Holbrook E Kohrt

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint An ecological-transactional model of significant risk factors for child psychopathology in outer mongolia
    Holbrook E Kohrt
    Division of Child and Adolescent Psychiatry and Child Development, Stanford University School of Medicine, 401 Quarry Road, MC 5719, Stanford, CA 94305, USA
    Child Psychiatry Hum Dev 35:163-81. 2004
  2. pmc New models and online calculator for predicting non-sentinel lymph node status in sentinel lymph node positive breast cancer patients
    Holbrook E Kohrt
    Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA
    BMC Cancer 8:66. 2008
  3. pmc Donor immunization with WT1 peptide augments antileukemic activity after MHC-matched bone marrow transplantation
    Holbrook E Kohrt
    Department of Medicine, Division of Blood and Marrow Transplantation, Stanford University, CA, USA
    Blood 118:5319-29. 2011
  4. pmc Stimulation of natural killer cells with a CD137-specific antibody enhances trastuzumab efficacy in xenotransplant models of breast cancer
    Holbrook E Kohrt
    Department of Medicine, Division of Oncology, Stanford University, Stanford, California, USA
    J Clin Invest 122:1066-75. 2012
  5. pmc Combination strategies to enhance antitumor ADCC
    Holbrook E Kohrt
    Department of Medicine, Division of Oncology, Stanford University, Stanford, CA, USA
    Immunotherapy 4:511-27. 2012
  6. pmc Treatment advances have not improved the early death rate in acute promyelocytic leukemia
    James Scott McClellan
    Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305 5821, USA
    Haematologica 97:133-6. 2012
  7. pmc High PD-1 expression and suppressed cytokine signaling distinguish T cells infiltrating follicular lymphoma tumors from peripheral T cells
    June H Myklebust
    Department of Medicine, Oncology Division, Stanford University, Stanford, CA, USA
    Blood 121:1367-76. 2013
  8. pmc Rapid development of exhaustion and down-regulation of eomesodermin limit the antitumor activity of adoptively transferred murine natural killer cells
    Saar Gill
    Divisions of Blood and Marrow Transplantation, Stanford University, Stanford, CA 94305, USA
    Blood 119:5758-68. 2012
  9. doi request reprint Tailored temozolomide therapy according to MGMT methylation status for elderly patients with acute myeloid leukemia
    Bruno C Medeiros
    Department of Medicine, Division of Hematology, Stanford University School of Medicine, California, USA
    Am J Hematol 87:45-50. 2012
  10. pmc CD137 stimulation enhances the antilymphoma activity of anti-CD20 antibodies
    Holbrook E Kohrt
    Department of Medicine, Division of Oncology, Stanford University Medical Center, Stanford, CA 94305, USA
    Blood 117:2423-32. 2011

Detail Information

Publications28

  1. ncbi request reprint An ecological-transactional model of significant risk factors for child psychopathology in outer mongolia
    Holbrook E Kohrt
    Division of Child and Adolescent Psychiatry and Child Development, Stanford University School of Medicine, 401 Quarry Road, MC 5719, Stanford, CA 94305, USA
    Child Psychiatry Hum Dev 35:163-81. 2004
    ..Structural equation modeling provides a useful technique to isolate specific sites for intervention, while maintaining a comprehensive perspective of risk factor interaction...
  2. pmc New models and online calculator for predicting non-sentinel lymph node status in sentinel lymph node positive breast cancer patients
    Holbrook E Kohrt
    Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA
    BMC Cancer 8:66. 2008
    ..Our goal was to develop new models to quantify the risk of NSLN metastasis in SLN-positive patients and to compare predictive capabilities to another widely used model...
  3. pmc Donor immunization with WT1 peptide augments antileukemic activity after MHC-matched bone marrow transplantation
    Holbrook E Kohrt
    Department of Medicine, Division of Blood and Marrow Transplantation, Stanford University, CA, USA
    Blood 118:5319-29. 2011
    ..These findings show that WT1 peptide vaccination of donor mice can dramatically enhance GvT activity after MHC-matched allogeneic BMT...
  4. pmc Stimulation of natural killer cells with a CD137-specific antibody enhances trastuzumab efficacy in xenotransplant models of breast cancer
    Holbrook E Kohrt
    Department of Medicine, Division of Oncology, Stanford University, Stanford, California, USA
    J Clin Invest 122:1066-75. 2012
    ....
  5. pmc Combination strategies to enhance antitumor ADCC
    Holbrook E Kohrt
    Department of Medicine, Division of Oncology, Stanford University, Stanford, CA, USA
    Immunotherapy 4:511-27. 2012
    ....
