Quynh Thu Le

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Evaluation of patterns of failure and subjective salivary function in patients treated with intensity modulated radiotherapy for head and neck squamous cell carcinoma
    Megan E Daly
    Department of Radiation Oncology, Stanford University Medical Center, Stanford, California 94305, USA
    Head Neck 29:211-20. 2007
  2. ncbi request reprint Lymph node metastasis in maxillary sinus carcinoma
    Q T Le
    Department of Radiation Oncology, Stanford University, CA 94305 5302, USA
    Int J Radiat Oncol Biol Phys 46:541-9. 2000
  3. ncbi request reprint Comparison of the comet assay and the oxygen microelectrode for measuring tumor oxygenation in head-and-neck cancer patients
    Quynh Thu Le
    Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA
    Int J Radiat Oncol Biol Phys 56:375-83. 2003
  4. ncbi request reprint Nasopharyngeal and oropharyngeal carcinomas: target delineation, therapy delivery and stereotactic boost procedures with intensity-modulated/ image-guided radiation therapy
    Quynh Thu Le
    Department of Radiation Oncology, Stanford University, Stanford, CA 94305 5302, USA
    Front Radiat Ther Oncol 40:208-31. 2007
  5. ncbi request reprint Identification of osteopontin as a prognostic plasma marker for head and neck squamous cell carcinomas
    Quynh Thu Le
    Department of Radiation Oncology, Center for Clinical Science Research South, Stanford, California 94305 5152, USA
    Clin Cancer Res 9:59-67. 2003
  6. ncbi request reprint Primary radiotherapy for localized orbital MALT lymphoma
    Quynh Thu Le
    Department of Radiation Oncology, Stanford University Medical Center, Stanford, CA 94305, USA
    Int J Radiat Oncol Biol Phys 52:657-63. 2002
  7. ncbi request reprint Treatment results of carcinoma in situ of the glottis: an analysis of 82 cases
    Q T Le
    Department of Radiation Oncology, Stanford University Medical Center, 300 Pasteur Dr, Stanford, CA 94305 5302, USA
    Arch Otolaryngol Head Neck Surg 126:1305-12. 2000
  8. ncbi request reprint Phase I study of tirapazamine plus cisplatin/etoposide and concurrent thoracic radiotherapy in limited-stage small cell lung cancer (S0004): a Southwest Oncology Group study
    Quynh Thu Le
    Department of Radiation Oncology, Stanford University, Stanford, California 94305 5847, USA
    Clin Cancer Res 10:5418-24. 2004
  9. ncbi request reprint An evaluation of tumor oxygenation and gene expression in patients with early stage non-small cell lung cancers
    Quynh Thu Le
    Department of Radiation Oncology, Stanford University Medical Center, Stanford, California 94305 5847, USA
    Clin Cancer Res 12:1507-14. 2006
  10. doi request reprint Metabolic imaging metrics correlate with survival in early stage lung cancer treated with stereotactic ablative radiotherapy
    Jonathan A Abelson
    Department of Radiation Oncology, School of Medicine, Stanford University, Stanford, CA 94305, USA
    Lung Cancer 78:219-24. 2012

Detail Information

Publications110 found, 100 shown here

  1. ncbi request reprint Evaluation of patterns of failure and subjective salivary function in patients treated with intensity modulated radiotherapy for head and neck squamous cell carcinoma
    Megan E Daly
    Department of Radiation Oncology, Stanford University Medical Center, Stanford, California 94305, USA
    Head Neck 29:211-20. 2007
    ....
  2. ncbi request reprint Lymph node metastasis in maxillary sinus carcinoma
    Q T Le
    Department of Radiation Oncology, Stanford University, CA 94305 5302, USA
    Int J Radiat Oncol Biol Phys 46:541-9. 2000
    ..To evaluate the incidence and prognostic significance of lymph node metastasis in maxillary sinus carcinoma...
  3. ncbi request reprint Comparison of the comet assay and the oxygen microelectrode for measuring tumor oxygenation in head-and-neck cancer patients
    Quynh Thu Le
    Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA
    Int J Radiat Oncol Biol Phys 56:375-83. 2003
    ..To compare the Eppendorf PO2 histograph and the alkaline comet assay as methods of measuring tumor hypoxia in patients with head-and-neck squamous cell carcinomas...
  4. ncbi request reprint Nasopharyngeal and oropharyngeal carcinomas: target delineation, therapy delivery and stereotactic boost procedures with intensity-modulated/ image-guided radiation therapy
    Quynh Thu Le
    Department of Radiation Oncology, Stanford University, Stanford, CA 94305 5302, USA
    Front Radiat Ther Oncol 40:208-31. 2007
    ..In addition, we also present data on the use of stereotactic radiotherapy as a boost to improve local control of nasopharyngeal carcinomas...
  5. ncbi request reprint Identification of osteopontin as a prognostic plasma marker for head and neck squamous cell carcinomas
    Quynh Thu Le
    Department of Radiation Oncology, Center for Clinical Science Research South, Stanford, California 94305 5152, USA
    Clin Cancer Res 9:59-67. 2003
    ..Tumor hypoxia modifies treatment efficacy and promotes tumor progression. Here, we investigated the relationship between osteopontin (OPN), tumor pO(2), and prognosis in patients with head and neck squamous cell carcinomas (HNSCC)...
