P A Khavari

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Modelling cancer in human skin tissue
    Paul A Khavari
    Veterans Affairs, Palo Alto Healthcare System, Palo Alto, California 94304, USA
    Nat Rev Cancer 6:270-80. 2006
  2. pmc CDK4 regulation by TNFR1 and JNK is required for NF-kappaB-mediated epidermal growth control
    Jennifer Y Zhang
    Veterans Affairs Palo Alto Healthcare System, Palo Alto, CA 94304, USA
    J Cell Biol 168:561-6. 2005
  3. pmc Gab1 and SHP-2 promote Ras/MAPK regulation of epidermal growth and differentiation
    Ti Cai
    Veterans Affairs Palo Alto Healthcare System and the Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cell Biol 159:103-12. 2002
  4. ncbi request reprint Genetic correction of inherited epidermal disorders
    P A Khavari
    Department of Veterans Affairs, Palo Alto, CA 94025 Program in Epithelial Biology, Stanford School of Medicine, Stanford University, Stanford, CA 94305, USA
    Hum Gene Ther 11:2277-82. 2000
  5. ncbi request reprint Conjugation of arginine oligomers to cyclosporin A facilitates topical delivery and inhibition of inflammation
    J B Rothbard
    CellGate, Sunnyvale, California 94086, USA
    Nat Med 6:1253-7. 2000
  6. ncbi request reprint Cutaneous gene transfer for skin and systemic diseases
    P A Khavari
    VA Palo Alto Healthcare System and the Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA, USA
    J Intern Med 252:1-10. 2002
  7. ncbi request reprint Therapeutic gene delivery to the skin
    P A Khavari
    Dermatology Service, V A Palo Alto Health Care System, CA 94304, USA
    Mol Med Today 3:533-8. 1997
  8. ncbi request reprint Specific triggering of the Fas signal transduction pathway in normal human keratinocytes
    R A Freiberg
    Veterans Administration Palo Alto Health Care System, Palo Alto, California 94304, USA
    J Biol Chem 271:31666-9. 1996
  9. ncbi request reprint Impact of laminin 5 beta3 gene versus protein replacement on gene expression patterns in junctional epidermolysis bullosa
    P B Robbins
    Veterans Affairs Palo Alto Healthcare System and the Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Hum Gene Ther 12:1443-8. 2001
  10. ncbi request reprint Sustainable correction of junctional epidermolysis bullosa via transposon-mediated nonviral gene transfer
    S Ortiz-Urda
    Program in Epithelial Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305, USA
    Gene Ther 10:1099-104. 2003

Research Grants

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Modelling cancer in human skin tissue
    Paul A Khavari
    Veterans Affairs, Palo Alto Healthcare System, Palo Alto, California 94304, USA
    Nat Rev Cancer 6:270-80. 2006
    ..Human-tissue cancer models therefore provide an opportunity to elucidate fundamental cancer mechanisms, to assess the oncogenic potency of mutations associated with specific human cancers and to develop new cancer therapies...
  2. pmc CDK4 regulation by TNFR1 and JNK is required for NF-kappaB-mediated epidermal growth control
    Jennifer Y Zhang
    Veterans Affairs Palo Alto Healthcare System, Palo Alto, CA 94304, USA
    J Cell Biol 168:561-6. 2005
    ..Therefore, epidermal homeostasis depends on antagonist regulation of CDK4 expression by NF-kappaB and TNFR1/JNK...
  3. pmc Gab1 and SHP-2 promote Ras/MAPK regulation of epidermal growth and differentiation
    Ti Cai
    Veterans Affairs Palo Alto Healthcare System and the Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cell Biol 159:103-12. 2002
    ..These data provide support for a Ras role in promoting epidermal proliferation and opposing differentiation and indicate that Gab1 and SHP-2 promote the undifferentiated epidermal cell state by facilitating Ras/MAPK signaling...
  4. ncbi request reprint Genetic correction of inherited epidermal disorders
    P A Khavari
    Department of Veterans Affairs, Palo Alto, CA 94025 Program in Epithelial Biology, Stanford School of Medicine, Stanford University, Stanford, CA 94305, USA
    Hum Gene Ther 11:2277-82. 2000
    ..Efforts in this human tissue model have laid the foundation for future efforts to extend this progress toward ex vivo cutaneous gene therapy trials in humans...
