Seung K Kim

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor
    S K Kim
    Howard Hughes Medical Institute and Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 95:13036-41. 1998
  2. pmc Activin receptor patterning of foregut organogenesis
    S K Kim
    Department of Developmental Biology, Stanford University, Stanford, California 94305 5329 USA
    Genes Dev 14:1866-71. 2000
  3. ncbi request reprint Pancreatic islet cell replacement: successes and opportunities
    Seung K Kim
    Beckman Center Room B300, Mail Stop 5329, Stanford University, 279 Campus Drive, Stanford, CA 94305, USA
    Ann N Y Acad Sci 961:41-3. 2002
  4. ncbi request reprint Intrinsic regulators of pancreatic beta-cell proliferation
    Jeremy J Heit
    Departments of Developmental Biology and Medicine Oncology Division, Stanford University School of Medicine, Stanford, California 94305, USA
    Annu Rev Cell Dev Biol 22:311-38. 2006
  5. ncbi request reprint Conserved mechanisms of glucose sensing and regulation by Drosophila corpora cardiaca cells
    Seung K Kim
    Department of Developmental Biology, Stanford University School of Medicine, Beckman Center B300, Stanford, California 94305 5329, USA
    Nature 431:316-20. 2004
  6. ncbi request reprint Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus
    Seung K Kim
    Department of Developmental Biology, Beckman Center B300, Stanford University School of Medicine, Stanford, California 94305 5329, USA
    Nat Genet 30:430-5. 2002
  7. pmc Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus
    Nora G Smart
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA
    PLoS Biol 4:e39. 2006
  8. ncbi request reprint GDF11 modulates NGN3+ islet progenitor cell number and promotes beta-cell differentiation in pancreas development
    Erin B Harmon
    Department of Developmental Biology, Stanford University, Stanford, CA 94305 5329, USA
    Development 131:6163-74. 2004
  9. pmc A molecular signature for purified definitive endoderm guides differentiation and isolation of endoderm from mouse and human embryonic stem cells
    Pei Wang
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, Califorina, USA
    Stem Cells Dev 21:2273-87. 2012
  10. ncbi request reprint Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitus
    Satyajit K Karnik
    Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA
    Science 318:806-9. 2007

Collaborators

Detail Information

Publications54

  1. pmc Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor
    S K Kim
    Howard Hughes Medical Institute and Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 95:13036-41. 1998
    ..Cyclopamine reveals the capacity of a broad region of the posterior embryonic foregut to form pancreatic cells and provides a means for expanding embryonic pancreas development...
  2. pmc Activin receptor patterning of foregut organogenesis
    S K Kim
    Department of Developmental Biology, Stanford University, Stanford, California 94305 5329 USA
    Genes Dev 14:1866-71. 2000
    ..Thus, activin receptor-mediated signaling regulates axial patterning, cell differentiation, and function of foregut-derived organs...
  3. ncbi request reprint Pancreatic islet cell replacement: successes and opportunities
    Seung K Kim
    Beckman Center Room B300, Mail Stop 5329, Stanford University, 279 Campus Drive, Stanford, CA 94305, USA
    Ann N Y Acad Sci 961:41-3. 2002
  4. ncbi request reprint Intrinsic regulators of pancreatic beta-cell proliferation
    Jeremy J Heit
    Departments of Developmental Biology and Medicine Oncology Division, Stanford University School of Medicine, Stanford, California 94305, USA
    Annu Rev Cell Dev Biol 22:311-38. 2006
    ..We speculate on how these advances may accelerate the discovery of new strategies for the treatment of diseases characterized by a deficiency or excess of beta-cells...
  5. ncbi request reprint Conserved mechanisms of glucose sensing and regulation by Drosophila corpora cardiaca cells
    Seung K Kim
    Department of Developmental Biology, Stanford University School of Medicine, Beckman Center B300, Stanford, California 94305 5329, USA
    Nature 431:316-20. 2004
    ..Thus, Drosophila CC cells are crucial regulators of glucose homeostasis and they use glucose-sensing and response mechanisms similar to islet cells...
