A M Krensky

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi Molecular biology of transplantation
    A M Krensky
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305 5208, USA
    Nephron 86:260-5. 2000
  2. ncbi Granulysin: a novel antimicrobial peptide of cytolytic T lymphocytes and natural killer cells
    A M Krensky
    Department of Pediatrics, Stanford University School of Medicine, CA 94305 5208, USA
    Biochem Pharmacol 59:317-20. 2000
  3. ncbi Granulysin, a new human cytolytic granule-associated protein with possible involvement in cell-mediated cytotoxicity
    S V Pena
    Department of Pediatrics, Stanford University School of Medicine, CA 94305, USA
    Semin Immunol 9:117-25. 1997
  4. ncbi A distinct pathway of cell-mediated apoptosis initiated by granulysin
    A A Kaspar
    Division of Immunology and Transplantation Biology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 167:350-6. 2001
  5. ncbi Biosynthesis of granulysin, a novel cytolytic molecule
    D A Hanson
    Department of Pediatrics, Stanford University School of Medicine, CA 94305 5208, USA
    Mol Immunol 36:413-22. 1999
  6. ncbi Granulysin: a novel antimicrobial
    J Kumar
    Department of Medicine, Division of Nephrology, Stanford University, Stanford, CA 94305, USA
    Expert Opin Investig Drugs 10:321-9. 2001
  7. ncbi Granulysin expression is a marker for acute rejection and steroid resistance in human renal transplantation
    M M Sarwal
    Department of Pediatrics, Stanford University, Stanford, CA 94305, USA
    Hum Immunol 62:21-31. 2001
  8. ncbi RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes
    A Song
    Department of Pediatrics, Stanford University School of Medicine, California 94305 5208, USA
    Immunity 10:93-103. 1999
  9. ncbi Processing, subcellular localization, and function of 519 (granulysin), a human late T cell activation molecule with homology to small, lytic, granule proteins
    S V Pena
    Department of Pediatrics, Stanford University School of Medicine, CA 94305, USA
    J Immunol 158:2680-8. 1997
  10. ncbi Genomic organization and transcriptional regulation of the RANTES chemokine gene
    P J Nelson
    Department of Pediatrics, Stanford University School of Medicine, CA 94305
    J Immunol 151:2601-12. 1993

