Siddhartha Jaiswal

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis
    Siddhartha Jaiswal
    Ludwig Center at Stanford, Stanford Cancer Center, Department of Pathology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 138:271-85. 2009
  2. pmc Macrophages as mediators of tumor immunosurveillance
    Siddhartha Jaiswal
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford Cancer Center, and Ludwig Center at Stanford, USA
    Trends Immunol 31:212-9. 2010
  3. pmc The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors
    Stephen B Willingham
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford University Medical Center, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 109:6662-7. 2012
  4. doi request reprint Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47
    Mark P Chao
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford Cancer Center, and Ludwig Center at Stanford, Stanford, CA 94305, USA
    Sci Transl Med 2:63ra94. 2010
  5. pmc CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells
    Ravindra Majeti
    Department of Internal Medicine, Division of Hematology, Stanford University, Palo Alto, CA 94304, USA
    Cell 138:286-99. 2009
  6. pmc Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice
    May H Han
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 209:1325-34. 2012
  7. doi request reprint Hematopoietic stem and progenitor cells and the inflammatory response
    Siddhartha Jaiswal
    Ludwig Center at Stanford, Stanford Cancer Center, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Ann N Y Acad Sci 1174:118-21. 2009
  8. pmc Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias
    Siddhartha Jaiswal
    Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 100:10002-7. 2003

Collaborators

Detail Information

Publications8

  1. pmc CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis
    Siddhartha Jaiswal
    Ludwig Center at Stanford, Stanford Cancer Center, Department of Pathology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 138:271-85. 2009
    ..We conclude that CD47 upregulation is an important mechanism that provides protection to normal HSCs during inflammation-mediated mobilization, and that leukemic progenitors co-opt this ability in order to evade macrophage killing...
  2. pmc Macrophages as mediators of tumor immunosurveillance
    Siddhartha Jaiswal
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford Cancer Center, and Ludwig Center at Stanford, USA
    Trends Immunol 31:212-9. 2010
    ..These results implicate macrophages in the immunosurveillance of hematopoietic cells and leukemias. The ability of macrophages to phagocytose tumor cells might be exploited therapeutically by blocking the CD47-SIRPalpha interaction...
  3. pmc The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors
    Stephen B Willingham
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford University Medical Center, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 109:6662-7. 2012
    ..CD47 is therefore a validated target for cancer therapies...
  4. doi request reprint Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47
    Mark P Chao
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford Cancer Center, and Ludwig Center at Stanford, Stanford, CA 94305, USA
    Sci Transl Med 2:63ra94. 2010
    ....
  5. pmc CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells
    Ravindra Majeti
    Department of Internal Medicine, Division of Hematology, Stanford University, Palo Alto, CA 94304, USA
    Cell 138:286-99. 2009
    ..In summary, increased CD47 expression is an independent, poor prognostic factor that can be targeted on human AML stem cells with blocking monoclonal antibodies capable of enabling phagocytosis of LSC...
  6. pmc Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice
    May H Han
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 209:1325-34. 2012
    ..Immune regulation and phagocytosis are mechanisms for CD47 signaling in autoimmune neuroinflammation. Depending on the cell type, location, and disease stage, CD47 has Janus-like roles, with opposing effects on EAE pathogenesis...
  7. doi request reprint Hematopoietic stem and progenitor cells and the inflammatory response
    Siddhartha Jaiswal
    Ludwig Center at Stanford, Stanford Cancer Center, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Ann N Y Acad Sci 1174:118-21. 2009
    ..How the HSPCs remain immune to destruction in a toxic inflammatory milieu is unknown...
  8. pmc Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias
    Siddhartha Jaiswal
    Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 100:10002-7. 2003
    ....