Seung Kim

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Specification of Drosophila corpora cardiaca neuroendocrine cells from mesoderm is regulated by Notch signaling
    Sangbin Park
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Genet 7:e1002241. 2011
  2. doi request reprint Gut insulin from Foxo1 loss
    Seung K Kim
    Departments of Developmental Biology and Medicine, Oncology Division, Stanford University School of Medicine, Stanford, California, USA
    Nat Genet 44:363-4. 2012
  3. ncbi request reprint Signaling and transcriptional control of pancreatic organogenesis
    Seung K Kim
    Departments of Developmental Biology and Medicine Oncology Division, Stanford UniversityStanford, California, 94305 5329, USA
    Curr Opin Genet Dev 12:540-7. 2002
  4. pmc Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus
    Nora G Smart
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA
    PLoS Biol 4:e39. 2006
  5. ncbi request reprint Intrinsic regulators of pancreatic beta-cell proliferation
    Jeremy J Heit
    Departments of Developmental Biology and Medicine Oncology Division, Stanford University School of Medicine, Stanford, California 94305, USA
    Annu Rev Cell Dev Biol 22:311-38. 2006
  6. ncbi request reprint Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus
    Seung K Kim
    Department of Developmental Biology, Beckman Center B300, Stanford University School of Medicine, Stanford, California 94305 5329, USA
    Nat Genet 30:430-5. 2002
  7. ncbi request reprint Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes
    Eric J Rulifson
    Department of Developmental Biology, Beckman Center B300, Stanford University, Stanford, CA 94305 5329, USA
    Science 296:1118-20. 2002
  8. ncbi request reprint Pancreatic islet cell replacement: successes and opportunities
    Seung K Kim
    Beckman Center Room B300, Mail Stop 5329, Stanford University, 279 Campus Drive, Stanford, CA 94305, USA
    Ann N Y Acad Sci 961:41-3. 2002
  9. ncbi request reprint Conserved mechanisms of glucose sensing and regulation by Drosophila corpora cardiaca cells
    Seung K Kim
    Department of Developmental Biology, Stanford University School of Medicine, Beckman Center B300, Stanford, California 94305 5329, USA
    Nature 431:316-20. 2004
  10. pmc Differentiation of insulin-producing cells from human neural progenitor cells
    Yuichi Hori
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA
    PLoS Med 2:e103. 2005

Collaborators

  • Rolf Bodmer
  • Eric J Rulifson
  • R Nusse
  • Yuichi Hori
  • Licia Selleri
  • Matthias Hebrok
  • John D Cahoy
  • Laura C Alonso
  • Lei Chen
  • Uta Francke
  • Gerald R Crabtree
  • I Lemischka
  • Denise Faustman
  • Jeremy J Heit
  • Satyajit K Karnik
  • Xueying Gu
  • Graeme W McLean
  • Nora G Smart
  • Asa A Apelqvist
  • Erin B Harmon
  • Sangbin Park
  • Erika L Bustamante
  • SHAWN L CHAVEZ
  • Takuya Sugiyama
  • Hainan Chen
  • Ingrid C Rulifson
  • Ping La
  • Monte M Winslow
  • Takeshi Akasaka
  • Joel R Neilson
  • Joseph R Arron
  • Julie Antonova
  • Ha Nam Nguyen
  • Renee A Reijo Pera
  • Juanito J Meneses
  • Albert C Silva
  • Michael H Yen
  • Ryan T Rodriguez
  • Derk ten Berge
  • Xianxin Hua
  • Patrick W Heiser
  • Yuqing Yang
  • Robert W Schnepp
  • Andrew Y Zhang
  • Makoto M Taketo
  • Magali Fontaine
  • Isabella A Graef
  • James N Topper
  • Raymond J Macdonald
  • Hai Wu
  • Susan Klinedinst
  • Nobuyuki Yamasaki
  • Alberto Polleri
  • Ching Pin Chang
  • Xin Gao
  • Karen Ocorr
  • Tsuyoshi Miyakawa
  • Orit Rozenblatt-Rosen
  • Yue Xiong
  • Christina M Hughes
  • Matthew Meyerson
  • Douglas H Osborne

