John P A Ioannidis

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. doi request reprint The false-positive to false-negative ratio in epidemiologic studies
    John P A Ioannidis
    Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA 94305, USA
    Epidemiology 22:450-6. 2011
  2. doi request reprint A roadmap for successful applications of clinical proteomics
    John P A Ioannidis
    Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA, USA
    Proteomics Clin Appl 5:241-7. 2011
  3. pmc Prognostic effect size of cardiovascular biomarkers in datasets from observational studies versus randomised trials: meta-epidemiology study
    Ioanna Tzoulaki
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    BMJ 343:d6829. 2011
  4. ncbi request reprint Publication and other reporting biases in cognitive sciences: detection, prevalence, and prevention
    John P A Ioannidis
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA Department of Statistics, Stanford University School of Humanities and Sciences, Stanford, CA 94305, USA Meta Research Innovation Center at Stanford METRICS, Stanford, CA 94305, USA Electronic address
    Trends Cogn Sci 18:235-41. 2014
  5. pmc Neglected tropical diseases: survey and geometry of randomised evidence
    Shanthi Kappagoda
    Center for Primary Care and Outcomes Research and Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, CA, USA
    BMJ 345:e6512. 2012
  6. pmc Practices and impact of primary outcome adjustment in randomized controlled trials: meta-epidemiologic study
    Nazmus Saquib
    Stanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    BMJ 347:f4313. 2013
  7. pmc Overlapping meta-analyses on the same topic: survey of published studies
    Konstantinos C Siontis
    Department of Medicine and Mayo School of Graduate Medical Education, College of Medicine, Mayo Clinic, Rochester, MN, USA
    BMJ 347:f4501. 2013
  8. pmc Evaluation of excess significance bias in animal studies of neurological diseases
    Konstantinos K Tsilidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    PLoS Biol 11:e1001609. 2013
  9. pmc Guidelines on chemotherapy in advanced stage gynecological malignancies: an evaluation of 224 professional societies and organizations
    Nikolaos P Polyzos
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    PLoS ONE 6:e20106. 2011
  10. pmc Concordance of sleep and pain outcomes of diverse interventions: an umbrella review
    Anthony G Doufas
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 7:e40891. 2012

Collaborators

Detail Information

Publications95

  1. doi request reprint The false-positive to false-negative ratio in epidemiologic studies
    John P A Ioannidis
    Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA 94305, USA
    Epidemiology 22:450-6. 2011
    ..This ultimately has implications for what is the acceptable FP:FN ratio and for how the results of published epidemiologic studies should be presented and interpreted...
  2. doi request reprint A roadmap for successful applications of clinical proteomics
    John P A Ioannidis
    Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA, USA
    Proteomics Clin Appl 5:241-7. 2011
    ..Enthusiasm for the clinical impact of proteomics may need to be tempered currently until robust evidence can be obtained, but some clinical successes should eventually be feasible...
  3. pmc Prognostic effect size of cardiovascular biomarkers in datasets from observational studies versus randomised trials: meta-epidemiology study
    Ioanna Tzoulaki
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    BMJ 343:d6829. 2011
    ..To compare the reported effect sizes of cardiovascular biomarkers in datasets from observational studies with those in datasets from randomised controlled trials...
  4. ncbi request reprint Publication and other reporting biases in cognitive sciences: detection, prevalence, and prevention
    John P A Ioannidis
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA Department of Statistics, Stanford University School of Humanities and Sciences, Stanford, CA 94305, USA Meta Research Innovation Center at Stanford METRICS, Stanford, CA 94305, USA Electronic address
    Trends Cogn Sci 18:235-41. 2014
    ..We also highlight emerging solutions (from study design to data analyses and reporting) to prevent bias and improve the fidelity in the field of cognitive science research. ..
  5. pmc Neglected tropical diseases: survey and geometry of randomised evidence
    Shanthi Kappagoda
    Center for Primary Care and Outcomes Research and Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, CA, USA
    BMJ 345:e6512. 2012
    ..To assess the quantity and distribution of evidence from randomised controlled trials for the treatment of the major neglected tropical diseases and to identify gaps in the evidence with network analysis...
