John Huguenard

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. Mattis J, Brill J, Evans S, Lerner T, Davidson T, Hyun M, et al. Frequency-dependent, cell type-divergent signaling in the hippocamposeptal projection. J Neurosci. 2014;34:11769-80 pubmed publisher
    ..Our results suggest that two independent populations of septal cells distinctly encode hippocampal feedback, enabling the septum to monitor ongoing patterns of activity in the hippocampus. ..
  2. Farzampour Z, Reimer R, Huguenard J. Endozepines. Adv Pharmacol. 2015;72:147-64 pubmed publisher
    ..2013). Herein, we review the literature on this topic, focusing on identification of the endogenous molecule and its region-specific expression and function. ..
  3. Farzampour Z, Huguenard J. Seizing upon mechanisms for impaired consciousness. Neuron. 2015;85:453-5 pubmed publisher
    ..In this issue of Neuron, Motelow et al. (2015) describe decreased cholinergic drive and suppressed subcortical arousal in seizures as a novel mechanism for impaired cortical function. ..
  4. Deleuze C, Huguenard J. Two classes of excitatory synaptic responses in rat thalamic reticular neurons. J Neurophysiol. 2016;116:995-1011 pubmed publisher
  5. Pangratz Fuehrer S, Sieghart W, Rudolph U, Parada I, Huguenard J. Early postnatal switch in GABAA receptor α-subunits in the reticular thalamic nucleus. J Neurophysiol. 2016;115:1183-95 pubmed publisher
    ..The postnatal switch in GABA(A)R subunits from α5 to α3 could facilitate spontaneous network activity in nRt that occurs at this developmental time point and which is proposed to play a role in early circuit development. ..
  6. Fogerson P, Huguenard J. Tapping the Brakes: Cellular and Synaptic Mechanisms that Regulate Thalamic Oscillations. Neuron. 2016;92:687-704 pubmed publisher
  7. Makinson C, Tanaka B, Sorokin J, Wong J, Christian C, Goldin A, et al. Regulation of Thalamic and Cortical Network Synchrony by Scn8a. Neuron. 2017;93:1165-1179.e6 pubmed publisher
    ..Our observation that loss of a single gene in the thalamus of an adult wild-type animal is sufficient to cause spike-wave discharges is striking and represents an example of absence epilepsy of thalamic origin. ..
  8. Sorokin J, Paz J, Huguenard J. Absence seizure susceptibility correlates with pre-ictal ? oscillations. J Physiol Paris. 2016;110:372-381 pubmed publisher
    ..These results argue that CTC networks undergo a pre-seizure state transition, possibly due to a functional reorganization of cortical microcircuits, which leads to the generation of absence seizures. ..