Roger Kornberg

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Structural basis of transcription: nucleotide selection by rotation in the RNA polymerase II active center
    Kenneth D Westover
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 119:481-9. 2004
  2. pmc A bridge to transcription by RNA polymerase
    Craig D Kaplan
    Department of Structural Biology, Stanford University, 299 Campus Dr, West, Stanford, CA 94305, USA
    J Biol 7:39. 2008
  3. ncbi request reprint The molecular basis of eukaryotic transcription (Nobel Lecture)
    Roger Kornberg
    Department of Structural Biology, Stanford University Medical School, 299 Campus Dr West, Stanford CA, 94305 5126, USA
    Angew Chem Int Ed Engl 46:6956-65. 2007
  4. ncbi request reprint Mediator and the mechanism of transcriptional activation
    Roger D Kornberg
    Department of Structural Biology, Stanford School of Medicine, Stanford, CA 94305, USA
    Trends Biochem Sci 30:235-9. 2005
  5. pmc The molecular basis of eukaryotic transcription
    Roger D Kornberg
    Stanford University School of Medicine, Stanford, CA 94305 5400, USA
    Proc Natl Acad Sci U S A 104:12955-61. 2007
  6. ncbi request reprint Head module control of mediator interactions
    Yuichiro Takagi
    Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Mol Cell 23:355-64. 2006
  7. ncbi request reprint Structural basis of transcription: an RNA polymerase II-TFIIB cocrystal at 4.5 Angstroms
    David A Bushnell
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305 5126, USA
    Science 303:983-8. 2004
  8. pmc Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
    Dong Wang
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 127:941-54. 2006
  9. ncbi request reprint Isolation and assay of the RSC chromatin-remodeling complex from Saccharomyces cerevisiae
    Yahli Lorch
    Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Methods Enzymol 377:316-22. 2004
  10. ncbi request reprint A complex of the Srb8, -9, -10, and -11 transcriptional regulatory proteins from yeast
    Tilman Borggrefe
    Department of Structural Biology, Stanford University School of Medicine, California 94305 5400, USA
    J Biol Chem 277:44202-7. 2002

Research Grants

  1. Structure of the Eukaryote Transcription Apparatus
    Roger Kornberg; Fiscal Year: 2009
  2. STRUCTURE OF RNA POLYMERASE II
    Roger Kornberg; Fiscal Year: 2007
  3. LIPID LAYER CRYSTALLIZATION TECHNIQUE
    Roger Kornberg; Fiscal Year: 1990
  4. STRUCTURE OF RNA POLYMERASE II
    Roger Kornberg; Fiscal Year: 2001
  5. CRYSTALLOGRAPHY OF THE EUKARYOTE TRANSCRIPTION APPARATUS
    Roger Kornberg; Fiscal Year: 2001
  6. Heavy Atom Electron Microscopy
    Roger Kornberg; Fiscal Year: 2001
  7. STRUCTURE OF RNA POLYMERASE II
    Roger Kornberg; Fiscal Year: 2002
  8. Heavy Atom Electron Microscopy
    Roger Kornberg; Fiscal Year: 2003
  9. Structure of the Eukaryote Transcription Apparatus
    Roger Kornberg; Fiscal Year: 2003
  10. Structure of the Eukaryote Transcription Apparatus
    Roger Kornberg; Fiscal Year: 2005

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Structural basis of transcription: nucleotide selection by rotation in the RNA polymerase II active center
    Kenneth D Westover
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 119:481-9. 2004
    ..3 a...
  2. pmc A bridge to transcription by RNA polymerase
    Craig D Kaplan
    Department of Structural Biology, Stanford University, 299 Campus Dr, West, Stanford, CA 94305, USA
    J Biol 7:39. 2008
    ....
  3. ncbi request reprint The molecular basis of eukaryotic transcription (Nobel Lecture)
    Roger Kornberg
    Department of Structural Biology, Stanford University Medical School, 299 Campus Dr West, Stanford CA, 94305 5126, USA
    Angew Chem Int Ed Engl 46:6956-65. 2007
  4. ncbi request reprint Mediator and the mechanism of transcriptional activation
    Roger D Kornberg
    Department of Structural Biology, Stanford School of Medicine, Stanford, CA 94305, USA
    Trends Biochem Sci 30:235-9. 2005
    ..The transduction of regulatory signals through this pathway is crucial for transcription of almost all pol II promoters in all eukaryote organisms...
