Francis Lin

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi Lymphocyte electrotaxis in vitro and in vivo
    Francis Lin
    Laboratory of Immunology and Vascular Biology, Department of Pathology, School of Medicine, Stanford University, Stanford, CA 94305, USA
    J Immunol 181:2465-71. 2008
  2. ncbi Modeling the role of homologous receptor desensitization in cell gradient sensing
    Francis Lin
    Department of Pathology, Laboratory of Immunology and Vascular Biology, School of Medicine, Stanford University, Stanford, CA 94305, USA
    J Immunol 181:8335-43. 2008
  3. ncbi T cell chemotaxis in a simple microfluidic device
    Francis Lin
    Laboratory of Immunology and Vascular Biology, Department of Pathology, School of Medicine, Stanford University, Stanford, California 94305, USA
    Lab Chip 6:1462-9. 2006
  4. ncbi Chapter 15. A microfluidics-based method for chemoattractant gradients
    Francis Lin
    Laboratory of Immunology and Vascular Biology, Department of Pathology, School of Medicine, Stanford University, Stanford, California, USA
    Methods Enzymol 461:333-47. 2009
  5. ncbi E-cadherin plays an essential role in collective directional migration of large epithelial sheets
    Li Li
    Department of Dermatology, School of Medicine, Institute for Regenerative Cures, University of California at Davis, Suite 1630, 2921 Stockton Blvd, Room 1617, Sacramento, CA 95817, USA
    Cell Mol Life Sci 69:2779-89. 2012
  6. ncbi Effective neutrophil chemotaxis is strongly influenced by mean IL-8 concentration
    Francis Lin
    Department of Physics and Astronomy, University of California at Irvine, Irvine, CA 92697, USA
    Biochem Biophys Res Commun 319:576-81. 2004
  7. ncbi Generation of stable concentration gradients in 2D and 3D environments using a microfluidic ladder chamber
    Wajeeh Saadi
    Department of Biomedical Engineering, University of California at Irvine, 3120 Natural Science II, Irvine, CA 92697, USA
    Biomed Microdevices 9:627-35. 2007

Collaborators

Detail Information

Publications7

  1. ncbi Lymphocyte electrotaxis in vitro and in vivo
    Francis Lin
    Laboratory of Immunology and Vascular Biology, Department of Pathology, School of Medicine, Stanford University, Stanford, CA 94305, USA
    J Immunol 181:2465-71. 2008
    ..Lymphocyte positioning within tissues can thus be manipulated by externally applied electric fields, and may be influenced by endogenous electrical potential gradients as well...
  2. ncbi Modeling the role of homologous receptor desensitization in cell gradient sensing
    Francis Lin
    Department of Pathology, Laboratory of Immunology and Vascular Biology, School of Medicine, Stanford University, Stanford, CA 94305, USA
    J Immunol 181:8335-43. 2008
    ..We propose that homologous receptor desensitization is critical for cellular navigation in complex chemoattractant fields...
  3. ncbi T cell chemotaxis in a simple microfluidic device
    Francis Lin
    Laboratory of Immunology and Vascular Biology, Department of Pathology, School of Medicine, Stanford University, Stanford, California 94305, USA
    Lab Chip 6:1462-9. 2006
    ..Acknowledging the importance of lymphocyte homing in the adaptive immune response, the ability to study T cell chemotaxis in microfluidic devices offers a new approach for investigating lymphocyte migration and chemotaxis in vitro...
  4. ncbi Chapter 15. A microfluidics-based method for chemoattractant gradients
    Francis Lin
    Laboratory of Immunology and Vascular Biology, Department of Pathology, School of Medicine, Stanford University, Stanford, California, USA
    Methods Enzymol 461:333-47. 2009
    ..In this chapter, the detailed method of analyzing the migration of human blood neutrophils and T cells in chemoattractant gradients with microfluidic devices is described...
  5. ncbi E-cadherin plays an essential role in collective directional migration of large epithelial sheets
    Li Li
    Department of Dermatology, School of Medicine, Institute for Regenerative Cures, University of California at Davis, Suite 1630, 2921 Stockton Blvd, Room 1617, Sacramento, CA 95817, USA
    Cell Mol Life Sci 69:2779-89. 2012
    ..Our study thus identifies a novel mechanism--E-cadherin dependence and coordinated traction forces of leading cells in collective directional migration of large epithelial sheets...
  6. ncbi Effective neutrophil chemotaxis is strongly influenced by mean IL-8 concentration
    Francis Lin
    Department of Physics and Astronomy, University of California at Irvine, Irvine, CA 92697, USA
    Biochem Biophys Res Commun 319:576-81. 2004
    ..In contrast, we find that the steepness of IL-8 gradients has no significant effect on effective chemotaxis...
  7. ncbi Generation of stable concentration gradients in 2D and 3D environments using a microfluidic ladder chamber
    Wajeeh Saadi
    Department of Biomedical Engineering, University of California at Irvine, 3120 Natural Science II, Irvine, CA 92697, USA
    Biomed Microdevices 9:627-35. 2007
    ..The Ladder Chamber's simple design and experimental implementation make it an attractive approach for investigating cell migration and other biological experiments in well-defined gradients in 2D surfaces as well as in 3D gels...