Research Topics
Genomes and Genes
| Seung K KimSummaryAffiliation: Stanford University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Conserved mechanisms of glucose sensing and regulation by Drosophila corpora cardiaca cellsSeung K Kim
Department of Developmental Biology, Stanford University School of Medicine, Beckman Center B300, Stanford, California 94305 5329, USA
Nature 431:316-20. 2004..Thus, Drosophila CC cells are crucial regulators of glucose homeostasis and they use glucose-sensing and response mechanisms similar to islet cells...- Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitusSeung K Kim
Department of Developmental Biology, Beckman Center B300, Stanford University School of Medicine, Stanford, California 94305 5329, USA
Nat Genet 30:430-5. 2002..Mutations affecting the Ipf1 protein may promote diabetes mellitus in mice and humans. This study suggests that perturbation of Pbx1 activity may also promote susceptibility to diabetes mellitus... 
Activin receptor patterning of foregut organogenesisS K Kim
Department of Developmental Biology, Stanford University, Stanford, California 94305 5329 USA
Genes Dev 14:1866-71. 2000..Thus, activin receptor-mediated signaling regulates axial patterning, cell differentiation, and function of foregut-derived organs...- Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitorS K Kim
Howard Hughes Medical Institute and Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Proc Natl Acad Sci U S A 95:13036-41. 1998..Cyclopamine reveals the capacity of a broad region of the posterior embryonic foregut to form pancreatic cells and provides a means for expanding embryonic pancreas development... - Intrinsic regulators of pancreatic beta-cell proliferationJeremy J Heit
Departments of Developmental Biology and Medicine Oncology Division, Stanford University School of Medicine, Stanford, California 94305, USA
Annu Rev Cell Dev Biol 22:311-38. 2006..We speculate on how these advances may accelerate the discovery of new strategies for the treatment of diseases characterized by a deficiency or excess of beta-cells... - Pancreatic islet cell replacement: successes and opportunitiesSeung K Kim
Beckman Center Room B300, Mail Stop 5329, Stanford University, 279 Campus Drive, Stanford, CA 94305, USA
Ann N Y Acad Sci 961:41-3. 2002 
Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitusNora G Smart
Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA
PLoS Biol 4:e39. 2006..Thus, our studies reveal that TGF-beta signaling is crucial for establishing and maintaining defining features of mature pancreatic beta cells...- GDF11 modulates NGN3+ islet progenitor cell number and promotes beta-cell differentiation in pancreas developmentErin B Harmon
Department of Developmental Biology, Stanford University, Stanford, CA 94305 5329, USA
Development 131:6163-74. 2004..Thus, our studies reveal mechanisms by which GDF11 regulates the production and maturation of islet progenitor cells in pancreas development... - A molecular signature for purified definitive endoderm guides differentiation and isolation of endoderm from mouse and human embryonic stem cellsPei Wang
Department of Developmental Biology, Stanford University School of Medicine, Stanford, Califorina, USA
Stem Cells Dev 21:2273-87. 2012..This work should accelerate our understanding of mechanisms regulating DE development in mice and humans, and guide further use of ES cells for tissue replacement... - Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitusSatyajit K Karnik
Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA
Science 318:806-9. 2007..These results expand our understanding of mechanisms underlying diabetes pathogenesis and reveal potential targets for therapy in diabetes... - Ablation of insulin-producing neurons in flies: growth and diabetic phenotypesEric J Rulifson
Department of Developmental Biology, Beckman Center B300, Stanford University, Stanford, CA 94305 5329, USA
Science 296:1118-20. 2002..Interestingly, the phenotype of flies lacking IPCs includes certain features of diabetes mellitus... - Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitusHainan Chen
Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
Genes Dev 23:975-85. 2009..Our discovery of Ezh2-dependent beta-cell proliferation revealed unique epigenetic mechanisms underlying normal beta-cell expansion and beta-cell regenerative failure in diabetes pathogenesis... - Differentiation of insulin-producing cells from human neural progenitor cellsYuichi Hori
Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA
PLoS Med 2:e103. 2005..Islets and neurons share features, including common developmental programs, and in some species brain neurons are the principal source of systemic insulin... 
