Research Topics
Genomes and GenesSpecies | Dale KaiserSummaryAffiliation: Stanford University Country: USA Publications
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Detail Information
Publications
Distinguishing features of delta-proteobacterial genomesSamuel Karlin
Department of Mathematics, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 103:11352-7. 2006..The predicted highly expressed genes from delta genomes reflect their different ecologies, metabolic strategies, and adaptations...
Computational prediction of human metabolic pathways from the complete human genomePedro Romero
Bioinformatics Research Group, SRI International, 333 Ravenswood Ave, Menlo Park, CA 94025, USA
Genome Biol 6:R2. 2005..Pathway assignments place genes in their larger biological context, and are a necessary first step toward quantitative modeling of metabolism...- Dynamics of fruiting body morphogenesisDale Kaiser
Departments of Biochemistry and Developmental Biology, Stanford University, Stanford, California 94305, USA
J Bacteriol 186:919-27. 2004..Although fruiting bodies are relatively large structures that contain 10(5) cells, no long-range interactions between cells were evident. For aggregation, M. xanthus appears to use local interactions between its cells... 
A microbial genetic journeyDale Kaiser
Department of Biochemistry, Stanford University, Stanford, California 94305, USA
Annu Rev Microbiol 60:1-25. 2006..We identified two cell-to-cell signals used to coordinate development. We have elucidated, in part, the signal transduction pathway for C-signal that directs the morphogenesis of a fruiting body...- Bacterial swarming: a re-examination of cell-movement patternsDale Kaiser
Departments of Biochemistry and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
Curr Biol 17:R561-70. 2007..By identifying patterns of movement that are common to swarms making use of different engines, a model of swarm choreography can be proposed... - Signaling in myxobacteriaDale Kaiser
Department of Biochemistry, Stanford University, Stanford, California 94305, USA
Annu Rev Microbiol 58:75-98. 2004..Traveling waves, streams, and sporulation have increasing thresholds for C-signal activity, and this progression ensures that spores form inside fruiting bodies... - Polar assembly of the type IV pilus secretin in Myxococcus xanthusEric Nudleman
Department of Developmental Biology, Stanford University School of Medicine, B300 Beckman Center, 279 Campus Drive, Stanford, CA 94305, USA
Mol Microbiol 60:16-29. 2006..We suggest that these proteins are parts of a polar superstructure that holds PilQ monomers in a cluster and ready for Tgl to bring about secretin assembly... - Enhancer-binding proteins with a forkhead-associated domain and the sigma54 regulon in Myxococcus xanthus fruiting body developmentLars Jelsbak
Department of Biochemistry, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 102:3010-5. 2005..Because FHA domains respond to phosphothreonine-containing proteins, these results suggest a regulatory link to the abundant Ser/Thr protein kinases in M. xanthus... - Myxobacteria, polarity, and multicellular morphogenesisDale Kaiser
Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305, USA
Cold Spring Harb Perspect Biol 2:a000380. 2010..Developmental gene expression is regulated by a network that is connected to the suppression of reversals... - Cell-to-cell transfer of bacterial outer membrane lipoproteinsEric Nudleman
Departments of Developmental Biology and Biochemistry, Stanford University School of Medicine, B300 Beckman Center, 279 Campus Drive, Stanford, CA 94305, USA
Science 309:125-7. 2005..The high transfer efficiency of Tgl and CglB proteins suggests that donor and recipient cells briefly fuse their outer membranes... 
Myxococcus-from single-cell polarity to complex multicellular patternsDale Kaiser
Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305, USA
Annu Rev Genet 42:109-30. 2008..Mgl.GTP then recognizes the engines that are currently in use and inactivates both of them. Meanwhile, new engines appear as instructed by the template, and the cell starts to glide in the opposite direction...- Regulating pilin expression reveals a threshold for S motility in Myxococcus xanthusLotte Jelsbak
Department of Biochemistry, Stanford University, Stanford, CA 94305 5329, USA
J Bacteriol 187:2105-12. 2005..This observation implies that a threshold concentration of pilin must be exceeded before the shear-sensitive material (pili) is polymerized in M. xanthus... - Mutations of the act promoter in Myxococcus xanthusThomas M A Gronewold
Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305 5329, USA
J Bacteriol 189:1836-44. 2007..We propose that, as cells engage in more C signaling, positive feedback raises the number of C-signal molecules per cell and drives the process of fruiting body development forward... - Pulling together with type IV piliEric Nudleman
Stanford University, Departments of Biochemistry and of Developmental Biology, Stanford, California 94305, USA
J Mol Microbiol Biotechnol 7:52-62. 2004.... - Coupling cell movement to multicellular development in myxobacteriaDale Kaiser
Stanford University, Departments of Biochemistry and Developmental Biology, Stanford, California 94305, USA
