L M Koran

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Olanzapine augmentation for treatment-resistant obsessive-compulsive disorder
    L M Koran
    Department of Psychiatry and Behavioral Sciences, Stanford Medical Center, Calif, USA
    J Clin Psychiatry 61:514-7. 2000
  2. doi request reprint Extended-release fluvoxamine and improvements in quality of life in patients with obsessive-compulsive disorder
    Lorrin M Koran
    Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA 94305, USA
    Compr Psychiatry 51:373-9. 2010
  3. ncbi request reprint Double-blind treatment with oral morphine in treatment-resistant obsessive-compulsive disorder
    Lorrin M Koran
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, CA 94305, USA
    J Clin Psychiatry 66:353-9. 2005
  4. ncbi request reprint Mirtazapine for obsessive-compulsive disorder: an open trial followed by double-blind discontinuation
    Lorrin M Koran
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Clin Psychiatry 66:515-20. 2005
  5. ncbi request reprint Pulse-loaded intravenous clomipramine in treatment-resistant obsessive-compulsive disorder
    Lorrin M Koran
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, CA 94305, USA
    J Clin Psychopharmacol 26:79-83. 2006
  6. ncbi request reprint Estimated prevalence of compulsive buying behavior in the United States
    Lorrin M Koran
    OCD Clinic, Rm 2363, 401 Quarry Rd, Stanford, CA 94305, USA
    Am J Psychiatry 163:1806-12. 2006
  7. ncbi request reprint Escitalopram treatment of kleptomania: an open-label trial followed by double-blind discontinuation
    Lorrin M Koran
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA, USA
    J Clin Psychiatry 68:422-7. 2007
  8. ncbi request reprint Duloxetine treatment of dysthymia and double depression: an open-label trial
    Lorrin M Koran
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, Calif, USA
    J Clin Psychiatry 68:761-5. 2007
  9. ncbi request reprint The prevalence of body dysmorphic disorder in the United States adult population
    Lorrin M Koran
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    CNS Spectr 13:316-22. 2008
  10. doi request reprint Double-blind study of dextroamphetamine versus caffeine augmentation for treatment-resistant obsessive-compulsive disorder
    Lorrin M Koran
    OCD Clinic, Stanford, CA 94305, USA
    J Clin Psychiatry 70:1530-5. 2009

