Takanari Inoue

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc An inducible translocation strategy to rapidly activate and inhibit small GTPase signaling pathways
    Takanari Inoue
    Stanford University, Department of Molecular Pharmacology, Clark Center, 318 Campus Drive, Stanford, California 94305 5439, USA
    Nat Methods 2:415-8. 2005
  2. pmc PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane
    Won Do Heo
    Department of Molecular Pharmacology, 318 Campus Drive, Clark Building, Stanford University Medical School, Stanford, CA 94305, USA
    Science 314:1458-61. 2006
  3. pmc Dissecting the role of PtdIns(4,5)P2 in endocytosis and recycling of the transferrin receptor
    Namiko Abe
    Graduate Program in Neurosciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cell Sci 121:1488-94. 2008
  4. pmc Synthetic activation of endogenous PI3K and Rac identifies an AND-gate switch for cell polarization and migration
    Takanari Inoue
    Chemical and Systems Biology, Bio X Program, Stanford University, Stanford, California, USA
    PLoS ONE 3:e3068. 2008
  5. ncbi request reprint Robust neuronal symmetry breaking by Ras-triggered local positive feedback
    Marc Fivaz
    Clark Center, Bio X, Department of Chemical and Systems Biology, Stanford University, 318 Campus Drive, Stanford, California 94305, USA
    Curr Biol 18:44-50. 2008
  6. pmc Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+ store depletion
    Jen Liou
    Department of Chemical and Systems Biology, Stanford University Medical School, 318 Campus Drive, Clark Center, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 104:9301-6. 2007
  7. pmc Rapid chemically induced changes of PtdIns(4,5)P2 gate KCNQ ion channels
    Byung Chang Suh
    Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, WA 98195, USA
    Science 314:1454-7. 2006
  8. pmc An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of nerve growth factor-stimulated PC12 cells
    Kazuhiro Aoki
    Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Biol 177:817-27. 2007
  9. pmc Selective photoinactivation of protein function through environment-sensitive switching of singlet oxygen generation by photosensitizer
    Takatoshi Yogo
    Graduate School of Pharmaceutical Sciences and Department of Pharmacology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 105:28-32. 2008
  10. ncbi request reprint Modification of intracellular Ca2+ dynamics by laser inactivation of inositol 1,4,5-trisphosphate receptor using membrane-permeant probes
    Takatoshi Yogo
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Chem Biol 11:1053-8. 2004

Research Grants

  1. Feedback and Crosstalk in Eukaryotic Chemotaxis
    Takanari Inoue; Fiscal Year: 2010

Collaborators

Detail Information

Publications11

  1. pmc An inducible translocation strategy to rapidly activate and inhibit small GTPase signaling pathways
    Takanari Inoue
    Stanford University, Department of Molecular Pharmacology, Clark Center, 318 Campus Drive, Stanford, California 94305 5439, USA
    Nat Methods 2:415-8. 2005
    ..As signaling processes often occur within minutes, such rapid perturbations provide a powerful tool to investigate the role, selectivity and timing of Rho GTPase-mediated signaling processes...
  2. pmc PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane
    Won Do Heo
    Department of Molecular Pharmacology, 318 Campus Drive, Clark Building, Stanford University Medical School, Stanford, CA 94305, USA
    Science 314:1458-61. 2006
    ....
  3. pmc Dissecting the role of PtdIns(4,5)P2 in endocytosis and recycling of the transferrin receptor
    Namiko Abe
    Graduate Program in Neurosciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cell Sci 121:1488-94. 2008
    ..This argues that receptor-mediated PtdIns(4,5)P(2) reduction preferentially suppresses AP-2-mediated targeting of cargo to endocytic sites rather than the assembly of clathrin coats or recycling of endocytic vesicles...
  4. pmc Synthetic activation of endogenous PI3K and Rac identifies an AND-gate switch for cell polarization and migration
    Takanari Inoue
    Chemical and Systems Biology, Bio X Program, Stanford University, Stanford, California, USA
    PLoS ONE 3:e3068. 2008
    ..This AND-gate control for cell polarization can explain how Rac can be employed for both PI3K-dependent and -independent signaling pathways coexisting in the same cell...
  5. ncbi request reprint Robust neuronal symmetry breaking by Ras-triggered local positive feedback
    Marc Fivaz
    Clark Center, Bio X, Department of Chemical and Systems Biology, Stanford University, 318 Campus Drive, Stanford, California 94305, USA
    Curr Biol 18:44-50. 2008
    ....
  6. pmc Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+ store depletion
    Jen Liou
    Department of Chemical and Systems Biology, Stanford University Medical School, 318 Campus Drive, Clark Center, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 104:9301-6. 2007
    ....
  7. pmc Rapid chemically induced changes of PtdIns(4,5)P2 gate KCNQ ion channels
    Byung Chang Suh
    Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, WA 98195, USA
    Science 314:1454-7. 2006
    ..Hence, the depletion of PI(4,5)P2 suffices to suppress current fully, and other second messengers are not needed. Our approach is ideally suited to study biological signaling networks involving membrane phosphoinositides...
  8. pmc An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of nerve growth factor-stimulated PC12 cells
    Kazuhiro Aoki
    Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Biol 177:817-27. 2007
    ....
  9. pmc Selective photoinactivation of protein function through environment-sensitive switching of singlet oxygen generation by photosensitizer
    Takatoshi Yogo
    Graduate School of Pharmaceutical Sciences and Department of Pharmacology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 105:28-32. 2008
    ....
  10. ncbi request reprint Modification of intracellular Ca2+ dynamics by laser inactivation of inositol 1,4,5-trisphosphate receptor using membrane-permeant probes
    Takatoshi Yogo
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Chem Biol 11:1053-8. 2004
    ..These results demonstrate the potency of the smCALI technique for the study of the roles of IP3R in complex intracellular Ca2+ dynamics...
  11. ncbi request reprint Hydrophobic modifications at 1-phosphate of inositol 1,4,5-trisphosphate analogues enhance receptor binding
    Waka Nakanishi
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
    Bioorg Med Chem Lett 12:911-3. 2002
    ..Our results show that hydrophobic modifications of the 1-phosphate moiety enhance the binding affinity, with considerable latitude of substituent structure...

Research Grants1

  1. Feedback and Crosstalk in Eukaryotic Chemotaxis
    Takanari Inoue; Fiscal Year: 2010
    ..Our unique perturbation approach can be a powerful strategy for not only dissecting the molecular mechanisms, but also interfering with these cell migration-related diseases. ..