Research Topics
Species | DOUGLAS FREDERICK LEVINSONSummaryAffiliation: Stanford University Country: USA Publications
Research Grants
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Detail Information
Publications
Genetics of recurrent early-onset major depression (GenRED): significant linkage on chromosome 15q25-q26 after fine mapping with single nucleotide polymorphism markersDouglas F Levinson
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 701A Welch Rd, Suite 3325, Palo Alto, CA 94304 5797, USA
Am J Psychiatry 164:259-64. 2007....- Genome-wide association study of multiplex schizophrenia pedigreesDouglas F Levinson
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif, USA
Am J Psychiatry 169:963-73. 2012..The authors used a genome-wide association study (GWAS) of multiply affected families to investigate the association of schizophrenia to common single-nucleotide polymorphisms (SNPs) and rare copy number variants (CNVs)... 
Statistical corrections of linkage data suggest predominantly cis regulations of gene expressionJianxin Shi
Department of Psychiatry and Behavioral Sciences, Stanford University, 701A Welch Road, Suite 3325, Stanford, California 94305, USA
BMC Proc 1:S145. 2007..4, LOD = 8.9), we detected linkage for the expression levels of 22 genes, 19 of which are cis. Limiting the analysis to cis regions, linkage was detected to the expression levels of 46 genes with 4.6 expected false positives (FDR = 10%)...
Copy number variants in schizophrenia: confirmation of five previous findings and new evidence for 3q29 microdeletions and VIPR2 duplicationsDouglas F Levinson
Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA 94304 5797, USA
Am J Psychiatry 168:302-16. 2011....- Genetics of recurrent early-onset major depression (GenRED): final genome scan reportPeter Holmans
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 701A Welch Rd, Suite 3325, Palo Alto, CA 94304 5797, USA
Am J Psychiatry 164:248-58. 2007.... - Linkage disequilibrium mapping of a chromosome 15q25-26 major depression linkage region and sequencing of NTRK3Ranjana Verma
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Biol Psychiatry 63:1185-9. 2008..Here we present initial linkage-disequilibrium (LD) fine mapping of this signal and sequence analysis of NTRK3 (neurotrophic receptor kinase-3), a biologically plausible candidate gene... - Genome-wide linkage and follow-up association study of postpartum mood symptomsPamela Belmonte Mahon
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA
Am J Psychiatry 166:1229-37. 2009..The authors then fine-mapped their best linkage regions, assessing single nucleotide polymorphisms (SNPs) for genetic association with postpartum symptoms... - Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophreniaJubao Duan
Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, Evanston Northwestern Healthcare and Feinberg School of Medicine, Northwestern University, Evanston, IL, USA
Am J Hum Genet 75:624-38. 2004..These data provide strong preliminary evidence that TRAR4 is a candidate gene for schizophrenia; replication is currently being attempted in additional clinical samples... - QuickSNP: an automated web server for selection of tagSNPsDeepak Grover
Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
Nucleic Acids Res 35:W115-20. 2007..The server is freely available and can be accessed at the URL http://bioinformoodics.jhmi.edu/quickSNP.pl... - Investigating the role of p11 (S100A10) sequence variation in susceptibility to major depressionRanjana Verma
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Med Genet B Neuropsychiatr Genet 144:1079-82. 2007..2%, P = 0.15). None of the tag SNPs showed any evidence of association. Our results do not support a major role for either common or rare p11 SNPs with MDD. Several limitations of the study are discussed... - A comparison of the familiality of chronic depression in recurrent early-onset depression pedigrees using different definitions of chronicityFrancis M Mondimore
Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
J Affect Disord 100:171-7. 2007..Because familial clustering is one component of diagnostic validity we compared family clustering of chronicity as defined in the DSM-IV to that of chronicity determined by an assessment of lifetime course of depressive illness... - Common variants on chromosome 6p22.1 are associated with schizophreniaJianxin Shi
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California 94304, USA
Nature 460:753-7. 2009..These results demonstrate that common schizophrenia susceptibility alleles can be detected. The characterization of these signals will suggest important directions for research on susceptibility mechanisms... - Narcolepsy is strongly associated with the T-cell receptor alpha locusJoachim Hallmayer
Center for Sleep Sciences, Stanford University School of Medicine, Palo Alto, California, USA
Nat Genet 41:708-11. 2009.... - The Internet-based MGS2 control sample: self report of mental illnessAlan R Sanders
Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, NorthShore University Healthsystem, Evanston, Ill 60201 3137, USA
Am J Psychiatry 167:854-65. 2010..The Molecular Genetics of Schizophrenia (MGS2) project recruited an adult control sample of non-Hispanic European-ancestry (N=3,364) and African American (N=1,301) subjects... - Premenstrual mood symptoms: study of familiality and personality correlates in mood disorder pedigreesJennifer L Payne
Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, 550 N Broadway, Baltimore, MD 21205, USA
Arch Womens Ment Health 12:27-34. 2009..Limitations include the retrospective interview, the lack of data on premenstrual dysphoric disorder, and the inability to control for factors such as medication use...
Research Grants
- Multicenter Genetics Studies of SchizophreniaDouglas Levinson; Fiscal Year: 2006....
- GENETIC LINKAGE OF SCHIZOPHRENIA AND RELATED STUDIESDouglas Levinson; Fiscal Year: 2005..abstract_text> ..
- Genetics of Early-Onset DepressionDouglas Levinson; Fiscal Year: 2007..abstract_text> ..
- Genome-Wide Association Study of SchizophreniaDouglas Levinson; Fiscal Year: 2007....
- MOLECULAR GENETICS OF SCHIZOPHRENIADouglas Levinson; Fiscal Year: 2007..The goal of the study is to identify one or more SZ susceptibility genes whose subsequent characterization inmolecular and functional studies will elucidate the pathophysiology and treatment of SZ. ..
- MOLECULAR GENETICS OF SCHIZOPHRENIADouglas Levinson; Fiscal Year: 2002..Power analyses suggest that this study would have excellent power to detect loci associated with lambda sibs of 1.4, and moderate power for a value of 1.3, i.e., loci with relatively small etiologic effects. ..
- MULTICENTER GENETIC STUDIES OF SCHIZOPHRENIADouglas Levinson; Fiscal Year: 2002..These studies may assist investigators in determining which candidate regions are most deserving of intensive efforts to find disease-related genes, and the most likely locations of these genes within the regions. ..
- GENETICS OF RECURRENT EARLY-ONSET DEPRESSIONDouglas Levinson; Fiscal Year: 2002..A timetable is proposed for rapid sharing of all biological materials, blinded clinical data, genotypes and linkage analyses with the scientific community through the NIMH-sponsored Center for Genetic Studies. ..