  5. pmc The molecular basis of eukaryotic transcription
    Roger D Kornberg
    Stanford University School of Medicine, Stanford, CA 94305 5400, USA
    Proc Natl Acad Sci U S A 104:12955-61. 2007
  6. ncbi request reprint Head module control of mediator interactions
    Yuichiro Takagi
    Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Mol Cell 23:355-64. 2006
    ..The head module evidently controls Mediator-RNA polymerase II and Mediator-promoter interactions...
  7. ncbi request reprint Structural basis of transcription: an RNA polymerase II-TFIIB cocrystal at 4.5 Angstroms
    David A Bushnell
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305 5126, USA
    Science 303:983-8. 2004
    ..The trajectory of promoter DNA determined by the C-terminal domain of TFIIB traverses sites of interaction with TFIIE, TFIIF, and TFIIH, serving to define their roles in the transcription initiation process...
  8. pmc Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
    Dong Wang
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 127:941-54. 2006
    ..A histidine side chain in the trigger loop, precisely positioned by these interactions, may literally "trigger" phosphodiester bond formation. Recognition and catalysis are thus coupled, ensuring the fidelity of transcription...
  9. ncbi request reprint Isolation and assay of the RSC chromatin-remodeling complex from Saccharomyces cerevisiae
    Yahli Lorch
    Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Methods Enzymol 377:316-22. 2004
  10. ncbi request reprint A complex of the Srb8, -9, -10, and -11 transcriptional regulatory proteins from yeast
    Tilman Borggrefe
    Department of Structural Biology, Stanford University School of Medicine, California 94305 5400, USA
    J Biol Chem 277:44202-7. 2002
    ....
  11. ncbi request reprint Mediator as a general transcription factor
    Yuichiro Takagi
    Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305 5400, USA
    J Biol Chem 281:80-9. 2006
    ..The possibility that Mediator serves as an anti-inhibitor, opposing the effects of global negative regulators, is largely excluded...
  12. pmc A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3
    Peter L Nagy
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 99:90-4. 2002
    ..These studies suggest that epigenetic regulation of developmental and sex-specific gene expression are species-specific readouts for a common chromatin remodeling machinery associated mechanistically with histone methylation...
  13. ncbi request reprint Removal of promoter nucleosomes by disassembly rather than sliding in vivo
    Hinrich Boeger
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Cell 14:667-73. 2004
    ..Whereas sliding would conserve the number of nucleosomes on the circle, we found that the number was diminished, demonstrating chromatin remodeling by nucleosome disassembly...
  14. pmc Affinity purification of specific chromatin segments from chromosomal loci in yeast
    Joachim Griesenbeck
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Cell Biol 23:9275-82. 2003
    ..Activator proteins interact in the manner anticipated from previous studies in vivo. This work opens the way to the direct study of specific gene regions of eukaryotic chromosomes in diverse functional and structural states...
  15. pmc The RNA polymerase II trigger loop functions in substrate selection and is directly targeted by alpha-amanitin
    Craig D Kaplan
    Department of Structural Biology, Stanford University, Stanford, CA 94305, USA
    Mol Cell 30:547-56. 2008
    ..We propose that alpha-amanitin-inhibited Pol II elongation, which is slow and exhibits reduced substrate selectivity, results from direct alpha-amanitin interference with the TL...
  16. pmc Mechanism of chromatin remodeling
    Yahli Lorch
    Department of Structural Biology, Stanford School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 107:3458-62. 2010
    ..Bulging of the DNA from the octamer surface is possible, and twisting is unavoidable, but neither is the basis of remodeling...
  17. ncbi request reprint Nucleosomes unfold completely at a transcriptionally active promoter
    Hinrich Boeger
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Cell 11:1587-98. 2003
    ..Although nucleosome loss occurs at all promoter sites, it is not complete at any of them, suggesting the existence of an equilibrium between the removal of nucleosomes and their reformation...
  18. pmc Complete, 12-subunit RNA polymerase II at 4.1-A resolution: implications for the initiation of transcription
    David A Bushnell
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 100:6969-73. 2003
    ....
  19. pmc Structure of an RNA polymerase II-TFIIB complex and the transcription initiation mechanism
    Xin Liu
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 327:206-9. 2010
    ..The two structures, taken together with others previously obtained, dispel long-standing mysteries of the transcription initiation process...
  20. ncbi request reprint Ubiquitin ligase activity of TFIIH and the transcriptional response to DNA damage
    Yuichiro Takagi
    Department of Structural Biology, School of Medicine, Stanford University, Stanford, California 94305, USA
    Mol Cell 18:237-43. 2005
    ..Rather, it correlates with reduced transcriptional induction of genes involved in DNA repair, suggesting that the E3 Ub ligase activity of TFIIH mediates the transcriptional response to DNA damage...
