Holger Karsunky

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Inflammatory reactions and severe neutropenia in mice lacking the transcriptional repressor Gfi1
    Holger Karsunky
    Institut für Zellbiologie Tumorforschung, IFZ, Universitatsklinikum Essen, D 45122 Essen, Germany
    Nat Genet 30:295-300. 2002
  2. pmc Flt3 ligand regulates dendritic cell development from Flt3+ lymphoid and myeloid-committed progenitors to Flt3+ dendritic cells in vivo
    Holger Karsunky
    Institute for Research in Biomedicine IRB, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
    J Exp Med 198:305-13. 2003
  3. pmc Flk2+ common lymphoid progenitors possess equivalent differentiation potential for the B and T lineages
    Holger Karsunky
    Institute of Stem Cell Biology and Regenerative Medicine, Department of Pathology, Stanford University School of Medicine, CA, USA
    Blood 111:5562-70. 2008
  4. ncbi request reprint Developmental origin of interferon-alpha-producing dendritic cells from hematopoietic precursors
    Holger Karsunky
    Department of Pathology, Stanford University School of Medicine, Stanford, Calif, USA
    Exp Hematol 33:173-81. 2005
  5. pmc Evaluation of the long-term reconstituting subset of hematopoietic stem cells with CD150
    Peter Papathanasiou
    Institute of Stem Cell Biology and Regenerative Medicine and Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    Stem Cells 27:2498-508. 2009
  6. pmc Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors
    Antonio Cozzio
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Genes Dev 17:3029-35. 2003
  7. pmc Identification of the earliest natural killer cell-committed progenitor in murine bone marrow
    John W Fathman
    Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Blood 118:5439-47. 2011
  8. ncbi request reprint Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9
    Chi Wai So
    Department of Pathology, Stanford University School of Medicine, Stanford 94305, USA
    Blood 103:3192-9. 2004
  9. pmc Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development
    Matthew A Inlay
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 23:2376-81. 2009
  10. pmc B-cell development fails in the absence of the Pbx1 proto-oncogene
    Mrinmoy Sanyal
    Department of Pathology, Stanford University, School of Medicine, Stanford, CA 94305, USA
    Blood 109:4191-9. 2007

