Philipp Leucht

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. doi request reprint Comparison of tricalcium phosphate cement and cancellous autograft as bone void filler in acetabular fractures with marginal impaction
    Philipp Leucht
    Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    Injury 44:969-74. 2013
  2. pmc Primary cilia act as mechanosensors during bone healing around an implant
    P Leucht
    Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    Med Eng Phys 35:392-402. 2013
  3. pmc Single column locking plate fixation is inadequate in two column acetabular fractures. A biomechanical analysis
    Kiarash Khajavi
    Department of Orthopaedic Surgery, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    J Orthop Surg Res 5:30. 2010
  4. doi request reprint Epidemiology of traumatic spine fractures
    Philipp Leucht
    Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University, Stanford, 257 Campus Drive, CA 94305, USA
    Injury 40:166-72. 2009
  5. pmc rBMP represses Wnt signaling and influences skeletal progenitor cell fate specification during bone repair
    Steve Minear
    Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford School of Medicine, Stanford, CA 94305, USA
    J Bone Miner Res 25:1196-207. 2010
  6. doi request reprint Indian hedgehog positively regulates calvarial ossification and modulates bone morphogenetic protein signaling
    Kelly Lenton
    Division of Plastic and Reconstructive Surgery, Department of Surgery, School of Medicine, Stanford University, Stanford, California 94028, USA
    Genesis 49:784-96. 2011
  7. pmc Estrogen/estrogen receptor alpha signaling in mouse posterofrontal cranial suture fusion
    Aaron W James
    Hagey Pediatric Regenerative Research Laboratory, Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, California, USA
    PLoS ONE 4:e7120. 2009
  8. doi request reprint Embryonic origin and Hox status determine progenitor cell fate during adult bone regeneration
    Philipp Leucht
    Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    Development 135:2845-54. 2008
  9. ncbi request reprint Bone regeneration is regulated by wnt signaling
    Jae Beom Kim
    Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University, Stanford, CA 94305 5148, USA
    J Bone Miner Res 22:1913-23. 2007
  10. doi request reprint Wnt proteins promote bone regeneration
    Steven Minear
    Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford School of Medicine, Stanford, CA 94305, USA
    Sci Transl Med 2:29ra30. 2010