  5. ncbi request reprint Conjugation of arginine oligomers to cyclosporin A facilitates topical delivery and inhibition of inflammation
    J B Rothbard
    CellGate, Sunnyvale, California 94086, USA
    Nat Med 6:1253-7. 2000
    ..These data establish a general strategy for enhancing delivery of poorly absorbed drugs across tissue barriers and provide a new topical approach to the treatment of inflammatory skin disorders...
  6. ncbi request reprint Cutaneous gene transfer for skin and systemic diseases
    P A Khavari
    VA Palo Alto Healthcare System and the Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA, USA
    J Intern Med 252:1-10. 2002
    ..Recent advances in vector design, administration, immune modulation, and regulation of gene expression have brought the field much nearer to clinical utility...
  7. ncbi request reprint Therapeutic gene delivery to the skin
    P A Khavari
    Dermatology Service, V A Palo Alto Health Care System, CA 94304, USA
    Mol Med Today 3:533-8. 1997
    ..Recent developments in models of gene delivery to the skin underscore key challenges that must be met before successful treatment of human disease by cutaneous gene delivery can be achieved...
  8. ncbi request reprint Specific triggering of the Fas signal transduction pathway in normal human keratinocytes
    R A Freiberg
    Veterans Administration Palo Alto Health Care System, Palo Alto, California 94304, USA
    J Biol Chem 271:31666-9. 1996
    ..These findings reveal that the Fas signal transduction pathway is active in keratinocytes, requires no induction, and dominantly overrides growth stimuli...
  9. ncbi request reprint Impact of laminin 5 beta3 gene versus protein replacement on gene expression patterns in junctional epidermolysis bullosa
    P B Robbins
    Veterans Affairs Palo Alto Healthcare System and the Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Hum Gene Ther 12:1443-8. 2001
    ..Our findings suggest that therapeutic gene and protein delivery may exert different effects on gene expression and thus may have implications for the development and analysis of molecular therapies for the treatment of genetic disorders...
  10. ncbi request reprint Sustainable correction of junctional epidermolysis bullosa via transposon-mediated nonviral gene transfer
    S Ortiz-Urda
    Program in Epithelial Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305, USA
    Gene Ther 10:1099-104. 2003
    ..Transposon-mediated gene delivery therefore affords an opportunity for stable gene delivery in JEB and other human diseases...
  11. ncbi request reprint Sustainable systemic delivery via a single injection of lentivirus into human skin tissue
    S C Baek
    Veterans Affairs Palo Alto Healcare System and Program in Epithelial Biology, Stanford University School of Medicine, CA 94305, USA
    Hum Gene Ther 12:1551-8. 2001
    ..These findings indicate that the skin can sustain dosed systemic delivery of therapeutic polypeptides via direct lentivector injection and thus provide an accessible and reversible approach for gene-based delivery to the bloodstream...
  12. pmc In vivo restoration of laminin 5 beta 3 expression and function in junctional epidermolysis bullosa
    P B Robbins
    Veterans Affairs Hospitals, Palo Alto Healthcare System, Palo Alto, CA 94025, USA
    Proc Natl Acad Sci U S A 98:5193-8. 2001
    ..These data support the utility of gene therapy for JEB and highlight the potential for gene delivery in the treatment of human genetic skin disease...
  13. pmc Mek1/2 gene dosage determines tissue response to oncogenic Ras signaling in the skin
    F A Scholl
    Department of Dermatology, Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Oncogene 28:1485-95. 2009
    ..Thus, the effects of oncogenic Ras on proliferation and differentiation in skin show a gene dosage-dependent requirement for the Erk1/2 MAPK cascade at the level of Mek1/2 MAPKKs...
  14. pmc Alterations in NF-kappaB function in transgenic epithelial tissue demonstrate a growth inhibitory role for NF-kappaB
    C S Seitz
    Department of Veterans Affairs, Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Proc Natl Acad Sci U S A 95:2307-12. 1998
    ....
  15. ncbi request reprint Peptide delivery to tissues via reversibly linked protein transduction sequences
    P B Robbins
    VA Palo Alto Health Care System and Stanford University, CA, USA
    Biotechniques 33:190-2, 194. 2002
    ....
  16. pmc Purification and biochemical heterogeneity of the mammalian SWI-SNF complex
    W Wang
    Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University, CA 94305 5428, USA
    EMBO J 15:5370-82. 1996
    ..Certain cell lines completely lack BRG1 and hbrm, indicating that they are not essential for cell viability and that the mammalian SWI-SNF complex may be tailored to the needs of a differentiated cell type...
