Research Topics
Genomes and Genes
| John P A IoannidisSummaryAffiliation: Stanford University Country: USA Publications
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Detail Information
Publications
A roadmap for successful applications of clinical proteomicsJohn P A Ioannidis
Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA, USA
Proteomics Clin Appl 5:241-7. 2011..Enthusiasm for the clinical impact of proteomics may need to be tempered currently until robust evidence can be obtained, but some clinical successes should eventually be feasible...- Knowledge integration in cancer: current landscape and future prospectsJohn P A Ioannidis
Stanford Prevention Research Center, 1265 Welch Rd, MSOB X306, Stanford University School of Medicine, Stanford, CA 94305, USA
Cancer Epidemiol Biomarkers Prev 22:3-10. 2013.... - Evaluation of excess statistical significance in meta-analyses of 98 biomarker associations with cancer riskKonstantinos K Tsilidis
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
J Natl Cancer Inst 104:1867-78. 2012..Numerous biomarkers have been associated with cancer risk. We assessed whether there is evidence for excess statistical significance in results of cancer biomarker studies, suggesting biases... - Correction of phenotype misclassification based on high-discrimination genetic predictive risk modelsJohn P A Ioannidis
Department of Medicine, Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA 94305, USA
Epidemiology 23:902-9. 2012.... - Scientific inbreeding and same-team replication: Type D personality as an exampleJohn P A Ioannidis
Stanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA Department of Statistics, Stanford University School of Humanities and Sciences, Stanford, CA, USA Electronic address
J Psychosom Res 73:408-10. 2012.... - Extrapolating from animals to humansJohn P A Ioannidis
Stanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford University School of Humanities and Sciences, Stanford, CA 94305, USA
Sci Transl Med 4:151ps15. 2012..Careful synthesis of data from multiple animal studies is needed to begin to assess the likelihood of successful cross-species translation (Fay et al., this issue)... - Predicting death: an empirical evaluation of predictive tools for mortalityGeorge C M Siontis
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
Arch Intern Med 171:1721-6. 2011..We aimed to evaluate the discriminating performance of predictive tools for death and the variability in this performance across different clinical conditions and studies... - Excess significance bias in the literature on brain volume abnormalitiesJohn P A Ioannidis
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, and Biomedical Research Institute, Foundation for Research and Technology Hellas, Ioannina, Greece
Arch Gen Psychiatry 68:773-80. 2011..Many studies report volume abnormalities in diverse brain structures in patients with various mental health conditions... - Comparison of effect sizes associated with biomarkers reported in highly cited individual articles and in subsequent meta-analysesJohn P A Ioannidis
Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
JAMA 305:2200-10. 2011..Many biomarkers are proposed in highly cited studies as determinants of disease risk, prognosis, or response to treatment, but few eventually transform clinical practice... - The false-positive to false-negative ratio in epidemiologic studiesJohn P A Ioannidis
Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA 94305, USA
Epidemiology 22:450-6. 2011..This ultimately has implications for what is the acceptable FP:FN ratio and for how the results of published epidemiologic studies should be presented and interpreted... 
Selective reporting biases in cancer prognostic factor studiesPanayiotis A Kyzas
Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece
J Natl Cancer Inst 97:1043-55. 2005..We recommend that meta-analyses thereof should maximize retrieval of information and standardize definitions...- Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomesJohn P A Ioannidis
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
JAMA 292:2105-14. 2004..Estrogen receptor alpha (ESR1) is a candidate gene for osteoporosis, but previous studies of ESR1 polymorphisms in this field were hampered by small sample size, lack of standardization, and inconclusive results... - 18F-fluorodeoxyglucose positron emission tomography to evaluate cervical node metastases in patients with head and neck squamous cell carcinoma: a meta-analysisPanayiotis A Kyzas
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
J Natl Cancer Inst 100:712-20. 2008..Management is most controversial for patients with a clinically negative (cN0) neck. We aimed to assess the diagnostic accuracy of 18F-FDG PET in detecting lymph node metastases in patients with HNSCC... 