  6. ncbi request reprint Primary radiotherapy for localized orbital MALT lymphoma
    Quynh Thu Le
    Department of Radiation Oncology, Stanford University Medical Center, Stanford, CA 94305, USA
    Int J Radiat Oncol Biol Phys 52:657-63. 2002
    ..To define the natural history, prognosis, and radiocurability of localized orbital extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT)...
  7. ncbi request reprint Treatment results of carcinoma in situ of the glottis: an analysis of 82 cases
    Q T Le
    Department of Radiation Oncology, Stanford University Medical Center, 300 Pasteur Dr, Stanford, CA 94305 5302, USA
    Arch Otolaryngol Head Neck Surg 126:1305-12. 2000
    ..To evaluate the results of different treatment modalities for carcinoma in situ of the glottis, and to identify important prognostic factors for outcome...
  8. ncbi request reprint Phase I study of tirapazamine plus cisplatin/etoposide and concurrent thoracic radiotherapy in limited-stage small cell lung cancer (S0004): a Southwest Oncology Group study
    Quynh Thu Le
    Department of Radiation Oncology, Stanford University, Stanford, California 94305 5847, USA
    Clin Cancer Res 10:5418-24. 2004
    ..To determine the feasibility and a recommended phase II dose of tirapazamine when combined with chemoradiotherapy in limited-stage small cell lung cancer (LSCLC)...
  9. ncbi request reprint An evaluation of tumor oxygenation and gene expression in patients with early stage non-small cell lung cancers
    Quynh Thu Le
    Department of Radiation Oncology, Stanford University Medical Center, Stanford, California 94305 5847, USA
    Clin Cancer Res 12:1507-14. 2006
    ..To directly assess tumor oxygenation in resectable non-small cell lung cancers (NSCLC) and to correlate tumor pO2 and the selected gene and protein expression to treatment outcomes...
  10. doi request reprint Metabolic imaging metrics correlate with survival in early stage lung cancer treated with stereotactic ablative radiotherapy
    Jonathan A Abelson
    Department of Radiation Oncology, School of Medicine, Stanford University, Stanford, CA 94305, USA
    Lung Cancer 78:219-24. 2012
    ....
  11. ncbi request reprint Galectin-1: a link between tumor hypoxia and tumor immune privilege
    Quynh Thu Le
    Department of Radiation Oncology, Stanford University Medical Center, 875 Blake Wilbur Drive, Stanford, CA 94305 5847, USA
    J Clin Oncol 23:8932-41. 2005
    ..To identify a 15-KDa novel hypoxia-induced secreted protein in head and neck squamous cell carcinomas (HNSCC) and to determine its role in malignant progression...
  12. ncbi request reprint Plasma osteopontin is an independent prognostic marker for head and neck cancers
    David Petrik
    Department of Radiation Oncology, Stanford University, Stanford, CA, USA
    J Clin Oncol 24:5291-7. 2006
    ..To confirm the relationship between plasma osteopontin (OPN) levels and treatment outcomes in head and neck squamous cell carcinoma (HNSCC) patients in an expanded study...
  13. doi request reprint Intensity-modulated radiotherapy in the treatment of oropharyngeal cancer: clinical outcomes and patterns of failure
    Megan E Daly
    Department of Radiation Oncology, Stanford University, Stanford, California 94305, USA
    Int J Radiat Oncol Biol Phys 76:1339-46. 2010
    ..To report outcomes, failures, and toxicities in patients treated with intensity-modulated radiotherapy (IMRT) for squamous cell carcinoma of the oropharynx...
  14. ncbi request reprint Lysyl oxidase is essential for hypoxia-induced metastasis
    Janine T Erler
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 440:1222-6. 2006
    ..Furthermore, LOX may be required to create a niche permissive for metastatic growth. Our findings indicate that LOX is essential for hypoxia-induced metastasis and is a good therapeutic target for preventing and treating metastases...
  15. ncbi request reprint Identification of hypoxia-regulated proteins in head and neck cancer by proteomic and tissue array profiling
    Yijun Chen
    Department of Radiation Oncology, Center for Clinical Sciences Research, Department of Surgery, Palo Alto VA Health Care System, Palo Alto, CA, USA
    Cancer Res 64:7302-10. 2004
    ..These data suggest that IKKbeta is a novel endogenous marker of tumor hypoxia and may represent a new target for anticancer therapy...
  16. doi request reprint Stereotactic radiosurgery for retreatment of gross perineural invasion in recurrent cutaneous squamous cell carcinoma of the head and neck
    Chad Tang
    Department of Radiation Oncology, Division of Medical Oncology, Stanford University, Stanford, CA, USA
    Am J Clin Oncol 36:293-8. 2013
    ..To report outcomes, failure patterns, and toxicity after stereotactic radiosurgery (SRS) for recurrent head and neck cutaneous squamous cell carcinoma with gross perineural invasion (GPNI)...
  17. pmc Prognostic value of metabolic tumor volume and velocity in predicting head-and-neck cancer outcomes
    Karen P Chu
    Department of Radiation Oncology, Stanford University Medical Center, Stanford, CA, USA
    Int J Radiat Oncol Biol Phys 83:1521-7. 2012
    ..We hypothesized that increases in MTV over time would correlate with tumor growth and biology, and would predict outcome. We sought to examine tumor growth over time in serial pretreatment PET-CT scans...
