Research Topics
Genomes and Genes | Albert KoongSummaryAffiliation: Stanford University Country: USA Publications
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Publications
Orthovoltage intraoperative radiation therapy for pancreatic adenocarcinomaPavan Bachireddy
Department of Radiation Oncology, Stanford Cancer Center, Stanford University, Stanford, CA, USA
Radiat Oncol 5:105. 2010..To analyze the outcomes of patients from a single institution treated with surgery and orthovoltage intraoperative radiotherapy (IORT) for pancreatic adenocarcinoma...- Identification of a biomarker panel using a multiplex proximity ligation assay improves accuracy of pancreatic cancer diagnosisStephanie T Chang
Department of Radiation Oncology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA
J Transl Med 7:105. 2009..Proximity ligation assay (PLA) is a highly sensitive technique for multiplex detection of biomarkers in plasma with little or no interfering background signal... 
Phase II study to assess the efficacy of conventionally fractionated radiotherapy followed by a stereotactic radiosurgery boost in patients with locally advanced pancreatic cancerAlbert C Koong
Department of Radiation Oncology, Stanford University School of Medicine, 269 Campus Drive West, Stanford, CA 94305
Int J Radiat Oncol Biol Phys 63:320-3. 2005..To determine the efficacy of concurrent 5-fluorouracil (5-FU) and intensity-modulated radiotherapy (IMRT) followed by body stereotactic radiosurgery (SRS) in patients with locally advanced pancreatic cancer...- Targeting XBP-1 as a novel anti-cancer strategyAlbert C Koong
Stanford University, Department of Radiation Oncology, CA 94305 5152, USA
Cancer Biol Ther 5:756-9. 2006..This review focuses on the role of the IRE1-XBP1 branch of the UPR and its role in mediating cell survival and tumor growth. Inhibition of this pathway will be discussed as a therapeutic strategy... - Phase I study of stereotactic radiosurgery in patients with locally advanced pancreatic cancerAlbert C Koong
Department of Radiation Oncology, Stanford University, Stanford, California 94305 5152, USA
Int J Radiat Oncol Biol Phys 58:1017-21. 2004..To determine the feasibility and toxicity of delivering stereotactic radiosurgery to patients with locally advanced pancreatic cancer... 
Intrafraction verification of gated RapidArc by using beam-level kilovoltage X-ray imagesRuijiang Li
Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California
Int J Radiat Oncol Biol Phys 83:e709-15. 2012..To verify the geometric accuracy of gated RapidArc treatment using kV images acquired during dose delivery...- Mature results from a randomized Phase II trial of cisplatin plus 5-fluorouracil and radiotherapy with or without tirapazamine in patients with resectable Stage IV head and neck squamous cell carcinomasQuynh Thu Le
Department of Radiation Oncology, Stanford University, Stanford, California 94305, USA
Cancer 106:1940-9. 2006.... - The role of tumor cell-derived connective tissue growth factor (CTGF/CCN2) in pancreatic tumor growthKevin L Bennewith
Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California, USA
Cancer Res 69:775-84. 2009.... - In vivo 1H magnetic resonance spectroscopy of lactate in patients with stage IV head and neck squamous cell carcinomaQuynh Thu Le
Department of Radiation Oncology, Stanford University Medical Center, Stanford, CA 94305 5847, USA
Int J Radiat Oncol Biol Phys 71:1151-7. 2008..To investigate in vivo(1)H magnetic resonance spectroscopy imaging of lactate for assessing tumor hypoxia in head and neck cancers and to determine its utility in predicting the response and outcomes... - Improved local control with stereotactic radiosurgical boost in patients with nasopharyngeal carcinomaQuynh-Thu Le
Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305-5302, USA
Int J Radiat Oncol Biol Phys 56:1046-54. 2003..CONCLUSION: STR boost after EBRT provided excellent local control in nasopharyngeal carcinoma patients. The incidence of late toxicity was acceptable. More effective systemic treatment is needed to achieve improved survival... - Evaluation of patterns of failure and subjective salivary function in patients treated with intensity modulated radiotherapy for head and neck squamous cell carcinomaMegan E Daly