Nat Rev Microbiol 1:45-54. 2003..The myxobacteria communicate with each other and coordinate their movements through a cell-contact-dependent signal. Here, the cell movements that culminate in the development of the multicellular fruiting body are reviewed... - Gliding motility and polarized slime secretionRosa Yu
Departments of Biochemistry and of Developmental Biology, Stanford University School of Medicine Stanford, CA 94305, USA
Mol Microbiol 63:454-67. 2007..Many of the pgl mutants are produced by transposon insertions in glycosyltransferase genes. It is proposed that these glycosyltransferases carry out the synthesis of a repeat unit polysaccharide that constitutes the slime... - Myxococcus xanthus swarms are driven by growth and regulated by a pacemakerDale Kaiser
Departments of Biochemistry, Stanford University School of Medicine, Stanford, California 94305, USA
J Bacteriol 193:5898-904. 2011..The periodic reversal of interacting rod-shaped cells promotes their alignment. Swarm organization ensures that each cell can move without blocking the movement of others... - Reversing cell polarity: evidence and hypothesisDale Kaiser
B300 Beckman Center, Department of Developmental Biology, 279 Campus Drive, Stanford University, Stanford, California 94305, USA
Curr Opin Microbiol 8:216-21. 2005..Cells reverse regularly every eight minutes in traveling waves, the reversal period is then prolonged enabling cells to form streams that enlarge tiny random aggregates into fruiting bodies... - act operon control of developmental gene expression in Myxococcus xanthusThomas M A Gronewold
Departments of Biochemistry and of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305-5329, USA
J Bacteriol 184:1172-9. 2002..The pattern of effects on these reporters shows how the C-signal differentially regulates the steps that together build a fruiting body and differentiate spores within it... - Sigma54 enhancer binding proteins and Myxococcus xanthus fruiting body developmentJimmy S Jakobsen
Departments of Biochemistry and Developmental Biology, Stanford University, Stanford, California 94305, USA
J Bacteriol 186:4361-8. 2004..Three were previously unknown genes, and they were inactivated to look for effects on fruiting body development. One knockout mutant produced fruiting bodies of abnormal shape that depended on the composition of the medium... - A biochemical oscillator explains several aspects of Myxococcus xanthus behavior during developmentOleg A Igoshin
Department of Physics, University of California, Berkeley, CA 94720, USA
Proc Natl Acad Sci U S A 101:15760-5. 2004..We also propose experiments to test the model... - A three-dimensional model of myxobacterial aggregation by contact-mediated interactionsOlga Sozinova
Department of Mathematics and Center for the Study of Biocomplexity, University of Notre Dame, Notre Dame, IN 46556-5670, USA
Proc Natl Acad Sci U S A 102:11308-12. 2005..We show that, at high cell density, cells stream around the traffic jam, generating a 3D hemispherical mound. Later, when the nuclear traffic jam dissolves, the aggregation center becomes a 3D ring of streaming cells... - 3-Hydroxy-3-methylglutaryl-coenzyme A (CoA) synthase is involved in biosynthesis of isovaleryl-CoA in the myxobacterium Myxococcus xanthus during fruiting body formationHelge B Bode
Institut für Pharmazeutische Biotechnologie, Universitat des Saarlandes, P O Box 151150, 66041 Saarbrucken, Germany
J Bacteriol 188:6524-8. 2006.... - Straight-chain fatty acids are dispensable in the myxobacterium Myxococcus xanthus for vegetative growth and fruiting body formationHelge B Bode
Institut für Pharmazeutische Biotechnologie, Universitat des Saarlandes, P O Box 151150, 66041 Saarbrucken, Germany
J Bacteriol 188:5632-4. 2006..Despite this drastic change in the fatty acid profile, no change in phenotype could be observed, which contrasts with previous interpretations of the role of straight-chain fatty acids in the organism's development... - Breaking symmetry in myxobacteriaOleg A Igoshin
Department of Molecular and Cellular Biology, University of California, Berkeley, California 94720-3112, USA
Curr Biol 14:R459-62. 2004 - Waves and aggregation patterns in myxobacteriaOleg A Igoshin
Department of Physics, University of California, Berkeley, CA 94720, USA
Proc Natl Acad Sci U S A 101:4256-61. 2004..Still later, pairs of motile aggregates coalesce to form larger aggregates that develop into fruiting bodies. Here we present a mathematical model that quantitatively explains these wave and aggregation phenomena... - How myxobacteria glideCharles Wolgemuth
Department of Molecular and Cellular Biology and ESPM, University of California, Berkeley 94720 3112, USA
Curr Biol 12:369-77. 2002..Recently, nozzle-like structures were discovered in cyanobacteria from which slime emanated at the same rate at which the bacteria moved. This strongly implicates slime extrusion as a propulsion mechanism for gliding... - A three-dimensional model of myxobacterial fruiting-body formationOlga Sozinova
Department of Mathematics and Center for the Study of Biocomplexity, University of Notre Dame, Notre Dame, IN 46556-5670, USA
Proc Natl Acad Sci U S A 103:17255-9. 2006....