Neonatal β cell development in mice and humans is regulated by calcineurin/NFATWilliam R Goodyer
Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
Dev Cell 23:21-34. 2012..Discovery of conserved pathways regulating β cell maturation and proliferation suggests new strategies for controlling β cell growth or replacement in human islet diseases...- Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and functionJeremy J Heit
Department of Developmental Biology, Stanford University, Stanford, California 94305, USA
Nature 443:345-9. 2006..Thus, calcineurin/NFAT signalling regulates multiple factors that control growth and hallmark beta-cell functions, revealing unique models for the pathogenesis and therapy of diabetes... - Wnt signaling regulates pancreatic beta cell proliferationIngrid C Rulifson
Department of Developmental Biology, Oncology Division, Stanford University, Stanford, CA 94305 5329, USA
Proc Natl Acad Sci U S A 104:6247-52. 2007..Thus, Wnt signaling is both necessary and sufficient for islet beta cell proliferation, and our study provides previously unrecognized evidence of a mechanism governing endocrine pancreas growth and function... - Regulation of pancreas development by hedgehog signalingM Hebrok
Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA
Development 127:4905-13. 2000..Defects in hedgehog signaling may lead to congenital pancreatic malformations and glucose intolerance... - Conserved markers of fetal pancreatic epithelium permit prospective isolation of islet progenitor cells by FACSTakuya Sugiyama
Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5329, USA
Proc Natl Acad Sci U S A 104:175-80. 2007..Our studies reveal previously undescribed strategies for prospective purification and analysis of pancreatic endocrine progenitor cells that should accelerate studies of islet development and replacement... - The beta-catenin homolog BAR-1 and LET-60 Ras coordinately regulate the Hox gene lin-39 during Caenorhabditis elegans vulval developmentD M Eisenmann
Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA
Development 125:3667-80. 1998..Our genetic and molecular experiments show that the vulval precursor cells can integrate the input from the BAR-1 and LET-60 Ras signaling pathways by coordinately regulating activity of the common target LIN-39 Hox... - The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cellsS M Kaech
Department of Developmental Biology, Stanford University School of Medicine, California 94305, USA
Cell 94:761-71. 1998..Each of the binding interactions within this complex is conserved, suggesting that this complex may also mediate basolateral localization in mammals... - Targeting SOX17 in human embryonic stem cells creates unique strategies for isolating and analyzing developing endodermPei Wang
Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
Cell Stem Cell 8:335-46. 2011..Thus, prospective isolation, lineage tracing, and developmental studies of SOX17(+) hESC progeny have revealed fundamental aspects of human endodermal biology... - Extensive and coordinated transcription of noncoding RNAs within cell-cycle promotersTiffany Hung
Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA
Nat Genet 43:621-9. 2011..These findings suggest potentially widespread roles for promoter lncRNAs in cell-growth control... - LET-23 receptor localization by the cell junction protein LIN-7 during C. elegans vulval inductionJ S Simske
Department of Developmental Biology, Stanford University Medical School, California 94305 5427, USA
Cell 85:195-204. 1996..These results suggest that proper localization of LET-23 receptor to the Pn.p cell junctions is required for signaling activity... - Inhibition of Caenorhabditis elegans vulval induction by gap-1 and by let-23 receptor tyrosine kinaseA Hajnal
Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305 USA
Genes Dev 11:2715-28. 1997..p, P4.p, and P8.p). This result suggests that LET-23 in proximal vulval precursor cells might bind and sequester the inductive signal LIN-3 EGF, thereby preventing diffusion of the inductive signal to distal vulval precursor cells... - Specification of Drosophila corpora cardiaca neuroendocrine cells from mesoderm is regulated by Notch signalingSangbin Park
Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, United States of America
PLoS Genet 7:e1002241. 2011..Understanding the cellular, genetic, signaling, and transcriptional basis of CC cell specification and expansion should accelerate discovery of molecular mechanisms regulating ontogeny of organs that control metabolism... - Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cellsYuichi Hori