  6. pmc Practices and impact of primary outcome adjustment in randomized controlled trials: meta-epidemiologic study
    Nazmus Saquib
    Stanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    BMJ 347:f4313. 2013
    ..To assess adjustment practices for primary outcomes of randomized controlled trials and their impact on the results...
  7. pmc Overlapping meta-analyses on the same topic: survey of published studies
    Konstantinos C Siontis
    Department of Medicine and Mayo School of Graduate Medical Education, College of Medicine, Mayo Clinic, Rochester, MN, USA
    BMJ 347:f4501. 2013
    ..To assess how common it is to have multiple overlapping meta-analyses of randomized trials published on the same topic...
  8. pmc Evaluation of excess significance bias in animal studies of neurological diseases
    Konstantinos K Tsilidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    PLoS Biol 11:e1001609. 2013
    ....
  9. pmc Guidelines on chemotherapy in advanced stage gynecological malignancies: an evaluation of 224 professional societies and organizations
    Nikolaos P Polyzos
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    PLoS ONE 6:e20106. 2011
    ..Clinical practice guidelines are important for guiding practice, but it is unclear if they are commensurate with the available evidence...
  10. pmc Concordance of sleep and pain outcomes of diverse interventions: an umbrella review
    Anthony G Doufas
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 7:e40891. 2012
    ..We performed an umbrella review of meta-analyses on treatments for diverse conditions in order to examine whether diverse medical treatments for different conditions have similar or divergent effects on pain and sleep...
  11. pmc Laboratory mouse models for the human genome-wide associations
    Georgios D Kitsios
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts, United States of America
    PLoS ONE 5:e13782. 2010
    ....
  12. pmc Individualized cost-effectiveness analysis
    John P A Ioannidis
    Stanford Prevention Research Center, Department of Medicine and Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Med 8:e1001058. 2011
    ..John Ioannidis and Alan Garber discuss how to use incremental cost-effectiveness ratios (ICER) and related metrics so they can be useful for decision-making at the individual level, whether used by clinicians or individual patients...
  13. pmc Comparative effect sizes in randomised trials from less developed and more developed countries: meta-epidemiological assessment
    Orestis A Panagiotou
    Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, University Campus, Ioannina, Greece
    BMJ 346:f707. 2013
    ..To compare treatment effects from randomised trials conducted in more developed versus less developed countries...
  14. doi request reprint Increasing value and reducing waste in research design, conduct, and analysis
    John P A Ioannidis
    Stanford Prevention Research Center, Department of Medicine, School of Medicine, Stanford University, Stanford, CA, USA Division of Epidemiology, School of Medicine, Stanford University, Stanford, CA, USA Department of Statistics, School of Humanities and Sciences, Stanford University, Stanford, CA, USA Meta Research Innovation Center at Stanford METRICS, Stanford University, Stanford, CA, USA Electronic address
    Lancet 383:166-75. 2014
    ....
  15. pmc Evidence-based de-implementation for contradicted, unproven, and aspiring healthcare practices
    Vinay Prasad
    National Cancer Institute, Bethesda, MD VP and Stanford Prevention Research Center, Departments of Medicine and Health Research and Policy, Stanford University School of Medicine, and Meta Research Innovation Center at Stanford METRICS, Medical School Office Building, Room X306, Stanford, CA 94305, USA
    Implement Sci 9:1. 2014
    ....
  16. doi request reprint Expressing death risk as condensed life experience and death intensity
    John P A Ioannidis
    Stanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Med Decis Making 33:853-9. 2013
    ..T will vary depending on the time window for which it is computed. I present examples for calculating T and λ using literature data on accidents, ascent to Mount Everest, and medical and surgical procedures. ..
  17. pmc The geometric increase in meta-analyses from China in the genomic era
    John P A Ioannidis
    Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 8:e65602. 2013
    ....
  18. doi request reprint Optimal type I and type II error pairs when the available sample size is fixed
    John P A Ioannidis
    Stanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Clin Epidemiol 66:903-910.e2. 2013
    ..To model how to select the optimal pair of type I and type II errors that maximize study value when there are constrains on the available study sample size...
  19. doi request reprint Evaluation of excess statistical significance in meta-analyses of 98 biomarker associations with cancer risk
    Konstantinos K Tsilidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    J Natl Cancer Inst 104:1867-78. 2012
    ..Numerous biomarkers have been associated with cancer risk. We assessed whether there is evidence for excess statistical significance in results of cancer biomarker studies, suggesting biases...
