Janet Kalesnikoff

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc New developments in mast cell biology
    Janet Kalesnikoff
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Immunol 9:1215-23. 2008
  2. doi request reprint Antiinflammatory and immunosuppressive functions of mast cells
    Janet Kalesnikoff
    Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
    Methods Mol Biol 677:207-20. 2011
  3. pmc Roles of RabGEF1/Rabex-5 domains in regulating Fc epsilon RI surface expression and Fc epsilon RI-dependent responses in mast cells
    Janet Kalesnikoff
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Blood 109:5308-17. 2007
  4. ncbi request reprint RabGEF1, a negative regulator of Ras signalling, mast cell activation and skin inflammation
    See Ying Tam
    Departments of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5324, USA
    Novartis Found Symp 271:115-24; discussion 124-30, 145-51. 2005
  5. pmc Evidence questioning cromolyn's effectiveness and selectivity as a 'mast cell stabilizer' in mice
    Tatsuya Oka
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Lab Invest 92:1472-82. 2012
  6. pmc Rapid desensitization induces internalization of antigen-specific IgE on mouse mast cells
    Tatsuya Oka
    Department of Pathology, Stanford University School of Medicine, Stanford, Calif
    J Allergy Clin Immunol 132:922-32.e1-16. 2013
  7. pmc Rabaptin-5 regulates receptor expression and functional activation in mast cells
    Eon J Rios
    Department of Pathology, Stanford University School of Medicine, CA, USA
    Blood 112:4148-57. 2008
  8. pmc Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice
    Jennifer N Lilla
    Department of Pathology, Stanford University School of Medicine, CA 94305 5324, USA
    Blood 118:6930-8. 2011
  9. ncbi request reprint Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B
    Michele A Grimbaldeston
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5176, USA
    Nat Immunol 8:1095-104. 2007
  10. pmc RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cells
    Janet Kalesnikoff
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Proc Natl Acad Sci U S A 103:2659-64. 2006

