Research Topics
| Helena Chmura KraemerSummaryAffiliation: Stanford University Country: USA Publications
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Detail Information
Publications
Mediators and moderators of treatment effects in randomized clinical trialsHelena Chmura Kraemer
Department of Psychiatry and Behavioral Sciences, Stanford University, Calif 94305, USA
Arch Gen Psychiatry 59:877-83. 2002..We recommend that RCTs routinely include and report such analyses...- Size of treatment effects and their importance to clinical research and practiceHelena Chmura Kraemer
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California 94305, USA
Biol Psychiatry 59:990-6. 2006..We recommend three equivalent effect sizes: number needed to treat, area under the receiver operating characteristic curve comparing T and C responses, and success rate difference, chosen specifically to convey clinical significance... - Caution regarding the use of pilot studies to guide power calculations for study proposalsHelena Chmura Kraemer
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif 94305, USA
Arch Gen Psychiatry 63:484-9. 2006..The argument herein is not meant to discourage clinical researchers from performing pilot studies (or review committees from requiring them) but simply to caution against their use for the objective of guiding power calculations... - Factors associated with psychiatric hospitalization of individuals diagnosed with dementia and comorbid bipolar disorderJohn O Brooks
Palo Alto Veterans Affairs Health Care System, Palo Alto, California 94304, USA
J Geriatr Psychiatry Neurol 19:72-7. 2006..These findings suggest that disorders with increased frequency in BD affect the course of dementia... - Moderators of treatment outcomes: clinical, research, and policy importanceHelena C Kraemer
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif 94305, USA
JAMA 296:1286-9. 2006 - Lifetime prevalence and pseudocomorbidity in psychiatric researchHelena Chmura Kraemer
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif 94305, USA
Arch Gen Psychiatry 63:604-8. 2006..This bias is what we refer to as pseudocomorbidity... - Correlation coefficients in medical research: from product moment correlation to the odds ratioHelena Chmura Kraemer
Department of Psychiatry and Behavioral Sciences, Stanford University, 401 Quarry Road, MC5717 Stanford, CA 94305, USA
Stat Methods Med Res 15:525-45. 2006..The present focus is on effect sizes indicating strength of correlation, that is, effect sizes that describe the strength of monotonic association between two random variables X and Y in a population... - A simple effect size indicator for two-group comparisons? A comment on r equivalentHelena Chmura Kraemer
Department of Psychiatry, Stanford University, Stanford, CA 94305, USA
Psychol Methods 10:413-9. 2005.... - Are certain multicenter randomized clinical trial structures misleading clinical and policy decisions?Helena Chmura Kraemer
Department of Psychiatry and Behavioral Sciences, Stanford University, 401 Quarry Road, 5717, Stanford, CA 94305, USA
Contemp Clin Trials 26:518-29. 2005.... - Categorical versus dimensional approaches to diagnosis: methodological challengesHelena Chmura Kraemer
Department of Psychiatry and Behavioral Sciences, C305, 401 Quarry Road, Stanford University School of Medicine, Stanford University, Stanford, CA 94305 5717, USA
J Psychiatr Res 38:17-25. 2004..We argue that failure to utilize the correct approach under the appropriate circumstances can result in impaired clinical and research decision-making... - "Rules" of evidence in assessing the efficacy and effectiveness of treatmentsHelena Chmura Kraemer
Department of Psychiatry and Behavioral Sciences, Stanford University, CA 94305, USA
Dev Neuropsychol 24:705-18. 2003.... - A new approach to integrating data from multiple informants in psychiatric assessment and research: mixing and matching contexts and perspectivesHelena C Kraemer
Department of Psychiatry and Behavioral Sciences, Stanford University, 4012 Quarry Road, MC 5717, Stanford, CA 94305, USA
Am J Psychiatry 160:1566-77. 2003..This report proposes a theory to explain observed patterns of interinformant discordance and suggests a new approach to using data from multiple informants to measure characteristics of interest... - Biomarkers in psychiatry: methodological issuesHelena Chmura Kraemer
Department of Psychiatry and Behavioral Sciences, Stanford University, CA 94305, USA
Am J Geriatr Psychiatry 10:653-9. 2002..Authors discuss methods for establishing the validity of a biomarker. Finally, they convey a word of caution about overinterpreting the clinical or scientific value of any biological measure... - Comments on 'Evaluating the added predictive ability of a new marker' by M. Pencina, R. D'Agostino, R. D'Agostino Jr, R. Vasan, Statistics in Medicine (DOI: 10.1002/sim.2929)Helena Chmura Kraemer
Department of Psychiatry and Behavioral Sciences, Stanford University of Medicine, Stanford, CA, USA
Stat Med 27:196-8. 2008 - Developing the diagnostic and statistical manual V: what will "statistical" mean in DSM-V?Helena Chmura Kraemer
Dept of Psychiatry and Behavioral Sciences, Stanford University, 401 Quarry Road, MS 5717, Stanford, CA 94305, USA
Soc Psychiatry Psychiatr Epidemiol 42:259-67. 2007.... 
