A M Krensky

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi Molecular biology of transplantation
    A M Krensky
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305 5208, USA
    Nephron 86:260-5. 2000
  2. ncbi Granulysin: a novel antimicrobial peptide of cytolytic T lymphocytes and natural killer cells
    A M Krensky
    Department of Pediatrics, Stanford University School of Medicine, CA 94305 5208, USA
    Biochem Pharmacol 59:317-20. 2000
  3. ncbi Granulysin, a new human cytolytic granule-associated protein with possible involvement in cell-mediated cytotoxicity
    S V Pena
    Department of Pediatrics, Stanford University School of Medicine, CA 94305, USA
    Semin Immunol 9:117-25. 1997
  4. ncbi A distinct pathway of cell-mediated apoptosis initiated by granulysin
    A A Kaspar
    Division of Immunology and Transplantation Biology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 167:350-6. 2001
  5. ncbi Biosynthesis of granulysin, a novel cytolytic molecule
    D A Hanson
    Department of Pediatrics, Stanford University School of Medicine, CA 94305 5208, USA
    Mol Immunol 36:413-22. 1999
  6. ncbi Granulysin: a novel antimicrobial
    J Kumar
    Department of Medicine, Division of Nephrology, Stanford University, Stanford, CA 94305, USA
    Expert Opin Investig Drugs 10:321-9. 2001
  7. ncbi Processing, subcellular localization, and function of 519 (granulysin), a human late T cell activation molecule with homology to small, lytic, granule proteins
    S V Pena
    Department of Pediatrics, Stanford University School of Medicine, CA 94305, USA
    J Immunol 158:2680-8. 1997
  8. ncbi RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes
    A Song
    Department of Pediatrics, Stanford University School of Medicine, California 94305 5208, USA
    Immunity 10:93-103. 1999
  9. ncbi Granulysin expression is a marker for acute rejection and steroid resistance in human renal transplantation
    M M Sarwal
    Department of Pediatrics, Stanford University, Stanford, CA 94305, USA
    Hum Immunol 62:21-31. 2001
  10. ncbi Granulysin blocks replication of varicella-zoster virus and triggers apoptosis of infected cells
    A Hata
    Department of Pediatrics, Stanford University School of Medicine, California 94305-5208, USA
    Viral Immunol 14:125-33. 2001

