Bingwei Lu

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint RNA interference technologies for understanding and treating neurodegenerative diseases
    Bingwei Lu
    Department of Pathology, and GRECC Program VAPAHCS, Stanford University School of Medicine, Stanford, CA 94304, USA
    Neuromolecular Med 6:1-12. 2004
  2. pmc Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin
    Yufeng Yang
    Department of Pathology and Geriatric Research, Education and Clinical Center Veterans Affairs Palo Alto Health Care System, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Proc Natl Acad Sci U S A 103:10793-8. 2006
  3. pmc Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery
    Yufeng Yang
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 105:7070-5. 2008
  4. pmc RNA metabolism in the pathogenesis of Parkinson׳s disease
    Bingwei Lu
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, United States Electronic address
    Brain Res 1584:105-15. 2014
  5. doi request reprint Neuronal mitophagy: long-distance delivery or eating locally?
    Bingwei Lu
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94321, USA Electronic address
    Curr Biol 24:R1006-8. 2014
  6. pmc Recent advances in using Drosophila to model neurodegenerative diseases
    Bingwei Lu
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Apoptosis 14:1008-20. 2009
  7. pmc Mitochondrial dynamics and neurodegeneration
    Bingwei Lu
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Lane 235, Stanford, CA 94305, USA
    Curr Neurol Neurosci Rep 9:212-9. 2009
  8. pmc Drosophila models of neurodegenerative diseases
    Bingwei Lu
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Annu Rev Pathol 4:315-42. 2009
  9. pmc Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway
    Kyu Sun Lee
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 27:2642-7. 2013
  10. pmc Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression
    Stephan Gehrke
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 466:637-41. 2010