Research Grants

Detail Information

Publications38

  1. ncbi request reprint Olanzapine augmentation for treatment-resistant obsessive-compulsive disorder
    L M Koran
    Department of Psychiatry and Behavioral Sciences, Stanford Medical Center, Calif, USA
    J Clin Psychiatry 61:514-7. 2000
    ..Since olanzapine and risperidone have similar serotonergic and dopaminergic receptor binding profiles, we tested the hypothesis that olanzapine augmentation would be beneficial in treatment-unresponsive OCD...
  2. doi request reprint Extended-release fluvoxamine and improvements in quality of life in patients with obsessive-compulsive disorder
    Lorrin M Koran
    Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA 94305, USA
    Compr Psychiatry 51:373-9. 2010
    ..We also hypothesized that greater OCD symptom improvement in the first 12 weeks of treatment would be associated with greater HRQOL improvement after 52 weeks of treatment...
  3. ncbi request reprint Double-blind treatment with oral morphine in treatment-resistant obsessive-compulsive disorder
    Lorrin M Koran
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, CA 94305, USA
    J Clin Psychiatry 66:353-9. 2005
    ..A case series reported substantial response to once-weekly oral morphine. We conducted a placebo-controlled, double-blind trial to investigate whether once-weekly oral morphine is effective in SRI-resistant OCD...
  4. ncbi request reprint Mirtazapine for obsessive-compulsive disorder: an open trial followed by double-blind discontinuation
    Lorrin M Koran
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Clin Psychiatry 66:515-20. 2005
    ..Mirtazapine enhances serotonergic function by a mechanism distinct from reuptake inhibition. Because a pilot study suggested effectiveness of mirtazapine in OCD, we conducted a controlled trial...
  5. ncbi request reprint Pulse-loaded intravenous clomipramine in treatment-resistant obsessive-compulsive disorder
    Lorrin M Koran
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, CA 94305, USA
    J Clin Psychopharmacol 26:79-83. 2006
    ..Small studies have suggested that intravenous clomipramine (CMI) may be more effective and induce faster improvement in obsessive-compulsive disorder than do orally administered serotonin reuptake inhibitors...
  6. ncbi request reprint Estimated prevalence of compulsive buying behavior in the United States
    Lorrin M Koran
    OCD Clinic, Rm 2363, 401 Quarry Rd, Stanford, CA 94305, USA
    Am J Psychiatry 163:1806-12. 2006
    ..8% to 16% of the adult U.S. population. To the authors' knowledge, no study has used a large general population sample to estimate its prevalence...
  7. ncbi request reprint Escitalopram treatment of kleptomania: an open-label trial followed by double-blind discontinuation
    Lorrin M Koran
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA, USA
    J Clin Psychiatry 68:422-7. 2007
    ..Kleptomania has no definitive treatment. Mixed reports of benefit from openly prescribed selective serotonin reuptake inhibitors led us to design a double-blind, placebo-controlled discontinuation trial of escitalopram...
  8. ncbi request reprint Duloxetine treatment of dysthymia and double depression: an open-label trial
    Lorrin M Koran
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, Calif, USA
    J Clin Psychiatry 68:761-5. 2007
    ..Antidepressants and some psychotherapies are often effective. We explored the efficacy of the antidepressant duloxetine, a serotonin and norepinephrine reuptake inhibitor...
  9. ncbi request reprint The prevalence of body dysmorphic disorder in the United States adult population
    Lorrin M Koran
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    CNS Spectr 13:316-22. 2008
    ..Limited surveys report widely varying prevalence estimates. To better establish the prevalence of BDD, we conducted a United States nationwide prevalence survey...
  10. doi request reprint Double-blind study of dextroamphetamine versus caffeine augmentation for treatment-resistant obsessive-compulsive disorder
    Lorrin M Koran
    OCD Clinic, Stanford, CA 94305, USA
    J Clin Psychiatry 70:1530-5. 2009
    ....
  11. ncbi request reprint Citalopram for compulsive shopping disorder: an open-label study followed by double-blind discontinuation
    Lorrin M Koran
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Calif, USA
    J Clin Psychiatry 64:793-8. 2003
    ..To test the hypothesis that citalopram is a safe, effective treatment for this disorder, we conducted a 7-week, open-label trial followed by a 9-week, double-blind, placebo-controlled discontinuation trial...
  12. ncbi request reprint Efficacy of sertraline in the long-term treatment of obsessive-compulsive disorder
    Lorrin M Koran
    Department of Psychiatry, Stanford University, CA 94305, USA
    Am J Psychiatry 159:88-95. 2002
    ..Despite the need for long-term treatment, the authors found no placebo-controlled studies that have examined the relapse-prevention efficacy of maintenance therapy...
  13. ncbi request reprint Sumatriptan, 5-HT(1D) receptors and obsessive-compulsive disorder
    L M Koran
    Department of Psychiatry and Behavioral Sciences, Stanford Medical Center, Stanford, CA, USA
