson's disease, the information will also provide insights for the understanding and treatment of this devastating brain disorder. ..
  9. Role of PAR-1 Kinase in Synaptogenesis
    Bingwei Lu; Fiscal Year: 2009
    ....
  10. Control of Asymmetric Neural Stem Cell Division
    Bingwei Lu; Fiscal Year: 2006
    ..We believe that knowledge gained from our study will influence mammalian NSC research and contribute to the understanding and treatment of neurological diseases in humans. ..
  11. Genetic Dissection of Mitochondria and Muscle Maintenance
    Bingwei Lu; Fiscal Year: 2009
    ..Since Pink1 is also involved in Parkinson's disease, the information will also provide insights for the understanding and treatment of this devastating brain disorder. ..
  12. Control of Asymmetric Neural Stem Cell Division
    Bingwei Lu; Fiscal Year: 2005
    ..We believe that knowledge gained from our study will influence mammalian NSC research and contribute to the understanding and treatment of neurological diseases in humans. ..