Detail Information

Publications22

  1. ncbi request reprint Inflammatory reactions and severe neutropenia in mice lacking the transcriptional repressor Gfi1
    Holger Karsunky
    Institut für Zellbiologie Tumorforschung, IFZ, Universitatsklinikum Essen, D 45122 Essen, Germany
    Nat Genet 30:295-300. 2002
    ..We conclude that Gfi1 influences the differentiation of myeloid precursors into granulocytes or monocytes and acts in limiting the inflammatory immune response...
  2. pmc Flt3 ligand regulates dendritic cell development from Flt3+ lymphoid and myeloid-committed progenitors to Flt3+ dendritic cells in vivo
    Holger Karsunky
    Institute for Research in Biomedicine IRB, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
    J Exp Med 198:305-13. 2003
    ....
  3. pmc Flk2+ common lymphoid progenitors possess equivalent differentiation potential for the B and T lineages
    Holger Karsunky
    Institute of Stem Cell Biology and Regenerative Medicine, Department of Pathology, Stanford University School of Medicine, CA, USA
    Blood 111:5562-70. 2008
    ..Thus, Flk2 expression defines a homogeneous, readily obtainable subset of bone marrow CLP that is completely lymphoid-committed and can differentiate equivalently well into both B and T lineages...
  4. ncbi request reprint Developmental origin of interferon-alpha-producing dendritic cells from hematopoietic precursors
    Holger Karsunky
    Department of Pathology, Stanford University School of Medicine, Stanford, Calif, USA
    Exp Hematol 33:173-81. 2005
    ....
  5. pmc Evaluation of the long-term reconstituting subset of hematopoietic stem cells with CD150
    Peter Papathanasiou
    Institute of Stem Cell Biology and Regenerative Medicine and Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    Stem Cells 27:2498-508. 2009
    ..This is important for the clarification of lineage relationships and the identification of bona fide regulators of stem cell self-renewal and differentiation both in normal and neoplastic tissues...
  6. pmc Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors
    Antonio Cozzio
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Genes Dev 17:3029-35. 2003
    ....
  7. pmc Identification of the earliest natural killer cell-committed progenitor in murine bone marrow
    John W Fathman
    Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Blood 118:5439-47. 2011
    ..Taken together, our data provide a high-resolution in vivo analysis of the earliest steps of NK cell commitment and maturation...
  8. ncbi request reprint Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9
    Chi Wai So
    Department of Pathology, Stanford University School of Medicine, Stanford 94305, USA
    Blood 103:3192-9. 2004
    ....
  9. pmc Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development
    Matthew A Inlay
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 23:2376-81. 2009
    ....
  10. pmc B-cell development fails in the absence of the Pbx1 proto-oncogene
    Mrinmoy Sanyal
    Department of Pathology, Stanford University, School of Medicine, Stanford, CA 94305, USA
    Blood 109:4191-9. 2007
    ..Thus, Pbx1 critically functions at a stage between hematopoietic stem cell development and B-cell commitment and, therefore, is one of the earliest-acting transcription factors that regulate de novo B-lineage lymphopoiesis...
  11. pmc Self-renewal of the long-term reconstituting subset of hematopoietic stem cells is regulated by Ikaros
    Peter Papathanasiou
    Institute of Stem Cell Biology and Regenerative Medicine, and Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Stem Cells 27:3082-92. 2009
    ....
  12. doi request reprint The adhesion molecule esam1 is a novel hematopoietic stem cell marker
    A G Lisa Ooi
    Institute of Stem Cell Biology and Regenerative Medicine, Department of Pathology, Stanford University School of Medicine, California, USA
    Stem Cells 27:653-61. 2009
    ..These studies identify Esam1 as a novel, widely applicable HSC-selective marker and suggest that Esam1 may play roles in both HSC proliferation and lineage decisions...
  13. pmc Heme oxygenase-1 deficiency leads to disrupted response to acute stress in stem cells and progenitors
    Yu An Cao
    Departments of Pediatrics, Stanford University School of Medicine, CA, USA
    Blood 112:4494-502. 2008
    ..Control of stem cell stress response by HO-1 presents opportunities for metabolic manipulation of stem cell-based therapies...
  14. ncbi request reprint MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice
    Chi Wai So
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cancer Cell 3:161-71. 2003
    ..This experimental modeling of ABL in mice highlights its origin from multipotential progenitors that arrest at a bipotential stage specifically targeted or induced by MLL oncogenes...
  15. ncbi request reprint Langerhans cells renew in the skin throughout life under steady-state conditions
    Miriam Merad
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94304, USA
    Nat Immunol 3:1135-41. 2002
    ..These data indicate that under steady-state conditions, LCs are maintained locally, but inflammatory changes in the skin result in their replacement by blood-borne LC progenitors...
  16. pmc Flk2+ myeloid progenitors are the main source of Langerhans cells
    Ines Mende
    Stanford Blood Center, 3373 Hillview Ave, Palo Alto, CA 94304, USA
    Blood 107:1383-90. 2006
    ..These results indicate that LCs are derived mainly from myeloid progenitors and are dependent on Flt3-ligand for their development...
  17. pmc The transcriptional repressor Gfi1 affects development of early, uncommitted c-Kit+ T cell progenitors and CD4/CD8 lineage decision in the thymus
    Raif Yücel
    Institut für Zellbiologie Tumorforschung, IFZ, Universitatsklinikum Essen, Virchowstrasse 173, D 45122 Essen, Germany
    J Exp Med 197:831-44. 2003
    ....
  18. ncbi request reprint CD101 surface expression discriminates potency among murine FoxP3+ regulatory T cells
    Irina Fernandez
    Departamento de Biologia Celular, Universidad Simon Bolivar, Caracas, Venezuela corrected
    J Immunol 179:2808-14. 2007
    ..Among the CD101(high) Treg all of the in vivo suppressor activity was contained within the CD62L(high) subpopulation. We conclude that CD101 expression distinguishes murine Treg with potent suppressor activity...
  19. pmc Novel role for EKLF in megakaryocyte lineage commitment
    Pilar Frontelo
    Mount Sinai School of Medicine, New York, NY 10029, USA
    Blood 110:3871-80. 2007
    ..Expression profiling and molecular analyses support these observations and suggest that megakaryocytic inhibition is achieved, at least in part, by EKLF repression of Fli-1 message levels...
  20. pmc Miz1 is required for early embryonic development during gastrulation
    Sovana Adhikary
    Institute for Molecular Biology and Tumor Research Institute for Cytobiology and Cytopathology, University of Marburg, 35033 Marburg, Germany
    Mol Cell Biol 23:7648-57. 2003
    ..Miz1(-/-) embryos succumb to massive apoptosis of ectodermal cells around day 7.5 of embryonic development. Our results show that Miz1 is required for early embryonic development during gastrulation...
  21. ncbi request reprint Loss of p27(Kip1) cooperates with cyclin E in T-cell lymphomagenesis
    Christoph Geisen
    Institut fur Zellbiologie, Universitatsklinikum Essen, Germany
    Oncogene 22:1724-9. 2003
    ....
  22. ncbi request reprint High levels of the onco-protein Gfi-1 accelerate T-cell proliferation and inhibit activation induced T-cell death in Jurkat T-cells
    Holger Karsunky
    Institut für Zellbiologie Tumorforschung, IFZ, Universitatsklinikum Essen, Virchowstrasse 173, D 45122 Essen, Germany
    Oncogene 21:1571-9. 2002
    ..These findings suggest that Gfi-1 contributes to T-cell lymphomagenesis by overriding a late G1 cell cycle checkpoint which controls activation induced death and S phase entry of T-cells...