Jonathan T C Liu
Affiliation: Stanford University
- Miniature near-infrared dual-axes confocal microscope utilizing a two-dimensional microelectromechanical systems scannerJonathan T C Liu
Edward L Ginzton Laboratory, Stanford University, Stanford, California 94305, USA
Opt Lett 32:256-8. 2007..Reflectance and fluorescence images are obtained with a laser source at 785 nm, demonstrating the ability to perform real-time optical biopsy...
- Efficient rejection of scattered light enables deep optical sectioning in turbid media with low-numerical-aperture optics in a dual-axis confocal architectureJonathan T C Liu
Stanford University, Department of Electrical Engineering, Ginzton Laboratory, and School of Medicine, James H Clark Center for Biomedical Engineering and Science, Stanford, California 94305, USA
J Biomed Opt 13:034020. 2008..Our results demonstrate efficient rejection of scattered light in a DACM, which enables deep optical sectioning in tissue with subcellular resolution that can distinguish between normal and premalignant pathologies...
- Micromirror-scanned dual-axis confocal microscope utilizing a gradient-index relay lens for image guidance during brain surgeryJonathan T C Liu
Stanford University School of Medicine, Clark Center for Biomedical Engineering and Science, Stanford, California 94305, USA
J Biomed Opt 15:026029. 2010..Optically sectioned fluorescence images of brain tissues are obtained in living mice to demonstrate the utility of this microscope for image-guided resections...
- In vivo near-infrared dual-axis confocal microendoscopy in the human lower gastrointestinal tractWibool Piyawattanametha
Stanford University, James H Clark Center for Biomedical Engineering and Sciences, Department of Pediatrics, Stanford, California 94305, USA
J Biomed Opt 17:021102. 2012..These results suggest that DAC microendoscopy may have utility for visualizing the anatomical and, perhaps, functional changes associated with colorectal pathology for the early detection of colorectal cancer...
- Functional imaging of colonic mucosa with a fibered confocal microscope for real-time in vivo pathologyThomas D Wang
Division of Gastroenterology, Stanford University School of Medicine, Stanford, California, USA
Clin Gastroenterol Hepatol 5:1300-5. 2007..The aim of this study was to show the use of functional optical imaging of viable mucosa for quantitative evaluation of colonic neoplasia in real time...
- Dual-axes confocal reflectance microscope for distinguishing colonic neoplasiaJonathan T C Liu
Ginzton Laboratory, Stanford University, Stanford, California 94305, USA
J Biomed Opt 11:054019. 2006..This design is scalable to millimeter dimensions, and the results demonstrate the potential for a miniature instrument to detect precancerous tissues, and hence to perform in vivo histopathology...
- A Raman-based endoscopic strategy for multiplexed molecular imagingCristina L Zavaleta
Department of Radiology, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 110:E2288-97. 2013..Using this endoscope as a key part of a multiplexed detection approach could allow endoscopists to distinguish between normal and precancerous tissues rapidly and to identify flat lesions that are otherwise missed...
- Quantifying cell-surface biomarker expression in thick tissues with ratiometric three-dimensional microscopyJonathan T C Liu
Ginzton Labs, Department of Electrical Engineering, Stanford University, Stanford, California, USA
Biophys J 96:2405-14. 2009..This strategy enables rapid, quantitative, and unambiguous volumetric microscopy of biomarker expression in thick tissues, including whole biopsies, and will enable real-time optical assessment of disease markers in the living body...
- Identification of cell surface targets through meta-analysis of microarray dataHenry Haeberle
Department of Pediatrics, Stanford University, Stanford, CA 94305, USA
Neoplasia 14:666-9. 2012..This bioinformatics method has broad utility for the identification of accessible molecular targets in a variety of cancers and will enable probe development for guided resection...