    Eur Neuropsychopharmacol 11:169-72. 2001
    ....
  14. ncbi request reprint Sertraline versus imipramine to prevent relapse in chronic depression
    L M Koran
    Stanford University Medical Center, CA, USA
    J Affect Disord 65:27-36. 2001
    ..Chronic depressions are common, disabling and under-treated, and long-term treatment is little studied. We report the continuation phase results from a long-term treatment study...
  15. ncbi request reprint Citalopram treatment of compulsive shopping: an open-label study
    Lorrin M Koran
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, Calif, USA
    J Clin Psychiatry 63:704-8. 2002
    ..Because an open-label trial suggested that fluovaxamine, a selective serotonin reuptake inhibitor (SSRI), is effective for this disorder, we tested the effectiveness of the SSRI citalopram...
  16. ncbi request reprint Pharmacotherapy of obsessive-compulsive disorder in a health maintenance organization
    L M Koran
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, CA 94305, USA
    Am J Health Syst Pharm 57:1972-8. 2000
    ..Despite the typically chronic course of OCD, many patients with OCD who were enrolled in a large HMO appeared not to receive an adequate trial of pharmacotherapy or ongoing pharmacotherapy...
  17. ncbi request reprint High-dose sertraline strategy for nonresponders to acute treatment for obsessive-compulsive disorder: a multicenter double-blind trial
    Philip T Ninan
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1841 Clifton Road, Atlanta, GA 30329, USA
    J Clin Psychiatry 67:15-22. 2006
    ..To evaluate the efficacy and safety of high-dose sertraline for patients with obsessive-compulsive disorder (OCD) who failed to respond to standard sertraline acute treatment...
  18. ncbi request reprint A 1-year naturalistic follow-up of patients with compulsive shopping disorder
    Elias Aboujaoude
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, Calif, USA
    J Clin Psychiatry 64:946-50. 2003
    ....
  19. ncbi request reprint Quetiapine augmentation in obsessive-compulsive disorder resistant to serotonin reuptake inhibitors: an open-label study
    Ann M Bogan
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, CA 94305, USA
    J Clin Psychiatry 66:73-9. 2005
    ..Case series reporting successful augmentation with risperidone and olanzapine led us to investigate quetiapine in OCD that was resistant to SRI treatment...
  20. ncbi request reprint Effect of concurrent anxiety on response to sertraline and imipramine in patients with chronic depression
    J M Russell
    University of Texas Medical Branch at Galveston, 301 University Boulevard, Department of Psychiatry and Behavioral Sciences, Route 0197, Galveston, TX 77555, USA
    Depress Anxiety 13:18-27. 2001
    ..High baseline levels of anxiety did not reduce overall antidepressant response but did somewhat delay the onset of response to sertraline or imipramine in patients with chronic depression...
  21. ncbi request reprint Refractory obsessive-compulsive disorder: state-of-the-art treatment
    Eric Hollander
    Department of Psychiatry, Compulsive, Impulsive, and Anxiety Disorders Program, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Clin Psychiatry 63:20-9. 2002
    ..The authors synthesize state-of-the-art treatment and give practical advice for clinicians...
  22. ncbi request reprint A double-blind, placebo-controlled study of the efficacy and safety of controlled-release fluvoxamine in patients with obsessive-compulsive disorder
    Eric Hollander
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Clin Psychiatry 64:640-7. 2003
    ....
  23. ncbi request reprint Medical disorders among patients admitted to a public-sector psychiatric inpatient unit
    Lorrin M Koran
    Department of Psychiatry and Behavioral Science, OCD Clinic, Stanford University Medical Center, Room 2363, 401 Quarry Road, Stanford, CA 94305, USA
    Psychiatr Serv 53:1623-5. 2002
    ..5 percent of the patients, respectively. Patients admitted to psychiatric inpatient units should be carefully evaluated for physical disease...
  24. ncbi request reprint Aripiprazole in schizophrenia patients with comorbid obsessive-compulsive symptoms: an open-label study of 15 patients
    Ira D Glick
    Stanford University School of Medicine, Department of Psychiatry, 401 Quarry Rd, Suite 2122, Stanford, CA 94305, USA
    J Clin Psychiatry 69:1856-9. 2008
    ..This study examined aripiprazole treatment of patients with comorbid schizophrenia and obsessive-compulsive symptoms (OCS) that did not meet full criteria for OCD...
  25. ncbi request reprint Venlafaxine in treatment-resistant obsessive-compulsive disorder
    Eric Hollander
    Department of Psychiatry, Compulsive, Impulsive, and Anxiety Disorders Program, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Clin Psychiatry 64:546-50. 2003
    ..Venlafaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI) that might be effective in the treatment of OCD, even among those who have failed previous SSRI trials...
  26. ncbi request reprint Fluoxetine in pathologic skin-picking: open-label and double-blind results
    M R Bloch
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, CA, USA