Department of Developmental Biology and Division of Oncology, Department of Medicine, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 99:16105-10. 2002..Strategies for producing cells that can replace islet functions described here can be adapted for similar uses with human cells... - Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4cSatyajit K Karnik
Departments of Developmental Biology and Medicine Oncology Division, Stanford University School of Medicine, Stanford, CA 94305 5329
Proc Natl Acad Sci U S A 102:14659-64. 2005..These studies suggest an epigenetic mechanism of tumor suppression: by promoting histone modifications, menin maintains transcription at multiple loci encoding cell cycle regulators essential for endocrine growth control... - PDGF signalling controls age-dependent proliferation in pancreatic β-cellsHainan Chen
Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
Nature 478:349-55. 2011..The discovery of a conserved pathway controlling age-dependent β-cell proliferation indicates new strategies for β-cell expansion... - Genome-wide analysis of developmental and sex-regulated gene expression profiles in Caenorhabditis elegansM Jiang
Department of Developmental Biology, Stanford University Medical Center, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 98:218-23. 2001..05). The sex-regulated genes provide a global view of the differences between the sexes at a molecular level and identify many genes likely to be involved in sex-specific differentiation and behavior... - Embryonic stem cells and islet replacement in diabetes mellitusJeremy J Heit
Department of Developmental Biology, Stanford University, 279 Campus Drive, Stanford, CA 94305, USA
Pediatr Diabetes 5:5-15. 2004..In this study, we review the recent advances in generating insulin-producing cells (IPC) from mouse and human ES (hES) cells... - NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21Joseph R Arron
Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
Nature 441:595-600. 2006..More generally, these observations suggest that the destabilization of regulatory circuits can underlie human disease... - Fluorescence-activated cell sorting purification of pancreatic progenitor cellsT Sugiyama
Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5329, USA
Diabetes Obes Metab 10:179-85. 2008..We discuss advantages and current limitations of experiments with purified pancreatic cells, and areas where future growth in our understanding is needed to advance experiments in pancreas biology based on cell purification... - Signaling specificity: the RTK/RAS/MAP kinase pathway in metazoansP B Tan
Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305
Trends Genet 15:145-9. 1999.... - The effects of toxoplasma infection on rodent behavior are dependent on dose of the stimulusA Vyas
Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
Neuroscience 148:342-8. 2007..This report also demonstrates that toxoplasma affects emotional valence of the cat odor as indicated by altered learned fear induced by cat odor... - Functional genomics: the worm scores a knockoutS K Kim
Department of Developmental Biology, Stanford University, California, Stanford 94305, USA
Curr Biol 11:R85-7. 2001.... - Epitope clusters in the major outer membrane protein of Chlamydia trachomatisS K Kim
Department of Microbiology and Immunology, Stanford University School of Medicine, 299 Campus Drive, Stanford, CA 94305, USA
Curr Opin Immunol 13:429-36. 2001.... - Protruding vulva mutants identify novel loci and Wnt signaling factors that function during Caenorhabditis elegans vulva developmentD M Eisenmann
Department of Developmental Biology, Stanford University, Stanford, California 94305, USA
Genetics 156:1097-116. 2000..In addition, two of these genes, bar-1 and mom-3/mig-14, are known to function in processes regulated by Wnt signaling, suggesting that a Wnt signaling pathway is acting during vulval development... - Http://C. elegans: mining the functional genomic landscapeS K Kim
Department of Developmental Biology, Stanford University Medical School, Stanford, California 94305, USA
Nat Rev Genet 2:681-9. 2001..These high-capacity approaches to studying gene function will provide new insights into invertebrate and vertebrate biology... - A gene expression map for Caenorhabditis elegansS K Kim
Department of Developmental Biology and Genetics, Stanford University Medical School, Stanford, CA 94305, USA
Science 293:2087-92. 2001.... - Hedgehog signaling in gastrointestinal development and diseaseE B Harmon
Department of Developmental Biology, Stanford University School of Medicine, USA
Curr Mol Med 2:67-82. 2002..Several diseases and congenital syndromes are known to result from genetic defects in Hedgehog signaling components, and this pathway may ultimately prove to be an important target for future diagnostic and therapeutic tools... - Polarized signaling: basolateral receptor localization in epithelial cells by PDZ-containing proteinsS K Kim