  20. doi request reprint Knowledge integration in cancer: current landscape and future prospects
    John P A Ioannidis
    Stanford Prevention Research Center, 1265 Welch Rd, MSOB X306, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cancer Epidemiol Biomarkers Prev 22:3-10. 2013
    ....
  21. doi request reprint Correction of phenotype misclassification based on high-discrimination genetic predictive risk models
    John P A Ioannidis
    Department of Medicine, Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA 94305, USA
    Epidemiology 23:902-9. 2012
    ....
  22. doi request reprint Scientific inbreeding and same-team replication: type D personality as an example
    John P A Ioannidis
    Stanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Psychosom Res 73:408-10. 2012
    ....
  23. doi request reprint Extrapolating from animals to humans
    John P A Ioannidis
    Stanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford University School of Humanities and Sciences, Stanford, CA 94305, USA
    Sci Transl Med 4:151ps15. 2012
    ..Careful synthesis of data from multiple animal studies is needed to begin to assess the likelihood of successful cross-species translation (Fay et al., this issue)...
  24. doi request reprint Comparison of effect sizes associated with biomarkers reported in highly cited individual articles and in subsequent meta-analyses
    John P A Ioannidis
    Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    JAMA 305:2200-10. 2011
    ..Many biomarkers are proposed in highly cited studies as determinants of disease risk, prognosis, or response to treatment, but few eventually transform clinical practice...
  25. doi request reprint Predicting death: an empirical evaluation of predictive tools for mortality
    George C M Siontis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Arch Intern Med 171:1721-6. 2011
    ..We aimed to evaluate the discriminating performance of predictive tools for death and the variability in this performance across different clinical conditions and studies...
  26. doi request reprint Excess significance bias in the literature on brain volume abnormalities
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, and Biomedical Research Institute, Foundation for Research and Technology Hellas, Ioannina, Greece
    Arch Gen Psychiatry 68:773-80. 2011
    ..Many studies report volume abnormalities in diverse brain structures in patients with various mental health conditions...
  27. ncbi request reprint Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes
    Lucia Sobrin
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
    Ophthalmology 119:1874-85. 2012
    ....
  28. ncbi request reprint Population-specific frequencies for LRRK2 susceptibility variants in the Genetic Epidemiology of Parkinson's Disease (GEO-PD) Consortium
    Michael G Heckman
    Biostatistics Unit, Mayo Clinic, Jacksonville, Florida, USA
    Mov Disord 28:1740-4. 2013
    ..Leucine-rich repeat kinase 2 variation related to disease susceptibility displays many features that reflect the nature of complex, late-onset sporadic disorders like Parkinson's disease...
  29. ncbi request reprint Prevention and management of non-communicable disease: the IOC consensus statement, Lausanne 2013
    Gordon O Matheson
    Division of Sports Medicine, Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, USA
    Sports Med 43:1075-88. 2013
    ..The outcome of the consensus meeting was the creation of the IOC Non-Communicable Diseases ad-hoc Working Group charged with the responsibility of moving this agenda forward. ..
  30. ncbi request reprint Selective reporting biases in cancer prognostic factor studies
    Panayiotis A Kyzas
    Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece
    J Natl Cancer Inst 97:1043-55. 2005
    ..We probed these biases in a meta-analysis of a prognostic factor for head and neck squamous cell cancer (HNSCC) mortality that has drawn wide attention--the status of the tumor suppressor protein TP53...
  31. ncbi request reprint Prevention and management of noncommunicable disease: the IOC Consensus Statement, Lausanne 2013
    Gordon O Matheson
    Division of Sports Medicine, Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, California Department of Orthopaedic Surgery, Human Performance Laboratory, Stanford University School of Medicine, Stanford, California Department of Healthy Policy and Management, Harvard University, Boston, Massachusetts Department of Sports Medicine, Oslo Sports Trauma Research Center, Norwegian School of Sports Science, Oslo, Norway Department of Epidemiology and Public Health, Population Health Domain Physical Activity Research Group, University College London, London, United Kingdom Orthopaedic Center, Ulleval University Hospital, University of Oslo, Oslo, Norway Departments of Exercise Science and Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina Åstrands Laboratory, The Swedish School of Sport and Health Sciences, Stockholm, Sweden Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden Clinical Sports and Exercise Medicine Research Group, UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa Departments of Medicine and Health Research and Policy, Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, California Department of Statistics, Stanford University School of Humanities and Sciences
    Clin J Sport Med 23:419-29. 2013
    ..The outcome of the consensus meeting was the creation of the IOC Non-Communicable Diseases ad hoc Working Group charged with the responsibility of moving this agenda forward...
