L C Lazzeroni

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc A generalized Defries-Fulker regression framework for the analysis of twin data
    Laura C Lazzeroni
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305 5723, USA
    Behav Genet 43:85-96. 2013
  2. pmc The cost of large numbers of hypothesis tests on power, effect size and sample size
    L C Lazzeroni
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5723, USA
    Mol Psychiatry 17:108-14. 2012
  3. ncbi request reprint A chronology of fine-scale gene mapping by linkage disequilibrium
    L C Lazzeroni
    Biostatistics Division, Department of Health Research and Policy, Stanford University, Stanford, California 94305, USA
    Stat Methods Med Res 10:57-76. 2001
  4. ncbi request reprint Genotype to phenotype: associations, errors and complexity
    Laura C Lazzeroni
    Dept of Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA
    Trends Genet 18:283-4. 2002
  5. doi request reprint A randomized trial of computer-based reminders and audit and feedback to improve HIV screening in a primary care setting
    V Sundaram
    VA Palo Alto Healthcare System, Palo Alto, CA, USA
    Int J STD AIDS 20:527-33. 2009
  6. pmc Prevalence of HIV infection among inpatients and outpatients in Department of Veterans Affairs health care systems: implications for screening programs for HIV
    Douglas K Owens
    VA Palo Alto Health Care System, Palo Alto, Calif, USA
    Am J Public Health 97:2173-8. 2007
  7. ncbi request reprint Accuracy, precision, and consistency of expert HIV type 1 genotype interpretation: an international comparison (The GUESS Study)
    Andrew R Zolopa
    Stanford University School of Medicine, Stanford, CA 94305 5107, USA
    Clin Infect Dis 41:92-9. 2005
  8. doi request reprint Physiological correlates of social avoidance behavior in children and adolescents with fragile x syndrome
    Scott S Hall
    Center for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University, 401 Quarry Road, Stanford, CA 94305 5795, USA
    J Am Acad Child Adolesc Psychiatry 48:320-9. 2009
  9. ncbi request reprint Cytomegalovirus retinitis after initiation of highly active antiretroviral therapy in HIV infected patients: natural history and clinical predictors
    Danny Y Lin
    Department of Ophthalmology, Stanford University Medical Center, Stanford, California 94305, USA
    Retina 22:268-77. 2002
  10. doi request reprint Opioid pharmacogenomics using a twin study paradigm: methods and procedures for determining familial aggregation and heritability
    Martin S Angst
    Department of Anesthesia, Stanford University School of Medicine, CA, USA
    Twin Res Hum Genet 13:412-25. 2010