  18. ncbi request reprint Tumor volume as a potential imaging-based risk-stratification factor in trimodality therapy for locally advanced non-small cell lung cancer
    Margaret M Kozak
    Department of Radiation Oncology, Stanford University, Stanford, California 94305 5847, USA
    J Thorac Oncol 6:920-6. 2011
    ....
  19. ncbi request reprint Improved local control with stereotactic radiosurgical boost in patients with nasopharyngeal carcinoma
    Quynh Thu Le
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305 5302, USA
    Int J Radiat Oncol Biol Phys 56:1046-54. 2003
    ..Stereotactic radiosurgery (STR) was used to boost the tumor site after EBRT to improve local control...
  20. ncbi request reprint A noninvasive approach for assessing tumor hypoxia in xenografts: developing a urinary marker for hypoxia
    Daniel W Nelson
    Department of Radiation Oncology, Stanford University, Stanford, California 94305 5847, USA
    Cancer Res 65:6151-8. 2005
    ..The 5HRE beta-hCG reporter system described here enables serial, noninvasive monitoring of tumor hypoxia in a mouse model by measuring a urinary reporter protein...
  21. pmc Postradiation metabolic tumor volume predicts outcome in head-and-neck cancer
    James D Murphy
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Int J Radiat Oncol Biol Phys 80:514-21. 2011
    ..To explore the prognostic value of metabolic tumor volume measured on postradiation (18)F-fluorodeoxyglucose positron emission tomography (PET) imaging in patients with head-and-neck cancer...
  22. ncbi request reprint Expression and prognostic significance of a panel of tissue hypoxia markers in head-and-neck squamous cell carcinomas
    Quynh Thu Le
    Department of Radiation Oncology, Stanford University, Stanford, CA 94305 5847, USA
    Int J Radiat Oncol Biol Phys 69:167-75. 2007
    ..To investigate the expression pattern of hypoxia-induced proteins identified as being involved in malignant progression of head-and-neck squamous cell carcinoma (HNSCC) and to determine their relationship to tumor pO(2) and prognosis...
  23. ncbi request reprint Hypoxia upregulates osteopontin expression in NIH-3T3 cells via a Ras-activated enhancer
    Yonghua Zhu
    Department of Radiation Oncology, 875 Blake Wilbur Dr, R CC G228, Stanford University, Stanford, CA 94305, USA
    Oncogene 24:6555-63. 2005
    ..Taken together, these results have identified a new hypoxia responsive transcriptional enhancer that is regulated by Akt signaling...
  24. pmc Identifying and targeting hypoxia in head and neck cancer: a brief overview of current approaches
    Quynh Thu Le
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Int J Radiat Oncol Biol Phys 69:S56-8. 2007
  25. pmc Validation that metabolic tumor volume predicts outcome in head-and-neck cancer
    Chad Tang
    Department of Radiation Oncology, Stanford University, Stanford, CA, USA
    Int J Radiat Oncol Biol Phys 83:1514-20. 2012
    ....
  26. doi request reprint Intrafraction verification of gated RapidArc by using beam-level kilovoltage X-ray images
    Ruijiang Li
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California
    Int J Radiat Oncol Biol Phys 83:e709-15. 2012
    ..To verify the geometric accuracy of gated RapidArc treatment using kV images acquired during dose delivery...
  27. doi request reprint Intensity-modulated radiotherapy for oral cavity squamous cell carcinoma: patterns of failure and predictors of local control
    Megan E Daly
    Department of Radiation Oncology, Stanford University Medical Center, Stanford, CA 94305, USA
    Int J Radiat Oncol Biol Phys 80:1412-22. 2011
    ..Few studies have evaluated the use of intensity-modulated radiotherapy (IMRT) for squamous cell carcinoma (SCC) of the oral cavity (OC). We report clinical outcomes and failure patterns for these patients...
  28. doi request reprint Intensity-modulated radiotherapy for locally advanced cancers of the larynx and hypopharynx
    Megan E Daly
    Department of Radiation Oncology, Stanford University Medical Center, Stanford, California, USA
    Head Neck 33:103-11. 2011
    ..Limited data evaluate intensity-modulated radiotherapy (IMRT) for cancers of the hypopharynx and larynx. We report clinical outcomes and failure patterns for these patients...
  29. doi request reprint Migration of implanted markers for image-guided lung tumor stereotactic ablative radiotherapy
    Julian C Hong
    Department of Radiation Oncology, Stanford University, CA, USA
    J Appl Clin Med Phys 14:4046. 2013
    ..Marker migration between implantation and simulation is limited and unlikely to cause geometric miss during tracking...
  30. doi request reprint Metabolic tumor volume is an independent prognostic factor in patients treated definitively for non-small-cell lung cancer
    Percy Lee
    Department of Radiation Oncology, Stanford University, CA, USA
    Clin Lung Cancer 13:52-8. 2012
    ..We evaluated the prognostic value of metabolic tumor volume (MTV), a measure of tumor burden on FDG-PET imaging, in patients with non-small-cell lung cancer (NSCLC) treated definitively...
  31. ncbi request reprint Metabolic tumor burden predicts for disease progression and death in lung cancer
    Percy Lee
    Department of Radiation Oncology, Stanford University, Stanford, CA 94305 5847, USA
    Int J Radiat Oncol Biol Phys 69:328-33. 2007
    ..However, stage may be simply a surrogate for underlying tumor burden. Our purpose was to assess the prognostic value of tumor burden measured by 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) imaging...