Collaborators

Detail Information

Publications34

  1. ncbi request reprint RNA interference technologies for understanding and treating neurodegenerative diseases
    Bingwei Lu
    Department of Pathology, and GRECC Program VAPAHCS, Stanford University School of Medicine, Stanford, CA 94304, USA
    Neuromolecular Med 6:1-12. 2004
    ..The prospects of the application of RNAi in clinical setting to treat these devastating diseases will also be presented...
  2. pmc Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin
    Yufeng Yang
    Department of Pathology and Geriatric Research, Education and Clinical Center Veterans Affairs Palo Alto Health Care System, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Proc Natl Acad Sci U S A 103:10793-8. 2006
    ..Together, these results implicate Pink1 and Parkin in a common pathway that regulates mitochondrial physiology and cell survival in Drosophila...
  3. pmc Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery
    Yufeng Yang
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 105:7070-5. 2008
    ..These results reveal a cell biological role for Pink1 and establish mitochondrial fission/fusion as a paradigm for PD research. Compounds that modulate mitochondrial fission/fusion could have therapeutic value in PD intervention...
  4. pmc RNA metabolism in the pathogenesis of Parkinson׳s disease
    Bingwei Lu
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, United States Electronic address
    Brain Res 1584:105-15. 2014
    ....
  5. doi request reprint Neuronal mitophagy: long-distance delivery or eating locally?
    Bingwei Lu
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94321, USA Electronic address
    Curr Biol 24:R1006-8. 2014
    ..Whether they do so in neurons has been controversial. A new study aims to resolve the controversy. ..
  6. pmc Recent advances in using Drosophila to model neurodegenerative diseases
    Bingwei Lu
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Apoptosis 14:1008-20. 2009
    ..It is anticipated that Drosophila models will further our understanding of mechanisms of neurodegeneration and facilitate the development of novel and rational treatments for these debilitating neurodegenerative diseases...
  7. pmc Mitochondrial dynamics and neurodegeneration
    Bingwei Lu
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Lane 235, Stanford, CA 94305, USA
    Curr Neurol Neurosci Rep 9:212-9. 2009
    ..These studies establish mitochondrial dynamics as a new paradigm for neurodegenerative disease research. Compounds that modulate mitochondrial fission/fusion could have therapeutic value in disease intervention...
  8. pmc Drosophila models of neurodegenerative diseases
    Bingwei Lu
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Annu Rev Pathol 4:315-42. 2009
    ..We anticipate that further exploration of the animal models will further our understanding of mechanisms of neurodegeneration as well as facilitate the development of rational treatments for debilitating degenerative diseases...
  9. pmc Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway
    Kyu Sun Lee
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 27:2642-7. 2013
    ..Our results emphasize the importance of mitochondria to N and NSC biology, with important implications for diseases associated with aberrant N signaling. ..
  10. pmc Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression
    Stephan Gehrke
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 466:637-41. 2010
    ..Our results implicate deregulated synthesis of E2F1/DP caused by the miRNA pathway impairment as a key event in LRRK2 pathogenesis and suggest novel miRNA-based therapeutic strategies...
  11. pmc Phospho-dependent ubiquitination and degradation of PAR-1 regulates synaptic morphology and tau-mediated Aβ toxicity in Drosophila
    Seongsoo Lee
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Commun 3:1312. 2012
    ..Our results provide new insights into the regulation of PAR-1 in various physiological processes and offer new therapeutic strategies for diseases involving PAR-1/MARK deregulation...
  12. ncbi request reprint Activation of PAR-1 kinase and stimulation of tau phosphorylation by diverse signals require the tumor suppressor protein LKB1
    Ji Wu Wang
    Department of Pathology, Stanford University School of Medicine, and Geriatric Research, Education, and Clinical Center Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
    J Neurosci 27:574-81. 2007
    ..These results reveal a new function for the tumor suppressor protein LKB1 in a signaling cascade through which the phosphorylation and function of tau is regulated by diverse signals under physiological and pathological conditions...
  13. pmc Tricornered/NDR kinase signaling mediates PINK1-directed mitochondrial quality control and tissue maintenance
    Zhihao Wu
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 27:157-62. 2013
    ..Genetically, mTORC2 and Trc act upstream of Parkin. Thus, multiplex kinase signaling is acting between PINK1 and Parkin to regulate MQC, a process highly conserved in mammals...
  14. ncbi request reprint The synaptic function of LRRK2
    Seongsoo Lee
    Department of Pathology, Stanford University School of Medicine, R270 Edwards Building, Stanford, CA 94305, U S A
    Biochem Soc Trans 40:1047-51. 2012
    ....
  15. pmc Neuroprotective effects of compounds with antioxidant and anti-inflammatory properties in a Drosophila model of Parkinson's disease
    Katharina Faust
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    BMC Neurosci 10:109. 2009
    ....
  16. pmc Interaction of Notch signaling modulator Numb with α-Adaptin regulates endocytosis of Notch pathway components and cell fate determination of neural stem cells
    Yan Song
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 287:17716-28. 2012
    ..These findings are likely to have important implications for cancer biology...
  17. pmc dp53 Restrains ectopic neural stem cell formation in the Drosophila brain in a non-apoptotic mechanism involving Archipelago and cyclin E
    Yingshi Ouyang
    Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 6:e28098. 2011
    ..This has important clinical implications...
  18. pmc LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction
    Seongsoo Lee
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosci 30:16959-69. 2010
    ..These results implicate synaptic dysfunction caused by deregulated protein synthesis and aberrant MT dynamics in LRRK2 pathogenesis and offer a new paradigm for understanding and ultimately treating PD...