Collaborators

Detail Information

Publications18

  1. ncbi Molecular biology of transplantation
    A M Krensky
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305 5208, USA
    Nephron 86:260-5. 2000
    ..Such information has proven important in understanding the action of immunosuppressive drugs and will prove useful in the design of new immunotherapies...
  2. ncbi Granulysin: a novel antimicrobial peptide of cytolytic T lymphocytes and natural killer cells
    A M Krensky
    Department of Pediatrics, Stanford University School of Medicine, CA 94305 5208, USA
    Biochem Pharmacol 59:317-20. 2000
    ..The identification of this novel molecule indicates a broader and perhaps more significant role for T lymphocytes in both innate and acquired antimicrobial defenses...
  3. ncbi Granulysin, a new human cytolytic granule-associated protein with possible involvement in cell-mediated cytotoxicity
    S V Pena
    Department of Pediatrics, Stanford University School of Medicine, CA 94305, USA
    Semin Immunol 9:117-25. 1997
    ..The 9kDa form localizes to dense, highly cytolytic granules and contains the SAPLIP homology domain. A recombinant granulysin protein, corresponding to the 9kDa form, is cytolytic against tumor cell targets...
  4. ncbi A distinct pathway of cell-mediated apoptosis initiated by granulysin
    A A Kaspar
    Division of Immunology and Transplantation Biology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 167:350-6. 2001
    ..Nevertheless, activation of caspase 3 is observed in granulysin-treated cells, suggesting that granulysin activates a novel pathway of CTL- and NK cell-mediated death distinct from granzyme- and death receptor-induced apoptosis...
  5. ncbi Biosynthesis of granulysin, a novel cytolytic molecule
    D A Hanson
    Department of Pediatrics, Stanford University School of Medicine, CA 94305 5208, USA
    Mol Immunol 36:413-22. 1999
    ....
  6. ncbi Granulysin: a novel antimicrobial
    J Kumar
    Department of Medicine, Division of Nephrology, Stanford University, Stanford, CA 94305, USA
    Expert Opin Investig Drugs 10:321-9. 2001
    ..Synthetic peptides derived from granulysin have differential activity against eukaryotic cells and bacteria. Selective bactericidal peptides may have therapeutic roles as novel antibiotics...
  7. ncbi Granulysin expression is a marker for acute rejection and steroid resistance in human renal transplantation
    M M Sarwal
    Department of Pediatrics, Stanford University, Stanford, CA 94305, USA
    Hum Immunol 62:21-31. 2001
    ..Memory CTL abound in steroid resistant grafts and may have a markedly different response to CSA immunotherapy, suggesting a possible mechanism for steroid resistance...
  8. ncbi RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes
    A Song
    Department of Pediatrics, Stanford University School of Medicine, California 94305 5208, USA
    Immunity 10:93-103. 1999
    ..While Rel proteins play the dominant role in RANTES gene expression in fibroblasts, RFLAT-1 is a strong transactivator for RANTES in T cells...
  9. ncbi Processing, subcellular localization, and function of 519 (granulysin), a human late T cell activation molecule with homology to small, lytic, granule proteins
    S V Pena
    Department of Pediatrics, Stanford University School of Medicine, CA 94305, USA
    J Immunol 158:2680-8. 1997
    ..Its lytic activity suggests the involvement of 519 in CTL effector function...
  10. ncbi Genomic organization and transcriptional regulation of the RANTES chemokine gene
    P J Nelson
    Department of Pediatrics, Stanford University School of Medicine, CA 94305
    J Immunol 151:2601-12. 1993
    ..Deletion analysis of the promoter region indicates that different transcriptional mechanisms control expression of RANTES in the various tissues studied...
  11. ncbi Granulysin blocks replication of varicella-zoster virus and triggers apoptosis of infected cells
    A Hata
    Department of Pediatrics, Stanford University School of Medicine, California 94305-5208, USA
    Viral Immunol 14:125-33. 2001
    ..Because granulysin is a product of natural killer cells and T lymphocytes, it is possible that its antiviral activity may act as a mediator of innate and adaptive immune mechanisms...
  12. ncbi Immunologic tolerance
    A M Krensky
    Department of Pediatrics, Stanford University, CA 94305 5164, USA
    Pediatr Nephrol 16:675-9. 2001
    ..This review highlights historical perspectives and recent progress in induction and maintenance of immunologic tolerance relevant to pediatric nephrology...
  13. ncbi An antimicrobial activity of cytolytic T cells mediated by granulysin
    S Stenger
    Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Science 282:121-5. 1998
    ..The ability of CTLs to kill intracellular M. tuberculosis was dependent on the presence of granulysin in cytotoxic granules, defining a mechanism by which T cells directly contribute to immunity against intracellular pathogens...
  14. ncbi Granulysin-dependent killing of intracellular and extracellular Mycobacterium tuberculosis by Vgamma9/Vdelta2 T lymphocytes
    F Dieli
    Dipartimento di Biopatologia, , Palermo, Italy
    J Infect Dis 184:1082-5. 2001
    ..Granulysin and perforin, both detected in Vgamma9/Vdelta2 T lymphocytes, play a major role, which indicates that Vgamma9/Vdelta2 T lymphocytes directly contribute to a protective host response against M. tuberculosis infection...
  15. ncbi Forest bathing enhances human natural killer activity and expression of anti-cancer proteins
    Q Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo
    Int J Immunopathol Pharmacol 20:3-8. 2007
    ....
  16. ncbi Localization of the human T lymphocyte activation gene 519 (D2S69E) to chromosome 2p12----q11
    T A Donlon
    Department of Pathology, Stanford University Medical Center, CA
    Cytogenet Cell Genet 53:230-1. 1990
    ..A significant proportion of the grains were situated over chromosome 2p12----q11, a region which contains other genes involved in immunologic functions...
  17. pmc The isolation and sequence of a novel gene from a human functional T cell line
    J Jongstra
    J Exp Med 165:601-14. 1987
    ..The data also show that normal, nontransformed, functional T cells express gene products that can not be readily identified in long-term tumor lines of the same cell lineage...
  18. ncbi Visiting a forest, but not a city, increases human natural killer activity and expression of anti-cancer proteins
    Q Li
    Department of Hygiene and Public Health, Nippon Medical School, Bunkyo ku, Tokyo, Japan
    Int J Immunopathol Pharmacol 21:117-27. 2008
    ..Phytoncides released from trees and decreased stress hormone may partially contribute to the increased NK activity...