Collaborators

Detail Information

Publications27

  1. pmc New developments in mast cell biology
    Janet Kalesnikoff
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Immunol 9:1215-23. 2008
    ....
  2. doi request reprint Antiinflammatory and immunosuppressive functions of mast cells
    Janet Kalesnikoff
    Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
    Methods Mol Biol 677:207-20. 2011
    ....
  3. pmc Roles of RabGEF1/Rabex-5 domains in regulating Fc epsilon RI surface expression and Fc epsilon RI-dependent responses in mast cells
    Janet Kalesnikoff
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Blood 109:5308-17. 2007
    ..By contrast, correction of these -/- phenotypes required a functional Vps9 domain. Thus, Fc epsilon RI-mediated mast cell functional activation is dependent on RabGEF1's GEF activity...
  4. ncbi request reprint RabGEF1, a negative regulator of Ras signalling, mast cell activation and skin inflammation
    See Ying Tam
    Departments of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5324, USA
    Novartis Found Symp 271:115-24; discussion 124-30, 145-51. 2005
    ....
  5. pmc Evidence questioning cromolyn's effectiveness and selectivity as a 'mast cell stabilizer' in mice
    Tatsuya Oka
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Lab Invest 92:1472-82. 2012
    ..These results question cromolyn's effectiveness and selectivity as an inhibitor of mast cell activation and mediator release in the mouse...
  6. pmc Rapid desensitization induces internalization of antigen-specific IgE on mouse mast cells
    Tatsuya Oka
    Department of Pathology, Stanford University School of Medicine, Stanford, Calif
    J Allergy Clin Immunol 132:922-32.e1-16. 2013
    ..However, the mechanisms underlying successful rapid desensitization are not fully understood...
  7. pmc Rabaptin-5 regulates receptor expression and functional activation in mast cells
    Eon J Rios
    Department of Pathology, Stanford University School of Medicine, CA, USA
    Blood 112:4148-57. 2008
    ..These findings show that, although dispensable for canonical Rab5 processes in mast cells, Rabaptin-5 importantly contributes to mast cell IgE-dependent immunologic function by enhancing mast cell receptor surface stability...
  8. pmc Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice
    Jennifer N Lilla
    Department of Pathology, Stanford University School of Medicine, CA 94305 5324, USA
    Blood 118:6930-8. 2011
    ....
  9. ncbi request reprint Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B
    Michele A Grimbaldeston
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5176, USA
    Nat Immunol 8:1095-104. 2007
    ....
  10. pmc RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cells
    Janet Kalesnikoff
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Proc Natl Acad Sci U S A 103:2659-64. 2006
    ..Thus, RabGEF1 plays a critical role in the regulation of SCF/c-Kit-mediated signaling events and biological responses in mast cells...
  11. doi request reprint A beneficial role for immunoglobulin E in host defense against honeybee venom
    Thomas Marichal
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Immunity 39:963-75. 2013
    ....
  12. pmc Mast cell anaphylatoxin receptor expression can enhance IgE-dependent skin inflammation in mice
    Beatrix Schäfer
    Department of Pathology, Stanford University School of Medicine, Stanford, Calif 94305 5324, USA
    J Allergy Clin Immunol 131:541-8.e1-9. 2013
    ..However, it is not clear to what extent mast cell expression of C3aR or C5aR influences C3a- or C5a-induced cutaneous responses or IgE-dependent mast cell activation and passive cutaneous anaphylaxis (PCA) in vivo...
  13. pmc Mast cell-derived TNF can exacerbate mortality during severe bacterial infections in C57BL/6-KitW-sh/W-sh mice
    Adrian M Piliponsky
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Am J Pathol 176:926-38. 2010
    ..typhimurium...
  14. ncbi request reprint Mast cells as "tunable" effector and immunoregulatory cells: recent advances
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Annu Rev Immunol 23:749-86. 2005
    ....
  15. ncbi request reprint Anaphylaxis: mechanisms of mast cell activation
    Janet Kalesnikoff
    Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
    Chem Immunol Allergy 95:45-66. 2010
    ..We will also discuss the use of mouse models to investigate the mechanisms that can contribute to anaphylaxis in that species in vivo, and the relevance of such mouse studies to human anaphylaxis...
  16. ncbi request reprint RabGEF1 is a negative regulator of mast cell activation and skin inflammation
    See Ying Tam
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Immunol 5:844-52. 2004
    ..Thus, RabGEF1 is a negative regulator of Fc epsilon RI-dependent mast cell activation, and a lack of RabGEF1 results in the development of skin inflammation in vivo...
  17. ncbi request reprint The role of SHIP in mast cell degranulation and IgE-induced mast cell survival
    Michael Huber
    Department of Molecular Immunology, Biology III, University of Freiburg and Max Planck Institute for Immunobiology, Freiburg, Germany
    Immunol Lett 82:17-21. 2002
    ..These studies demonstrate that mast cell sensitization by IgE is an active rather than a passive process...
  18. ncbi request reprint SHIP represses mast cell activation and reveals that IgE alone triggers signaling pathways which enhance normal mast cell survival
    Janet Kalesnikoff
    Terry Fox Laboratory, BC Cancer Agency, 601 West, 10th Avenue, BC, V5Z 1L3, Vancouver, Canada
    Mol Immunol 38:1201-6. 2002
    ..Moreover, IgE alone maintains Bcl-X(L) levels and enhances the adhesion of BMMCs to fibronectin and this likely enhances their survival still further...
  19. ncbi request reprint SHIP negatively regulates IgE + antigen-induced IL-6 production in mast cells by inhibiting NF-kappa B activity
    Janet Kalesnikoff
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    J Immunol 168:4737-46. 2002
    ....
  20. ncbi request reprint IgE alone stimulates mast cell adhesion to fibronectin via pathways similar to those used by IgE + antigen but distinct from those used by Steel factor
    Vivian Lam
    Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada
    Blood 102:1405-13. 2003
    ..Furthermore, our data suggest that FN acts synergistically with IgE to prolong intracellular phosphorylation events and to enhance IgE-induced inflammatory cytokine production and BMMC survival...
  21. pmc IgE-induced mast cell survival requires the prolonged generation of reactive oxygen species
    Laura M Sly
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    J Immunol 181:3850-60. 2008
    ..In support of the essential role that IgE-induced ROS plays in IgE-enhanced BMMC survival, we found the addition of H(2)O(2) to IgE+Ag-stimulated BMMCs leads to IL-3 secretion...
  22. ncbi request reprint SHIP, SHIP2, and PTEN activities are regulated in vivo by modulation of their protein levels: SHIP is up-regulated in macrophages and mast cells by lipopolysaccharide
    Laura M Sly
    The Terry Fox Laboratory, British Columbia Cancer Agency, 601 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
    Exp Hematol 31:1170-81. 2003
    ..We also highlight the critical role that SHIP plays in lipopolysaccharide-induced macrophage activation and in endotoxin tolerance...
  23. ncbi request reprint SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts
    Sunao Takeshita
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Med 8:943-9. 2002
    ..Thus, SHIP negatively regulates osteoclast formation and function and the absence of this enzyme results in severe osteoporosis...
  24. ncbi request reprint Dysregulated FcepsilonRI signaling and altered Fyn and SHIP activities in Lyn-deficient mast cells
    Valerie Hernandez-Hansen
    Department of Pathology and Cancer Research and Treatment Center, University of New Mexico School of Medicine, CRF 205, 2325 Camino de Salud, Albuquerque, NM 87131, USA
    J Immunol 173:100-12. 2004
    ..The unexpected absence of the transient receptor potential channel, Trpc4, from Lyn(-/-) BMMCs may additionally contribute to their altered signaling properties...
  25. pmc Protein kinase C-delta is a negative regulator of antigen-induced mast cell degranulation
    Michael Leitges
    Max Planck Institute for Experimental Endocrinology, 30625 Hannover, Germany
    Mol Cell Biol 22:3970-80. 2002
    ..Altogether, our data suggest that PKC-delta is a negative regulator of antigen-induced mast cell degranulation...
  26. ncbi request reprint LPS-induced upregulation of SHIP is essential for endotoxin tolerance
    Laura M Sly
    The Terry Fox Laboratory, BC Cancer Agency, 601 West 10th Avenue, Vancouver, British Columbia, V5Z 1L3, Canada
    Immunity 21:227-39. 2004
    ..In vivo studies with SHIP(+/+) and SHIP(-/-) mice confirm these in vitro findings and show a correlation between the duration of endotoxin tolerance and elevated SHIP levels...
  27. ncbi request reprint Nipping cat allergy with fusion proteins
    Janet Kalesnikoff
    Nat Med 11:381-2. 2005