A compendium of genome-wide associations for cancer: critical synopsis and reappraisalJohn P A Ioannidis
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
J Natl Cancer Inst 102:846-58. 2010..At present, the utility of GWA-identified risk loci in risk stratification for cancer is limited...- Effect of formal statistical significance on the credibility of observational associationsJohn P A Ioannidis
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
Am J Epidemiol 168:374-83; discussion 384-90. 2008..Bayes factors may be used routinely to interpret "significant" associations... - Effects of CCR5-delta32 and CCR2-64I alleles on disease progression of perinatally HIV-1-infected children: an international meta-analysisJohn P A Ioannidis
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
AIDS 17:1631-8. 2003..Among perinatally infected children, the effects of certain alleles of the CCR5 and CCR2 genes on the rate of disease progression remain unclear. We addressed the effects of CCR5-delta32 and CCR2-64I in an international meta-analysis... - Associations of polymorphisms of eight muscle- or metabolism-related genes with performance in Mount Olympus marathon runnersGeorgios I Tsianos
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45 110, Greece
J Appl Physiol 108:567-74. 2010..BDKRB2 rs1799722 and ADRB2 rs1042713 have some support for being implicated in endurance performance among habitual runners and require further investigation... - Multiple-treatments meta-analysis of chemotherapy and targeted therapies in advanced breast cancerDavide Mauri
Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
J Natl Cancer Inst 100:1780-91. 2008..Many systemic nonhormonal regimens have been evaluated across several hundreds of randomized trials in advanced breast cancer. We aimed to quantify the relative merits of these regimens in prolonging survival... - Cytotoxic T-lymphocyte associated antigen 4 gene polymorphisms and autoimmune thyroid disease: a meta-analysisFotini K Kavvoura
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
J Clin Endocrinol Metab 92:3162-70. 2007.... - CYP2D6 polymorphisms and the risk of tardive dyskinesia in schizophrenia: a meta-analysisNikolaos A Patsopoulos
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
Pharmacogenet Genomics 15:151-8. 2005..003). CYP2D6 loss of function alleles may predispose to tardive dyskinesia in patients with schizophrenia under treatment, but bias cannot be excluded... - Clinical outcome prediction by microRNAs in human cancer: a systematic reviewViswam S Nair
Division of Pulmonary and Critical Care Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
J Natl Cancer Inst 104:528-40. 2012..MicroRNA (miR) expression may have prognostic value for many types of cancers. However, the miR literature comprises many small studies. We systematically reviewed and synthesized the evidence... - Evaluating novel agent effects in multiple-treatments meta-regressionGeorgia Salanti
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
Stat Med 29:2369-83. 2010.... - Association of GSTM1, GSTT1, and GSTP1 gene polymorphisms with the risk of prostate cancer: a meta-analysisChristos Ntais
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
Cancer Epidemiol Biomarkers Prev 14:176-81. 2005..For GSTT1, larger studies gave different results than smaller ones. The meta-analysis shows that these three polymorphisms are unlikely to be major determinants of susceptibility to prostate cancer on a wide population basis... - Comparison of large versus smaller randomized trials for mental health-related interventionsDespina G Contopoulos-Ioannidis
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
Am J Psychiatry 162:578-84. 2005..The extent of disagreement between large and smaller randomized, controlled trials on mental health issues is unknown. The authors aimed to compare the results of large versus smaller trials on mental health-related interventions... - Mortality in systemic sclerosis: an international meta-analysis of individual patient dataJohn P A Ioannidis
Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
Am J Med 118:2-10. 2005..Studies on mortality associated with systemic sclerosis have been limited by small sample sizes. We aimed to obtain large-scale evidence on survival outcomes and predictors for this disease... - Survival with aromatase inhibitors and inactivators versus standard hormonal therapy in advanced breast cancer: meta-analysisDavide Mauri
Department of Medical Oncology, University of Ioannina School of Medicine, Ioannina 45110, Greece
J Natl Cancer Inst 98:1285-91. 2006.... - Concordance of functional in vitro data and epidemiological associations in complex disease geneticsJohn P A Ioannidis
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
Genet Med 8:583-93. 2006..We provide suggestions for improving the design and reporting of studies addressing both in vitro and epidemiological effects... - Vitamin D receptor gene polymorphisms and risk of prostate cancer: a meta-analysisChristos Ntais
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
Cancer Epidemiol Biomarkers Prev 12:1395-402. 2003..03 (95% CI, 0.86-1.23; no between-study heterogeneity) for the f versus F allele. The meta-analysis shows that these four polymorphisms are unlikely to be major determinants of susceptibility to prostate cancer on a wide population basis... - Maternal viral load and rate of disease progression among vertically HIV-1-infected children: an international meta-analysisJohn P A Ioannidis
