PETER KENT JACKSON

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Linking tumor suppression, DNA damage and the anaphase-promoting complex
    Peter K Jackson
    Stanford University School of Medicine, 300 Pasteur Drive, Palo Alto, CA 94305, USA
    Trends Cell Biol 14:331-4. 2004
  2. doi request reprint Nek8 couples renal ciliopathies to DNA damage and checkpoint control
    Peter K Jackson
    Baxter Laboratory, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA Electronic address
    Mol Cell 51:407-8. 2013
  3. pmc Cyclin E uses Cdc6 as a chromatin-associated receptor required for DNA replication
    L Furstenthal
    Department of Pathology, Stangford University School of Medicine, Palo Alto, California 94305, USA
    J Cell Biol 152:1267-78. 2001
  4. pmc Xenopus Cdc14 alpha/beta are localized to the nucleolus and centrosome and are required for embryonic cell division
    Brett K Kaiser
    Departments of Pathology and Microbiology and Immunology, Program in Cancer Biology, Stanford University School of Medicine, Stanford, CA 94305 USA
    BMC Cell Biol 5:27. 2004
  5. pmc Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1
    David V Hansen
    Department of Pathology, Stanford University School of Medicine, Palo Alto, CA 94305, USA
    Mol Biol Cell 15:5623-34. 2004
  6. ncbi request reprint The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1
    Adam G Eldridge
    Department of Cancer Biology, Stanford University School of Medicine, CA 94305, USA
    Cell 124:367-80. 2006
  7. pmc Oncogenic regulators and substrates of the anaphase promoting complex/cyclosome are frequently overexpressed in malignant tumors
    Norman L Lehman
    Department of Pathology, MC5324, Stanford University, Stanford, CA, USA
    Am J Pathol 170:1793-805. 2007
  8. pmc Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor
    Julie J Miller
    Program in Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 20:2410-20. 2006
  9. ncbi request reprint Overexpression of the anaphase promoting complex/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cells
    Norman L Lehman
    Department of Pathology, Stanford University, Stanford, California 94305, USA
    Cell Cycle 5:1569-73. 2006
  10. ncbi request reprint E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)
    Jerry Y Hsu
    Department of Pathology and Program in Biophysics, Stanford University School of Medicine, CA 94305, USA
    Nat Cell Biol 4:358-66. 2002

Research Grants

  1. Proteolytic Control of Early Events in Mitosis
    Peter Jackson; Fiscal Year: 2007
  2. A NOVEL F BOX PROTEIN REGULATING MITOSIS
    Peter Jackson; Fiscal Year: 2004
  3. Cyclin Control DNA Replication and Mitosis
    Peter Jackson; Fiscal Year: 2005
  4. CYCLIN CONTROL OF DNA REPLICATION
    Peter Jackson; Fiscal Year: 2001