  32. pmc Protective effect of LRRK2 p.R1398H on risk of Parkinson's disease is independent of MAPT and SNCA variants
    Michael G Heckman
    Section of Biostatistics, Mayo Clinic, Jacksonville, FL, USA Electronic address
    Neurobiol Aging 35:266.e5-14. 2014
    ..R1398H genotypes. Our results indicate that the association of LRRK2 p.R1398H with Parkinson's disease is independent of SNCA and MAPT variants, and vice versa, in Caucasian and Asian populations...
  33. ncbi request reprint Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomes
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    JAMA 292:2105-14. 2004
    ..Estrogen receptor alpha (ESR1) is a candidate gene for osteoporosis, but previous studies of ESR1 polymorphisms in this field were hampered by small sample size, lack of standardization, and inconclusive results...
  34. doi request reprint 18F-fluorodeoxyglucose positron emission tomography to evaluate cervical node metastases in patients with head and neck squamous cell carcinoma: a meta-analysis
    Panayiotis A Kyzas
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    J Natl Cancer Inst 100:712-20. 2008
    ..Management is most controversial for patients with a clinically negative (cN0) neck. We aimed to assess the diagnostic accuracy of 18F-FDG PET in detecting lymph node metastases in patients with HNSCC...
  35. ncbi request reprint Effects of CCR5-delta32 and CCR2-64I alleles on disease progression of perinatally HIV-1-infected children: an international meta-analysis
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    AIDS 17:1631-8. 2003
    ..Among perinatally infected children, the effects of certain alleles of the CCR5 and CCR2 genes on the rate of disease progression remain unclear. We addressed the effects of CCR5-delta32 and CCR2-64I in an international meta-analysis...
  36. pmc A compendium of genome-wide associations for cancer: critical synopsis and reappraisal
    John P A Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    J Natl Cancer Inst 102:846-58. 2010
    ..At present, the utility of GWA-identified risk loci in risk stratification for cancer is limited...
  37. doi request reprint Effect of formal statistical significance on the credibility of observational associations
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Am J Epidemiol 168:374-83; discussion 384-90. 2008
    ..Bayes factors may be used routinely to interpret "significant" associations...
  38. ncbi request reprint Cytotoxic T-lymphocyte associated antigen 4 gene polymorphisms and autoimmune thyroid disease: a meta-analysis
    Fotini K Kavvoura
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    J Clin Endocrinol Metab 92:3162-70. 2007
    ....
  39. ncbi request reprint Multiple-treatments meta-analysis of chemotherapy and targeted therapies in advanced breast cancer
    Davide Mauri
    Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    J Natl Cancer Inst 100:1780-91. 2008
    ..Many systemic nonhormonal regimens have been evaluated across several hundreds of randomized trials in advanced breast cancer. We aimed to quantify the relative merits of these regimens in prolonging survival...
  40. ncbi request reprint CYP2D6 polymorphisms and the risk of tardive dyskinesia in schizophrenia: a meta-analysis
    Nikolaos A Patsopoulos
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Pharmacogenet Genomics 15:151-8. 2005
    ..003). CYP2D6 loss of function alleles may predispose to tardive dyskinesia in patients with schizophrenia under treatment, but bias cannot be excluded...
  41. doi request reprint Associations of polymorphisms of eight muscle- or metabolism-related genes with performance in Mount Olympus marathon runners
    Georgios I Tsianos
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45 110, Greece
    J Appl Physiol (1985) 108:567-74. 2010
    ..BDKRB2 rs1799722 and ADRB2 rs1042713 have some support for being implicated in endurance performance among habitual runners and require further investigation...