Collaborators

Detail Information

Publications23

  1. doi request reprint Comparison of tricalcium phosphate cement and cancellous autograft as bone void filler in acetabular fractures with marginal impaction
    Philipp Leucht
    Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    Injury 44:969-74. 2013
    ..To compare clinical and radiological outcome between acetabular fractures with marginal impaction that were treated with either cancellous bone graft (CBG) or tricalcium phosphate cement (TPC) as bone void filler...
  2. pmc Primary cilia act as mechanosensors during bone healing around an implant
    P Leucht
    Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    Med Eng Phys 35:392-402. 2013
    ..The ability to manipulate the genetic background of peri-implant cells within the context of a whole, living tissue provides a rare opportunity to explore mechanotransduction from a multi-scale perspective...
  3. pmc Single column locking plate fixation is inadequate in two column acetabular fractures. A biomechanical analysis
    Kiarash Khajavi
    Department of Orthopaedic Surgery, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    J Orthop Surg Res 5:30. 2010
    ..abstract:..
  4. doi request reprint Epidemiology of traumatic spine fractures
    Philipp Leucht
    Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University, Stanford, 257 Campus Drive, CA 94305, USA
    Injury 40:166-72. 2009
    ..To illustrate the correlations and effects of age, gender and cause of accident on the type of vertebral fracture and fracture distribution, as well as on the likelihood to sustain an associated injury or neurological deficit...
  5. pmc rBMP represses Wnt signaling and influences skeletal progenitor cell fate specification during bone repair
    Steve Minear
    Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford School of Medicine, Stanford, CA 94305, USA
    J Bone Miner Res 25:1196-207. 2010
    ..These mechanistic insights may be particularly useful for optimizing the reparative potential of rBMPs while simultaneously minimizing their adverse outcomes...
  6. doi request reprint Indian hedgehog positively regulates calvarial ossification and modulates bone morphogenetic protein signaling
    Kelly Lenton
    Division of Plastic and Reconstructive Surgery, Department of Surgery, School of Medicine, Stanford University, Stanford, California 94028, USA
    Genesis 49:784-96. 2011
    ..In conjunction with the newly recognized roles of Hedgehog deregulation in craniosynostosis, our study defines Ihh as an important positive regulator of cranial bone ossification...
  7. pmc Estrogen/estrogen receptor alpha signaling in mouse posterofrontal cranial suture fusion
    Aaron W James
    Hagey Pediatric Regenerative Research Laboratory, Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, California, USA
    PLoS ONE 4:e7120. 2009
    ..Estrogens are associated with growth plate fusion of endochondral bones. In the following study, we explore the previously unknown significance of estrogen/estrogen receptor signaling in cranial suture biology...
  8. doi request reprint Embryonic origin and Hox status determine progenitor cell fate during adult bone regeneration
    Philipp Leucht
    Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    Development 135:2845-54. 2008
    ..Thus, embryonic origin and Hox gene expression status distinguish neural crest-derived from mesoderm-derived skeletal progenitor cells, and both characteristics influence the process of adult bone regeneration...
  9. ncbi request reprint Bone regeneration is regulated by wnt signaling
    Jae Beom Kim
    Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University, Stanford, CA 94305 5148, USA
    J Bone Miner Res 22:1913-23. 2007
    ..Herein, we studied the role of Wnt signaling in skeletal tissue regeneration...
  10. doi request reprint Wnt proteins promote bone regeneration
    Steven Minear
    Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford School of Medicine, Stanford, CA 94305, USA
    Sci Transl Med 2:29ra30. 2010
    ..The end result was faster bone regeneration. Because Wnt signaling is conserved in mammalian tissue repair, this protein-based approach may have widespread applications in regenerative medicine...
  11. pmc Sonic Hedgehog influences the balance of osteogenesis and adipogenesis in mouse adipose-derived stromal cells
    Aaron W James
    Hagey Pediatric Regenerative Medicine Laboratory, Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, California 94305 5148, USA
    Tissue Eng Part A 16:2605-16. 2010
    ..These data suggest that Hedgehog signaling directs the lineage differentiation of mesodermal stem cells and represents a promising strategy for skeletal tissue regeneration...
  12. pmc Fgf-9 is required for angiogenesis and osteogenesis in long bone repair
    Bjorn Behr
    Children s Surgical Research Program, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 107:11853-8. 2010
    ..Moreover, this study further supports the embryonic phenotype previously observed in the developing limb, thus promoting the concept that healing processes in adult organisms may recapitulate embryonic skeletal development...
  13. pmc Inhibition of histone deacetylase activity in reduced oxygen environment enhances the osteogenesis of mouse adipose-derived stromal cells
    Yue Xu
    Plastic and Reconstructive Surgery Division, Hagey Pediatric Regenerative Research Laboratory, Department of Surgery, Stanford University School of Medicine, Stanford University, Stanford, California 94305 5148, USA
    Tissue Eng Part A 15:3697-707. 2009
    ..In conclusion, HDACi significantly promote the osteogenic differentiation of mASCs exposed to reduced oxygen tension; HDACi may hold promise for future clinical applications of ASCs for skeletal regeneration...
  14. pmc Accelerated bone repair after plasma laser corticotomies
    Philipp Leucht
    Department of Surgery, Stanford University, Stanford, CA
    Ann Surg 246:140-50. 2007
    ..To reveal, on a cellular and molecular level, how skeletal regeneration of a corticotomy is enhanced when using laser-plasma mediated ablation compared with conventional mechanical tissue removal...
  15. doi request reprint Wnt signaling promotes Müller cell proliferation and survival after injury
    Bo Liu
    Department of Surgery, Division of Plastic and Reconstructive Surgery, and Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford, California 94305, USA
    Invest Ophthalmol Vis Sci 54:444-53. 2013
    ..Here, we tested the function of Wnt signaling in the postinjury retina, focusing on its ability to influence mammalian Müller cell dedifferentiation, proliferation, and neurogenesis...
  16. pmc Wnt3a reestablishes osteogenic capacity to bone grafts from aged animals
    Philipp Leucht
    Department of Orthopaedic Surgery, Stanford School of Medicine, Stanford, CA 94305, USA
    J Bone Joint Surg Am 95:1278-88. 2013
    ..The mechanisms underlying this fatty change are unknown, but they may relate to the level of Wnt signaling within the aged marrow cavity...
  17. doi request reprint CXCR4 antagonism attenuates load-induced periosteal bone formation in mice
    Philipp Leucht
    Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, California
    J Orthop Res 31:1828-38. 2013
    ..Our data suggest that SDF-1/CXCR4 signaling plays a critical role in skeletal mechanoadaptation, and may represent a unique therapeutic target for prevention and treatment of age-related and disuse bone loss...
  18. pmc Liposomal packaging generates Wnt protein with in vivo biological activity
    Nathan T Morrell
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University, Stanford, California, United States of America
    PLoS ONE 3:e2930. 2008
    ..When delivered subcutaneously, Wnt3a liposomes induce hair follicle neogenesis, demonstrating their robust biological activity in a regenerative context...
  19. doi request reprint Beta-catenin-dependent Wnt signaling in mandibular bone regeneration
    Philipp Leucht
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University Medical School, 257 Campus Drive, Stanford, CA 94305 5148, USA
    J Bone Joint Surg Am 90:3-8. 2008
    ..Taken together, these data underscore the functional requirement for Wnt signaling in cranial skeletal healing...
  20. ncbi request reprint Visualizing in vivo liposomal drug delivery in real-time
    Jae Beom Kim
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University, Stanford, CA 94305 5148, USA
    J Drug Target 15:632-9. 2007
    ..These data present a strategy to monitor liposomal drug delivery in vivo with luciferin...
  21. ncbi request reprint Wnt signaling mediates regional specification in the vertebrate face
    Samantha A Brugmann
    Department of Plastic and Reconstructive Surgery, Stanford University, Stanford, CA 94305, USA
    Development 134:3283-95. 2007
    ..Collectively, these data elucidate a new role for Wnt signaling in regional specification of the vertebrate face, and suggest possible mechanisms whereby species-specific facial features are generated...
  22. pmc FAK-Mediated mechanotransduction in skeletal regeneration
    Philipp Leucht
    Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University, Stanford, California, United States of America
    PLoS ONE 2:e390. 2007
    ..Our data provide a new framework in which to consider how physical forces and molecular signals are synchronized during the program of skeletal regeneration...
  23. pmc Effect of mechanical stimuli on skeletal regeneration around implants
    Philipp Leucht
    Department of Plastic and Reconstructive Surgery, Stanford University, 257 Campus Drive, PSRL Building, Stanford, CA 94305, USA
    Bone 40:919-30. 2007
    ..By comparing strain measurements with cellular and molecular analyses, we developed an understanding of the correlation between strain magnitudes and fate decisions of cells shaping the skeletal regenerate...