NORMAN LEHMAN

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi Primary paraspinal leiomyosarcoma invading the cervical spinal canal successfully treated with surgery, radiotherapy, and chemotherapy. Case report
    Norman L Lehman
    Department of Pathology, Stanford University Medical Center, Stanford, California 94305, USA
    J Neurosurg Spine 6:441-6. 2007
  2. pmc Oncogenic regulators and substrates of the anaphase promoting complex/cyclosome are frequently overexpressed in malignant tumors
    Norman L Lehman
    Department of Pathology, MC5324, Stanford University, Stanford, CA, USA
    Am J Pathol 170:1793-805. 2007
  3. ncbi Synchronous subarachnoid drop metastases from a pituitary adenoma with multiple recurrences. Case report
    Norman L Lehman
    Department of Pathology, Stanford University Medical Center, Stanford, California 94305, USA
    J Neurosurg 98:1120-3. 2003
  4. ncbi Cortical ependymoma. A case report and review
    Norman L Lehman
    Department of Pathology, Stanford University Medical Center, Calif 94305, USA
    Pediatr Neurosurg 39:50-4. 2003
  5. ncbi Malignant PEComa of the skull base
    Norman L Lehman
    Department of Pathology, Stanford University Medical Center, Stanford, CA 94305, USA
    Am J Surg Pathol 28:1230-2. 2004
  6. ncbi Recessive dystrophic epidermolysis bullosa associated with mesangioproliferative glomerulonephritis and multifocal necrotizing leucoencephalopathy of the pons
    T D Lehman
    Department of Dermatology, Stanford University Medical Center, Stanford, CA 94305, U S A
    Br J Dermatol 151:1266-9. 2004
  7. ncbi Overexpression of the anaphase promoting complex/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cells
    Norman L Lehman
    Department of Pathology, Stanford University, Stanford, California 94305, USA
    Cell Cycle 5:1569-73. 2006
  8. doi Intramedullary papillary ependymoma with choroid plexus differentiation and cerebrospinal fluid dissemination to the brain
    Mohanpal S Dulai
    Department of Pathology, Stanford University Medical Center, Stanford, California, USA
    J Neurosurg Pediatr 5:511-7. 2010
  9. pmc Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor
    Julie J Miller
    Program in Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 20:2410-20. 2006
  10. doi Emi1 protein accumulation implicates misregulation of the anaphase promoting complex/cyclosome pathway in ovarian clear cell carcinoma
    Ines Gütgemann
    Department of Pathology, Stanford University, Stanford, CA, USA
    Mod Pathol 21:445-54. 2008