  42. ncbi request reprint The emergence of networks in human genome epidemiology: challenges and opportunities
    Daniela Seminara
    Epidemiology and Genetics Research Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, NIH, EPN Bldg, Rm 5142, MSC 7393, 6130 Executive Blvd, Bethesda, MD 20892, USA
    Epidemiology 18:1-8. 2007
  43. pmc Clinical outcome prediction by microRNAs in human cancer: a systematic review
    Viswam S Nair
    Division of Pulmonary and Critical Care Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Natl Cancer Inst 104:528-40. 2012
    ..MicroRNA (miR) expression may have prognostic value for many types of cancers. However, the miR literature comprises many small studies. We systematically reviewed and synthesized the evidence...
  44. ncbi request reprint Comparison of large versus smaller randomized trials for mental health-related interventions
    Despina G Contopoulos-Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Am J Psychiatry 162:578-84. 2005
    ..The extent of disagreement between large and smaller randomized, controlled trials on mental health issues is unknown. The authors aimed to compare the results of large versus smaller trials on mental health-related interventions...
  45. doi request reprint Evaluating novel agent effects in multiple-treatments meta-regression
    Georgia Salanti
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Stat Med 29:2369-83. 2010
    ....
  46. ncbi request reprint Association of GSTM1, GSTT1, and GSTP1 gene polymorphisms with the risk of prostate cancer: a meta-analysis
    Christos Ntais
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Cancer Epidemiol Biomarkers Prev 14:176-81. 2005
    ..For GSTT1, larger studies gave different results than smaller ones. The meta-analysis shows that these three polymorphisms are unlikely to be major determinants of susceptibility to prostate cancer on a wide population basis...
  47. pmc Replication of past candidate loci for common diseases and phenotypes in 100 genome-wide association studies
    Konstantinos C M Siontis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Eur J Hum Genet 18:832-7. 2010
    ..15-0.43). Overall, few of the numerous genetic associations proposed in the candidate gene era have been replicated in GWASs, but those that have been conclusively replicated have large genetic effects that should not be discarded...
  48. ncbi request reprint Unavailability of online supplementary scientific information from articles published in major journals
    Evangelos Evangelou
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    FASEB J 19:1943-4. 2005
    ..Here we show that in 4.7% and 9.6% of articles with online supplementary material, some of the supplements became unavailable within 2 and 5 years of their publication, respectively...
  49. ncbi request reprint Mortality in systemic sclerosis: an international meta-analysis of individual patient data
    John P A Ioannidis
    Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Am J Med 118:2-10. 2005
    ..Studies on mortality associated with systemic sclerosis have been limited by small sample sizes. We aimed to obtain large-scale evidence on survival outcomes and predictors for this disease...
  50. ncbi request reprint Survival with aromatase inhibitors and inactivators versus standard hormonal therapy in advanced breast cancer: meta-analysis
    Davide Mauri
    Department of Medical Oncology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    J Natl Cancer Inst 98:1285-91. 2006
    ..We performed a meta-analysis of randomized controlled trials that compared several generations of aromatase inhibitors and inactivators with standard hormonal treatment in patients with advanced breast cancer...
  51. ncbi request reprint Limited benefit of antiretroviral resistance testing in treatment-experienced patients: a meta-analysis
    Ermioni T Panidou
    Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    AIDS 18:2153-61. 2004
    ....
  52. ncbi request reprint Vitamin D receptor gene polymorphisms and risk of prostate cancer: a meta-analysis
    Christos Ntais
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Cancer Epidemiol Biomarkers Prev 12:1395-402. 2003
    ..03 (95% CI, 0.86-1.23; no between-study heterogeneity) for the f versus F allele. The meta-analysis shows that these four polymorphisms are unlikely to be major determinants of susceptibility to prostate cancer on a wide population basis...
  53. ncbi request reprint Concordance of functional in vitro data and epidemiological associations in complex disease genetics
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Genet Med 8:583-93. 2006
    ..We aimed to assess whether epidemiological evidence on genetic associations for complex diseases concord with in vitro functional data...
  54. ncbi request reprint Safety reporting in randomized trials of mental health interventions
    Panagiotis N Papanikolaou
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Am J Psychiatry 161:1692-7. 2004
    ..The authors aimed to evaluate the adequacy of the reporting of safety information in publications of randomized trials of mental-health-related interventions...
