Craig D Kaplan

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Polyadenylation site choice in yeast is affected by competition between Npl3 and polyadenylation factor CFI
    Miriam E Bucheli
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    RNA 13:1756-64. 2007
  2. ncbi Interaction between transcription elongation factors and mRNA 3'-end formation at the Saccharomyces cerevisiae GAL10-GAL7 locus
    Craig D Kaplan
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 280:913-22. 2005
  3. pmc The RNA polymerase II trigger loop functions in substrate selection and is directly targeted by alpha-amanitin
    Craig D Kaplan
    Department of Structural Biology, Stanford University, Stanford, CA 94305, USA
    Mol Cell 30:547-56. 2008
  4. ncbi Transcription elongation factors repress transcription initiation from cryptic sites
    Craig D Kaplan
    Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Science 301:1096-9. 2003
  5. pmc Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
    Dong Wang
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 127:941-54. 2006
  6. pmc Tfb6, a previously unidentified subunit of the general transcription factor TFIIH, facilitates dissociation of Ssl2 helicase after transcription initiation
    Kenji Murakami
    Department of Structural Biology, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 109:4816-21. 2012
  7. pmc Trigger loop dynamics mediate the balance between the transcriptional fidelity and speed of RNA polymerase II
    Matthew H Larson
    Biophysics Program, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 109:6555-60. 2012
  8. pmc A bridge to transcription by RNA polymerase
    Craig D Kaplan
    Department of Structural Biology, Stanford University, 299 Campus Dr, West, Stanford, CA 94305, USA
    J Biol 7:39. 2008
  9. ncbi Regulatory oversight of the iron trade: posttranscriptional regulation in yeast
    Craig D Kaplan
    Department of Structural Biology, Stanford University, Palo Alto, CA 94305, USA
    Cell Metab 2:4-6. 2005

Research Grants

Collaborators

Detail Information

Publications9

  1. pmc Polyadenylation site choice in yeast is affected by competition between Npl3 and polyadenylation factor CFI
    Miriam E Bucheli
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    RNA 13:1756-64. 2007
    ..Our results support a model in which balanced competition of Npl3 with mRNA processing factors may promote recognition of proper polyadenylation sites while suppressing cryptic sites...
  2. ncbi Interaction between transcription elongation factors and mRNA 3'-end formation at the Saccharomyces cerevisiae GAL10-GAL7 locus
    Craig D Kaplan
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 280:913-22. 2005
    ..Overall, these results provide new evidence for a connection between the transcription elongation factor Spt6 and 3'-end formation in vivo...
  3. pmc The RNA polymerase II trigger loop functions in substrate selection and is directly targeted by alpha-amanitin
    Craig D Kaplan
    Department of Structural Biology, Stanford University, Stanford, CA 94305, USA
    Mol Cell 30:547-56. 2008
    ..We propose that alpha-amanitin-inhibited Pol II elongation, which is slow and exhibits reduced substrate selectivity, results from direct alpha-amanitin interference with the TL...
  4. ncbi Transcription elongation factors repress transcription initiation from cryptic sites
    Craig D Kaplan
    Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Science 301:1096-9. 2003
    ..Other elongation and chromatin factors, including Spt16 and histone H3, appear to contribute to this control...
  5. pmc Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
    Dong Wang
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 127:941-54. 2006
    ..A histidine side chain in the trigger loop, precisely positioned by these interactions, may literally "trigger" phosphodiester bond formation. Recognition and catalysis are thus coupled, ensuring the fidelity of transcription...
  6. pmc Tfb6, a previously unidentified subunit of the general transcription factor TFIIH, facilitates dissociation of Ssl2 helicase after transcription initiation
    Kenji Murakami
    Department of Structural Biology, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 109:4816-21. 2012
    ..Tfb6 does not, however, dissociate Ssl2 from TFIIH in the context of a fully assembled transcription preinitiation complex. Our findings suggest a dynamic state of Ssl2, allowing its engagement in multiple cellular processes...
  7. pmc Trigger loop dynamics mediate the balance between the transcriptional fidelity and speed of RNA polymerase II
    Matthew H Larson
    Biophysics Program, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 109:6555-60. 2012
    ....
  8. pmc A bridge to transcription by RNA polymerase
    Craig D Kaplan
    Department of Structural Biology, Stanford University, 299 Campus Dr, West, Stanford, CA 94305, USA
    J Biol 7:39. 2008
    ....
  9. ncbi Regulatory oversight of the iron trade: posttranscriptional regulation in yeast
    Craig D Kaplan
    Department of Structural Biology, Stanford University, Palo Alto, CA 94305, USA
    Cell Metab 2:4-6. 2005
    ..These studies demonstrate sophisticated systems that limit iron uptake under conditions of abundance and lead to metabolic remodeling when iron is limited...

Research Grants1

  1. Biochemical analysis of Pol II elongation complexes and mechanism
    CRAIG KAPLAN; Fiscal Year: 2007
    ..Insights into Pol II function will allow a better understanding of how Pol II may be misregulated in disease states in other species, such as humans. ..