  6. ncbi request reprint Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus
    Seung K Kim
    Department of Developmental Biology, Beckman Center B300, Stanford University School of Medicine, Stanford, California 94305 5329, USA
    Nat Genet 30:430-5. 2002
    ..Mutations affecting the Ipf1 protein may promote diabetes mellitus in mice and humans. This study suggests that perturbation of Pbx1 activity may also promote susceptibility to diabetes mellitus...
  7. pmc Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus
    Nora G Smart
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA
    PLoS Biol 4:e39. 2006
    ..Thus, our studies reveal that TGF-beta signaling is crucial for establishing and maintaining defining features of mature pancreatic beta cells...
  8. ncbi request reprint GDF11 modulates NGN3+ islet progenitor cell number and promotes beta-cell differentiation in pancreas development
    Erin B Harmon
    Department of Developmental Biology, Stanford University, Stanford, CA 94305 5329, USA
    Development 131:6163-74. 2004
    ..Thus, our studies reveal mechanisms by which GDF11 regulates the production and maturation of islet progenitor cells in pancreas development...
  9. pmc A molecular signature for purified definitive endoderm guides differentiation and isolation of endoderm from mouse and human embryonic stem cells
    Pei Wang
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, Califorina, USA
    Stem Cells Dev 21:2273-87. 2012
    ..This work should accelerate our understanding of mechanisms regulating DE development in mice and humans, and guide further use of ES cells for tissue replacement...
  10. ncbi request reprint Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitus
    Satyajit K Karnik
    Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA
    Science 318:806-9. 2007
    ..These results expand our understanding of mechanisms underlying diabetes pathogenesis and reveal potential targets for therapy in diabetes...
  11. ncbi request reprint Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes
    Eric J Rulifson
    Department of Developmental Biology, Beckman Center B300, Stanford University, Stanford, CA 94305 5329, USA
    Science 296:1118-20. 2002
    ..Interestingly, the phenotype of flies lacking IPCs includes certain features of diabetes mellitus...
  12. pmc Differentiation of insulin-producing cells from human neural progenitor cells
    Yuichi Hori
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA
    PLoS Med 2:e103. 2005
    ..Islets and neurons share features, including common developmental programs, and in some species brain neurons are the principal source of systemic insulin...
  13. pmc Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus
    Hainan Chen
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 23:975-85. 2009
    ..Our discovery of Ezh2-dependent beta-cell proliferation revealed unique epigenetic mechanisms underlying normal beta-cell expansion and beta-cell regenerative failure in diabetes pathogenesis...
  14. pmc Reconstituting pancreas development from purified progenitor cells reveals genes essential for islet differentiation
    Takuya Sugiyama
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5329, USA
    Proc Natl Acad Sci U S A 110:12691-6. 2013
    ..Discovering the function of genes regulating pancreas development with our system should enrich strategies for regenerating islets for treating diabetes mellitus. ..
  15. pmc Neonatal β cell development in mice and humans is regulated by calcineurin/NFAT
    William R Goodyer
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Dev Cell 23:21-34. 2012
    ..Discovery of conserved pathways regulating β cell maturation and proliferation suggests new strategies for controlling β cell growth or replacement in human islet diseases...
  16. ncbi request reprint Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function
    Jeremy J Heit
    Department of Developmental Biology, Stanford University, Stanford, California 94305, USA
    Nature 443:345-9. 2006
    ..Thus, calcineurin/NFAT signalling regulates multiple factors that control growth and hallmark beta-cell functions, revealing unique models for the pathogenesis and therapy of diabetes...
  17. pmc Wnt signaling regulates pancreatic beta cell proliferation
    Ingrid C Rulifson
    Department of Developmental Biology, Oncology Division, Stanford University, Stanford, CA 94305 5329, USA
    Proc Natl Acad Sci U S A 104:6247-52. 2007
    ..Thus, Wnt signaling is both necessary and sufficient for islet beta cell proliferation, and our study provides previously unrecognized evidence of a mechanism governing endocrine pancreas growth and function...
  18. ncbi request reprint Regulation of pancreas development by hedgehog signaling
    M Hebrok
    Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA
    Development 127:4905-13. 2000
    ..Defects in hedgehog signaling may lead to congenital pancreatic malformations and glucose intolerance...