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Linking tumor suppression, DNA damage and the anaphase-promoting complex
    Peter K Jackson
    Stanford University School of Medicine, 300 Pasteur Drive, Palo Alto, CA 94305, USA
    Trends Cell Biol 14:331-4. 2004
    ..Furthermore, another recent study shows that protein kinase A, which is a key growth regulator, inhibits the APC during mitosis in yeast...
  2. doi request reprint Nek8 couples renal ciliopathies to DNA damage and checkpoint control
    Peter K Jackson
    Baxter Laboratory, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA Electronic address
    Mol Cell 51:407-8. 2013
    ..2013) discover a molecular link between the Nek8 kinase, mutated in the renal ciliopathy nephronophthisis, and DNA damage control by cyclin A/Cdk2 and ATR-Chk1, providing new ideas for targeted therapies limiting tissue degeneration. ..
  3. pmc Cyclin E uses Cdc6 as a chromatin-associated receptor required for DNA replication
    L Furstenthal
    Department of Pathology, Stangford University School of Medicine, Palo Alto, California 94305, USA
    J Cell Biol 152:1267-78. 2001
    ..These three phases of cyclin E association with chromatin may facilitate the diverse activities of cyclin E--Cdk2 in initiating replication, blocking rereplication, and allowing resetting of origins after mitosis...
  4. pmc Xenopus Cdc14 alpha/beta are localized to the nucleolus and centrosome and are required for embryonic cell division
    Brett K Kaiser
    Departments of Pathology and Microbiology and Immunology, Program in Cancer Biology, Stanford University School of Medicine, Stanford, CA 94305 USA
    BMC Cell Biol 5:27. 2004
    ..Therefore, it is of great interest to examine the function Cdc14 homologs in other vertebrate species...
  5. pmc Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1
    David V Hansen
    Department of Pathology, Stanford University School of Medicine, Palo Alto, CA 94305, USA
    Mol Biol Cell 15:5623-34. 2004
    ..These data support the hypothesis that Plk1 activates the APC by directing the SCF-dependent destruction of Emi1 in prophase...
  6. ncbi request reprint The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1
    Adam G Eldridge
    Department of Cancer Biology, Stanford University School of Medicine, CA 94305, USA
    Cell 124:367-80. 2006
    ..We propose that the balance of Evi5 and Polo-like kinase activities determines the timely accumulation of Emi1 and cyclin, ensuring mitotic fidelity...
  7. pmc Oncogenic regulators and substrates of the anaphase promoting complex/cyclosome are frequently overexpressed in malignant tumors
    Norman L Lehman
    Department of Pathology, MC5324, Stanford University, Stanford, CA, USA
    Am J Pathol 170:1793-805. 2007
    ..This profile of misregulated mitotic APC/C substrates and regulators in malignant tumors suggests that analysis of this pathway may be diagnostically useful and represent a potentially important therapeutic target...
  8. pmc Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor
    Julie J Miller
    Program in Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 20:2410-20. 2006
    ..The combination of a degron/E3 recognition site and an anti-ligase function in Emi1 suggests a general model for how E3 substrates evolve to become pseudosubstrate inhibitors...
  9. ncbi request reprint Overexpression of the anaphase promoting complex/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cells
    Norman L Lehman
    Department of Pathology, Stanford University, Stanford, California 94305, USA
    Cell Cycle 5:1569-73. 2006
    ..This represents a potentially important mechanism by which pRb and p53 dysfunction may contribute to tumorigenesis through the generation of genomic instability...
  10. ncbi request reprint E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)
    Jerry Y Hsu
    Department of Pathology and Program in Biophysics, Stanford University School of Medicine, CA 94305, USA
    Nat Cell Biol 4:358-66. 2002
    ..These data suggest that E2F can activate both transcription of cyclin A and the hEmi1-dependent stabilization of APC(Cdh1) targets, such as cyclin A, to promote S phase entry...
  11. ncbi request reprint The END network couples spindle pole assembly to inhibition of the anaphase-promoting complex/cyclosome in early mitosis
    Kenneth H Ban
    Program in Cancer Biology, Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Dev Cell 13:29-42. 2007
    ..The organization of the APC/C on the spindle also provides a framework for understanding microtubule-dependent organization of protein destruction...
  12. pmc CaMKII and polo-like kinase 1 sequentially phosphorylate the cytostatic factor Emi2/XErp1 to trigger its destruction and meiotic exit
    David V Hansen
    Program in Cancer Biology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 103:608-13. 2006
    ....
  13. ncbi request reprint Climbing the Greatwall to mitosis
    Peter K Jackson
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Mol Cell 22:156-7. 2006
    ..2006) shows that Greatwall is required for the positive feedback loop that removes inhibitory tyrosine phosphate from the central mitotic regulatory kinase Cdc2...
  14. pmc A role for the anaphase-promoting complex inhibitor Emi2/XErp1, a homolog of early mitotic inhibitor 1, in cytostatic factor arrest of Xenopus eggs
    Jeffrey J Tung
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 102:4318-23. 2005
    ..These results identify Emi2 as a candidate CSF maintenance protein...