  55. doi request reprint Comparisons of established risk prediction models for cardiovascular disease: systematic review
    George C M Siontis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    BMJ 344:e3318. 2012
    ..To evaluate the evidence on comparisons of established cardiovascular risk prediction models and to collect comparative information on their relative prognostic performance...
  56. ncbi request reprint Maternal viral load and rate of disease progression among vertically HIV-1-infected children: an international meta-analysis
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    AIDS 18:99-108. 2004
    ....
  57. doi request reprint Pancreatitis potentially associated drugs as a risk factor for post-endoscopic retrograde cholangiopancreatography pancreatitis: a prospective cohort study
    Dimitrios E Sigounas
    1st Division of Internal Medicine and Hepato Gastroenterology Unit, School of Medicine, University of Ioannina, Ioannina, Greece
    Pancreas 42:601-6. 2013
    ....
  58. ncbi request reprint Impact of violations and deviations in Hardy-Weinberg equilibrium on postulated gene-disease associations
    Thomas A Trikalinos
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45100, Greece
    Am J Epidemiol 163:300-9. 2006
    ..Postulated genetic associations with modest-sized odds ratios and borderline statistical significance may not be robust in such sensitivity analyses...
  59. doi request reprint Consistency of genome-wide associations across major ancestral groups
    Evangelia E Ntzani
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, 45110 Ioannina, Greece
    Hum Genet 131:1057-71. 2012
    ....
  60. ncbi request reprint CTLA-4 gene polymorphisms and susceptibility to type 1 diabetes mellitus: a HuGE Review and meta-analysis
    Fotini K Kavvoura
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Am J Epidemiol 162:3-16. 2005
    ..99, 95% CI: 0.64, 1.55) or the *T allele of the C(-318)T polymorphism (OR = 0.92, 95% CI: 0.45, 1.89). This meta-analysis demonstrates that the CTLA-4*G genotype is associated with type 1 diabetes...
  61. ncbi request reprint The Gini coefficient as a measure for understanding accrual inequalities in multicenter clinical studies
    Anna Bettina Haidich
    Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    J Clin Epidemiol 57:341-8. 2004
    ..Clinical sites participating in multicenter trials may have unequal performance in recruiting subjects. We propose using the Gini coefficient as a quantitative measure of site accrual inequalities...
  62. ncbi request reprint Establishment of genetic associations for complex diseases is independent of early study findings
    Thomas A Trikalinos
    Clinical and Molecular Epidemiology Unit and Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Eur J Hum Genet 12:762-9. 2004
    ..Conversely, many genuine epidemiological associations would be missed, if research were abandoned after early underpowered 'negative' studies...
  63. ncbi request reprint 'Racial' differences in genetic effects for complex diseases
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Nat Genet 36:1312-8. 2004
    ..Genetic markers for proposed gene-disease associations vary in frequency across populations, but their biological impact on the risk for common diseases may usually be consistent across traditional 'racial' boundaries...
  64. ncbi request reprint Quality of reporting of cancer prognostic marker studies: association with reported prognostic effect
    Panayiotis A Kyzas
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    J Natl Cancer Inst 99:236-43. 2007
    ..Issues of reported study quality have not been addressed empirically with large-scale data in the cancer prognostic literature...
  65. doi request reprint Synthesis of observational studies should consider credibility ceilings
    Georgia Salanti
    The Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina, School of Medicine, Ioannina, Greece
    J Clin Epidemiol 62:115-22. 2009
    ..Meta-analyses of observational studies often get spuriously precise results. We aimed to factor this skepticism in meta-analysis calculations...
  66. ncbi request reprint Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand
    Evangelos Evangelou
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Arthritis Rheum 60:1710-21. 2009
    ..To examine these associations, we performed a large-scale meta-analysis of individual-level data...
  67. pmc Family-based versus unrelated case-control designs for genetic associations
    Evangelos Evangelou
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    PLoS Genet 2:e123. 2006
    ..Conclusions were largely similar in diverse subgroup analyses. Unrelated case-control and family-based designs give overall similar estimates of association. We cannot rule out rare large biases or common small biases...