Research Grants

Collaborators

Detail Information

Publications21

  1. pmc A generalized Defries-Fulker regression framework for the analysis of twin data
    Laura C Lazzeroni
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305 5723, USA
    Behav Genet 43:85-96. 2013
    ..Due to the simplicity of its structure, extensions of the model have the potential to encompass generalized linear models, censored and truncated data; and gene by environment interactions...
  2. pmc The cost of large numbers of hypothesis tests on power, effect size and sample size
    L C Lazzeroni
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5723, USA
    Mol Psychiatry 17:108-14. 2012
    ..The results are reassuring in an era of extreme multiple testing...
  3. ncbi request reprint A chronology of fine-scale gene mapping by linkage disequilibrium
    L C Lazzeroni
    Biostatistics Division, Department of Health Research and Policy, Stanford University, Stanford, California 94305, USA
    Stat Methods Med Res 10:57-76. 2001
    ..The suggested methods fall into two main groups, those that rely on pairwise statistics and those that rely on haplotypes. This paper reviews each strategy's development from a chronological perspective...
  4. ncbi request reprint Genotype to phenotype: associations, errors and complexity
    Laura C Lazzeroni
    Dept of Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA
    Trends Genet 18:283-4. 2002
    ..The Keystone Symposium on Genotype to Phenotype: Focus on Disease was held in Santa Fe, New Mexico, USA, from 19 to 24 February 2002...
  5. doi request reprint A randomized trial of computer-based reminders and audit and feedback to improve HIV screening in a primary care setting
    V Sundaram
    VA Palo Alto Healthcare System, Palo Alto, CA, USA
    Int J STD AIDS 20:527-33. 2009
    ..Providers were unaware of the high rates of risky behaviour in their patient population and perceived important barriers to testing. Low-intensity clinical reminders and feedback did not increase rates of screening...
  6. pmc Prevalence of HIV infection among inpatients and outpatients in Department of Veterans Affairs health care systems: implications for screening programs for HIV
    Douglas K Owens
    VA Palo Alto Health Care System, Palo Alto, Calif, USA
    Am J Public Health 97:2173-8. 2007
    ..We sought to determine the prevalence of HIV in both inpatient and outpatient settings in 6 Department of Veterans Affairs (VA) health care sites...
  7. ncbi request reprint Accuracy, precision, and consistency of expert HIV type 1 genotype interpretation: an international comparison (The GUESS Study)
    Andrew R Zolopa
    Stanford University School of Medicine, Stanford, CA 94305 5107, USA
    Clin Infect Dis 41:92-9. 2005
    ..We sought to determine how much agreement exists within a group of experts in the interpretation of complex genotypes...
  8. doi request reprint Physiological correlates of social avoidance behavior in children and adolescents with fragile x syndrome
    Scott S Hall
    Center for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University, 401 Quarry Road, Stanford, CA 94305 5795, USA
    J Am Acad Child Adolesc Psychiatry 48:320-9. 2009
    ..To date, almost all studies in this area have been confounded by inclusion of task demands in addition to social demands...
  9. ncbi request reprint Cytomegalovirus retinitis after initiation of highly active antiretroviral therapy in HIV infected patients: natural history and clinical predictors
    Danny Y Lin
    Department of Ophthalmology, Stanford University Medical Center, Stanford, California 94305, USA
    Retina 22:268-77. 2002
    ..To characterize the natural course and clinical predictors of cytomegalovirus (CMV) retinitis in human immunodeficiency virus (HIV)-infected patients after initiation of highly active antiretroviral therapy (HAART)...
  10. doi request reprint Opioid pharmacogenomics using a twin study paradigm: methods and procedures for determining familial aggregation and heritability
    Martin S Angst
    Department of Anesthesia, Stanford University School of Medicine, CA, USA
    Twin Res Hum Genet 13:412-25. 2010
    ..Methods and first results including heritability estimates for heat and cold pain sensitivity should be of interest to investigators considering similar studies...
  11. pmc HIV testing of at risk patients in a large integrated health care system
    Douglas K Owens
    VA Palo Alto Healthcare System, Palo Alto, CA, USA
    J Gen Intern Med 22:315-20. 2007
    ..Understanding HIV screening practices and barriers to HIV testing is an important prelude to designing successful HIV screening programs. Our objective was to evaluate current practice patterns for identification of HIV...
  12. ncbi request reprint A conditional inference framework for extending the transmission/disequilibrium test
    L C Lazzeroni
    Department Genetics, Stanford University, Calif 94305 5405, USA
    Hum Hered 48:67-81. 1998
    ..In the case of multiple loci, the conditional perspective provides a straightforward correction for multiple tests that can be substantially more powerful than the standard Bonferroni correction...
  13. pmc Linkage disequilibrium and gene mapping: an empirical least-squares approach
    L C Lazzeroni
    Department of Statistics, Stanford University, Stanford, CA 94305 5405, USA
    Am J Hum Genet 62:159-70. 1998
    ..One advantage of the approach is its use of the observed covariance structure of the data, which can be highly informative as to the gene location. I illustrate the method on the cystic fibrosis data of Kerem et al...
  14. ncbi request reprint Allele sharing and allelic association I: sib pair tests with increased power
    Laura C Lazzeroni
    Division of Biostatistics, Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California 94305, USA
    Genet Epidemiol 22:328-44. 2002
    ..This study also provides new insight into the trade-off between tests of allelic association and tests of allele sharing...
  15. pmc FKBP5 polymorphisms and antidepressant response in geriatric depression
    Jane E Sarginson
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5485, USA
    Am J Med Genet B Neuropsychiatr Genet 153:554-60. 2010
    ..These results suggest that FKBP5 is unlikely to play a major role in determining antidepressant treatment outcomes in geriatric patients...
  16. ncbi request reprint The effect of diagnosis with HIV infection on health-related quality of Life
    Shyoko Honiden
    VA Palo Alto Health Care System 111A, 3801 Miranda Avenue, Palo Alto, CA
    Qual Life Res 15:69-82. 2006
    ..Years after diagnosis, although half of the patients believed that diagnosis reduced health-related quality of life, one-third reported improved health-related quality of life...
  17. ncbi request reprint Cost-effectiveness of screening for HIV in the era of highly active antiretroviral therapy
    Gillian D Sanders
    Duke Clinical Research Institute, Duke University, Durham, NC 27715, USA
    N Engl J Med 352:570-85. 2005
    ..The costs, benefits, and cost-effectiveness of screening for human immunodeficiency virus (HIV) in health care settings during the era of highly active antiretroviral therapy (HAART) have not been determined...
  18. ncbi request reprint Association of IL4R haplotypes with type 1 diabetes
    Daniel B Mirel
    Department of Human Genetics, Roche Molecular Systems, Alameda, California 94501, USA
    Diabetes 51:3336-41. 2002
    ..These findings suggest an important role for the IL4R gene in immune-related disease susceptibility and illustrate the value of using multi-SNP haplotype information in association studies...
  19. ncbi request reprint The role of a common adenosine monophosphate deaminase (AMPD)-1 polymorphism in outcomes of ischemic and nonischemic heart failure
    Matthew J Kolek
    Cardiovascular Department, LDS Hospital, Salt Lake City, UT 84143, USA
    J Card Fail 11:677-83. 2005
    ..A common variant of the adenosine monophosphate deaminase (AMPD)-1 gene (C34T) results in enzymatic inactivity and may increase adenosine in cardiac muscle and confer cardioprotection through ischemic preconditioning...
  20. pmc A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure
    Stephen B Liggett
    Department of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 103:11288-93. 2006
    ..We conclude that beta(1)AR-389 variation alters signaling in multiple models and affects the beta-blocker therapeutic response in HF and, thus, might be used to individualize treatment of the syndrome...
  21. ncbi request reprint Keratin variants associate with progression of fibrosis during chronic hepatitis C infection
    Pavel Strnad
    Department of Medicine, Palo Alto VA Medical Center, Palo Alto, CA 94304, USA
    Hepatology 43:1354-63. 2006
    ..The unique 100% segregation of the most common K8 variant, R341H, with an intronic deletion suggests that one of these two genetic changes might lead to the other...

Research Grants6

  1. COMPLEX TRAIT MAPPING--MODELS AND SEMIPARAMETRIC METHODS
    Laura Lazzeroni; Fiscal Year: 2005
    ....
  2. 6/6 - The Genetics of Endophenotypes and Schizophrenia
    Laura C Lazzeroni; Fiscal Year: 2010
    ..Once we understand the genetic architecture of these abnormalities, new medications that aim to improve the functioning and quality of life of schizophrenia patients can be developed. ..