  21. pmc Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution
    Dong Wang
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 324:1203-6. 2009
    ..Structure determination of a cocrystal with TFIIS reveals a rearrangement whereby cleavage of the RNA may take place...
  22. pmc Schizosacharomyces pombe RNA polymerase II at 3.6-A resolution
    Henrik Spahr
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 106:9185-90. 2009
    ..pombe and humans. Amino acid changes apparently responsible for the structural differences are also conserved between S. pombe and humans, suggesting that the S. pombe structure may be a good surrogate for that of the human enzyme...
  23. ncbi request reprint Structural basis of eukaryotic gene transcription
    Hinrich Boeger
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    FEBS Lett 579:899-903. 2005
    ..X-ray and electron crystallography have led to a picture of the entire transcription initiation complex, elucidating the mechanisms of promoter recognition, DNA unwinding, abortive initiation, and promoter escape...
  24. pmc Chromatin remodeling by nucleosome disassembly in vitro
    Yahli Lorch
    Department of Structural Biology, Stanford University School of Medicine, CA 94305 5126, USA
    Proc Natl Acad Sci U S A 103:3090-3. 2006
    ..RSC and related chromatin-remodeling complexes may be responsible for the removal of promoter nucleosomes during transcriptional activation in vivo...
  25. ncbi request reprint Chromatin and transcription: where do we go from here
    Roger D Kornberg
    Department of Structural Biology, Stanford School of Medicine, Stanford, California 94305, USA
    Curr Opin Genet Dev 12:249-51. 2002
  26. ncbi request reprint Revised subunit structure of yeast transcription factor IIH (TFIIH) and reconciliation with human TFIIH
    Yuichiro Takagi
    Department of Structural Biology, Stanford University School of Medicine, California 94305 5400, USA
    J Biol Chem 278:43897-900. 2003
    ..This reassignment of subunits resolves a longstanding discrepancy between yeast and human TFIIH complexes...
  27. pmc Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution
    David A Bushnell
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305 5126, USA
    Proc Natl Acad Sci U S A 99:1218-22. 2002
    ..The structure of the complex indicates the likely basis of inhibition and gives unexpected insight into the transcription mechanism...
  28. ncbi request reprint Structural basis of transcription: separation of RNA from DNA by RNA polymerase II
    Kenneth D Westover
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305 5126, USA
    Science 303:1014-6. 2004
    ..This separation of nucleic acid strands is brought about by interaction with a set of proteins loops in a strand/loop network. Formation of the network must occur in the transition from abortive initiation to promoter escape...
  29. pmc Chromatin remodeling by DNA bending, not twisting
    Yahli Lorch
    Department of Structural Biology, School of Medicine, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 102:1329-32. 2005
    ..These findings suggest a remodeling process involving bending, but not twisting, of the DNA and further point to the propagation of a bent region (loop or bulge) from one end of the nucleosome to the other...
  30. pmc Synthesis and bioconjugation of 2 and 3 nm-diameter gold nanoparticles
    Christopher J Ackerson
    Department of Structural Biology, Stanford School of Medicine, 299 Campus Drive West, Stanford, California 94305, USA
    Bioconjug Chem 21:214-8. 2010
    ..Conjugates with antibody Fc fragment could be used to identify TAP-tagged proteins of interest in electron micrographs, through the binding of a pair of particles to the pair of protein A domains in the TAP tag...
  31. pmc Diffusion of nucleoside triphosphates and role of the entry site to the RNA polymerase II active center
    Nizar N Batada
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305 5126, USA
    Proc Natl Acad Sci U S A 101:17361-4. 2004
    ..Binding to the entry site greatly enhances the lifetime of an NTP in the active center region, and it prevents "backtracking" and the consequent occlusion of the active site...
  32. ncbi request reprint Purification of defined chromosomal domains
    Joachim Griesenbeck
    Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Methods Enzymol 375:170-8. 2004
  33. ncbi request reprint Electron microscopic analysis of the RSC chromatin remodeling complex
    Francisco J Asturias
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Methods Enzymol 376:48-62. 2004
  34. ncbi request reprint Structure of the yeast RNA polymerase II holoenzyme: Mediator conformation and polymerase interaction
    Joshua A Davis
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Cell 10:409-15. 2002
    ..Implications for the possible mechanism of transcription regulation by Mediator are discussed...
