Joshua W Knowles

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. doi request reprint Measurement of insulin-mediated glucose uptake: direct comparison of the modified insulin suppression test and the euglycemic, hyperinsulinemic clamp
    Joshua W Knowles
    Stanford University, Division of Cardiovascular Medicine, Falk CVRC, 300 Pasteur Dr, Stanford, CA 94305 5406, USA
    Metabolism 62:548-53. 2013
  2. pmc Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD
    Joshua W Knowles
    Division of Cardiovascular Medicine, Falk Cardiovascular Research Building, Stanford University School of Medicine, Stanford, CA 94305 5406, USA
    BMC Med Genet 9:23. 2008
  3. doi request reprint Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease
    Themistocles L Assimes
    Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Hum Genet 123:399-408. 2008
  4. pmc Characterizing the admixed African ancestry of African Americans
    Fouad Zakharia
    Department of Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Genome Biol 10:R141. 2009
  5. pmc Phased whole-genome genetic risk in a family quartet using a major allele reference sequence
    Frederick E Dewey
    Center for Inherited Cardiovascular Disease, Division of Cardiovascular Medicine, Stanford University, Stanford, California, USA
    PLoS Genet 7:e1002280. 2011
  6. pmc Susceptibility locus for clinical and subclinical coronary artery disease at chromosome 9p21 in the multi-ethnic ADVANCE study
    Themistocles L Assimes
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5406, USA
    Hum Mol Genet 17:2320-8. 2008
  7. ncbi request reprint Association of polymorphisms in platelet and hemostasis system genes with acute myocardial infarction
    Joshua W Knowles
    Stanford University School of Medicine, Stanford, CA 94305 5405, USA
    Am Heart J 154:1052-8. 2007
  8. doi request reprint Latent obstruction and left atrial size are predictors of clinical deterioration leading to septal reduction in hypertrophic cardiomyopathy
    Gherardo Finocchiaro
    Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Palo Alto, California Electronic address
    J Card Fail 20:236-43. 2014
  9. ncbi request reprint Genetic susceptibility to peripheral arterial disease: a dark corner in vascular biology
    Joshua W Knowles
    Falk Cardiovascular Research Building, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94305 5406, USA
    Arterioscler Thromb Vasc Biol 27:2068-78. 2007
  10. doi request reprint Exploring predisposition and treatment response--the promise of genomics
    Stephen Pan
    Biomedical Informatics Training Program, Stanford University, Stanford, CA, USA
    Prog Cardiovasc Dis 55:56-63. 2012