Detail Information

Publications25

  1. pmc Specification of Drosophila corpora cardiaca neuroendocrine cells from mesoderm is regulated by Notch signaling
    Sangbin Park
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Genet 7:e1002241. 2011
    ..Understanding the cellular, genetic, signaling, and transcriptional basis of CC cell specification and expansion should accelerate discovery of molecular mechanisms regulating ontogeny of organs that control metabolism...
  2. doi request reprint Gut insulin from Foxo1 loss
    Seung K Kim
    Departments of Developmental Biology and Medicine, Oncology Division, Stanford University School of Medicine, Stanford, California, USA
    Nat Genet 44:363-4. 2012
    ..Ectopic gut insulin production was sufficient to ameliorate glucose control in mice with conditional pancreatic β-cell loss and diabetes mellitus...
  3. ncbi request reprint Signaling and transcriptional control of pancreatic organogenesis
    Seung K Kim
    Departments of Developmental Biology and Medicine Oncology Division, Stanford UniversityStanford, California, 94305 5329, USA
    Curr Opin Genet Dev 12:540-7. 2002
    ..Two, largely independent endocrine cell lineages develop during the formation of the embryonic pancreas. Lineage tracing has begun to refine our understanding of the origins of the acinar, ductal and islet cells...
  4. pmc Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus
    Nora G Smart
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA
    PLoS Biol 4:e39. 2006
    ..Thus, our studies reveal that TGF-beta signaling is crucial for establishing and maintaining defining features of mature pancreatic beta cells...
  5. ncbi request reprint Intrinsic regulators of pancreatic beta-cell proliferation
    Jeremy J Heit
    Departments of Developmental Biology and Medicine Oncology Division, Stanford University School of Medicine, Stanford, California 94305, USA
    Annu Rev Cell Dev Biol 22:311-38. 2006
    ..We speculate on how these advances may accelerate the discovery of new strategies for the treatment of diseases characterized by a deficiency or excess of beta-cells...
  6. ncbi request reprint Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus
    Seung K Kim
    Department of Developmental Biology, Beckman Center B300, Stanford University School of Medicine, Stanford, California 94305 5329, USA
    Nat Genet 30:430-5. 2002
    ..Mutations affecting the Ipf1 protein may promote diabetes mellitus in mice and humans. This study suggests that perturbation of Pbx1 activity may also promote susceptibility to diabetes mellitus...
  7. ncbi request reprint Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes
    Eric J Rulifson
    Department of Developmental Biology, Beckman Center B300, Stanford University, Stanford, CA 94305 5329, USA
    Science 296:1118-20. 2002
    ..Interestingly, the phenotype of flies lacking IPCs includes certain features of diabetes mellitus...
  8. ncbi request reprint Pancreatic islet cell replacement: successes and opportunities
    Seung K Kim
    Beckman Center Room B300, Mail Stop 5329, Stanford University, 279 Campus Drive, Stanford, CA 94305, USA
    Ann N Y Acad Sci 961:41-3. 2002
  9. ncbi request reprint Conserved mechanisms of glucose sensing and regulation by Drosophila corpora cardiaca cells
    Seung K Kim
    Department of Developmental Biology, Stanford University School of Medicine, Beckman Center B300, Stanford, California 94305 5329, USA
    Nature 431:316-20. 2004
    ..Thus, Drosophila CC cells are crucial regulators of glucose homeostasis and they use glucose-sensing and response mechanisms similar to islet cells...
  10. pmc Differentiation of insulin-producing cells from human neural progenitor cells
    Yuichi Hori
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA
    PLoS Med 2:e103. 2005
    ..Islets and neurons share features, including common developmental programs, and in some species brain neurons are the principal source of systemic insulin...
  11. ncbi request reprint GDF11 modulates NGN3+ islet progenitor cell number and promotes beta-cell differentiation in pancreas development
    Erin B Harmon
    Department of Developmental Biology, Stanford University, Stanford, CA 94305 5329, USA
    Development 131:6163-74. 2004
    ..Thus, our studies reveal mechanisms by which GDF11 regulates the production and maturation of islet progenitor cells in pancreas development...
  12. ncbi request reprint Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitus
    Satyajit K Karnik
    Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA
    Science 318:806-9. 2007
    ..These results expand our understanding of mechanisms underlying diabetes pathogenesis and reveal potential targets for therapy in diabetes...
  13. pmc Wnt signaling regulates pancreatic beta cell proliferation
    Ingrid C Rulifson
    Department of Developmental Biology, Oncology Division, Stanford University, Stanford, CA 94305 5329, USA