  6. pmc Treatment advances have not improved the early death rate in acute promyelocytic leukemia
    James Scott McClellan
    Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305 5821, USA
    Haematologica 97:133-6. 2012
    ..Our findings show that early death is now the greatest contributor to treatment failure in this otherwise highly curable form of leukemia...
  7. pmc High PD-1 expression and suppressed cytokine signaling distinguish T cells infiltrating follicular lymphoma tumors from peripheral T cells
    June H Myklebust
    Department of Medicine, Oncology Division, Stanford University, Stanford, CA, USA
    Blood 121:1367-76. 2013
    ..Because FL TILs in vivo probably receive suppressive signals through PD-1, this provides a rationale for testing PD-1 Ab in combination with immunotherapy in patients with FL...
  8. pmc Rapid development of exhaustion and down-regulation of eomesodermin limit the antitumor activity of adoptively transferred murine natural killer cells
    Saar Gill
    Divisions of Blood and Marrow Transplantation, Stanford University, Stanford, CA 94305, USA
    Blood 119:5758-68. 2012
    ..Further, novel approaches may be required to circumvent the described dysfunctional phenotype...
  9. doi request reprint Tailored temozolomide therapy according to MGMT methylation status for elderly patients with acute myeloid leukemia
    Bruno C Medeiros
    Department of Medicine, Division of Hematology, Stanford University School of Medicine, California, USA
    Am J Hematol 87:45-50. 2012
    ..The trial was registered on www.ClinicalTrials.gov as #NCT00611247...
  10. pmc CD137 stimulation enhances the antilymphoma activity of anti-CD20 antibodies
    Holbrook E Kohrt
    Department of Medicine, Division of Oncology, Stanford University Medical Center, Stanford, CA 94305, USA
    Blood 117:2423-32. 2011
    ..These results support a novel, sequential antibody approach against B-cell malignancies by targeting first the tumor and then the host immune system...
  11. pmc Quantitative, architectural analysis of immune cell subsets in tumor-draining lymph nodes from breast cancer patients and healthy lymph nodes
    A Francesca Setiadi
    Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 5:e12420. 2010
    ..To gain additional mechanistic and prognostic insights, a need for quantitative architectural analysis arises in studying immune cell-cancer interactions within the tumor microenvironment and tumor-draining lymph nodes (TDLNs)...
  12. pmc Prediction of survival in diffuse large B-cell lymphoma based on the expression of 2 genes reflecting tumor and microenvironment
    Ash A Alizadeh
    Department of Medicine, Division of Oncology, Stanford University, Stanford, CA, USA
    Blood 118:1350-8. 2011
    ..We conclude that the measurement of a single gene expressed by tumor cells (LMO2) and a single gene expressed by the immune microenvironment (TNFRSF9) powerfully predicts overall survival in patients with DLBCL...
  13. pmc CD8+CD44(hi) but not CD4+CD44(hi) memory T cells mediate potent graft antilymphoma activity without GVHD
    Suparna Dutt
    Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Blood 117:3230-9. 2011
    ..In conclusion, the memory CD8(+) T-cell subset separated graft antilymphoma activity from GVHD more effectively than naive T cells, memory CD4(+) T cells, or memory total T cells...
  14. pmc Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma
    Mark P Chao
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford Cancer Center, and Ludwig Center at Stanford, Stanford University, Palo Alto, CA 94304, USA
    Cell 142:699-713. 2010
    ..These antibodies synergized through a mechanism combining Fc receptor (FcR)-dependent and FcR-independent stimulation of phagocytosis that might be applicable to many other cancers...
  15. pmc Anti-KIR antibody enhancement of anti-lymphoma activity of natural killer cells as monotherapy and in combination with anti-CD20 antibodies
    Holbrook E Kohrt
    Department of Medicine, Division of Oncology, Stanford University, Stanford, CA
    Blood 123:678-86. 2014
    ....
  16. ncbi request reprint Identification of gene microarray expression profiles in patients with chronic graft-versus-host disease following allogeneic hematopoietic cell transplantation
    Holbrook E Kohrt
    Department of Medicine Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 USA
    Clin Immunol 148:124-35. 2013
    ..In addition, we identified three genes that were important regulators of extracellular matrix. Validation of this discovery phase study will determine if the identified genes have diagnostic, prognostic or therapeutic implications...
  17. pmc Adoptive cell therapy for lymphoma with CD4 T cells depleted of CD137-expressing regulatory T cells
    Matthew J Goldstein
    Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
    Cancer Res 72:1239-47. 2012
    ..In conclusion, our findings identify 2 surface markers that can be used to facilitate the enrichment of antitumor CD4 T cells while depleting an inhibitory T(reg) population...