  68. ncbi request reprint Assessment of cumulative evidence on genetic associations: interim guidelines
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Int J Epidemiol 37:120-32. 2008
    ..Future empirical research and consensus development are needed to develop an integrated model for combining epidemiological and biological evidence in the rapidly evolving field of investigation of genetic factors...
  69. ncbi request reprint Prosthesis infection: diagnosis after total joint arthroplasty with antigranulocyte scintigraphy with 99mTc-labeled monoclonal antibodies--a meta-analysis
    Emilios E Pakos
    Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, University Campus, Ioannina, 45110, Greece
    Radiology 242:101-8. 2007
    ..To perform a meta-analysis of diagnostic studies regarding the accuracy of antigranulocyte scintigraphy (AGS) with monoclonal antibodies in the identification of prosthesis infection after total hip or knee arthroplasty...
  70. doi request reprint Improving validation practices in "omics" research
    John P A Ioannidis
    Stanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 334:1230-2. 2011
    ..Several strategies may be useful, including routine replication, public data and protocol availability, funding incentives, reproducibility rewards or penalties, and targeted repeatability checks...
  71. ncbi request reprint Genetic associations in large versus small studies: an empirical assessment
    John P A Ioannidis
    Department of Hygiene, University of Ioannina School of Medicine, Ioannina, Greece
    Lancet 361:567-71. 2003
    ..Our aim was to assess how often large studies arrive at different conclusions than smaller studies, and whether this situation arises more frequently when findings of first published studies disagree with those of subsequent research...
  72. pmc Origin and funding of the most frequently cited papers in medicine: database analysis
    Nikolaos A Patsopoulos
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    BMJ 332:1061-4. 2006
    ..To evaluate changes in the role of academics and the sources of funding for the medical research cited most frequently over the past decade...
  73. ncbi request reprint Extended-interval aminoglycoside administration for children: a meta-analysis
    Despina G Contopoulos-Ioannidis
    Departments of Pediatrics, University of Ioannina School of Medicine, Ioannina, Greece
    Pediatrics 114:e111-8. 2004
    ....
  74. ncbi request reprint Almost all articles on cancer prognostic markers report statistically significant results
    Panayiotis A Kyzas
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Eur J Cancer 43:2559-79. 2007
    ..Under strong reporting bias, statistical significance loses its discriminating ability for the importance of prognostic markers...
  75. ncbi request reprint The role of FcgammaRIIA and IIIA polymorphisms in autoimmune diseases
    Fotini B Karassa
    Clinical and Molecular Epidemiology Unit and Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Biomed Pharmacother 58:286-91. 2004
    ..Besides the epidemiologic and pathophysiologic interest, this knowledge may be of use in the future in designing novel therapeutic interventions...
  76. ncbi request reprint A road map for efficient and reliable human genome epidemiology
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, and Biomedical Research Institute, Foundation for Research and Technology Hellas, Ioannina 45110, Greece
    Nat Genet 38:3-5. 2006
    ..Systematic reviews will be expanded to include more meta-analyses of individual-level data and prospective meta-analyses. Field synopses will offer regularly updated overviews...
  77. ncbi request reprint Claims of sex differences: an empirical assessment in genetic associations
    Nikolaos A Patsopoulos
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Greece
    JAMA 298:880-93. 2007
    ..Many studies try to probe for differences in risks between men and women, and this is a major challenge in the expanding literature of associations between genetic variants and common diseases or traits...
  78. ncbi request reprint Selective discussion and transparency in microarray research findings for cancer outcomes
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Eur J Cancer 43:1999-2010. 2007
    ..Only three studies had scanned images, raw and processed data available. Processing details varied. Public transparency and unbiased interpretation of findings can be improved in microarray research...
  79. ncbi request reprint SRD5A2 gene polymorphisms and the risk of prostate cancer: a meta-analysis
    Christos Ntais
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Cancer Epidemiol Biomarkers Prev 12:618-24. 2003
    ....
  80. pmc Meta-analysis in genome-wide association datasets: strategies and application in Parkinson disease
    Evangelos Evangelou
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    PLoS ONE 2:e196. 2007
    ..However, for the detection of small genetic effects, single studies may be underpowered. Power may be improved by combining genome-wide datasets with meta-analytic techniques...