Detail Information

Publications20

  1. doi request reprint Measurement of insulin-mediated glucose uptake: direct comparison of the modified insulin suppression test and the euglycemic, hyperinsulinemic clamp
    Joshua W Knowles
    Stanford University, Division of Cardiovascular Medicine, Falk CVRC, 300 Pasteur Dr, Stanford, CA 94305 5406, USA
    Metabolism 62:548-53. 2013
    ..To determine the agreement between SSPG and M and to develop transformation equations to convert SSPG to M and vice versa, we directly compared these two measurements in the same individuals...
  2. pmc Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD
    Joshua W Knowles
    Division of Cardiovascular Medicine, Falk Cardiovascular Research Building, Stanford University School of Medicine, Stanford, CA 94305 5406, USA
    BMC Med Genet 9:23. 2008
    ..We tested whether single nucleotide polymorphisms (SNPs) in OLR1 are associated with clinically significant CAD in the Atherosclerotic Disease, VAscular FuNction, & Geneti C Epidemiology (ADVANCE) study...
  3. doi request reprint Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease
    Themistocles L Assimes
    Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Hum Genet 123:399-408. 2008
    ..However, additional studies are needed to exclude modest effects of promoter variation in ALOX5 on the risk of CAD assuming a recessive mode of inheritance...
  4. pmc Characterizing the admixed African ancestry of African Americans
    Fouad Zakharia
    Department of Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Genome Biol 10:R141. 2009
    ..To focus on African ancestry, we reduced the data to include only those genotypes in each African American determined statistically to be African in origin...
  5. pmc Phased whole-genome genetic risk in a family quartet using a major allele reference sequence
    Frederick E Dewey
    Center for Inherited Cardiovascular Disease, Division of Cardiovascular Medicine, Stanford University, Stanford, California, USA
    PLoS Genet 7:e1002280. 2011
    ..These ethnicity-specific, family-based approaches to interpretation of genetic variation are emblematic of the next generation of genetic risk assessment using whole-genome sequencing...
  6. pmc Susceptibility locus for clinical and subclinical coronary artery disease at chromosome 9p21 in the multi-ethnic ADVANCE study
    Themistocles L Assimes
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5406, USA
    Hum Mol Genet 17:2320-8. 2008
    ..Further investigations in other populations are needed to confirm or refute our findings...
  7. ncbi request reprint Association of polymorphisms in platelet and hemostasis system genes with acute myocardial infarction
    Joshua W Knowles
    Stanford University School of Medicine, Stanford, CA 94305 5405, USA
    Am Heart J 154:1052-8. 2007
    ..Genetic polymorphisms may affect the balance between coagulation and fibrinolysis and thereby affect individual vulnerability to acute myocardial infarction (MI) among patients with underlying coronary atherosclerosis...
  8. doi request reprint Latent obstruction and left atrial size are predictors of clinical deterioration leading to septal reduction in hypertrophic cardiomyopathy
    Gherardo Finocchiaro
    Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Palo Alto, California Electronic address
    J Card Fail 20:236-43. 2014
    ..The aim of this study was to determine the role of exercise echocardiography in the evaluation of latent obstruction and in predicting clinical deterioration in HCM patients...
  9. ncbi request reprint Genetic susceptibility to peripheral arterial disease: a dark corner in vascular biology
    Joshua W Knowles
    Falk Cardiovascular Research Building, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94305 5406, USA
    Arterioscler Thromb Vasc Biol 27:2068-78. 2007
    ..We discuss the advantages and limitations of genetic studies and highlight the need for collaborative networks of PAD investigators for shedding light on this dark corner of vascular biology...
  10. doi request reprint Exploring predisposition and treatment response--the promise of genomics
    Stephen Pan
    Biomedical Informatics Training Program, Stanford University, Stanford, CA, USA
    Prog Cardiovasc Dis 55:56-63. 2012
    ....
  11. doi request reprint Unexplained double-chambered left ventricle associated with contracting right ventricular aneurysm and right atrial enlargement
    Gherardo Finocchiaro
    Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California
    Echocardiography 31:E80-4. 2014
    ..We will discuss the differential diagnosis, genetic testing and possible prognostic implications. ..
  12. pmc Clinical assessment incorporating a personal genome
    Euan A Ashley
    Center for Inherited Cardiovascular Disease, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Lancet 375:1525-35. 2010
    ..The cost of genomic information has fallen steeply, but the clinical translation of genetic risk estimates remains unclear. We aimed to undertake an integrated analysis of a complete human genome in a clinical context...
  13. pmc A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease
    Themistocles L Assimes
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5406, USA
    Atherosclerosis 198:136-44. 2008
    ..We tested the hypothesis that exonic and/or promoter single nucleotide polymorphisms (SNPs) in the human 12/15-LOX gene (ALOX15) alter the risk of symptomatic coronary artery disease (CAD)...
  14. doi request reprint Pharmacogenetics of heart failure: evidence, opportunities, and challenges for cardiovascular pharmacogenomics
    Matthew T Wheeler
    Division of Cardiovascular Medicine, Department of Medicine, Stanford University, 300 Pasteur Drive, Falk CVRC MC 5406, Stanford, CA 94305, USA
    J Cardiovasc Transl Res 1:25-36. 2008
    ..With the dawn of the genomic age, further pharmacogenetic and new pharmacogenomic studies will advance our ability to tailor the treatment of heart failure...
  15. doi request reprint Prevalence and clinical correlates of right ventricular dysfunction in patients with hypertrophic cardiomyopathy
    Gherardo Finocchiaro
    Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California Electronic address
    Am J Cardiol 113:361-7. 2014
    ..RV dysfunction based on the TAPSE was independently associated with an increased likelihood of death or transplantation. ..
  16. pmc Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations
    Marc A Coram
    Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA
    Am J Hum Genet 92:904-16. 2013
    ....
  17. pmc The evolution and refinement of traditional risk factors for cardiovascular disease
    Emil M deGoma
    Division of Cardiovascular Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA
    Cardiol Rev 20:118-29. 2012
    ....
  18. pmc Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies
    Themistocles L Assimes
    Department of Medicine, Stanford University School of Medicine, Stanford, California 94304 1334, USA
    J Am Coll Cardiol 56:1552-63. 2010
    ..We sought to replicate the association between the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism (rs20455), and clinical coronary artery disease (CAD)...
  19. pmc Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity
    Ping Liang
    Stanford University School of Medicine, Lorry I Lokey Stem Cell Research Building, 265 Campus Drive, Stanford, CA 94305 5111
    Circulation 127:1677-91. 2013
    ....
  20. ncbi request reprint Increased atherosclerosis and smooth muscle cell hypertrophy in natriuretic peptide receptor A-/-apolipoprotein E-/- mice
    Matthew R Alexander
    Department of Pathology and Laboratory Medicine, University of North Carolina, 710 Brinkhous Bullitt Bldg, Chapel Hill, NC 27599 7525, USA
    Arterioscler Thromb Vasc Biol 23:1077-82. 2003
    ..To examine the role of natriuretic peptide signaling in atherosclerosis, we crossbred mice that lack natriuretic peptide receptor A (NPRA; Npr1-/-) with atherosclerosis-prone mice that lack apolipoprotein E (apoE; Apoe-/-)...