  32. doi request reprint Results from a single institution phase II trial of concurrent docetaxel/carboplatin/radiotherapy followed by surgical resection and consolidation docetaxel/carboplatin in stage III non-small-cell lung cancer
    Millie Das
    Department of Medicine, Division of Oncology, Stanford University, CA, USA
    Clin Lung Cancer 12:280-5. 2011
    ..We hypothesized that using a trimodality approach in selected patients with stage IIIA/IIIB disease would be both feasible and efficacious with reasonable toxicity...
  33. ncbi request reprint Radiotherapy for nonadenoid cystic carcinomas of major salivary glands
    Melody P Chung
    Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA
    Am J Otolaryngol 34:425-30. 2013
    ..To report outcomes in patients treated with postoperative radiotherapy for nonadenoid cystic carcinomas of the major salivary glands...
  34. doi request reprint A population-based comparative effectiveness study of radiation therapy techniques in stage III non-small cell lung cancer
    Jeremy P Harris
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California
    Int J Radiat Oncol Biol Phys 88:872-84. 2014
    ..We therefore performed a population-based comparative effectiveness analysis of IMRT, conventional 3-dimensional conformal radiation therapy (3D-CRT), and 2-dimensional radiation therapy (2D-RT) in stage III NSCLC...
  35. pmc A novel aldehyde dehydrogenase-3 activator (Alda-89) protects submandibular gland function from irradiation without accelerating tumor growth
    Nan Xiao
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA
    Clin Cancer Res 19:4455-64. 2013
    ....
  36. ncbi request reprint Mature results from a randomized Phase II trial of cisplatin plus 5-fluorouracil and radiotherapy with or without tirapazamine in patients with resectable Stage IV head and neck squamous cell carcinomas
    Quynh Thu Le
    Department of Radiation Oncology, Stanford University, Stanford, California 94305, USA
    Cancer 106:1940-9. 2006
    ....
  37. pmc Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche
    Janine T Erler
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cancer Cell 15:35-44. 2009
    ..CD11b+ cells and LOX also colocalize in biopsies of human metastases. Our findings demonstrate a critical role for LOX in premetastatic niche formation and support targeting LOX for the treatment and prevention of metastatic disease...
  38. ncbi request reprint Advanced-staged tonsillar squamous carcinoma: organ preservation versus surgical management of the primary site
    Haider Ali Shirazi
    Department of Radiation Oncology, 875 Blake Wilbur Dr, R CC G228, Stanford University, Stanford, CA 94305, USA
    Head Neck 28:587-94. 2006
    ..Our aim was to review our experience in the management of advanced tonsillar squamous cell carcinoma (SCC) and to compare treatment outcomes between patients treated with and without surgery to the primary site...
  39. ncbi request reprint Clinical role of 18F-FDG PET/CT in the management of squamous cell carcinoma of the head and neck and thyroid carcinoma
    Andrew Quon
    Division of Nuclear Medicine, Department of Radiology, Stanford University Medical Center, Stanford, California 94305, USA
    J Nucl Med 48:58S-67S. 2007
    ....
  40. ncbi request reprint Extranodal nonorbital indolent lymphomas of the head and neck: relationship between tumor control and radiotherapy
    Dhara MacDermed
    Department of Radiation Oncology, Stanford University Medical Center, CA 94305, USA
    Int J Radiat Oncol Biol Phys 59:788-95. 2004
    ..To review our experience managing extranodal nonorbital indolent lymphomas of the head and neck...
  41. ncbi request reprint Stereotactic ablative radiotherapy for reirradiation of locally recurrent lung tumors
    Nicholas Trakul
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305 5847, USA
    J Thorac Oncol 7:1462-5. 2012
    ..Here we report our experience with SABR for lung tumors in previously irradiated regions...
  42. doi request reprint Long-term outcomes of surgery followed by radiation therapy for minor salivary gland carcinomas
    Youssef H Zeidan
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California, U S A
    Laryngoscope 123:2675-80. 2013
    ..In this study we evaluated the outcomes and prognostic factors in patients with minor salivary gland cancers treated with adjuvant radiation therapy...
  43. ncbi request reprint Patterns of patient movement during frameless image-guided radiosurgery
    Martin J Murphy
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Int J Radiat Oncol Biol Phys 55:1400-8. 2003
    ..We have analyzed the target position records for all of these cases to assess the frequency, magnitude, and case-by-case patterns of patient movement...
  44. ncbi request reprint Tumor volume-adapted dosing in stereotactic ablative radiotherapy of lung tumors
    Nicholas Trakul
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA
    Int J Radiat Oncol Biol Phys 84:231-7. 2012
    ..Current stereotactic ablative radiotherapy (SABR) protocols for lung tumors prescribe a uniform dose regimen irrespective of tumor size. We report the outcomes of a lung tumor volume-adapted SABR dosing strategy...
  45. pmc The relationship between human papillomavirus status and other molecular prognostic markers in head and neck squamous cell carcinomas
    Christina S Kong
    Department of Pathology, Stanford University, Santa Cruz, CA, USA
    Int J Radiat Oncol Biol Phys 74:553-61. 2009
    ....
  46. ncbi request reprint Positron-emission tomography for surveillance of head and neck cancer
    William R Ryan
    Department of Otolaryngology Head and Neck Surgery, Stanford University School of Medicine, Stanford, California 94305, USA
    Laryngoscope 115:645-50. 2005
    ..To determine the diagnostic accuracy and the ideal timing of fluoro-fluorodeoxyglucose positron-emission tomography (PET) in the posttreatment surveillance of head and neck mucosal squamous cell carcinoma (HNSCC)...