  35. pmc Structural analysis of the RSC chromatin-remodeling complex
    Francisco J Asturias
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:13477-80. 2002
    ..Results of nuclease protection analysis are consistent with nucleosome binding in the cavity. Such binding could explain the ability of RSC to expose nucleosomal DNA in the presence of ATP without loss of associated histones...
  36. ncbi request reprint RNA polymerase II/TFIIF structure and conserved organization of the initiation complex
    Wen Hsiang Chung
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cell 12:1003-13. 2003
    ..The structure of the RNAPII/TFIIF complex suggests a model for the organization of a minimal transcription initiation complex...
  37. pmc Nucleosome retention and the stochastic nature of promoter chromatin remodeling for transcription
    Hinrich Boeger
    Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    Cell 133:716-26. 2008
    ....
  38. ncbi request reprint An autobiographic conversation with Roger D. Kornberg on his work on transcription regulation
    Roger D Kornberg
    Cell Death Differ 14:1977-80. 2007
  39. ncbi request reprint A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II
    Henri Marc Bourbon
    Mol Cell 14:553-7. 2004
  40. ncbi request reprint [The Nobel Prize in Chemistry for 2006 for molecular unravelment of DNA transcription]
    J Brouwer
    Universiteit Leiden, Leids Instituut voor Chemisch Onderzoek, afd Moleculaire Genetica, Leiden
    Ned Tijdschr Geneeskd 150:2854-6. 2006
    ..Kornberg's work has provided more insight into the various stages of the transcription process and possible disruptions that lead to illness...
  41. ncbi request reprint [Roger Kornberg]
    Toshio Fukasawa
    Tanpakushitsu Kakusan Koso 51:2356-9. 2006
  42. pmc Association of the Mediator complex with enhancers of active genes
    Laurent Kuras
    Centre de Genetique Moleculaire, Centre National de la Recherche Scientifique, 91198 Gif sur Yvette, France
    Proc Natl Acad Sci U S A 100:13887-91. 2003
    ..These findings support the idea of Mediator as a primary conduit of regulatory information from enhancers to promoters in eukaryotic cells...
  43. ncbi request reprint Structure of a thiol monolayer-protected gold nanoparticle at 1.1 A resolution
    Pablo D Jadzinsky
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 318:430-3. 2007
    ..The particles are chiral, with the two enantiomers alternating in the crystal lattice. The discrete nature of the particle may be explained by the closing of a 58-electron shell...

Research Grants54

  1. Structure of the Eukaryote Transcription Apparatus
    Roger Kornberg; Fiscal Year: 2009
    ....
  2. STRUCTURE OF RNA POLYMERASE II
    Roger Kornberg; Fiscal Year: 2007
    ....
  3. LIPID LAYER CRYSTALLIZATION TECHNIQUE
    Roger Kornberg; Fiscal Year: 1990
    ..The monolayer X-ray diffraction technique will be developed and applied to obtain information missing from the electron microscope image analysis...
  4. STRUCTURE OF RNA POLYMERASE II
    Roger Kornberg; Fiscal Year: 2001
    ..They are likely to be more closely related to one another than to the enzyme from Saccharomyces cerevisiae, the object of our current investigations. ..
  5. CRYSTALLOGRAPHY OF THE EUKARYOTE TRANSCRIPTION APPARATUS
    Roger Kornberg; Fiscal Year: 2001
    ....
  6. Heavy Atom Electron Microscopy
    Roger Kornberg; Fiscal Year: 2001
    ..3) Construction of a modified scFv library, as well as computational tools, for use of the method by the biomedical research community. ..
  7. STRUCTURE OF RNA POLYMERASE II
    Roger Kornberg; Fiscal Year: 2002
    ..They are likely to be more closely related to one another than to the enzyme from Saccharomyces cerevisiae, the object of our current investigations. ..
  8. Heavy Atom Electron Microscopy
    Roger Kornberg; Fiscal Year: 2003
    ..3) Construction of a modified scFv library, as well as computational tools, for use of the method by the biomedical research community. ..
  9. Structure of the Eukaryote Transcription Apparatus
    Roger Kornberg; Fiscal Year: 2003
    ..For example, mutations in subunits of factor H are responsible for a number of inherited human disease syndromes. Mutations in RSC or RSC-related proteins are implicated in oncogenesis. ..
  10. Structure of the Eukaryote Transcription Apparatus
    Roger Kornberg; Fiscal Year: 2005
    ..For example, mutations in subunits of factor H are responsible for a number of inherited human disease syndromes. Mutations in RSC or RSC-related proteins are implicated in oncogenesis. ..