Collaborators

Detail Information

Publications17

  1. ncbi Molecular biology of transplantation
    A M Krensky
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305 5208, USA
    Nephron 86:260-5. 2000
    ..Such information has proven important in understanding the action of immunosuppressive drugs and will prove useful in the design of new immunotherapies...
  2. ncbi Granulysin: a novel antimicrobial peptide of cytolytic T lymphocytes and natural killer cells
    A M Krensky
    Department of Pediatrics, Stanford University School of Medicine, CA 94305 5208, USA
    Biochem Pharmacol 59:317-20. 2000
    ..The identification of this novel molecule indicates a broader and perhaps more significant role for T lymphocytes in both innate and acquired antimicrobial defenses...
  3. ncbi Granulysin, a new human cytolytic granule-associated protein with possible involvement in cell-mediated cytotoxicity
    S V Pena
    Department of Pediatrics, Stanford University School of Medicine, CA 94305, USA
    Semin Immunol 9:117-25. 1997
    ..The 9kDa form localizes to dense, highly cytolytic granules and contains the SAPLIP homology domain. A recombinant granulysin protein, corresponding to the 9kDa form, is cytolytic against tumor cell targets...
  4. ncbi A distinct pathway of cell-mediated apoptosis initiated by granulysin
    A A Kaspar
    Division of Immunology and Transplantation Biology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 167:350-6. 2001
    ..Nevertheless, activation of caspase 3 is observed in granulysin-treated cells, suggesting that granulysin activates a novel pathway of CTL- and NK cell-mediated death distinct from granzyme- and death receptor-induced apoptosis...
  5. ncbi Biosynthesis of granulysin, a novel cytolytic molecule
    D A Hanson
    Department of Pediatrics, Stanford University School of Medicine, CA 94305 5208, USA
    Mol Immunol 36:413-22. 1999
    ....
  6. ncbi Granulysin: a novel antimicrobial
    J Kumar
    Department of Medicine, Division of Nephrology, Stanford University, Stanford, CA 94305, USA
    Expert Opin Investig Drugs 10:321-9. 2001
    ..Synthetic peptides derived from granulysin have differential activity against eukaryotic cells and bacteria. Selective bactericidal peptides may have therapeutic roles as novel antibiotics...
  7. ncbi Processing, subcellular localization, and function of 519 (granulysin), a human late T cell activation molecule with homology to small, lytic, granule proteins
    S V Pena
    Department of Pediatrics, Stanford University School of Medicine, CA 94305, USA
    J Immunol 158:2680-8. 1997
    ..Its lytic activity suggests the involvement of 519 in CTL effector function...
  8. ncbi RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes
    A Song
    Department of Pediatrics, Stanford University School of Medicine, California 94305 5208, USA
    Immunity 10:93-103. 1999
    ..While Rel proteins play the dominant role in RANTES gene expression in fibroblasts, RFLAT-1 is a strong transactivator for RANTES in T cells...
  9. ncbi Granulysin expression is a marker for acute rejection and steroid resistance in human renal transplantation
    M M Sarwal
    Department of Pediatrics, Stanford University, Stanford, CA 94305, USA
    Hum Immunol 62:21-31. 2001
    ..Memory CTL abound in steroid resistant grafts and may have a markedly different response to CSA immunotherapy, suggesting a possible mechanism for steroid resistance...
  10. ncbi Granulysin blocks replication of varicella-zoster virus and triggers apoptosis of infected cells
    A Hata
    Department of Pediatrics, Stanford University School of Medicine, California 94305-5208, USA
    Viral Immunol 14:125-33. 2001
    ..Because granulysin is a product of natural killer cells and T lymphocytes, it is possible that its antiviral activity may act as a mediator of innate and adaptive immune mechanisms...
  11. ncbi Immunologic tolerance
    A M Krensky
    Department of Pediatrics, Stanford University, CA 94305 5164, USA
    Pediatr Nephrol 16:675-9. 2001
    ..This review highlights historical perspectives and recent progress in induction and maintenance of immunologic tolerance relevant to pediatric nephrology...
  12. ncbi An antimicrobial activity of cytolytic T cells mediated by granulysin
    S Stenger
    Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Science 282:121-5. 1998
    ..The ability of CTLs to kill intracellular M. tuberculosis was dependent on the presence of granulysin in cytotoxic granules, defining a mechanism by which T cells directly contribute to immunity against intracellular pathogens...
  13. ncbi Forest bathing enhances human natural killer activity and expression of anti-cancer proteins
    Q Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo
    Int J Immunopathol Pharmacol 20:3-8. 2007
    ....
  14. ncbi Granulysin-dependent killing of intracellular and extracellular Mycobacterium tuberculosis by Vgamma9/Vdelta2 T lymphocytes
    F Dieli
    Dipartimento di Biopatologia, , Palermo, Italy
    J Infect Dis 184:1082-5. 2001
    ..Granulysin and perforin, both detected in Vgamma9/Vdelta2 T lymphocytes, play a major role, which indicates that Vgamma9/Vdelta2 T lymphocytes directly contribute to a protective host response against M. tuberculosis infection...
  15. ncbi Localization of the human T lymphocyte activation gene 519 (D2S69E) to chromosome 2p12----q11
    T A Donlon
    Department of Pathology, Stanford University Medical Center, CA
    Cytogenet Cell Genet 53:230-1. 1990
    ..A significant proportion of the grains were situated over chromosome 2p12----q11, a region which contains other genes involved in immunologic functions...
  16. pmc The isolation and sequence of a novel gene from a human functional T cell line
    J Jongstra
    J Exp Med 165:601-14. 1987
    ..The data also show that normal, nontransformed, functional T cells express gene products that can not be readily identified in long-term tumor lines of the same cell lineage...
  17. ncbi Visiting a forest, but not a city, increases human natural killer activity and expression of anti-cancer proteins
    Q Li
    Department of Hygiene and Public Health, Nippon Medical School, Bunkyo ku, Tokyo, Japan
    Int J Immunopathol Pharmacol 21:117-27. 2008
    ..Phytoncides released from trees and decreased stress hormone may partially contribute to the increased NK activity...