  19. pmc Conserved markers of fetal pancreatic epithelium permit prospective isolation of islet progenitor cells by FACS
    Takuya Sugiyama
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5329, USA
    Proc Natl Acad Sci U S A 104:175-80. 2007
    ..Our studies reveal previously undescribed strategies for prospective purification and analysis of pancreatic endocrine progenitor cells that should accelerate studies of islet development and replacement...
  20. ncbi request reprint The beta-catenin homolog BAR-1 and LET-60 Ras coordinately regulate the Hox gene lin-39 during Caenorhabditis elegans vulval development
    D M Eisenmann
    Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA
    Development 125:3667-80. 1998
    ..Our genetic and molecular experiments show that the vulval precursor cells can integrate the input from the BAR-1 and LET-60 Ras signaling pathways by coordinately regulating activity of the common target LIN-39 Hox...
  21. pmc The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells
    S M Kaech
    Department of Developmental Biology, Stanford University School of Medicine, California 94305, USA
    Cell 94:761-71. 1998
    ..Each of the binding interactions within this complex is conserved, suggesting that this complex may also mediate basolateral localization in mammals...
  22. pmc Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters
    Tiffany Hung
    Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA
    Nat Genet 43:621-9. 2011
    ..These findings suggest potentially widespread roles for promoter lncRNAs in cell-growth control...
  23. pmc Targeting SOX17 in human embryonic stem cells creates unique strategies for isolating and analyzing developing endoderm
    Pei Wang
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell Stem Cell 8:335-46. 2011
    ..Thus, prospective isolation, lineage tracing, and developmental studies of SOX17(+) hESC progeny have revealed fundamental aspects of human endodermal biology...
  24. pmc Inhibition of Caenorhabditis elegans vulval induction by gap-1 and by let-23 receptor tyrosine kinase
    A Hajnal
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305 USA
    Genes Dev 11:2715-28. 1997
    ..p, P4.p, and P8.p). This result suggests that LET-23 in proximal vulval precursor cells might bind and sequester the inductive signal LIN-3 EGF, thereby preventing diffusion of the inductive signal to distal vulval precursor cells...
  25. ncbi request reprint LET-23 receptor localization by the cell junction protein LIN-7 during C. elegans vulval induction
    J S Simske
    Department of Developmental Biology, Stanford University Medical School, California 94305 5427, USA
    Cell 85:195-204. 1996
    ..These results suggest that proper localization of LET-23 receptor to the Pn.p cell junctions is required for signaling activity...
  26. pmc Specification of Drosophila corpora cardiaca neuroendocrine cells from mesoderm is regulated by Notch signaling
    Sangbin Park
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Genet 7:e1002241. 2011
    ..Understanding the cellular, genetic, signaling, and transcriptional basis of CC cell specification and expansion should accelerate discovery of molecular mechanisms regulating ontogeny of organs that control metabolism...
  27. pmc Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells
    Yuichi Hori
    Department of Developmental Biology and Division of Oncology, Department of Medicine, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 99:16105-10. 2002
    ..Strategies for producing cells that can replace islet functions described here can be adapted for similar uses with human cells...
  28. pmc Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c
    Satyajit K Karnik
    Departments of Developmental Biology and Medicine Oncology Division, Stanford University School of Medicine, Stanford, CA 94305 5329
    Proc Natl Acad Sci U S A 102:14659-64. 2005
    ..These studies suggest an epigenetic mechanism of tumor suppression: by promoting histone modifications, menin maintains transcription at multiple loci encoding cell cycle regulators essential for endocrine growth control...
  29. pmc PDGF signalling controls age-dependent proliferation in pancreatic β-cells
    Hainan Chen
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 478:349-55. 2011
    ..The discovery of a conserved pathway controlling age-dependent β-cell proliferation indicates new strategies for β-cell expansion...
  30. pmc Genome-wide analysis of developmental and sex-regulated gene expression profiles in Caenorhabditis elegans
    M Jiang
    Department of Developmental Biology, Stanford University Medical Center, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 98:218-23. 2001
    ..05). The sex-regulated genes provide a global view of the differences between the sexes at a molecular level and identify many genes likely to be involved in sex-specific differentiation and behavior...