Department of Radiation Oncology, Stanford University Medical Center, Stanford, California 94305, USA
Head Neck 29:211-20. 2007.... - Four-dimensional cone-beam computed tomography using an on-board imagerTianfang Li
Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305, USA
Med Phys 33:3825-33. 2006.... - Automated contour mapping with a regional deformable modelMing Chao
Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305 5847, USA
Int J Radiat Oncol Biol Phys 70:599-608. 2008..To develop a regional narrow-band algorithm to auto-propagate the contour surface of a region of interest (ROI) from one phase to other phases of four-dimensional computed tomography (4D-CT)... - Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic nicheJanine T Erler
Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
Cancer Cell 15:35-44. 2009..CD11b+ cells and LOX also colocalize in biopsies of human metastases. Our findings demonstrate a critical role for LOX in premetastatic niche formation and support targeting LOX for the treatment and prevention of metastatic disease... - The relationship between human papillomavirus status and other molecular prognostic markers in head and neck squamous cell carcinomasChristina S Kong
Department of Pathology, Stanford University, Santa Cruz, CA, USA
Int J Radiat Oncol Biol Phys 74:553-61. 2009.... - Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effectYijun Chen
Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California, USA
PLoS ONE 4:e7033. 2009.... - EUS-guided gold fiducial insertion for image-guided radiation therapy of pancreatic cancer: 50 successful cases without fluoroscopyWalter G Park
Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California, USA
Gastrointest Endosc 71:513-8. 2010..Application of IGRT to unresectable pancreatic cancer requires the use of fiducials to track the precise location of the tumor. Fiducial markers have been successfully placed endoscopically... - Phase II trial of preoperative 3D conformal radiotherapy, protracted venous infusion 5-fluorouracil, and weekly CPT-11, followed by surgery for ultrasound-staged T3 rectal cancerVivek K Mehta
Department of Radiation Oncology, Stanford University Medical Center, Stanford, CA, USA
Int J Radiat Oncol Biol Phys 55:132-7. 2003..We report the results from a Phase II trial of preoperative radiotherapy (RT), CPT-11, and 5-FU for patients with ultrasound-staged T3 rectal cancer... - Reducing respiratory motion artifacts in positron emission tomography through retrospective stackingBrian Thorndyke
Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305, USA
Med Phys 33:2632-41. 2006..These phantom and patient studies demonstrate that RS can correct for lesion motion and deformation, while substantially improving tumor visibility and background noise... - Comparison of the comet assay and the oxygen microelectrode for measuring tumor oxygenation in head-and-neck cancer patientsQuynh Thu Le
Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA
Int J Radiat Oncol Biol Phys 56:375-83. 2003..To compare the Eppendorf PO2 histograph and the alkaline comet assay as methods of measuring tumor hypoxia in patients with head-and-neck squamous cell carcinomas... - Enhanced 4D cone-beam CT with inter-phase motion modelTianfang Li
Department of Radiation Oncology, Stanford University School of Medicine, Clinical Cancer Center, 875 Blake Wilbur Drive, Stanford, California 94305 5847, USA
Med Phys 34:3688-95. 2007..Several strategies of the motion derivation are discussed, and the resultant images are assessed with numerical simulations as well as a clinical case... - Seventh Edition (2010) of the AJCC/UICC Staging System for Gastric Adenocarcinoma: Is there Room for Improvement?Manali I Patel
Department of Medicine, Division of Oncology, Stanford University Medical Center, Stanford, CA, USA