    Proc Natl Acad Sci U S A 104:6247-52. 2007
    ..Thus, Wnt signaling is both necessary and sufficient for islet beta cell proliferation, and our study provides previously unrecognized evidence of a mechanism governing endocrine pancreas growth and function...
  14. pmc Conserved markers of fetal pancreatic epithelium permit prospective isolation of islet progenitor cells by FACS
    Takuya Sugiyama
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5329, USA
    Proc Natl Acad Sci U S A 104:175-80. 2007
    ..Our studies reveal previously undescribed strategies for prospective purification and analysis of pancreatic endocrine progenitor cells that should accelerate studies of islet development and replacement...
  15. ncbi request reprint NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21
    Joseph R Arron
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 441:595-600. 2006
    ..More generally, these observations suggest that the destabilization of regulatory circuits can underlie human disease...
  16. pmc Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c
    Satyajit K Karnik
    Departments of Developmental Biology and Medicine Oncology Division, Stanford University School of Medicine, Stanford, CA 94305 5329
    Proc Natl Acad Sci U S A 102:14659-64. 2005
    ..These studies suggest an epigenetic mechanism of tumor suppression: by promoting histone modifications, menin maintains transcription at multiple loci encoding cell cycle regulators essential for endocrine growth control...
  17. pmc Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells
    Yuichi Hori
    Department of Developmental Biology and Division of Oncology, Department of Medicine, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 99:16105-10. 2002
    ..Strategies for producing cells that can replace islet functions described here can be adapted for similar uses with human cells...
  18. pmc The ATP-sensitive potassium (KATP) channel-encoded dSUR gene is required for Drosophila heart function and is regulated by tinman
    Takeshi Akasaka
    Del E Webb Center for Neurosciences and Aging, The Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:11999-2004. 2006
    ..dSUR provides a model for addressing how embryonic regulators of myocardial cell commitment can contribute to the establishment and maintenance of cardiac performance...
  19. ncbi request reprint Cells for repair: breakout session summary
    Denise L Faustman
    Immunology Laboratory, Massachusetts General Hospital, Harvard Medical School, Building 149 Room 3601, Thirteenth Street, Charlestown, MA 02129, USA
    Ann N Y Acad Sci 961:45-7. 2002
  20. pmc Menin-mediated caspase 8 expression in suppressing multiple endocrine neoplasia type 1
    Ping La
    Abramson Family Cancer Research Institute, Department of Cancer Biology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6160, USA
    J Biol Chem 282:31332-40. 2007
    ..Together, our results indicate that menin enhances the caspase 8 expression by binding the caspase 8 locus, and suggest that menin suppresses MEN1 tumorigenesis, at least in part, by up-regulating caspase 8 expression...
  21. pmc Glucose infusion in mice: a new model to induce beta-cell replication
    Laura C Alonso
    University of Pittsburgh, Division of Endocrinology, 200 Lothrop St, BST E1140, Pittsburgh, PA 15261, USA
    Diabetes 56:1792-801. 2007
    ..Thus, we have developed a new model to study the regulation of compensatory beta-cell replication, and we describe important novel characteristics of mouse beta-cell responses to glucose in the living pancreas...
  22. doi request reprint Characterization of six new human embryonic stem cell lines (HSF7, -8, -9, -10, -12, and -13) derived under minimal-animal component conditions
    SHAWN L CHAVEZ
    Department of Obstetrics, Gynecology and Reproductive Sciences, Center for Reproductive Sciences, University of California, San Francisco, San Francisco, CA 94143 0556, USA
    Stem Cells Dev 17:535-46. 2008
    ..This suggests that the hESC lines described here are valuable models for both future in vitro and in vivo studies, which may aid in the progression toward clinical-grade cell therapy...
  23. ncbi request reprint Embryonic stem cells and islet replacement in diabetes mellitus
    Jeremy J Heit
    Department of Developmental Biology, Stanford University, 279 Campus Drive, Stanford, CA 94305, USA
    Pediatr Diabetes 5:5-15. 2004
    ..In this study, we review the recent advances in generating insulin-producing cells (IPC) from mouse and human ES (hES) cells...
  24. ncbi request reprint Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function
    Jeremy J Heit
    Department of Developmental Biology, Stanford University, Stanford, California 94305, USA
    Nature 443:345-9. 2006
    ..Thus, calcineurin/NFAT signalling regulates multiple factors that control growth and hallmark beta-cell functions, revealing unique models for the pathogenesis and therapy of diabetes...