  47. doi request reprint A planned neck dissection is not necessary in all patients with N2-3 head-and-neck cancer after sequential chemoradiotherapy
    Scott G Soltys
    Department of Radiation Oncology, Stanford University Medical Center, Stanford, CA 94305 5847, USA
    Int J Radiat Oncol Biol Phys 83:994-9. 2012
    ..To assess the role of a planned neck dissection (PND) after sequential chemoradiotherapy for patients with head-and-neck cancer with N2-N3 nodal disease...
  48. pmc Quantitation of human papillomavirus DNA in plasma of oropharyngeal carcinoma patients
    Hongbin Cao
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305 5847, USA
    Int J Radiat Oncol Biol Phys 82:e351-8. 2012
    ..To determine whether human papillomavirus (HPV) DNA can be detected in the plasma of patients with HPV-positive oropharyngeal carcinoma (OPC) and to monitor its temporal change during radiotherapy...
  49. doi request reprint Dose reconstruction for volumetric modulated arc therapy (VMAT) using cone-beam CT and dynamic log files
    Jianguo Qian
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Phys Med Biol 55:3597-610. 2010
    ..The method reported here affords an objective means for dosimetric evaluation of VMAT delivery and is useful for adaptive VMAT in future...
  50. pmc Tumor galectin-1 mediates tumor growth and metastasis through regulation of T-cell apoptosis
    Alice Banh
    Department of Radiation Oncology, Stanford University, Stanford, California 94305, USA
    Cancer Res 71:4423-31. 2011
    ..Our findings establish that tumor rather than host Gal-1 is responsible for mediating tumor progression through intratumoral immunomodulation, with broad implications in developing novel targeting strategies for Gal-1 in cancer...
  51. ncbi request reprint XBP1 is essential for survival under hypoxic conditions and is required for tumor growth
    Lorenzo Romero-Ramirez
    Department of Radiation Oncology, Stanford University, Stanford, California 94305 5152, USA
    Cancer Res 64:5943-7. 2004
    ..Taken together, these studies directly implicate XBP1 as an essential survival factor for hypoxic stress and tumor growth...
  52. ncbi request reprint Phase II study to assess the efficacy of conventionally fractionated radiotherapy followed by a stereotactic radiosurgery boost in patients with locally advanced pancreatic cancer
    Albert C Koong
    Department of Radiation Oncology, Stanford University School of Medicine, 269 Campus Drive West, Stanford, CA 94305
    Int J Radiat Oncol Biol Phys 63:320-3. 2005
    ..To determine the efficacy of concurrent 5-fluorouracil (5-FU) and intensity-modulated radiotherapy (IMRT) followed by body stereotactic radiosurgery (SRS) in patients with locally advanced pancreatic cancer...
  53. ncbi request reprint Phase II double-blind randomized study comparing oral aloe vera versus placebo to prevent radiation-related mucositis in patients with head-and-neck neoplasms
    Catherine K Su
    Department of Radiation Oncology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5302, USA
    Int J Radiat Oncol Biol Phys 60:171-7. 2004
    ..In a single-institution, double-blind, prospective, randomized trial, we determined whether oral aloe vera gel can reduce radiation-induced mucositis in head-and-neck cancer patients...
  54. ncbi request reprint Results of a phase I dose-escalation study using single-fraction stereotactic radiotherapy for lung tumors
    Quynh Thu Le
    Department of Radiation Oncology, Stanford University, Stanford, California, USA
    J Thorac Oncol 1:802-9. 2006
    ..The purpose of this study was to report initial results of a phase I study using single-fraction stereotactic radiotherapy (RT) in patients with inoperable lung tumors...
  55. ncbi request reprint The effectiveness of breath-holding to stabilize lung and pancreas tumors during radiosurgery
    Martin J Murphy
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Int J Radiat Oncol Biol Phys 53:475-82. 2002
    ..To evaluate the effect of breath-holding on the short-term reproducibility and long-term variability of tumor position during image-guided radiosurgery...
  56. ncbi request reprint Long-term outcomes after external beam irradiation and brachytherapy boost for base-of-tongue cancers
    Iris C Gibbs
    Department of Radiation Oncology, Stanford University, Stanford, CA 94305 5302, USA
    Int J Radiat Oncol Biol Phys 57:489-94. 2003
    ..To assess long-term efficacy and toxicity associated with external beam irradiation (EBRT) and interstitial (192)Ir implantation for the treatment of squamous carcinoma of the base of tongue...
  57. pmc Loss of the p53/p63 target PERP is an early event in oral carcinogenesis and correlates with higher rate of local relapse
    Christina S Kong
    Department of Pathology, Stanford University, Stanford, California 94305 5324, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol 115:95-103. 2013
    ..PERP is a p53/p63-regulated gene encoding a desmosomal protein that plays a critical role in cell-cell adhesion and tumor suppression...
  58. ncbi request reprint Intensity-modulated radiotherapy for tumors of the nasal cavity and paranasal sinuses: clinical outcomes and patterns of failure
    Ellen A Wiegner
    Department of Radiation Oncology, Stanford University, Stanford, CA, USA
    Int J Radiat Oncol Biol Phys 83:243-51. 2012
    ..To report outcomes in patients treated with intensity-modulated radiotherapy (IMRT) for tumors of the paranasal sinuses and nasal cavity (PNS/NC)...