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
AIDS 18:99-108. 2004.... - Limited benefit of antiretroviral resistance testing in treatment-experienced patients: a meta-analysisErmioni T Panidou
Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
AIDS 18:2153-61. 2004..Current guidelines widely recommending the use of antiretroviral resistance testing in clinical practice are not commensurate with the available evidence... - Unavailability of online supplementary scientific information from articles published in major journalsEvangelos Evangelou
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
FASEB J 19:1943-4. 2005..Here we show that in 4.7% and 9.6% of articles with online supplementary material, some of the supplements became unavailable within 2 and 5 years of their publication, respectively... - Impact of violations and deviations in Hardy-Weinberg equilibrium on postulated gene-disease associationsThomas A Trikalinos
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45100, Greece
Am J Epidemiol 163:300-9. 2006..Postulated genetic associations with modest-sized odds ratios and borderline statistical significance may not be robust in such sensitivity analyses... - Consistency of genome-wide associations across major ancestral groupsEvangelia E Ntzani
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, 45110 Ioannina, Greece
Hum Genet 131:1057-71. 2012.... - Establishment of genetic associations for complex diseases is independent of early study findingsThomas A Trikalinos
Clinical and Molecular Epidemiology Unit and Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
Eur J Hum Genet 12:762-9. 2004..Conversely, many genuine epidemiological associations would be missed, if research were abandoned after early underpowered 'negative' studies... - Synthesis of observational studies should consider credibility ceilingsGeorgia Salanti
The Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina, School of Medicine, Ioannina, Greece
J Clin Epidemiol 62:115-22. 2009..Meta-analyses of observational studies often get spuriously precise results. We aimed to factor this skepticism in meta-analysis calculations... - Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and handEvangelos Evangelou
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
Arthritis Rheum 60:1710-21. 2009..To examine these associations, we performed a large-scale meta-analysis of individual-level data... - Replication of past candidate loci for common diseases and phenotypes in 100 genome-wide association studiesKonstantinos C M Siontis
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
Eur J Hum Genet 18:832-7. 2010..15-0.43). Overall, few of the numerous genetic associations proposed in the candidate gene era have been replicated in GWASs, but those that have been conclusively replicated have large genetic effects that should not be discarded... - 'Racial' differences in genetic effects for complex diseasesJohn P A Ioannidis
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
Nat Genet 36:1312-8. 2004..Genetic markers for proposed gene-disease associations vary in frequency across populations, but their biological impact on the risk for common diseases may usually be consistent across traditional 'racial' boundaries... - CTLA-4 gene polymorphisms and susceptibility to type 1 diabetes mellitus: a HuGE Review and meta-analysisFotini K Kavvoura
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
Am J Epidemiol 162:3-16. 2005..99, 95% CI: 0.64, 1.55) or the *T allele of the C(-318)T polymorphism (OR = 0.92, 95% CI: 0.45, 1.89). This meta-analysis demonstrates that the CTLA-4*G genotype is associated with type 1 diabetes... - Family-based versus unrelated case-control designs for genetic associationsEvangelos Evangelou
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
PLoS Genet 2:e123. 2006..Conclusions were largely similar in diverse subgroup analyses. Unrelated case-control and family-based designs give overall similar estimates of association. We cannot rule out rare large biases or common small biases... - The Gini coefficient as a measure for understanding accrual inequalities in multicenter clinical studiesAnna-Bettina Haidich
Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
J Clin Epidemiol 57:341-8. 2004..010). CONCLUSION: The Gini coefficient may be easily and routinely incorporated in the description of the characteristics of a clinical study and may provide insights about its enrollment pattern... - Quality of reporting of cancer prognostic marker studies: association with reported prognostic effectPanayiotis A Kyzas
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
J Natl Cancer Inst 99:236-43. 2007..Issues of reported study quality have not been addressed empirically with large-scale data in the cancer prognostic literature... - Prosthesis infection: diagnosis after total joint arthroplasty with antigranulocyte scintigraphy with 99mTc-labeled monoclonal antibodies--a meta-analysisEmilios E Pakos
Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, University Campus, Ioannina, 45110, Greece