  15. ncbi request reprint Emi1 class of proteins regulate entry into meiosis and the meiosis I to meiosis II transition in Xenopus oocytes
    Jeffrey J Tung
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Cell Cycle 4:478-82. 2005
    ..Prior ablation of Cdc20, addition of methyl-ubiquitin, or addition of nondestructible Delta90 cyclin B rescues the MI-MII transition in Emi1-inhibited oocytes...
  16. ncbi request reprint Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase
    Florence Margottin-Goguet
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Dev Cell 4:813-26. 2003
    ..We hypothesize that Emi1 destruction relieves a late prophase checkpoint for APC activation...
  17. ncbi request reprint Ubiquitinating a phosphorylated Cdk inhibitor on the blades of the Cdc4 beta-propeller
    Peter K Jackson
    Programs in Chemical Biology and Cancer Biology and Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Cell 112:142-4. 2003
    ..This structure provides insights into the binding interaction and how a precise mechanism involving multiple regulatory phosphorylations may be mediated by a single binding site...
  18. pmc A specific form of phospho protein phosphatase 2 regulates anaphase-promoting complex/cyclosome association with spindle poles
    Jorge Z Torres
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Biol Cell 21:897-904. 2010
    ..Thus, cyclin B/Cdk1 and PPP2 regulate the dynamic association of APC/C with spindle poles in early mitosis, a step necessary for proper spindle formation...
  19. ncbi request reprint Emi1 is required for cytostatic factor arrest in vertebrate eggs
    Julie D R Reimann
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    Nature 416:850-4. 2002
    ..Addition of Emi1 to these Emi1-depleted extracts blocks premature inactivation of the CSF-arrested state. Emi1 is required to arrest unfertilized eggs at metaphase of meiosis II and seems to be the long-sought mediator of CSF activity...
  20. ncbi request reprint Accessory proteins for melanocortin signaling: attractin and mahogunin
    Lin He
    Departments of Pediatrics and Genetics and the Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA
    Ann N Y Acad Sci 994:288-98. 2003
    ..Like Attractin, Mahogunin is conserved in invertebrate genomes, and its absence causes a pleiotropic phenotype that includes spongiform neurodegeneration...
  21. ncbi request reprint Screening of tissue microarrays for ubiquitin proteasome system components in tumors
    Norman L Lehman
    Department of Pathology, Stanford University School of Medicine, Palo Alto, California, USA
    Methods Enzymol 399:334-55. 2005
    ..In this article, we provide an introduction to the use of TMAs to study the expression of UPS component proteins and substrates in tumors by immunohistochemistry...
  22. ncbi request reprint Spongiform degeneration in mahoganoid mutant mice
    Lin He
    Department of Pediatrics, Department of Genetics, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 299:710-2. 2003
    ..Similarities in phenotype, expression, and genetic interactions suggest that mahoganoid and Atrn genes are part of a conserved pathway for regulated protein turnover whose function is essential for neuronal viability...
  23. ncbi request reprint Control of the centriole and centrosome cycles by ubiquitination enzymes
    David V Hansen
    Programs in Chemical Biology and Cancer Biology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California, CA 94305 5324, USA
    Oncogene 21:6209-21. 2002
  24. ncbi request reprint The SCF ubiquitin ligase: an extended look
    Peter K Jackson
    Stanford University School of Medicine, Department of Pathology, 300 Pasteur Drive, Palo Alto, CA 94305, USA
    Mol Cell 9:923-5. 2002
    ..A new crystal structure of the SCF(Skp2) ubiquitin ligase shows the molecular organization of this complex and raises important questions as to how substrate ubiquitination is accomplished...
  25. doi request reprint High-throughput generation of tagged stable cell lines for proteomic analysis
    Jorge Z Torres
    Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
    Proteomics 9:2888-91. 2009
    ..We have applied this method to the study of cell-cycle regulators and novel microtubule-associated proteins...
  26. ncbi request reprint The E3 ubiquitin ligase GREUL1 anteriorizes ectoderm during Xenopus development
    Annette G M Borchers
    Department of Genetics, Stanford University, Stanford, CA 94305, USA
    Dev Biol 251:395-408. 2002
    ..Mutation of these cysteines also compromises GREUL1's ability to induce cement gland. Thus, GREUL1's RING domain is necessary for both the ubiquitination of substrates and for the conversion of ectoderm to an anterior fate...

Research Grants20

  1. Proteolytic Control of Early Events in Mitosis
    Peter Jackson; Fiscal Year: 2007
    ..abstract_text> ..
  2. A NOVEL F BOX PROTEIN REGULATING MITOSIS
    Peter Jackson; Fiscal Year: 2004
    ..Understanding how SBP5 blocks mitosis and induces apoptosis may provide important insight for creating new cancer chemotherapeutic drugs that act similarly or synergistically with vinca alkaloids and Taxol. ..
  3. Cyclin Control DNA Replication and Mitosis
    Peter Jackson; Fiscal Year: 2005
    ..These aims will both map Cdc 14-regulated pathways and begin to define the critical Cdk and Cdcl4 targets for regulating steps in mitosis and genome stability. ..
  4. CYCLIN CONTROL OF DNA REPLICATION
    Peter Jackson; Fiscal Year: 2001
    ....