  17. ncbi request reprint Characterization of a cofactor that regulates dimerization of a mammalian homeodomain protein
    D B Mendel
    Howard Hughes Medical Institute, Stanford University, CA 94305
    Science 254:1762-7. 1991
    ..These results indicate that DCoH regulates formation of transcriptionally active tetrameric complexes and may contribute to the developmental specificity of the complex...
  18. pmc Modeling inducible human tissue neoplasia identifies an extracellular matrix interaction network involved in cancer progression
    Jason A Reuter
    Veterans Affairs Palo Alto Healthcare System, Palo Alto, CA 94306, USA
    Cancer Cell 15:477-88. 2009
    ..Thus, integrating network modeling and temporal gene expression analysis of inducible human neoplasia provides an approach to prioritize and characterize genes functioning in cancer progression...
  19. pmc Selective role for Mek1 but not Mek2 in the induction of epidermal neoplasia
    Florence A Scholl
    Stanford University School of Medicine, Stanford, California 94305, USA
    Cancer Res 69:3772-8. 2009
    ..These data show that Mek1 is important for skin tumor development and that Mek2 cannot compensate for the loss of Mek1 function in this setting...
  20. ncbi request reprint A laminin-collagen complex drives human epidermal carcinogenesis through phosphoinositol-3-kinase activation
    Elizabeth A Waterman
    Dermatology Service, Palo Alto VAHCS, Palo Alto, California 94305, USA
    Cancer Res 67:4264-70. 2007
    ..This uncoupling of stable adhesion from tumor progression in our studies suggests that laminin-332/collagen VII interaction promotes epidermal carcinogenesis through signaling rather than adhesion...
  21. ncbi request reprint CDK4 coexpression with Ras generates malignant human epidermal tumorigenesis
    Mirella Lazarov
    VAPalo Alto Healthcare System, Palo Alto and the Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA
    Nat Med 8:1105-14. 2002
    ..These data identify a new role for oncogenic Ras in CDK4 regulation and highlight the functional importance of CDK4 suppression in preventing uncontrolled growth...
  22. pmc Use of human tissue to assess the oncogenic activity of melanoma-associated mutations
    Yakov Chudnovsky
    Veterans Affairs Palo Alto Healthcare System, Palo Alto, California 94304, USA
    Nat Genet 37:745-9. 2005
    ..Here we characterize pathways sufficient to generate human melanocytic neoplasia and show that genetically altered human tissue facilitates functional analysis of mutations observed in human tumors...
  23. pmc Melanoma genetics and the development of rational therapeutics
    Yakov Chudnovsky
    Veterans Affairs Palo Alto Healthcare System, Palo Alto, California, USA
    J Clin Invest 115:813-24. 2005
    ..No current treatments substantially enhance patient survival once metastasis has occurred. This review focuses on recent insights into melanoma genetics and new therapeutic approaches being developed based on these advances...
  24. ncbi request reprint Type VII collagen is required for Ras-driven human epidermal tumorigenesis
    Susana Ortiz-Urda
    VA Palo Alto Healthcare System, Palo Alto, CA 94304, USA
    Science 307:1773-6. 2005
    ..Tumor-stroma interactions mediated by collagen VII thus promote neoplasia, and retention of NC1 sequences in a subset of RDEB patients may contribute to their increased susceptibility to squamous cell carcinoma...
  25. ncbi request reprint Targets for molecular therapy of skin cancer
    Cheryl L Green
    Program in Epithelial Biology, Stanford University School of Medicine, 269 Campus Drive, Room 2145, Stanford, CA 94305, USA
    Semin Cancer Biol 14:63-9. 2004
    ..New modalities designed to target these specific proteins may represent promising approaches to therapy of human skin cancers...
  26. ncbi request reprint Mek1 alters epidermal growth and differentiation
    Florence A Scholl
    VA Palo Alto Healthcare System, Palo Alto, California 94305, USA
    Cancer Res 64:6035-40. 2004
    ..Mek1 is thus sufficient to promote the proliferative epithelial phenotype in a manner independent of intact kinase function...
  27. ncbi request reprint Inducible activation of Ras and Raf in adult epidermis
    Masahito Tarutani
    Veterans Affairs Valo Alto Healthcare System and the Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Cancer Res 63:319-23. 2003
    ..Epidermal expression of inducible Raf produced similar changes. These findings indicate that activation of Ras in adult epidermis promotes proliferation and inhibits differentiation and that Raf is sufficient to mediate these effects...