Assessment of factors influencing preservation of dignity at life's end: creation and the cross-cultural validation of the preservation of dignity card-sort toolVyjeyanthi S Periyakoil
Department of Medicine, Division of General Internal Medicine and the VA Palo Alto Health Care System, Palo Alto, California, USA
J Palliat Med 13:495-500. 2010..Preserving patient dignity is a sentinel premise of palliative care. This study was conducted to gain a better understanding of factors influencing preservation of dignity in the last chapter of life...- Care management for low-risk patients with heart failure: a randomized, controlled trialRobert Frank DeBusk
Stanford University School of Medicine, Stanford, California 94304 5735, USA
Ann Intern Med 141:606-13. 2004..Nurse care management programs for patients with chronic illness have been shown to be safe and effective... 
How to assess the clinical impact of treatments on patients, rather than the statistical impact of treatments on measuresHelena Chmura Kraemer
Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA
Int J Methods Psychiatr Res 20:63-72. 2011..The strategies discussed here are possible solutions to this dilemma. It is crucial to develop successful strategies to assess the effects of treatments on individual patients...- Measures of clinical significanceHelena Chmura Kraemer
Stanford University, Stanford, CA, USA
J Am Acad Child Adolesc Psychiatry 42:1524-9. 2003 - Toward non-parametric and clinically meaningful moderators and mediatorsHelena Chmura Kraemer
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, U S A
Stat Med 27:1679-92. 2008..Methods based on non-parametric methods specifically designed to facilitate considerations of clinical significance are here introduced for binary moderators and mediators and the discussion opened for what would be needed in general... - Events per person-time (incidence rate): a misleading statistic?Helena Chmura Kraemer
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 943305, USA
Stat Med 28:1028-39. 2009..More careful design and survival analyses are recommended in place of use of EPTs... - DSM categories and dimensions in clinical and research contextsHelena Chmura Kraemer
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94301, USA
Int J Methods Psychiatr Res 16:S8-S15. 2007..Possible objections to the proposal are discussed, concluding with some general criteria for implementing this proposal... - Reconsidering the odds ratio as a measure of 2x2 association in a populationHelena Chmura Kraemer
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA
Stat Med 23:257-70. 2004..In studies assessing reliability or heritability, we recommend the intraclass kappa. In studies in which one binary variable is assessed against a binary criterion, we recommend the weighted kappa... - Determining gene moderation of environmental risk factors for a mental disorder: a "perfect storm" of methodological problemsHelena Chmura Kraemer
Stanford University, CA, USA
Int J Methods Psychiatr Res 21:185-94. 2012.... - How and why criteria defining moderators and mediators differ between the Baron & Kenny and MacArthur approachesHelena Chmura Kraemer
Department of Psychiatry and Behavioral Sciences, Stanford University, CA, USA
Health Psychol 27:S101-8. 2008.... - Creation and the empirical validation of the dignity card-sort tool to assess factors influencing erosion of dignity at life's endVyjeyanthi S Periyakoil
Department of Medicine, Stanford University, Palo Alto, California 94304, USA
J Palliat Med 12:1125-30. 2009..The DCT is a promising tool that may help clinicians identify key factors resulting in perceptions of erosion of dignity in adult palliative care patients... - Clinical trials design lessons from the CATIE studyHelena Chmura Kraemer
Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA 94301, USA
Am J Psychiatry 166:1222-8. 2009.... - On disentangling states versus traits: demonstration of a new technique using the Alzheimer's disease assessment scaleJoy L Taylor
Department of Veterans Affairs, Sierra-Pacific Mental Illness Research, Education, and Clinical Center, Palo Alto, California 94304, USA
Alzheimer Dis Assoc Disord 16:254-60. 2002..We discuss how state-trait analyses can be helpful in focusing attention on those areas of assessment most likely to accomplish specific objectives...