  31. ncbi request reprint NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21
    Joseph R Arron
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 441:595-600. 2006
    ..More generally, these observations suggest that the destabilization of regulatory circuits can underlie human disease...
  32. pmc Gene regulatory networks governing pancreas development
    H Efsun Arda
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5329, USA
    Dev Cell 25:5-13. 2013
    ..We envision similar approaches would be useful for understanding the development of other organs...
  33. ncbi request reprint Embryonic stem cells and islet replacement in diabetes mellitus
    Jeremy J Heit
    Department of Developmental Biology, Stanford University, 279 Campus Drive, Stanford, CA 94305, USA
    Pediatr Diabetes 5:5-15. 2004
    ..In this study, we review the recent advances in generating insulin-producing cells (IPC) from mouse and human ES (hES) cells...
  34. ncbi request reprint Signaling specificity: the RTK/RAS/MAP kinase pathway in metazoans
    P B Tan
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305
    Trends Genet 15:145-9. 1999
    ....
  35. ncbi request reprint Polarized signaling: basolateral receptor localization in epithelial cells by PDZ-containing proteins
    S K Kim
    Department of Developmental Biology, Stanford University Medical Center, CA 94305 5427, USA
    Curr Opin Cell Biol 9:853-9. 1997
    ..Exciting recent reports suggest that receptor localization to neuronal synapses and the basolateral membrane domains of epithelia may involve a common molecular mechanism involving localization by PDZ-containing proteins...
  36. pmc Protruding vulva mutants identify novel loci and Wnt signaling factors that function during Caenorhabditis elegans vulva development
    D M Eisenmann
    Department of Developmental Biology, Stanford University, Stanford, California 94305, USA
    Genetics 156:1097-116. 2000
    ..In addition, two of these genes, bar-1 and mom-3/mig-14, are known to function in processes regulated by Wnt signaling, suggesting that a Wnt signaling pathway is acting during vulval development...
  37. ncbi request reprint Functional genomics: the worm scores a knockout
    S K Kim
    Department of Developmental Biology, Stanford University, California, Stanford 94305, USA
    Curr Biol 11:R85-7. 2001
    ....
  38. doi request reprint Fluorescence-activated cell sorting purification of pancreatic progenitor cells
    T Sugiyama
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5329, USA
    Diabetes Obes Metab 10:179-85. 2008
    ..We discuss advantages and current limitations of experiments with purified pancreatic cells, and areas where future growth in our understanding is needed to advance experiments in pancreas biology based on cell purification...
  39. ncbi request reprint Epitope clusters in the major outer membrane protein of Chlamydia trachomatis
    S K Kim
    Department of Microbiology and Immunology, Stanford University School of Medicine, 299 Campus Drive, Stanford, CA 94305, USA
    Curr Opin Immunol 13:429-36. 2001
    ....
  40. ncbi request reprint Http://C. elegans: mining the functional genomic landscape
    S K Kim
    Department of Developmental Biology, Stanford University Medical School, Stanford, California 94305, USA
    Nat Rev Genet 2:681-9. 2001
    ..These high-capacity approaches to studying gene function will provide new insights into invertebrate and vertebrate biology...
  41. pmc The effects of toxoplasma infection on rodent behavior are dependent on dose of the stimulus
    A Vyas
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    Neuroscience 148:342-8. 2007
    ..This report also demonstrates that toxoplasma affects emotional valence of the cat odor as indicated by altered learned fear induced by cat odor...
  42. ncbi request reprint A gene expression map for Caenorhabditis elegans
    S K Kim
    Department of Developmental Biology and Genetics, Stanford University Medical School, Stanford, CA 94305, USA
    Science 293:2087-92. 2001
    ....
  43. ncbi request reprint Hedgehog signaling in gastrointestinal development and disease
    E B Harmon
    Department of Developmental Biology, Stanford University School of Medicine, USA
    Curr Mol Med 2:67-82. 2002
    ..Several diseases and congenital syndromes are known to result from genetic defects in Hedgehog signaling components, and this pathway may ultimately prove to be an important target for future diagnostic and therapeutic tools...