Radiology 242:101-8. 2007..To perform a meta-analysis of diagnostic studies regarding the accuracy of antigranulocyte scintigraphy (AGS) with monoclonal antibodies in the identification of prosthesis infection after total hip or knee arthroplasty... - Comparisons of established risk prediction models for cardiovascular disease: systematic reviewGeorge C M Siontis
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
BMJ 344:e3318. 2012..To evaluate the evidence on comparisons of established cardiovascular risk prediction models and to collect comparative information on their relative prognostic performance... - Improving validation practices in "omics" researchJohn P A Ioannidis
Stanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Science 334:1230-2. 2011..Several strategies may be useful, including routine replication, public data and protocol availability, funding incentives, reproducibility rewards or penalties, and targeted repeatability checks... - Prognostic effect size of cardiovascular biomarkers in datasets from observational studies versus randomised trials: meta-epidemiology studyIoanna Tzoulaki
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
BMJ 343:d6829. 2011..To compare the reported effect sizes of cardiovascular biomarkers in datasets from observational studies with those in datasets from randomised controlled trials... - Early extreme contradictory estimates may appear in published research: the Proteus phenomenon in molecular genetics research and randomized trialsJohn P A Ioannidis
Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
J Clin Epidemiol 58:543-9. 2005..We hypothesized that controversial data are attractive to investigators and editors, and thus the most extreme, opposite results would appear very early rather than late, as data accumulate, provided data can be generated rapidly... - Safety reporting in randomized trials of mental health interventionsPanagiotis N Papanikolaou
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
Am J Psychiatry 161:1692-7. 2004..CONCLUSIONS: Safety reporting is largely neglected across trials of mental-health-related interventions, thus hindering the assessment of risk-benefit ratios for rational decision making in mental health care... - Extended-interval aminoglycoside administration for children: a meta-analysisDespina G Contopoulos-Ioannidis
Departments of Pediatrics, University of Ioannina School of Medicine, Ioannina, Greece
Pediatrics 114:e111-8. 2004..This approach minimizes cost, simplifies administration, and provides similar or even potentially improved efficacy and safety, compared with MDD of these drugs... - The role of FcgammaRIIA and IIIA polymorphisms in autoimmune diseasesFotini B Karassa
Clinical and Molecular Epidemiology Unit and Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
Biomed Pharmacother 58:286-91. 2004..Besides the epidemiologic and pathophysiologic interest, this knowledge may be of use in the future in designing novel therapeutic interventions... - SRD5A2 gene polymorphisms and the risk of prostate cancer: a meta-analysisChristos Ntais
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
Cancer Epidemiol Biomarkers Prev 12:618-24. 2003.... - Genetic associations in large versus small studies: an empirical assessmentJohn P A Ioannidis
Department of Hygiene, University of Ioannina School of Medicine, Ioannina, Greece
Lancet 361:567-71. 2003..Our aim was to assess how often large studies arrive at different conclusions than smaller studies, and whether this situation arises more frequently when findings of first published studies disagree with those of subsequent research... - Why most published research findings are falseJohn P A Ioannidis
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
PLoS Med 2:e124. 2005..In this essay, I discuss the implications of these problems for the conduct and interpretation of research... - A road map for efficient and reliable human genome epidemiologyJohn P A Ioannidis
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, and Biomedical Research Institute, Foundation for Research and Technology Hellas, Ioannina 45110, Greece
Nat Genet 38:3-5. 2006..Systematic reviews will be expanded to include more meta-analyses of individual-level data and prospective meta-analyses. Field synopses will offer regularly updated overviews... - Meta-analysis in genome-wide association datasets: strategies and application in Parkinson diseaseEvangelos Evangelou
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
PLoS ONE 2:e196. 2007..However, for the detection of small genetic effects, single studies may be underpowered. Power may be improved by combining genome-wide datasets with meta-analytic techniques... - Interpretation of tests of heterogeneity and bias in meta-analysisJohn P A Ioannidis
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
J Eval Clin Pract 14:951-7. 2008..Suggestions are made on how to avoid these flaws, use these tests properly and learn from them... - Persistence of contradicted claims in the literatureAthina Tatsioni
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
JAMA 298:2517-26. 2007..Some research findings based on observational epidemiology are contradicted by randomized trials, but may nevertheless still be supported in some scientific circles... - The elderly were under-represented in osteoarthritis clinical trialsGeorge Liberopoulos