Ann Surg Oncol 20:1631-8. 2013..We sought to validate the new system on a U.S. population database... - Evaluation of the geometric accuracy of surrogate-based gated VMAT using intrafraction kilovoltage x-ray imagesRuijiang Li
Department of Radiation Oncology, Stanford University, Stanford, CA 94305 5847, USA
Med Phys 39:2686-93. 2012..To evaluate the geometric accuracy of beam targeting in external surrogate-based gated volumetric modulated arc therapy (VMAT) using kilovoltage (kV) x-ray images acquired during dose delivery... - First study of on-treatment volumetric imaging during respiratory gated VMATKihwan Choi
Department of Electrical Engineering, Stanford University, Stanford, California 94305 and Department of Radiation Oncology, Stanford University, Stanford, California 94305
Med Phys 40:040701. 2013..This anatomical information may be valuable for geometric verification and treatment guidance, and useful for verification of treatment dose delivery, accumulation, and adaptation in the future... - Quantitative PET of EGFR expression in xenograft-bearing mice using 64Cu-labeled cetuximab, a chimeric anti-EGFR monoclonal antibodyWeibo Cai
The Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University School of Medicine, 1201 Welch Rd P095, Stanford, CA 94305 5484, USA
Eur J Nucl Med Mol Imaging 34:850-8. 2007..Here we report for the first time the quantitative positron emission tomography (PET) imaging of EGFR expression in xenograft-bearing mice using 64Cu-labeled cetuximab... - Safety and efficacy of percutaneous fiducial marker implantation for image-guided radiation therapyNishita Kothary
Division of Interventional Radiology, Stanford University Medical Center, 300 Pasteur Dr, H3652, Stanford, CA 94305 5642, USA
J Vasc Interv Radiol 20:235-9. 2009..To evaluate the safety and technical success rate of percutaneous fiducial marker implantation in preparation for image-guided radiation therapy... - Impaired interferon signaling is a common immune defect in human cancerRebecca J Critchley-Thorne
Division of Hematology, Department of Medicine, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 106:9010-5. 2009.... - Phase II double-blind randomized study comparing oral aloe vera versus placebo to prevent radiation-related mucositis in patients with head-and-neck neoplasmsCatherine K Su
Department of Radiation Oncology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305-5302, USA
Int J Radiat Oncol Biol Phys 60:171-7. 2004..Oral aloe vera did not improve tolerance to head-and-neck radiotherapy, decrease mucositis, reduce soreness, or otherwise improve patient well-being... - Sample classification from protein mass spectrometry, by 'peak probability contrasts'Robert Tibshirani
Department of Health, Research and Policy, Stanford University, CA 94305, USA
Bioinformatics 20:3034-44. 2004..It is also much more interpretable biologically. The peak probability contrast method is a potentially useful tool for sample classification from protein mass spectrometry data... - ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growthLori S Hart
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 5156, USA
J Clin Invest 122:4621-34. 2012..Our findings establish a role for UPR as an enhancer of c-Myc-induced transformation and suggest that UPR inhibition may be particularly effective against malignancies characterized by c-Myc overexpression... - Overview of image-guided radiation therapyLei Xing
Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305-5847, USA
Med Dosim 31:91-112. 2006..We introduce various new IGRT concepts and approaches, and hope to provide the reader with a comprehensive understanding of the emerging clinical IGRT technologies. Some important research topics will also be addressed... - Connective tissue growth factor-specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasisNadja Dornhöfer
Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California, USA
Cancer Res 66:5816-27. 2006..Together, these studies implicate CTGF as a new target in pancreatic cancer and suggest that inhibition of CTGF with a human monoclonal antibody may control primary and metastatic tumor growth... - An evaluation of tumor oxygenation and gene expression in patients with early stage non-small cell lung cancersQuynh Thu Le