  59. doi request reprint On-board imaging validation of optically guided stereotactic radiosurgery positioning system for conventionally fractionated radiotherapy for paranasal sinus and skull base cancer
    Peter G Maxim
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305 5847, USA
    Int J Radiat Oncol Biol Phys 81:1153-9. 2011
    ..To evaluate the positioning accuracy of an optical positioning system for stereotactic radiosurgery in a pilot experience of optically guided, conventionally fractionated, radiotherapy for paranasal sinus and skull base tumors...
  60. pmc Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation
    Xin Huang
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94025, USA
    Mol Cell 35:856-67. 2009
    ..Taken together, these data implicate an important role for mir-210 in regulating the hypoxic response of tumor cells and tumor growth...
  61. ncbi request reprint Imaging features associated with disease progression after stereotactic ablative radiotherapy for stage I non-small-cell lung cancer
    David B Shultz
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA
    Clin Lung Cancer 15:294-301.e3. 2014
    ..The aim of this study was to identify imaging-based predictors of progression in patients treated with SABR for stage I NSCLC...
  62. pmc Opportunities and challenges in the era of molecularly targeted agents and radiation therapy
    Steven H Lin
    Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 097, Houston, TX 77030, USA
    J Natl Cancer Inst 105:686-93. 2013
    ....
  63. ncbi request reprint Sample classification from protein mass spectrometry, by 'peak probability contrasts'
    Robert Tibshirani
    Department of Health, Research and Policy, Stanford University, CA 94305, USA
    Bioinformatics 20:3034-44. 2004
    ..We illustrate the method on matrix-assisted laser desorption and ionization mass spectrometry data from a study of ovarian cancers...
  64. ncbi request reprint Lens dose in MLC-based IMRT treatments of the head and neck
    Todd Pawlicki
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305 5487, USA
    Int J Radiat Oncol Biol Phys 59:293-9. 2004
    ....
  65. pmc Hypoxia in models of lung cancer: implications for targeted therapeutics
    Edward E Graves
    Department of Radiation Oncology, Stanford University, California 94305 5847, USA
    Clin Cancer Res 16:4843-52. 2010
    ....
  66. doi request reprint Excellent local control with stereotactic radiotherapy boost after external beam radiotherapy in patients with nasopharyngeal carcinoma
    Wendy Hara
    Department of Radiation Oncology, Stanford University, Stanford, CA 94305 5847, USA
    Int J Radiat Oncol Biol Phys 71:393-400. 2008
    ..To determine long-term outcomes in patients receiving stereotactic radiotherapy (SRT) as a boost after external beam radiotherapy (EBRT) for locally advanced nasopharyngeal carcinoma (NPC)...
  67. ncbi request reprint Stereotactic radiosurgery for lung tumors: preliminary report of a phase I trial
    Richard I Whyte
    Department of Cardiothoracic Surgery, Stanford University, Stanford, California 94305 5407, USA
    Ann Thorac Surg 75:1097-101. 2003
    ..Stereotactic radiosurgery is well established for the treatment of intracranial neoplasms but its use for lung tumors is novel...
  68. ncbi request reprint Quantification of motion of different thoracic locations using four-dimensional computed tomography: implications for radiotherapy planning
    Peter G Maxim
    Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA
    Int J Radiat Oncol Biol Phys 69:1395-401. 2007
    ....
  69. pmc Molecular imaging of hypoxia-inducible factor 1 alpha and von Hippel-Lindau interaction in mice
    Clara Y H Choi
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305 5152, USA
    Mol Imaging 7:139-46. 2008
    ..This method represents a new approach for studying interaction of proteins involved in the regulation of protein degradation...
  70. pmc Evaluation of ProExC as a prognostic marker in oropharyngeal squamous cell carcinomas
    Anne M Mills
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Am J Surg Pathol 36:1158-64. 2012
    ..These findings indicate that ProExC does not perform well enough to be used as a prognostic marker in oropharyngeal SCC. p16 should be used and scored as positive when at least half the tumor is strongly stained...
  71. pmc Prognostic and predictive significance of plasma HGF and IL-8 in a phase III trial of chemoradiation with or without tirapazamine in locoregionally advanced head and neck cancer
    Quynh Thu Le
    Radiation Oncology and Pathology, Stanford University, Stanford, CA, USA
    Clin Cancer Res 18:1798-807. 2012
    ..We evaluated the role of circulating HGF and IL-8 as prognostic and predictive factors for efficacy of tirapazamine (TPZ), a hypoxic cell cytotoxin...
  72. pmc A novel aldehyde dehydrogenase-3 activator leads to adult salivary stem cell enrichment in vivo
    Alice Banh
    Department of Radiation Oncology, Stanford University, California, 94305, USA
    Clin Cancer Res 17:7265-72. 2011
    ..To assess aldehyde dehydrogenase (ALDH) expression in adult human and murine submandibular gland (SMG) stem cells and to determine the effect of ALDH3 activation in SMG stem cell enrichment...
  73. pmc The tumor microenvironment in non-small-cell lung cancer
    Edward E Graves
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA
    Semin Radiat Oncol 20:156-63. 2010
    ..Presently, there are several promising modalities to image hypoxia and the tumor vasculature; these include dynamic perfusion imaging and positron emission tomography scanning with radiolabled nitroimidazoles...