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
J Clin Epidemiol 62:1218-23. 2009..Osteoarthritis is the most common disease affecting joints in the elderly. We aimed to evaluate if elderly patients are properly represented in clinical trials of diverse osteoarthritis interventions... - Almost all articles on cancer prognostic markers report statistically significant resultsPanayiotis A Kyzas
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
Eur J Cancer 43:2559-79. 2007..Under strong reporting bias, statistical significance loses its discriminating ability for the importance of prognostic markers... - Assessment of cumulative evidence on genetic associations: interim guidelinesJohn P A Ioannidis
Clinical and Molecular Epidemiology Unit, University of Ioannina School of Medicine, Ioannina 45110, Greece
Int J Epidemiol 37:120-32. 2008..Future empirical research and consensus development are needed to develop an integrated model for combining epidemiological and biological evidence in the rapidly evolving field of investigation of genetic factors... - Extreme between-study homogeneity in meta-analyses could offer useful insightsJohn P A Ioannidis
Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
J Clin Epidemiol 59:1023-32. 2006..Meta-analyses are routinely evaluated for the presence of large between-study heterogeneity. We examined whether it is also important to probe whether there is extreme between-study homogeneity... - Implications of small effect sizes of individual genetic variants on the design and interpretation of genetic association studies of complex diseasesJohn P A Ioannidis
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
Am J Epidemiol 164:609-14. 2006..These collaborative studies ideally should be designed up front to also assess more complex gene-gene and gene-environment interactions... - Claims of sex differences: an empirical assessment in genetic associationsNikolaos A Patsopoulos
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Greece
JAMA 298:880-93. 2007..Many studies try to probe for differences in risks between men and women, and this is a major challenge in the expanding literature of associations between genetic variants and common diseases or traits... - Selective discussion and transparency in microarray research findings for cancer outcomesJohn P A Ioannidis
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
Eur J Cancer 43:1999-2010. 2007..Only three studies had scanned images, raw and processed data available. Processing details varied. Public transparency and unbiased interpretation of findings can be improved in microarray research... - Origin and funding of the most frequently cited papers in medicine: database analysisNikolaos A Patsopoulos
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
BMJ 332:1061-4. 2006..Such research is increasingly funded by industry, often exclusively so. Academics may be losing control of the clinical research agenda... - Effects of different chemotherapy regimens on survival for advanced cervical cancer: systematic review and meta-analysisSpyridon Tzioras
Department of Obstetrics and Gynaecology, University of Ioannina School of Medicine, Ioannina, Greece
Cancer Treat Rev 33:24-38. 2007..A large number of trials have assessed various chemotherapy regimens for the treatment of advanced cervical cancer, but there is uncertainty about the magnitude of survival benefits... - Ala45Thr polymorphism of the NEUROD1 gene and diabetes susceptibility: a meta-analysisFotini K Kavvoura
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, 45110, Greece
Hum Genet 116:192-9. 2005..083). The Ala45Thr polymorphism of the NEUROD1 gene has no effect on susceptibility to T2D. It may however be a risk factor for susceptibility to T1D, in particular for subjects of Asian descent, although bias cannot be totally excluded... - Association of the CYP17 gene polymorphism with the risk of prostate cancer: a meta-analysisChristos Ntais
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Greece
Cancer Epidemiol Biomarkers Prev 12:120-6. 2003..Previously reported associations may reflect publication bias, although it is also possible that the polymorphism may be important in subjects of African descent... - Contradicted and initially stronger effects in highly cited clinical researchJohn P A Ioannidis
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
JAMA 294:218-28. 2005..Controversy and uncertainty ensue when the results of clinical research on the effectiveness of interventions are subsequently contradicted. Controversies are most prominent when high-impact research is involved... - Different black box warning labeling for same-class drugsOrestis A Panagiotou
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
J Gen Intern Med 26:603-10. 2011..Absence of a BBW or asynchronous addition of a BBW among same-class drugs could have major implications... - Partisan perspectives in the medical literature: a study of high frequency editorialists favoring hormone replacement therapyAthina Tatsioni
Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
J Gen Intern Med 25:914-9. 2010..Unfavorable results of major studies have led to a large shrinkage of the market for hormone replacement therapy (HRT) in the last 6 years. Some scientists continue to strongly support the use of HRT...