  19. pmc Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria
    Song Liu
    Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Genet 8:e1002537. 2012
    ..Moreover, the different effects of loss of PINK1 function on Miro protein level in Drosophila and mouse cells may offer one explanation of the distinct phenotypic manifestations of PINK1 mutants in these two species...
  20. pmc A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spines
    Wendou Yu
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Hum Mol Genet 21:1384-90. 2012
    ..Our results reveal a critical role for PAR-1/MARK kinases in AD pathogenesis and suggest PAR-1/MARK inhibitors as potential therapeutics for AD and possibly other tauopathies where aberrant tau hyperphosphorylation is involved...
  21. pmc PAR-1 kinase phosphorylates Dlg and regulates its postsynaptic targeting at the Drosophila neuromuscular junction
    Yali Zhang
    Department of Pathology, Stanford University School of Medicine, GRECC VAPAHCS, Palo Alto, CA 94304, USA
    Neuron 53:201-15. 2007
    ..Control of Dlg synaptic targeting by PAR-1-mediated phosphorylation thus constitutes a critical event in synaptogenesis...
  22. pmc Reduction of protein translation and activation of autophagy protect against PINK1 pathogenesis in Drosophila melanogaster
    Song Liu
    Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Genet 6:e1001237. 2010
    ..Our results reveal complex cellular responses to PINK1 inactivation and suggest novel therapeutic strategies through manipulation of the compensatory responses...
  23. pmc Synapses and dendritic spines as pathogenic targets in Alzheimer's disease
    Wendou Yu
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Neural Plast 2012:247150. 2012
    ..Synaptic and dendritic spine pathology is also observed in other neurodegenerative disease. It is possible that some common pathogenic mechanisms may underlie the synaptic and dendritic spine pathology in neurodegenerative diseases...
  24. pmc Regulation of cell growth by Notch signaling and its differential requirement in normal vs. tumor-forming stem cells in Drosophila
    Yan Song
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 25:2644-58. 2011
    ..Our findings highlight the importance of Notch-regulated cell growth in stem cell maintenance and reveal a stronger dependence on eIF4E function and cell growth by CSCs, which might be exploited therapeutically...
  25. pmc The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons
    Wendou Yu
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Hum Mol Genet 20:3227-40. 2011
    ..These results, together with previous findings in Drosophila dopaminergic neurons, indicate that the PINK1/Parkin pathway plays conserved roles in regulating neuronal mitochondrial dynamics and function...
  26. pmc Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb-induced ectopic neuroblast formation in Drosophila
    Yingshi Ouyang
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Development 138:2185-96. 2011
    ..Reduction of Dronc activity facilitates ENF induced by phospho-Numb. Our findings uncover a molecular mechanism that regulates Numb activity and suggest a novel role for Dronc caspase in regulating neural stem cell homeostasis...
  27. pmc Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling
    Yufeng Yang
    Department of Pathology, Stanford University School of Medicine, and Geriatric Research, Education and Clinical Center Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Proc Natl Acad Sci U S A 102:13670-5. 2005
    ..Manipulation of PI3K/Akt signaling may therefore offer therapeutic benefits for the treatment of PD...
  28. doi request reprint PINK1 and Parkin control localized translation of respiratory chain component mRNAs on mitochondria outer membrane
    Stephan Gehrke
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell Metab 21:95-108. 2015
    ..Our results reveal previously unknown functions of PINK1/Parkin in RNA metabolism and suggest new approaches to mitochondrial restoration and disease intervention. ..
  29. pmc Mitochondrial morphogenesis, distribution, and Parkinson disease: insights from PINK1
    Yufeng Yang
    Department of Pathology, Stanford University School of Medicine, Stanford Geriatric Research Education and Clinical Center, Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA
    J Neuropathol Exp Neurol 68:953-63. 2009
    ....
  30. pmc Synergistic contribution of SMAD signaling blockade and high localized cell density in the differentiation of neuroectoderm from H9 cells
    Chao Liu
    Department of Histology and Embryology, Institute of Stem Cell and Tissue Engineering, Anhui Medical University, Hefei, Anhui 230032, China Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, CA 94143, USA Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA Electronic address
    Biochem Biophys Res Commun 452:895-900. 2014
    ..Taken together, this study highlights the need to develop innovative strategies or techniques based on LCDs for generating neural progenies from human ESCs...
  31. pmc Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
    Yuzuru Imai
    Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    EMBO J 27:2432-43. 2008
    ..Our results suggest that chronic inactivation of 4E-BP by LRRK2 with pathogenic mutations deregulates protein translation, eventually resulting in age-dependent loss of DA neurons...
  32. pmc Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon
    Hongyan Wang
    Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore, Singapore 117604
    Nature 449:96-100. 2007
    ..Our results reveal a biochemical link between the cell cycle and the asymmetric protein localization machinery, and indicate that Polo can inhibit progenitor self-renewal by regulating the localization and function of Numb...
  33. ncbi request reprint HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites
    Chad A Dickey
    Mayo Clinic Jacksonville, College of Medicine, Jacksonville, Florida, USA
    FASEB J 20:753-5. 2006
    ....
  34. ncbi request reprint Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila
    Yufeng Yang
    Laboratory of Developmental Neurobiology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuron 37:911-24. 2003
    ..Our study implicates Parkin as a central player in the molecular pathway of Parkinson's disease (PD) and suggests that manipulating Parkin expression may provide a novel avenue of PD therapy...

Research Grants1

  1. Interaction Between DJ-1 and TSC1-TSC2/TOR Signaling in Cell Survival
    Bingwei Lu; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..