L C Lazzeroni
Affiliation: Stanford University
- A generalized Defries-Fulker regression framework for the analysis of twin dataLaura C Lazzeroni
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305 5723, USA
Behav Genet 43:85-96. 2013..Due to the simplicity of its structure, extensions of the model have the potential to encompass generalized linear models, censored and truncated data; and gene by environment interactions...
- The cost of large numbers of hypothesis tests on power, effect size and sample sizeL C Lazzeroni
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5723, USA
Mol Psychiatry 17:108-14. 2012..The results are reassuring in an era of extreme multiple testing...
- A chronology of fine-scale gene mapping by linkage disequilibriumL C Lazzeroni
Biostatistics Division, Department of Health Research and Policy, Stanford University, Stanford, California 94305, USA
Stat Methods Med Res 10:57-76. 2001..The suggested methods fall into two main groups, those that rely on pairwise statistics and those that rely on haplotypes. This paper reviews each strategy's development from a chronological perspective...
- Genotype to phenotype: associations, errors and complexityLaura C Lazzeroni
Dept of Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA
Trends Genet 18:283-4. 2002..The Keystone Symposium on Genotype to Phenotype: Focus on Disease was held in Santa Fe, New Mexico, USA, from 19 to 24 February 2002...
- A randomized trial of computer-based reminders and audit and feedback to improve HIV screening in a primary care settingV Sundaram
VA Palo Alto Healthcare System, Palo Alto, CA, USA
Int J STD AIDS 20:527-33. 2009..Providers were unaware of the high rates of risky behaviour in their patient population and perceived important barriers to testing. Low-intensity clinical reminders and feedback did not increase rates of screening...
- Prevalence of HIV infection among inpatients and outpatients in Department of Veterans Affairs health care systems: implications for screening programs for HIVDouglas K Owens
VA Palo Alto Health Care System, Palo Alto, Calif, USA
Am J Public Health 97:2173-8. 2007..We sought to determine the prevalence of HIV in both inpatient and outpatient settings in 6 Department of Veterans Affairs (VA) health care sites...
- Accuracy, precision, and consistency of expert HIV type 1 genotype interpretation: an international comparison (The GUESS Study)Andrew R Zolopa
Stanford University School of Medicine, Stanford, CA 94305 5107, USA
Clin Infect Dis 41:92-9. 2005..We sought to determine how much agreement exists within a group of experts in the interpretation of complex genotypes...
- Physiological correlates of social avoidance behavior in children and adolescents with fragile x syndromeScott S Hall
Center for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University, 401 Quarry Road, Stanford, CA 94305 5795, USA
J Am Acad Child Adolesc Psychiatry 48:320-9. 2009..To date, almost all studies in this area have been confounded by inclusion of task demands in addition to social demands...
- Cytomegalovirus retinitis after initiation of highly active antiretroviral therapy in HIV infected patients: natural history and clinical predictorsDanny Y Lin
Department of Ophthalmology, Stanford University Medical Center, Stanford, California 94305, USA
Retina 22:268-77. 2002..To characterize the natural course and clinical predictors of cytomegalovirus (CMV) retinitis in human immunodeficiency virus (HIV)-infected patients after initiation of highly active antiretroviral therapy (HAART)...
- Opioid pharmacogenomics using a twin study paradigm: methods and procedures for determining familial aggregation and heritabilityMartin S Angst
Department of Anesthesia, Stanford University School of Medicine, CA, USA
Twin Res Hum Genet 13:412-25. 2010..Methods and first results including heritability estimates for heat and cold pain sensitivity should be of interest to investigators considering similar studies...
- HIV testing of at risk patients in a large integrated health care systemDouglas K Owens
VA Palo Alto Healthcare System, Palo Alto, CA, USA
J Gen Intern Med 22:315-20. 2007..Understanding HIV screening practices and barriers to HIV testing is an important prelude to designing successful HIV screening programs. Our objective was to evaluate current practice patterns for identification of HIV...