Research Grants

  1. Control of Genomic Stability by Emi1 and Securin
    NORMAN LEHMAN; Fiscal Year: 2007

Collaborators

Detail Information

Publications21

  1. ncbi Primary paraspinal leiomyosarcoma invading the cervical spinal canal successfully treated with surgery, radiotherapy, and chemotherapy. Case report
    Norman L Lehman
    Department of Pathology, Stanford University Medical Center, Stanford, California 94305, USA
    J Neurosurg Spine 6:441-6. 2007
    ....
  2. pmc Oncogenic regulators and substrates of the anaphase promoting complex/cyclosome are frequently overexpressed in malignant tumors
    Norman L Lehman
    Department of Pathology, MC5324, Stanford University, Stanford, CA, USA
    Am J Pathol 170:1793-805. 2007
    ..This profile of misregulated mitotic APC/C substrates and regulators in malignant tumors suggests that analysis of this pathway may be diagnostically useful and represent a potentially important therapeutic target...
  3. ncbi Synchronous subarachnoid drop metastases from a pituitary adenoma with multiple recurrences. Case report
    Norman L Lehman
    Department of Pathology, Stanford University Medical Center, Stanford, California 94305, USA
    J Neurosurg 98:1120-3. 2003
    ..This case demonstrates that subarachnoid metastasis of a pituitary adenoma, particularly when it follows multiple operations, is not invariably widely disseminated or associated with a very poor prognosis...
  4. ncbi Cortical ependymoma. A case report and review
    Norman L Lehman
    Department of Pathology, Stanford University Medical Center, Calif 94305, USA
    Pediatr Neurosurg 39:50-4. 2003
    ..This case illustrates the importance of establishing an accurate neuropathologic tissue diagnosis of all pediatric cortical tumors...
  5. ncbi Malignant PEComa of the skull base
    Norman L Lehman
    Department of Pathology, Stanford University Medical Center, Stanford, CA 94305, USA
    Am J Surg Pathol 28:1230-2. 2004
    ..This report describes an apparent case of a malignant PEComa of the skull base in a 49-year-old woman, a previously undescribed location for this lesion...
  6. ncbi Recessive dystrophic epidermolysis bullosa associated with mesangioproliferative glomerulonephritis and multifocal necrotizing leucoencephalopathy of the pons
    T D Lehman
    Department of Dermatology, Stanford University Medical Center, Stanford, CA 94305, U S A
    Br J Dermatol 151:1266-9. 2004
    ..Although mesangioproliferative glomerulonephritis has previously been described in association with RDEB, to our knowledge this is the first report of MNL in a patient with RDEB...
  7. ncbi Overexpression of the anaphase promoting complex/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cells
    Norman L Lehman
    Department of Pathology, Stanford University, Stanford, California 94305, USA
    Cell Cycle 5:1569-73. 2006
    ..This represents a potentially important mechanism by which pRb and p53 dysfunction may contribute to tumorigenesis through the generation of genomic instability...
  8. doi Intramedullary papillary ependymoma with choroid plexus differentiation and cerebrospinal fluid dissemination to the brain
    Mohanpal S Dulai
    Department of Pathology, Stanford University Medical Center, Stanford, California, USA
    J Neurosurg Pediatr 5:511-7. 2010
    ..The histopathological and clinical courses of this rare spinal papillary ependymoma exhibiting mixed ependymal and choroid plexus-like differentiation are discussed...
  9. pmc Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor
    Julie J Miller
    Program in Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 20:2410-20. 2006
    ..The combination of a degron/E3 recognition site and an anti-ligase function in Emi1 suggests a general model for how E3 substrates evolve to become pseudosubstrate inhibitors...
  10. doi Emi1 protein accumulation implicates misregulation of the anaphase promoting complex/cyclosome pathway in ovarian clear cell carcinoma
    Ines Gütgemann
    Department of Pathology, Stanford University, Stanford, CA, USA
    Mod Pathol 21:445-54. 2008
    ..These findings represent a potentially important insight into the molecular pathway underlying ovarian carcinogenesis and provide a possible cell cycle model for the development and progression of ovarian clear cell carcinoma...
  11. ncbi Future potential of thymidylate synthase inhibitors in cancer therapy
    Norman L Lehman
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Expert Opin Investig Drugs 11:1775-87. 2002
    ....
  12. ncbi Early neonatal diagnosis of long-chain 3-hydroxyacyl coenzyme a dehydrogenase and mitochondrial trifunctional protein deficiencies
    Susan R Hintz
    Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University, Palo Alto, California 94304, USA
    Mol Genet Metab 75:120-7. 2002
    ..However, timely analysis and reporting of results to clinicians are essential, because these disorders can manifest in the first few days of life...
  13. ncbi Gliosarcoma with melanocytic differentiation
    Mohanpal S Dulai
    Department of Pathology, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305, USA
    Acta Neuropathol 115:357-61. 2008
    ....
  14. ncbi Screening of tissue microarrays for ubiquitin proteasome system components in tumors
    Norman L Lehman
    Department of Pathology, Stanford University School of Medicine, Palo Alto, California, USA
    Methods Enzymol 399:334-55. 2005
    ..In this article, we provide an introduction to the use of TMAs to study the expression of UPS component proteins and substrates in tumors by immunohistochemistry...
  15. pmc Patterns of brain infiltration and secondary structure formation in supratentorial ependymal tumors
    Norman L Lehman
    Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    J Neuropathol Exp Neurol 67:900-10. 2008
    ..Cortical ependymomas and angiocentric gliomas may comprise a group of locally infiltrative ependymal tumors that are associated with an excellent prognosis after gross total surgical resection...
  16. ncbi Dural marginal zone lymphoma with massive amyloid deposition: rare low-grade primary central nervous system B-cell lymphoma. Case report
    Norman L Lehman
    Department of Pathology, Stanford University Medical Center, California 94305 5324, USA
    J Neurosurg 96:368-72. 2002
    ..Extranodal MZL is a rare low-grade primary CNS B-cell lymphoma that may be associated with amyloidosis. It should be considered in the differential diagnosis of CNS lymphoproliferative lesions and CNS amyloidosis...
  17. pmc Loss of Emi1-dependent anaphase-promoting complex/cyclosome inhibition deregulates E2F target expression and elicits DNA damage-induced senescence
    Emmy W Verschuren
    Department of Tumor Biology and Angiogenesis, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Mol Cell Biol 27:7955-65. 2007
    ..Our data suggest that maintenance of a protein stabilization/mRNA expression positive-feedback circuit fueled by Emi1 is required for accurate cell cycle progression, maintenance of DNA integrity, and prevention of cellular senescence...
  18. doi Central nervous system tumors with ependymal features: a broadened spectrum of primarily ependymal differentiation?
    Norman L Lehman
    Hermelin Brain Tumor Center, Henry Ford Health System, Detroit, MI 48202, USA
    J Neuropathol Exp Neurol 67:177-88. 2008
    ..These issues are addressed in the context of early morphologic insights of Bailey and Cushing, Friede, and others; contemporary oncologic concepts; and recent relevant molecular and tumor stem cell studies...
  19. pmc GRP78 is overexpressed in glioblastomas and regulates glioma cell growth and apoptosis
    Hae Kyung Lee
    Department of Neurosurgery and Hermelin Brain Tumor Center, Henry Ford Health System, Detroit, MI 48202, USA
    Neuro Oncol 10:236-43. 2008
    ..Thus, GRP78 contributes to the increased apoptosis resistance and growth of glioma cells and may provide a target for enhancing the therapeutic responsiveness of these tumors...
  20. ncbi Histologic findings of disc, end plate and neural elements after coblation of nucleus pulposus: an experimental nucleoplasty study
    Yung C Chen
    Spinal Diagnostics and Treatment Center, Daly City, CA 94015, USA
    Spine J 3:466-70. 2003
    ..Nucleoplasty, a new minimally invasive procedure using patented coblation technology, combines coagulation and ablation for partial removal of the nucleus pulposus to decompress the disc...
  21. pmc Expression of CYP4A1 in U251 human glioma cell induces hyperproliferative phenotype in vitro and rapidly growing tumors in vivo
    Austin M Guo
    Henry Ford Hospital, Detroit, Michigan 48202, USA
    J Pharmacol Exp Ther 327:10-9. 2008
    ..This suggests that 20-HETE may have proto-oncogenic properties in U251 human gliomas. Further studies are needed to determine whether 20-HETE plays a role promoting growth of some human gliomas...

Research Grants1

  1. Control of Genomic Stability by Emi1 and Securin
    NORMAN LEHMAN; Fiscal Year: 2007
    ..abstract_text> ..