Department of Developmental Biology, Stanford University Medical Center, CA 94305 5427, USA
Curr Opin Cell Biol 9:853-9. 1997..Exciting recent reports suggest that receptor localization to neuronal synapses and the basolateral membrane domains of epithelia may involve a common molecular mechanism involving localization by PDZ-containing proteins... - Signaling and transcriptional control of pancreatic organogenesisSeung K Kim
Departments of Developmental Biology and Medicine Oncology Division, Stanford UniversityStanford, California, 94305 5329, USA
Curr Opin Genet Dev 12:540-7. 2002..Two, largely independent endocrine cell lineages develop during the formation of the embryonic pancreas. Lineage tracing has begun to refine our understanding of the origins of the acinar, ductal and islet cells... - A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegansM R Lackner
Department of Developmental Biology, Stanford University Medical Center, California 94305
Genes Dev 8:160-73. 1994..We used a new type of mosaic analysis to show that mpk-1 acts cell autonomously in the Pn.p cells. Our results show that mpk-1 plays an important functional role as an activator in ras-mediated cell signaling in vivo... - Gut insulin from Foxo1 lossSeung K Kim
Departments of Developmental Biology and Medicine, Oncology Division, Stanford University School of Medicine, Stanford, California, USA
Nat Genet 44:363-4. 2012..Ectopic gut insulin production was sufficient to ameliorate glucose control in mice with conditional pancreatic β-cell loss and diabetes mellitus... - Deconstructing pancreas development to reconstruct human islets from pluripotent stem cellsKristen D McKnight
Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5329, USA
Cell Stem Cell 6:300-8. 2010.... - A targeted RNAi screen for genes involved in chromosome morphogenesis and nuclear organization in the Caenorhabditis elegans germlineM P Colaiácovo
Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305 5329, USA
Genetics 162:113-28. 2002..In addition to genes involved in key meiotic prophase events, we identified genes involved in meiotic progression, germline proliferation, and chromosome organization and/or segregation during mitotic growth... - Tight junctions, membrane-associated guanylate kinases and cell signalingS K Kim
Department of Developmental Biology, Stanford University Medical School, CA 94305, USA
Curr Opin Cell Biol 7:641-9. 1995.... - The ATP-sensitive potassium (KATP) channel-encoded dSUR gene is required for Drosophila heart function and is regulated by tinmanTakeshi Akasaka
Del E Webb Center for Neurosciences and Aging, The Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 103:11999-2004. 2006..dSUR provides a model for addressing how embryonic regulators of myocardial cell commitment can contribute to the establishment and maintenance of cardiac performance... - Cells for repair: breakout session summaryDenise L Faustman
Immunology Laboratory, Massachusetts General Hospital, Harvard Medical School, Building 149 Room 3601, Thirteenth Street, Charlestown, MA 02129, USA
Ann N Y Acad Sci 961:45-7. 2002 - Characterization of six new human embryonic stem cell lines (HSF7, -8, -9, -10, -12, and -13) derived under minimal-animal component conditionsSHAWN L CHAVEZ
Department of Obstetrics, Gynecology and Reproductive Sciences, Center for Reproductive Sciences, University of California, San Francisco, San Francisco, CA 94143 0556, USA
Stem Cells Dev 17:535-46. 2008..This suggests that the hESC lines described here are valuable models for both future in vitro and in vivo studies, which may aid in the progression toward clinical-grade cell therapy... - Glucose infusion in mice: a new model to induce beta-cell replicationLaura C Alonso
University of Pittsburgh, Division of Endocrinology, 200 Lothrop St, BST E1140, Pittsburgh, PA 15261, USA
Diabetes 56:1792-801. 2007..Thus, we have developed a new model to study the regulation of compensatory beta-cell replication, and we describe important novel characteristics of mouse beta-cell responses to glucose in the living pancreas... - Menin-mediated caspase 8 expression in suppressing multiple endocrine neoplasia type 1Ping La
Abramson Family Cancer Research Institute, Department of Cancer Biology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6160, USA
J Biol Chem 282:31332-40. 2007..Together, our results indicate that menin enhances the caspase 8 expression by binding the caspase 8 locus, and suggest that menin suppresses MEN1 tumorigenesis, at least in part, by up-regulating caspase 8 expression...