  74. pmc In vivo 1H magnetic resonance spectroscopy of lactate in patients with stage IV head and neck squamous cell carcinoma
    Quynh Thu Le
    Department of Radiation Oncology, Stanford University Medical Center, Stanford, CA 94305 5847, USA
    Int J Radiat Oncol Biol Phys 71:1151-7. 2008
    ..To investigate in vivo(1)H magnetic resonance spectroscopy imaging of lactate for assessing tumor hypoxia in head and neck cancers and to determine its utility in predicting the response and outcomes...
  75. pmc Integrating biologically targeted therapy in head and neck squamous cell carcinomas
    Quynh Thu Le
    Department of Radiation Oncology, Stanford University, Stanford, CA 94305 5847, USA
    Semin Radiat Oncol 19:53-62. 2009
    ....
  76. pmc MYB expression and translocation in adenoid cystic carcinomas and other salivary gland tumors with clinicopathologic correlation
    Robert B West
    Department of Pathology, Stanford University Medical Center, CA, USA
    Am J Surg Pathol 35:92-9. 2011
    ..A chromosomal translocation involving the genes encoding the transcription factors, MYB and NFIB, has been recently discovered in these tumors...
  77. ncbi request reprint Indirect MR lymphangiography of the head and neck using conventional gadolinium contrast: a pilot study in humans
    Billy W Loo
    Department of Radiation Oncology, Stanford University, Stanford, CA 94305 5847, USA, and Department of General Surgery, Singapore General Hospital, Singapore
    Int J Radiat Oncol Biol Phys 66:462-8. 2006
    ....
  78. pmc Image-based modeling of tumor shrinkage in head and neck radiation therapy
    Ming Chao
    Department of Radiation Oncology, Stanford University School of Medicine, 875 Blake Wilbur Drive, Stanford, California 94305 5847, USA
    Med Phys 37:2351-8. 2010
    ..This article presents a novel framework for image-based modeling of tumor change and demonstrates its performance with synthetic images and clinical cases...
  79. doi request reprint CD44(+) cells have cancer stem cell-like properties in nasopharyngeal carcinoma
    Agnieszka M Janisiewicz
    Department of Otolaryngology Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    Int Forum Allergy Rhinol 2:465-70. 2012
    ..These "cancer stem cells" (CSCs) are CD44(+) in several epithelial malignancies. We examined the potential of CD44 to identify the CSC population in nasopharyngeal carcinoma (NPC)...
  80. ncbi request reprint Nonsurgical therapy for stages I and II non-small cell lung cancer
    Quynh Thu Le
    Department of Radiation Oncology, Stanford Cancer Center, 875 Blake Wilbur Drive, MC 5847, Stanford University, Stanford, CA 94305 5847, USA
    Hematol Oncol Clin North Am 19:237-61, v-vi. 2005
    ....
  81. ncbi request reprint Retrospective IMRT dose reconstruction based on cone-beam CT and MLC log-file
    Louis Lee
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305 5847, USA
    Int J Radiat Oncol Biol Phys 70:634-44. 2008
    ..The aim of this work is to reconstruct the intensity-modulated radiation therapy dose delivered to an HN patient using the CBCT and multileaf collimator (MLC) log-files...
  82. pmc Imaging the unfolded protein response in primary tumors reveals microenvironments with metabolic variations that predict tumor growth
    Michael T Spiotto
    Department of Radiation Oncology, Stanford University, Stanford, California 94305 5152, USA
    Cancer Res 70:78-88. 2010
    ..Finally, XBP1-luciferase activity correlated with tumor growth rates. Visualizing distinct signaling pathways in primary tumors reveals unique tumor microenvironments with distinct metabolic signatures that can predict for tumor growth...
  83. pmc Metabolic tumor volume predicts for recurrence and death in head-and-neck cancer
    Trang H La
    Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA
    Int J Radiat Oncol Biol Phys 74:1335-41. 2009
    ....
  84. pmc The RGD domain of human osteopontin promotes tumor growth and metastasis through activation of survival pathways
    Donald Courter
    Department of Radiation Oncology, Stanford University, Stanford, California, United States of America
    PLoS ONE 5:e9633. 2010
    ..Here, we use genetic approaches to systematically investigate the function of the RGD domain in different OPN isoforms on tumor progression and metastasis for 2 different solid tumor models...
  85. doi request reprint Palifermin reduces severe mucositis in definitive chemoradiotherapy of locally advanced head and neck cancer: a randomized, placebo-controlled study
    Quynh Thu Le
    Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA
    J Clin Oncol 29:2808-14. 2011
    ..This randomized, placebo-controlled, double-blind study evaluated the efficacy and safety of palifermin to reduce OM associated with definitive chemoradiotherapy for locally advanced HNC...
  86. pmc New developments in radiation therapy for head and neck cancer: intensity-modulated radiation therapy and hypoxia targeting
    Nancy Y Lee
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Semin Oncol 35:236-50. 2008
    ..The second half of the review will focus on approaches for assessing tumor hypoxia and on the strategies for targeting this important microenvironmental factor in HNC...
  87. doi request reprint Linac-based on-board imaging feasibility and the dosimetric consequences of head roll in head-and-neck IMRT plans
    Gwe Ya Kim
    Department of Radiation Oncology, Stanford University, Stanford, CA, USA
    Med Dosim 33:93-9. 2008
    ....