  18. pmc Cytotoxic T lymphocyte responses against melanocytes and melanoma
    Gwendolen Y Chang
    Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, California, USA
    J Transl Med 9:122. 2011
    ..To uncouple vitiligo from melanoma destruction, it is important to understand if CTLs can respond against melanoma and melanocytes at different levels...
  19. doi request reprint Acute myeloid leukaemia in the elderly: a review
    Daniel A Pollyea
    Divisions of Hematology and Oncology, Department of Internal Medicine, University Cancer Center, Stanford University School of Medicine, 875 Blake Wilbur Drive, Stanford, CA 94305, USA
    Br J Haematol 152:524-42. 2011
    ..Elderly patients, with their narrow therapeutic window, are well positioned to derive a benefit from these novel agents, and therefore, despite a difficult past, there are reasons to be optimistic about the future of elderly AML...
  20. doi request reprint Second-line mitoxantrone, etoposide, and cytarabine for acute myeloid leukemia: a single-center experience
    Holbrook E Kohrt
    Department of Medicine, Division of Hematology, Stanford University, Stanford, CA 94305, USA
    Am J Hematol 85:877-81. 2010
    ..3 and 7.6 months, P = 0.36). Despite risk stratification by the European Prognostic Index, our series demonstrates inferior rates of response and survival, illustrating the limited activity of this regimen in our cohort...
  21. pmc Profile of immune cells in axillary lymph nodes predicts disease-free survival in breast cancer
    Holbrook E Kohrt
    Division of Hematology, Department of Medicine, Stanford University, Stanford, California, USA
    PLoS Med 2:e284. 2005
    ....
  22. pmc The chemoattractant chemerin suppresses melanoma by recruiting natural killer cell antitumor defenses
    Russell K Pachynski
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 209:1427-35. 2012
    ....
  23. pmc TLI and ATG conditioning with low risk of graft-versus-host disease retains antitumor reactions after allogeneic hematopoietic cell transplantation from related and unrelated donors
    Holbrook E Kohrt
    Department of Medicine, Stanford University School of Medicine, CA 94305, USA
    Blood 114:1099-109. 2009
    ..Active trial registration currently at clinicaltrials.gov under IDs of NCT00185640 and NCT00186615...
  24. pmc Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by Treg depletion
    Roch Houot
    Department of Medicine, Division of Oncology, Stanford University, CA, USA
    Blood 114:3431-8. 2009
    ..Moreover, the antitumor activity of anti-CD137 mAb could be further enhanced by depletion of regulatory T cell (T(regs)). These results support the evaluation of anti-CD137 therapy in clinical trials for patients with lymphoma...
  25. doi request reprint Immunophenotypic features of acute myeloid leukemia with inv(3)(q21q26.2)/t(3;3)(q21;q26.2)
    Bruno C Medeiros
    Department of Medicine, Division of Hematology, Stanford University, Stanford, CA, USA
    Leuk Res 34:594-7. 2010
    ..2). Differential karyotype and expression of certain antigens were noted in patients with de novo AML with inv(3)(q21q26.2) vs. those with inv(3)(q21q26.2)-containing blasts...
  26. pmc NKT cells, Treg, and their interactions in bone marrow transplantation
    Holbrook E Kohrt
    Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Eur J Immunol 40:1862-9. 2010
    ..In addition, we also examine the interactions between NKT cells and Treg in the context of BMT, and integrate the data from murine experimental models with the observations made in humans...
  27. ncbi request reprint Rapid assessment of recognition efficiency and functional capacity of antigen-specific T-cell responses
    Holbrook E Kohrt
    Department of Medicine, Division of Hematology, Stanford University, Stanford, California 94305, USA
    J Immunother 28:297-305. 2005
    ..Techniques, as presented here, that rapidly assess the overall antigen sensitivity, recognition efficiency, and functional status of patients' T-cell responses will guide future vaccine trials and immunotherapies...
  28. ncbi request reprint Distribution of distress in post-socialist Mongolia: a cultural epidemiology of yadargaa
    Brandon A Kohrt
    Department of Anthropology, Emory University, 1557 Pierce Drive, Atlanta, GA 30322, USA
    Soc Sci Med 58:471-85. 2004
    ..In conclusion, yadargaa strongly associates with disenfranchised groups in the capitalist economy. As a culturally constructed indicator of quality of life, yadargaa is a window into the lives of women and men in post-socialist Mongolia...