Department of Radiation Oncology, Stanford University Medical Center, Stanford, California 94305 5847, USA
Clin Cancer Res 12:1507-14. 2006..To directly assess tumor oxygenation in resectable non-small cell lung cancers (NSCLC) and to correlate tumor pO2 and the selected gene and protein expression to treatment outcomes... - The unfolded protein response: a novel component of the hypoxic stress response in tumorsDouglas E Feldman
Department of Radiation Oncology, Stanford University Medical Center, Stanford, CA 94305-5152, USA
Mol Cancer Res 3:597-605. 2005..Targeting various components of the UPR is a promising therapeutic strategy. Understanding the relationship between hypoxia, the UPR, and tumor growth is crucial to improving current cancer therapies... - Galectin-1: a link between tumor hypoxia and tumor immune privilegeQuynh Thu Le
Department of Radiation Oncology, Stanford University Medical Center, 875 Blake Wilbur Drive, Stanford, CA 94305 5847, USA
J Clin Oncol 23:8932-41. 2005..To identify a 15-KDa novel hypoxia-induced secreted protein in head and neck squamous cell carcinomas (HNSCC) and to determine its role in malignant progression... - Estimating DNA repair by sequential evaluation of head and neck tumor radiation sensitivity using the comet assayDavid J Terris
Division of Otolaryngology Head and Neck Surgery, Stanford University Medical Center, R135, Edwards Bldg, Stanford, CA 94305 5328, USA
Arch Otolaryngol Head Neck Surg 128:698-702. 2002..The alkaline comet assay is a microelectrophoretic technique for detecting single-strand DNA breaks, and may be used as an indirect measure of hypoxia by determining the radiation sensitivity of individual cells... - A noninvasive approach for assessing tumor hypoxia in xenografts: developing a urinary marker for hypoxiaDaniel W Nelson
Department of Radiation Oncology, Stanford University, Stanford, California 94305-5847, USA
Cancer Res 65:6151-8. 2005..The 5HRE beta-hCG reporter system described here enables serial, noninvasive monitoring of tumor hypoxia in a mouse model by measuring a urinary reporter protein... - Hypoxia upregulates osteopontin expression in NIH-3T3 cells via a Ras-activated enhancerYonghua Zhu
Department of Radiation Oncology, 875 Blake Wilbur Dr, R. CC-G228, Stanford University, Stanford, CA 94305, USA
Oncogene 24:6555-63. 2005..Taken together, these results have identified a new hypoxia responsive transcriptional enhancer that is regulated by Akt signaling... - Identification of hypoxia-regulated proteins in head and neck cancer by proteomic and tissue array profilingYijun Chen
Department of Radiation Oncology, Center for Clinical Sciences Research, Department of Surgery, Palo Alto VA Health Care System, Palo Alto, CA, USA
Cancer Res 64:7302-10. 2004..These data suggest that IKKbeta is a novel endogenous marker of tumor hypoxia and may represent a new target for anticancer therapy... - XBP1 is essential for survival under hypoxic conditions and is required for tumor growthLorenzo Romero-Ramirez
Department of Radiation Oncology, Stanford University, Stanford, California 94305-5152, USA
Cancer Res 64:5943-7. 2004..Taken together, these studies directly implicate XBP1 as an essential survival factor for hypoxic stress and tumor growth... - Identification of osteopontin as a prognostic plasma marker for head and neck squamous cell carcinomasQuynh Thu Le
Department of Radiation Oncology, Center for Clinical Science Research South, Stanford, California 94305 5152, USA
Clin Cancer Res 9:59-67. 2003..Tumor hypoxia modifies treatment efficacy and promotes tumor progression. Here, we investigated the relationship between osteopontin (OPN), tumor pO(2), and prognosis in patients with head and neck squamous cell carcinomas (HNSCC)... - Plasma osteopontin is an independent prognostic marker for head and neck cancersDavid Petrik
Department of Radiation Oncology, Stanford University, Stanford, CA, USA
J Clin Oncol 24:5291-7. 2006.... - Expression and prognostic significance of a panel of tissue hypoxia markers in head-and-neck squamous cell carcinomasQuynh Thu Le