  88. pmc Validation of lysyl oxidase as a prognostic marker for metastasis and survival in head and neck squamous cell carcinoma: Radiation Therapy Oncology Group trial 90-03
    Quynh Thu Le
    Department of Radiation Oncology, Stanford University, Stanford, CA 94305 5847, USA
    J Clin Oncol 27:4281-6. 2009
    ..To validate lysyl oxidase (LOX), a hypoxia-related protein, as a marker for metastasis in an independent head and neck cancer (HNC) patient group enrolled onto a prospective trial...
  89. ncbi request reprint High retention and safety of percutaneously implanted endovascular embolization coils as fiducial markers for image-guided stereotactic ablative radiotherapy of pulmonary tumors
    Julian C Hong
    Department of Radiation Oncology, Stanford University, Stanford, California 94305 5847, USA
    Int J Radiat Oncol Biol Phys 81:85-90. 2011
    ....
  90. ncbi request reprint A comparison study of different PCR assays in measuring circulating plasma epstein-barr virus DNA levels in patients with nasopharyngeal carcinoma
    Quynh Thu Le
    Department of Radiation Oncology, Stanford University, Stanford, California 94305 5407, USA
    Clin Cancer Res 11:5700-7. 2005
    ..To compare the performance of three PCR assays in measuring circulating Epstein-Barr virus (EBV). DNA levels in nasopharyngeal carcinoma patients and to confirm its prognostic significance...
  91. ncbi request reprint Lung cancer in women: exploring sex differences in susceptibility, biology, and therapeutic response
    Jessica S Donington
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, CA 94303, USA
    Clin Lung Cancer 8:22-9. 2006
    ..Several phase II trials with small-molecule inhibitors of Src are under way or have been initiated in lung cancer and in other malignancies, as discussed herein...
  92. pmc Clinical biomarkers for hypoxia targeting
    Quynh Thu Le
    Department of Radiation Oncology, Stanford University, 875 Blake Wilbur Dr, MC 5847, Stanford, CA 94305 5847, USA
    Cancer Metastasis Rev 27:351-62. 2008
    ..This chapter will focus on the development of clinical biomarkers for hypoxia targeting...
  93. ncbi request reprint Therapeutic exploitation of the physiological and molecular genetic alterations in head and neck cancer
    Quynh Thu Le
    Stanford University School of Medicine, Department of Radiation Oncology, Stanford, California 94305 5032, USA
    Clin Cancer Res 9:4287-95. 2003
    ..This review will summarize these new molecular and physiological based strategies that can be used for both treatment and chemoprevention of head and neck squamous cell carcinoma...
  94. ncbi request reprint Comparison of treatment results between adult and juvenile nasopharyngeal carcinoma
    N Lance Downing
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305 5847, USA
    Int J Radiat Oncol Biol Phys 75:1064-70. 2009
    ..In contrast to the adult variant, little is known about the juvenile form. This study examined the treatment results between adult (aNPC) and juvenile NPC (jNPC) patients for future treatment considerations in jNPC...
  95. ncbi request reprint PET of EGFR antibody distribution in head and neck squamous cell carcinoma models
    Gang Niu
    Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, California 94305 5484, USA
    J Nucl Med 50:1116-23. 2009
    ....
  96. doi request reprint Higher incidence of head and neck cancers among Vietnamese American men in California
    Edith J Filion
    Department of Radiation Oncology, Stanford University, Stanford, CA
    Head Neck 32:1336-44. 2010
    ..Our aim was to determine the incidence rates of head and neck cancer in Vietnamese Californians compared with other Asian and non-Asian Californians...
  97. pmc Head and neck cancer-specific survival based on socioeconomic status in Asians and Pacific Islanders
    Karen P Chu
    Stanford University Medical Center, Stanford, California 94305 5847, USA
    Cancer 117:1935-45. 2011
    ..This study's purpose was to examine the effect of SES on disease-specific survival (DSS) and overall survival (OS) in APIs with HNC using population-based data...
  98. ncbi request reprint Radiation therapy for intracranial germ cell tumors
    Daphne A Haas-Kogan
    Department of Radiation Oncology, University of California, San Francisco, CA 94143, USA
    Int J Radiat Oncol Biol Phys 56:511-8. 2003
    ....
  99. ncbi request reprint The use of plasma surface-enhanced laser desorption/ionization time-of-flight mass spectrometry proteomic patterns for detection of head and neck squamous cell cancers
    Scott G Soltys
    Department of Radiation Oncology, and Health Policy and Research, Stanford University, Stanford, California 94305 5847, USA
    Clin Cancer Res 10:4806-12. 2004
    ....
  100. ncbi request reprint Hypoxic gene expression and metastasis
    Quynh Thu Le
    Division of Cancer and Radiation Biology, Stanford University School of Medicine, Department of Radiation Oncology, CCSR South, Room 1255, 269 Campus Drive, Stanford, CA 94305 5152
    Cancer Metastasis Rev 23:293-310. 2004
    ..Particular emphasis is given to recent findings that provide insight to the role of hypoxia in the metastatic process...
  101. pmc Strategic plans to promote head and neck cancer translational research within the radiation therapy oncology group: a report from the translational research program
    Christine H Chung
    Head and Neck Cancer Subcommittee, Translational Research Program, Radiation Therapy Oncology Group Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 6307, USA
    Int J Radiat Oncol Biol Phys 69:S67-78. 2007
    ..In this position paper we outline strategic plans to further promote translational research within the framework of the RTOG...