Research Grants15

  1. Control of Pancreas Growth/Development
    Seung Kim; Fiscal Year: 2001
    ..The genetic, molecular and physiologic analyses of Smad2-mediated TGF-beta signaling will add to our understanding of the principles of vertebrate organogenesis, and may lead to new cell-replacement strategies for diabetes mellitus. ..
  2. Regulation of Facultative Islet Growth and Development by Calcineurin and NFAT
    Seung K Kim; Fiscal Year: 2010
    ..Thus, these studies may lead to new diagnostic, prognostic, or therapeutic strategies for a broad range of human diseases, including neuro-endocrine tumors, and diabetes mellitus. ..
  3. Men1 Control of Endocrine Cell Growth and Differentiation
    Seung K Kim; Fiscal Year: 2010
    ....
  4. Regulation of Facultative Islet Growth and Development by Calcineurin and NFAT
    Seung Kim; Fiscal Year: 2009
    ..Thus, these studies may lead to new diagnostic, prognostic, or therapeutic strategies for a broad range of human diseases, including neuro-endocrine tumors, and diabetes mellitus. ..
  5. Men1 Control of Endocrine Cell Growth and Differentiation
    Seung Kim; Fiscal Year: 2009
    ....
  6. Regulation of Facultative Islet Growth and Development by Calcineurin and NFAT
    Seung Kim; Fiscal Year: 2007
    ..Thus, these studies may lead to new diagnostic, prognostic, or therapeutic strategies for a broad range of human diseases, including neuro-endocrine tumors, and diabetes mellitus. ..
  7. Men1 Control of Endocrine Cell Growth and Differentiation
    Seung Kim; Fiscal Year: 2007
    ....
  8. Regulation of Facultative Islet Growth and Development by Calcineurin and NFAT
    Seung Kim; Fiscal Year: 2006
    ..Thus, these studies may lead to new diagnostic, prognostic, or therapeutic strategies for a broad range of human diseases, including neuro-endocrine tumors, and diabetes mellitus. ..
  9. Men1 Control of Endocrine Cell Growth & Differentiation
    Seung Kim; Fiscal Year: 2006
    ....
  10. Control of Pancreas Growth/Development
    Seung Kim; Fiscal Year: 2004
    ..The genetic, molecular and physiologic analyses of Smad2-mediated TGF-beta signaling will add to our understanding of the principles of vertebrate organogenesis, and may lead to new cell-replacement strategies for diabetes mellitus. ..
  11. Control of Pancreas Growth/Development
    Seung Kim; Fiscal Year: 2003
    ..The genetic, molecular and physiologic analyses of Smad2-mediated TGF-beta signaling will add to our understanding of the principles of vertebrate organogenesis, and may lead to new cell-replacement strategies for diabetes mellitus. ..
  12. Control of Pancreas Growth/Development
    Seung Kim; Fiscal Year: 2002
    ..The genetic, molecular and physiologic analyses of Smad2-mediated TGF-beta signaling will add to our understanding of the principles of vertebrate organogenesis, and may lead to new cell-replacement strategies for diabetes mellitus. ..
  13. Regulation of Facultative Islet Growth and Development by Calcineurin and NFAT
    Seung K Kim; Fiscal Year: 2010
    ..Thus, these studies may lead to new diagnostic, prognostic, or therapeutic strategies for a broad range of human diseases, including neuro-endocrine tumors, and diabetes mellitus. ..