  44. ncbi request reprint Signaling and transcriptional control of pancreatic organogenesis
    Seung K Kim
    Departments of Developmental Biology and Medicine Oncology Division, Stanford UniversityStanford, California, 94305 5329, USA
    Curr Opin Genet Dev 12:540-7. 2002
    ..Two, largely independent endocrine cell lineages develop during the formation of the embryonic pancreas. Lineage tracing has begun to refine our understanding of the origins of the acinar, ductal and islet cells...
  45. ncbi request reprint A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans
    M R Lackner
    Department of Developmental Biology, Stanford University Medical Center, California 94305
    Genes Dev 8:160-73. 1994
    ..We used a new type of mosaic analysis to show that mpk-1 acts cell autonomously in the Pn.p cells. Our results show that mpk-1 plays an important functional role as an activator in ras-mediated cell signaling in vivo...
  46. doi request reprint Gut insulin from Foxo1 loss
    Seung K Kim
    Departments of Developmental Biology and Medicine, Oncology Division, Stanford University School of Medicine, Stanford, California, USA
    Nat Genet 44:363-4. 2012
    ..Ectopic gut insulin production was sufficient to ameliorate glucose control in mice with conditional pancreatic β-cell loss and diabetes mellitus...
  47. pmc Deconstructing pancreas development to reconstruct human islets from pluripotent stem cells
    Kristen D McKnight
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5329, USA
    Cell Stem Cell 6:300-8. 2010
    ....
  48. pmc A targeted RNAi screen for genes involved in chromosome morphogenesis and nuclear organization in the Caenorhabditis elegans germline
    M P Colaiácovo
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305 5329, USA
    Genetics 162:113-28. 2002
    ..In addition to genes involved in key meiotic prophase events, we identified genes involved in meiotic progression, germline proliferation, and chromosome organization and/or segregation during mitotic growth...
  49. ncbi request reprint Tight junctions, membrane-associated guanylate kinases and cell signaling
    S K Kim
    Department of Developmental Biology, Stanford University Medical School, CA 94305, USA
    Curr Opin Cell Biol 7:641-9. 1995
    ....
  50. pmc The ATP-sensitive potassium (KATP) channel-encoded dSUR gene is required for Drosophila heart function and is regulated by tinman
    Takeshi Akasaka
    Del E Webb Center for Neurosciences and Aging, The Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:11999-2004. 2006
    ..dSUR provides a model for addressing how embryonic regulators of myocardial cell commitment can contribute to the establishment and maintenance of cardiac performance...
  51. ncbi request reprint Cells for repair: breakout session summary
    Denise L Faustman
    Immunology Laboratory, Massachusetts General Hospital, Harvard Medical School, Building 149 Room 3601, Thirteenth Street, Charlestown, MA 02129, USA
    Ann N Y Acad Sci 961:45-7. 2002
  52. pmc Menin-mediated caspase 8 expression in suppressing multiple endocrine neoplasia type 1
    Ping La
    Abramson Family Cancer Research Institute, Department of Cancer Biology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6160, USA
    J Biol Chem 282:31332-40. 2007
    ..Together, our results indicate that menin enhances the caspase 8 expression by binding the caspase 8 locus, and suggest that menin suppresses MEN1 tumorigenesis, at least in part, by up-regulating caspase 8 expression...
  53. pmc Glucose infusion in mice: a new model to induce beta-cell replication
    Laura C Alonso
    University of Pittsburgh, Division of Endocrinology, 200 Lothrop St, BST E1140, Pittsburgh, PA 15261, USA
    Diabetes 56:1792-801. 2007
    ..Thus, we have developed a new model to study the regulation of compensatory beta-cell replication, and we describe important novel characteristics of mouse beta-cell responses to glucose in the living pancreas...
  54. doi request reprint Characterization of six new human embryonic stem cell lines (HSF7, -8, -9, -10, -12, and -13) derived under minimal-animal component conditions
    SHAWN L CHAVEZ
    Department of Obstetrics, Gynecology and Reproductive Sciences, Center for Reproductive Sciences, University of California, San Francisco, San Francisco, CA 94143 0556, USA
    Stem Cells Dev 17:535-46. 2008
    ..This suggests that the hESC lines described here are valuable models for both future in vitro and in vivo studies, which may aid in the progression toward clinical-grade cell therapy...