  81. doi request reprint Interpretation of tests of heterogeneity and bias in meta-analysis
    John P A Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    J Eval Clin Pract 14:951-7. 2008
    ..Suggestions are made on how to avoid these flaws, use these tests properly and learn from them...
  82. ncbi request reprint Implications of small effect sizes of individual genetic variants on the design and interpretation of genetic association studies of complex diseases
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Am J Epidemiol 164:609-14. 2006
    ..These collaborative studies ideally should be designed up front to also assess more complex gene-gene and gene-environment interactions...
  83. ncbi request reprint Extreme between-study homogeneity in meta-analyses could offer useful insights
    John P A Ioannidis
    Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    J Clin Epidemiol 59:1023-32. 2006
    ..Meta-analyses are routinely evaluated for the presence of large between-study heterogeneity. We examined whether it is also important to probe whether there is extreme between-study homogeneity...
  84. pmc Why most published research findings are false
    John P A Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    PLoS Med 2:e124. 2005
    ..In this essay, I discuss the implications of these problems for the conduct and interpretation of research...
  85. doi request reprint The elderly were under-represented in osteoarthritis clinical trials
    George Liberopoulos
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    J Clin Epidemiol 62:1218-23. 2009
    ..Osteoarthritis is the most common disease affecting joints in the elderly. We aimed to evaluate if elderly patients are properly represented in clinical trials of diverse osteoarthritis interventions...
  86. ncbi request reprint Persistence of contradicted claims in the literature
    Athina Tatsioni
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    JAMA 298:2517-26. 2007
    ..Some research findings based on observational epidemiology are contradicted by randomized trials, but may nevertheless still be supported in some scientific circles...
  87. ncbi request reprint Early extreme contradictory estimates may appear in published research: the Proteus phenomenon in molecular genetics research and randomized trials
    John P A Ioannidis
    Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    J Clin Epidemiol 58:543-9. 2005
    ..We hypothesized that controversial data are attractive to investigators and editors, and thus the most extreme, opposite results would appear very early rather than late, as data accumulate, provided data can be generated rapidly...
  88. ncbi request reprint Contradicted and initially stronger effects in highly cited clinical research
    John P A Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    JAMA 294:218-28. 2005
    ..Controversy and uncertainty ensue when the results of clinical research on the effectiveness of interventions are subsequently contradicted. Controversies are most prominent when high-impact research is involved...
  89. pmc Different black box warning labeling for same-class drugs
    Orestis A Panagiotou
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    J Gen Intern Med 26:603-10. 2011
    ..Absence of a BBW or asynchronous addition of a BBW among same-class drugs could have major implications...
  90. pmc Partisan perspectives in the medical literature: a study of high frequency editorialists favoring hormone replacement therapy
    Athina Tatsioni
    Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    J Gen Intern Med 25:914-9. 2010
    ..Unfavorable results of major studies have led to a large shrinkage of the market for hormone replacement therapy (HRT) in the last 6 years. Some scientists continue to strongly support the use of HRT...
  91. ncbi request reprint Ala45Thr polymorphism of the NEUROD1 gene and diabetes susceptibility: a meta-analysis
    Fotini K Kavvoura
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, 45110, Greece
    Hum Genet 116:192-9. 2005
    ..083). The Ala45Thr polymorphism of the NEUROD1 gene has no effect on susceptibility to T2D. It may however be a risk factor for susceptibility to T1D, in particular for subjects of Asian descent, although bias cannot be totally excluded...
  92. ncbi request reprint Effects of different chemotherapy regimens on survival for advanced cervical cancer: systematic review and meta-analysis
    Spyridon Tzioras
    Department of Obstetrics and Gynaecology, University of Ioannina School of Medicine, Ioannina, Greece
    Cancer Treat Rev 33:24-38. 2007
    ..A large number of trials have assessed various chemotherapy regimens for the treatment of advanced cervical cancer, but there is uncertainty about the magnitude of survival benefits...
  93. ncbi request reprint Association of the CYP17 gene polymorphism with the risk of prostate cancer: a meta-analysis
    Christos Ntais
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Greece
    Cancer Epidemiol Biomarkers Prev 12:120-6. 2003
    ..Previously reported associations may reflect publication bias, although it is also possible that the polymorphism may be important in subjects of African descent...