  28. ncbi request reprint Stable nonviral genetic correction of inherited human skin disease
    Susana Ortiz-Urda
    VA Palo Alto Healthcare System and the Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA
    Nat Med 8:1166-70. 2002
    ..These findings establish a practical approach to nonviral genetic correction of severe human genetic disorders requiring stable genomic integration of large DNA sequences...
  29. ncbi request reprint PhiC31 integrase-mediated nonviral genetic correction of junctional epidermolysis bullosa
    Susana Ortiz-Urda
    VA Palo Alto Healthcare System and Program in Epithelial Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305, USA
    Hum Gene Ther 14:923-8. 2003
    ..Furthermore, corrected JEB tissue restored hemidesmosome formation and abolished histologic evidence of subepidermal blistering. These findings provide an approach to durable nonviral correction of JEB...
  30. pmc Tumor necrosis factor receptor 1/c-Jun-NH2-kinase signaling promotes human neoplasia
    Jennifer Y Zhang
    Department of Medicine, Division of Dermatology, Duke University School of Medicine, Trent Drive, Durham, NC 27710, USA
    Cancer Res 67:3827-34. 2007
    ..The TNFR1/MKK7/JNK/AP1 cascade thus promotes human neoplasia and represents a potential therapeutic target for human epithelial cancers...
  31. ncbi request reprint Mek1/2 MAPK kinases are essential for Mammalian development, homeostasis, and Raf-induced hyperplasia
    Florence A Scholl
    Veterans Affairs Palo Alto Healthcare System, Palo Alto, CA 94304, USA
    Dev Cell 12:615-29. 2007
    ..These data indicate that Mek1/2 are functionally redundant in the epidermis, where they act as a linear relay in the MAPK pathway to mediate development and homeostasis...
  32. pmc NF-kappaB RelA opposes epidermal proliferation driven by TNFR1 and JNK
    Jennifer Y Zhang
    VA Palo Alto Healthcare System, Palo Alto, California 94305, USA
    Genes Dev 18:17-22. 2004
    ..Thus, RelA antagonizes TNFR1-JNK proliferative signals in epidermis and plays a nonredundant role in restraining epidermal growth...
  33. ncbi request reprint Oxygen deprivation provokes melanoma
    Amy E Adams
    Nat Med 12:168-9. 2006
  34. pmc The class II phosphoinositide 3-kinase C2beta is not essential for epidermal differentiation
    Kazutoshi Harada
    Veterans Affairs Palo Alto Healthcare System, CA 94304, USA
    Mol Cell Biol 25:11122-30. 2005
    ..Induction of differentiation markers was unaffected in the absence of C2alpha and C2beta. These findings indicate that class II PI3Ks are not essential for epidermal differentiation...
  35. ncbi request reprint Lentivectors for regulated and reversible cutaneous gene delivery
    Zurab Siprashvili
    VA Alto Healthcare System, Palo Alto, California 94025, USA
    Mol Ther 9:93-100. 2004
    ..These findings establish an approach to durable, topically controlled systemic delivery of therapeutic proteins from human skin tissue...
  36. ncbi request reprint Intracellular delivery of functional proteins via decoration with transporter peptides
    Zurab Siprashvili
    VA Palo Alto Healthcare System, Palo Alto, CA 94025, USA
    Mol Ther 9:721-8. 2004
    ..Decoration with transporter peptides thus provides an attractive general means of intracellular delivery of functional proteins in vitro and in tissue...
  37. pmc Injection of genetically engineered fibroblasts corrects regenerated human epidermolysis bullosa skin tissue
    Susana Ortiz-Urda
    Veterans Affairs Palo Alto Healthcare System, Palo Alto, California, USA
    J Clin Invest 111:251-5. 2003
    ..This article was published online in advance of the print edition. The date of publication is available from the JCI website, http://www.jci.org...
  38. ncbi request reprint Divergent gene regulation and growth effects by NF-kappa B in epithelial and mesenchymal cells of human skin
    Kaede Hinata
    Program in Epithelial Biology, Stanford University School of Medicine, CA 94305, USA
    Oncogene 22:1955-64. 2003
    ....

Research Grants2

  1. Postgraduate Training Program Epithelial Biology
    PAUL KHAVARI; Fiscal Year: 2007
    ..The Stanford Postgraduate Training Program in Epithelial Biology, AR07422, aims to train future leaders in the field of research relevant to human skin disease. ..