    Psychosomatics 42:314-9. 2001
    ..Larger studies are needed to determine which individuals are likely to respond to fluoxetine and the relative effectiveness of fluoxetine, other SSRIs, and other forms of treatment...
  27. ncbi request reprint Double-blind switch study of imipramine or sertraline treatment of antidepressant-resistant chronic depression
    Michael E Thase
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 59:233-9. 2002
    ..Although various strategies have been proposed to treat antidepressant nonresponders, little controlled research has been published that examines prospectively the use of switching to an alternate antidepressant...
  28. doi request reprint The prevalence of pathologic skin picking in US adults
    Nancy J Keuthen
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Compr Psychiatry 51:183-6. 2010
    ..Despite increasing recognition of the potentially severe medical and psychosocial costs of pathologic skin picking (PSP), no large-sample, randomized investigation of its prevalence in a national population has been conducted...
  29. ncbi request reprint Adequacy of pharmacotherapy among medicaid-enrolled patients newly diagnosed with obsessive-compulsive disorder
    Cheryl S Hankin
    BioMedEcon LLC, Moss Beach, CA, USA
    CNS Spectr 14:695-703. 2009
    ..To determine the adequacy of pharmacotherapy received by patients with newly-diagnosed obsessive-compulsive disorder (OCD), based on current practice guidelines...
  30. ncbi request reprint Continuation treatment of chronic depression: a comparison of nefazodone, cognitive behavioral analysis system of psychotherapy, and their combination
    James H Kocsis
    Department of Psychiatry, Weill Cornell Medical College, New York, NY 10021, USA
    Psychopharmacol Bull 37:73-87. 2003
    ..COMB was associated with less symptom re-emergence during the continuation phase than either monotherapy, particularly for partial remitters...
  31. ncbi request reprint Does psychosocial functioning improve independent of depressive symptoms? A comparison of nefazodone, psychotherapy, and their combination
    Robert M A Hirschfeld
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, Texas 77555 0188, USA
    Biol Psychiatry 51:123-33. 2002
    ..This study compared efficacy of nefazodone, psychotherapy, and their combination in improving psychosocial functioning in chronically depressed outpatients...
  32. ncbi request reprint Potential markers for problematic internet use: a telephone survey of 2,513 adults
    Elias Aboujaoude
    Impulse Control Disorders Clinic, Department of Psychiatry and Behavioral Medicine, Stanford University School of Medicine, Palo Alto, CA 94305, USA
    CNS Spectr 11:750-5. 2006
    ..However, for a subset of users, the medium may have become a consuming problem that exhibits features of impulse control disorders recognized in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition...
  33. ncbi request reprint Practice guideline for the treatment of patients with obsessive-compulsive disorder
    Lorrin M Koran
    Am J Psychiatry 164:5-53. 2007
  34. ncbi request reprint Escitalopram for compulsive buying disorder: a double-blind discontinuation study
    Lorrin M Koran
    J Clin Psychopharmacol 27:225-7. 2007
  35. ncbi request reprint Citalopram intravenous infusion in resistant obsessive-compulsive disorder: an open trial
    Stefano Pallanti
    Istituto di Neuroscienze, and University of Florence, School of Medicine, Italy
    J Clin Psychiatry 63:796-801. 2002
    ..The selective serotonin reuptake inhibitor citalopram is effective for OCD when administered orally. We investigated whether intravenous citalopram would rapidly benefit OCD patients unresponsive to orally administered SRIs...
  36. ncbi request reprint Neurological soft signs as predictors of treatment response to selective serotonin reuptake inhibitors in obsessive-compulsive disorder
    Eric Hollander
    Mt Sinai School of Medicine, One Gustave Levy Place, Box 1230, NY, NY 10029, USA
    J Neuropsychiatry Clin Neurosci 17:472-7. 2005
    ..These subtle neurological abnormalities may implicate a potential subgroup of OCD patients with poorer treatment response. This may have treatment implications and therefore serve as a screening tool in OCD...
  37. ncbi request reprint A case of kleptomania correlating with premenstrual dysphoria
    Elias Aboujaoude
    J Clin Psychiatry 65:725-6. 2004
  38. ncbi request reprint Serotonin-1D hypothesis of obsessive-compulsive disorder: an update
    Joseph Zohar
    Division of Psychiatry, Chaim Sheba Medical Center, Tel Hashomer, Tel Aviv University, Israel
    J Clin Psychiatry 65:18-21. 2004
    ..However, taking into account that OCD is a heterogeneous syndrome, the 5-HT(1D) hypothesis requires further investigation in order to disentangle the role of the 5-HT(1D) receptor in this common and often severe disorder...

Research Grants3

  1. PULSE LOADED IV CLOMIPRAMINE IN UNRESPONSIVE OCD
    Lorrin Koran; Fiscal Year: 2001
    ..outcome can be predicted from baseline clinical information. (Throughout this revised grant application, revisions are indicated by bold type face, except that the new Introduction is in ordinary typeface). ..