- A conditional inference framework for extending the transmission/disequilibrium testL C Lazzeroni
Department Genetics, Stanford University, Calif 94305 5405, USA
Hum Hered 48:67-81. 1998..In the case of multiple loci, the conditional perspective provides a straightforward correction for multiple tests that can be substantially more powerful than the standard Bonferroni correction...
- Linkage disequilibrium and gene mapping: an empirical least-squares approachL C Lazzeroni
Department of Statistics, Stanford University, Stanford, CA 94305 5405, USA
Am J Hum Genet 62:159-70. 1998..One advantage of the approach is its use of the observed covariance structure of the data, which can be highly informative as to the gene location. I illustrate the method on the cystic fibrosis data of Kerem et al...
- Allele sharing and allelic association I: sib pair tests with increased powerLaura C Lazzeroni
Division of Biostatistics, Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California 94305, USA
Genet Epidemiol 22:328-44. 2002..This study also provides new insight into the trade-off between tests of allelic association and tests of allele sharing...
- FKBP5 polymorphisms and antidepressant response in geriatric depressionJane E Sarginson
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5485, USA
Am J Med Genet B Neuropsychiatr Genet 153:554-60. 2010..These results suggest that FKBP5 is unlikely to play a major role in determining antidepressant treatment outcomes in geriatric patients...
- The effect of diagnosis with HIV infection on health-related quality of LifeShyoko Honiden
VA Palo Alto Health Care System 111A, 3801 Miranda Avenue, Palo Alto, CA
Qual Life Res 15:69-82. 2006..Years after diagnosis, although half of the patients believed that diagnosis reduced health-related quality of life, one-third reported improved health-related quality of life...
- Cost-effectiveness of screening for HIV in the era of highly active antiretroviral therapyGillian D Sanders
Duke Clinical Research Institute, Duke University, Durham, NC 27715, USA
N Engl J Med 352:570-85. 2005..The costs, benefits, and cost-effectiveness of screening for human immunodeficiency virus (HIV) in health care settings during the era of highly active antiretroviral therapy (HAART) have not been determined...
- Association of IL4R haplotypes with type 1 diabetesDaniel B Mirel
Department of Human Genetics, Roche Molecular Systems, Alameda, California 94501, USA
Diabetes 51:3336-41. 2002..These findings suggest an important role for the IL4R gene in immune-related disease susceptibility and illustrate the value of using multi-SNP haplotype information in association studies...
- The role of a common adenosine monophosphate deaminase (AMPD)-1 polymorphism in outcomes of ischemic and nonischemic heart failureMatthew J Kolek
Cardiovascular Department, LDS Hospital, Salt Lake City, UT 84143, USA
J Card Fail 11:677-83. 2005..A common variant of the adenosine monophosphate deaminase (AMPD)-1 gene (C34T) results in enzymatic inactivity and may increase adenosine in cardiac muscle and confer cardioprotection through ischemic preconditioning...
- A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failureStephen B Liggett
Department of Medicine, University of Maryland, Baltimore, MD 21201, USA
Proc Natl Acad Sci U S A 103:11288-93. 2006..We conclude that beta(1)AR-389 variation alters signaling in multiple models and affects the beta-blocker therapeutic response in HF and, thus, might be used to individualize treatment of the syndrome...
- Keratin variants associate with progression of fibrosis during chronic hepatitis C infectionPavel Strnad
Department of Medicine, Palo Alto VA Medical Center, Palo Alto, CA 94304, USA
Hepatology 43:1354-63. 2006..The unique 100% segregation of the most common K8 variant, R341H, with an intronic deletion suggests that one of these two genetic changes might lead to the other...
- COMPLEX TRAIT MAPPING--MODELS AND SEMIPARAMETRIC METHODSLaura Lazzeroni; Fiscal Year: 2005....
- 6/6 - The Genetics of Endophenotypes and SchizophreniaLaura C Lazzeroni; Fiscal Year: 2010..Once we understand the genetic architecture of these abnormalities, new medications that aim to improve the functioning and quality of life of schizophrenia patients can be developed. ..