  11. STRUCTURE OF RNA POLYMERASE II
    Roger Kornberg; Fiscal Year: 2005
    ....
  12. Structure of the Eukaryote Transcription Apparatus
    Roger D Kornberg; Fiscal Year: 2010
    ....
  13. STRUCTURE OF RNA POLYMERASE II
    Roger Kornberg; Fiscal Year: 2009
    ....
  14. Structure of the Eukaryote Transcription Apparatus
    Roger Kornberg; Fiscal Year: 2007
    ..For type specifications, see instructions on page 6.) RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page Description, ..
  15. Gene Activation In Vitro
    Roger D Kornberg; Fiscal Year: 2011
    ....
  16. STRUCTURE OF RNA POLYMERASE II
    Roger Kornberg; Fiscal Year: 2006
    ....
  17. Structure of the Eukaryote Transcription Apparatus
    Roger Kornberg; Fiscal Year: 2006
    ..For example, mutations in subunits of factor H are responsible for a number of inherited human disease syndromes. Mutations in RSC or RSC-related proteins are implicated in oncogenesis. ..
  18. STRUCTURE OF RNA POLYMERASE II
    Roger Kornberg; Fiscal Year: 2000
    ..They are likely to be more closely related to one another than to the enzyme from Saccharomyces cerevisiae, the object of our current investigations. ..
  19. LIPID LAYER CRYSTALLIZATION TECHNIQUE
    Roger Kornberg; Fiscal Year: 1991
    ..The monolayer X-ray diffraction technique will be developed and applied to obtain information missing from the electron microscope image analysis...
  20. CRYSTALLOGRAPHY OF THE EUKARYOTE TRANSCRIPTION APPARATUS
    Roger Kornberg; Fiscal Year: 1993
    ....
  21. Gene Activation In Vitro
    Roger Kornberg; Fiscal Year: 2009
    ....
  22. RNA POLYMERASE II TRANSCRIPTION SYSTEM FROM YEAST
    Roger Kornberg; Fiscal Year: 2007
    ..2. Reconstitution and functional analysis of mediator. 3. Characterization of mammalian mediator. 4. Reconstitution of yeast TAF-dependent transcription in vitro. 5. Studies of RSC-nucleosome interaction. ..
  23. CRYSTALLOGRAPHY OF THE EUKARYOTE TRANSCRIPTION APPARATUS
    Roger Kornberg; Fiscal Year: 2000
    ....
  24. STRUCTURE OF RNA POLYMERASE II
    Roger Kornberg; Fiscal Year: 2003
    ..They are likely to be more closely related to one another than to the enzyme from Saccharomyces cerevisiae, the object of our current investigations. ..
  25. Structure of the Eukaryote Transcription Apparatus
    Roger Kornberg; Fiscal Year: 2002
    ..For example, mutations in subunits of factor H are responsible for a number of inherited human disease syndromes. Mutations in RSC or RSC-related proteins are implicated in oncogenesis. ..
  26. Gene Activation In Vitro
    Roger D Kornberg; Fiscal Year: 2010
    ....
  27. STRUCTURE OF RNA POLYMERASE II
    Roger D Kornberg; Fiscal Year: 2010
    ....
  28. Heavy Atom Electron Microscopy
    Roger Kornberg; Fiscal Year: 2002
    ..3) Construction of a modified scFv library, as well as computational tools, for use of the method by the biomedical research community. ..
  29. STRUCTURE OF RNA POLYMERASE II
    Roger Kornberg; Fiscal Year: 2004
    ....
  30. CRYSTALLOGRAPHY OF THE EUKARYOTE TRANSCRIPTION APPARATUS
    Roger Kornberg; Fiscal Year: 1992
    ....
  31. Heavy Atom Electron Microscopy
    Roger Kornberg; Fiscal Year: 2004
    ..3) Construction of a modified scFv library, as well as computational tools, for use of the method by the biomedical research community. ..
  32. Structure of the Eukaryote Transcription Apparatus
    Roger Kornberg; Fiscal Year: 2004
    ..For example, mutations in subunits of factor H are responsible for a number of inherited human disease syndromes. Mutations in RSC or RSC-related proteins are implicated in oncogenesis. ..
  33. CRYSTALLOGRAPHY OF THE EUKARYOTE TRANSCRIPTION APPARATUS
    Roger Kornberg; Fiscal Year: 1999
    ....
  34. STRUCTURE OF RNA POLYMERASE II
    Roger Kornberg; Fiscal Year: 1999
    ....