Department of Radiation Oncology, Stanford University, Stanford, CA 94305 5847, USA
Int J Radiat Oncol Biol Phys 69:167-75. 2007..To investigate the expression pattern of hypoxia-induced proteins identified as being involved in malignant progression of head-and-neck squamous cell carcinoma (HNSCC) and to determine their relationship to tumor pO(2) and prognosis... - Amplification of tumor hypoxic responses by macrophage migration inhibitory factor-dependent hypoxia-inducible factor stabilizationMillicent Winner
Molecular Targets Program, James Graham Brown Cancer Center and Department of Radiation Oncology, University of Louisville, 580 South Preston Street, Louisville, KY, USA
Cancer Res 67:186-93. 2007..This functional interdependence between HIF-1alpha and MIF may represent an important and previously unrecognized pro-tumorigenic axis... - Hypoxia and the unfolded protein responseConstantinos Koumenis
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Methods Enzymol 435:275-93. 2007.... - Multiplexed proximity ligation assays to profile putative plasma biomarkers relevant to pancreatic and ovarian cancerSimon Fredriksson
Stanford Genome Technology Center, Bio X, Stanford University, Stanford, CA, USA
Clin Chem 54:582-9. 2008..Sensitive methods are needed for biomarker discovery and validation. We tested one promising technology, multiplex proximity ligation assay (PLA), in a pilot study profiling plasma biomarkers in pancreatic and ovarian cancer... - Results of a phase I dose-escalation study using single-fraction stereotactic radiotherapy for lung tumorsQuynh Thu Le
Department of Radiation Oncology, Stanford University, Stanford, California, USA
J Thorac Oncol 1:802-9. 2006..The purpose of this study was to report initial results of a phase I study using single-fraction stereotactic radiotherapy (RT) in patients with inoperable lung tumors... - Multiplexed protein detection by proximity ligation for cancer biomarker validationSimon Fredriksson
Stanford Genome Technology Center, Stanford, California 94305, USA
Nat Methods 4:327-9. 2007..The procedure can use a single polyclonal antibody batch for each target protein, simplifying affinity-reagent creation for new biomarker candidates... - High-dose single-fraction radiotherapy: exploiting a new biology?J Martin Brown
Int J Radiat Oncol Biol Phys 71:324-5. 2008 - Identification of mitogen-activated protein kinase signaling pathways that confer resistance to endoplasmic reticulum stress in Saccharomyces cerevisiaeYijun Chen
Department of Radiation Oncology, Center for Clinical Sciences Research, Stanford University Medical Center, Stanford, CA 94305, USA
Mol Cancer Res 3:669-77. 2005..We propose that the SLT2 MAPK pathway is an important cell survival signaling pathway during ER stress. This study shows the feasibility of using the yeast deletion pool to identify relevant mammalian orthologues of the UPR... - The use of plasma surface-enhanced laser desorption/ionization time-of-flight mass spectrometry proteomic patterns for detection of head and neck squamous cell cancersScott G Soltys
Department of Radiation Oncology, and Health Policy and Research, Stanford University, Stanford, California 94305-5847, USA
Clin Cancer Res 10:4806-12. 2004..Further improvement and validation of this approach is needed to determine its usefulness in screening for this disease... - Stereotactic body radiotherapy for unresectable pancreatic cancerStephanie T Chang
Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
Front Radiat Ther Oncol 40:386-94. 2007..SBRT is an effective method of treating patients resulting in excellent local control. Current research is aimed at defining the optimal method of combining this treatment with other cancer therapies...
Research Grants
- The Role of XBP1 During Hypoxia and Tumor GrowthAlbert Koong; Fiscal Year: 2007..Ultimately, these studies may not only lead to the development of novel anticancer therapies based upon inhibition of XBP1 in tumors, but may also provide fundamental insights into our understanding of tumorigenesis. ..