Andy Hudmon

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Neuronal CA2+/calmodulin-dependent protein kinase II: the role of structure and autoregulation in cellular function
    Andy Hudmon
    Department of Neurobiology, Stanford University School of Medicine, 299 Campus Drive, Stanford, California 94305, USA
    Annu Rev Biochem 71:473-510. 2002
  2. ncbi request reprint Head module control of mediator interactions
    Yuichiro Takagi
    Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Mol Cell 23:355-64. 2006
  3. pmc CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation
    Andy Hudmon
    Department of Neurobiology, Stanford University, Stanford, CA 94305, USA
    J Cell Biol 171:537-47. 2005
  4. ncbi request reprint A mechanism for Ca2+/calmodulin-dependent protein kinase II clustering at synaptic and nonsynaptic sites based on self-association
    Andy Hudmon
    Department of Neurobiology, Stanford University, Stanford, California 94305, USA
    J Neurosci 25:6971-83. 2005
  5. pmc Structure-function of the multifunctional Ca2+/calmodulin-dependent protein kinase II
    Andy Hudmon
    Department of Neurobiology, Fairchild Bldg, D217 299 Campus Drive, Stanford University Medical School, Stanford, CA 94305 5125, USA
    Biochem J 364:593-611. 2002
  6. ncbi request reprint Chemical quenched flow kinetic studies indicate an intraholoenzyme autophosphorylation mechanism for Ca2+/calmodulin-dependent protein kinase II
    J Michael Bradshaw
    Department of Neurobiology, Stanford University, Stanford, California 94305, USA
    J Biol Chem 277:20991-8. 2002
  7. ncbi request reprint Revised subunit structure of yeast transcription factor IIH (TFIIH) and reconciliation with human TFIIH
    Yuichiro Takagi
    Department of Structural Biology, Stanford University School of Medicine, California 94305 5400, USA
    J Biol Chem 278:43897-900. 2003
  8. pmc Displacement of alpha-actinin from the NMDA receptor NR1 C0 domain By Ca2+/calmodulin promotes CaMKII binding
    Michelle A Merrill
    Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242 1109, USA
    Biochemistry 46:8485-97. 2007
  9. doi request reprint Phosphorylation of sodium channel Na(v)1.8 by p38 mitogen-activated protein kinase increases current density in dorsal root ganglion neurons
    Andy Hudmon
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 28:3190-201. 2008
  10. ncbi request reprint Voltage-gated sodium channel Nav1.6 is modulated by p38 mitogen-activated protein kinase
    Ellen K Wittmack
    Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 25:6621-30. 2005

Collaborators

  • J Michael Bradshaw
  • Francisco Asturias
  • Geoffrey S Pitt
  • Roger Kornberg
  • S G Waxman
  • Howard Schulman
  • Yuichiro Takagi
  • Michelle A Merrill
  • Xiao Yu
  • Jin Sung Choi
  • Sulayman D Dib-Hajj
  • Ellen K Wittmack
  • Hirofumi Komori
  • Johannes W Hell
  • Jason A Bartos
  • Bo Zhou
  • Sijiu Liu
  • Xiaoling Guo
  • Zulfiqar Malik
  • A Soren Leonard
  • Jin Peng Sun
  • Madeline A Shea
  • Zhong Yin Zhang
  • Zeynep Akyol
  • Yantao He
  • Andreas H Ehrensberger
  • Jesse A Brown
  • Guillermo Calero
  • Anthony M Rush
  • Hediye Erdjument-Bromage
  • Paul Tempst
  • Wei Hau Chang

Detail Information

Publications12

  1. ncbi request reprint Neuronal CA2+/calmodulin-dependent protein kinase II: the role of structure and autoregulation in cellular function
    Andy Hudmon
    Department of Neurobiology, Stanford University School of Medicine, 299 Campus Drive, Stanford, California 94305, USA
    Annu Rev Biochem 71:473-510. 2002
    ....
  2. ncbi request reprint Head module control of mediator interactions
    Yuichiro Takagi
    Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Mol Cell 23:355-64. 2006
    ..The head module evidently controls Mediator-RNA polymerase II and Mediator-promoter interactions...
  3. pmc CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation
    Andy Hudmon
    Department of Neurobiology, Stanford University, Stanford, CA 94305, USA
    J Cell Biol 171:537-47. 2005
    ..These findings clarify the molecular basis of CDF and demonstrate a novel enzymatic mechanism by which ion channel gating can be modulated by activity...
  4. ncbi request reprint A mechanism for Ca2+/calmodulin-dependent protein kinase II clustering at synaptic and nonsynaptic sites based on self-association
    Andy Hudmon
    Department of Neurobiology, Stanford University, Stanford, California 94305, USA
    J Neurosci 25:6971-83. 2005
    ..We discuss the potential function of CaMKII self-association as a tag of synaptic activity...
  5. pmc Structure-function of the multifunctional Ca2+/calmodulin-dependent protein kinase II
    Andy Hudmon
    Department of Neurobiology, Fairchild Bldg, D217 299 Campus Drive, Stanford University Medical School, Stanford, CA 94305 5125, USA
    Biochem J 364:593-611. 2002
    ..The molecular determinants and mechanisms producing these processes are discussed as they relate to the structure-function of this multifunctional protein kinase...
  6. ncbi request reprint Chemical quenched flow kinetic studies indicate an intraholoenzyme autophosphorylation mechanism for Ca2+/calmodulin-dependent protein kinase II
    J Michael Bradshaw
    Department of Neurobiology, Stanford University, Stanford, California 94305, USA
    J Biol Chem 277:20991-8. 2002
    ..The ability of CaM kinase II to autophosphorylate through an intraholoenzyme, intersubunit mechanism is likely central to its functions of decoding Ca(2+) spike frequency and providing a sustained response to Ca(2+) signals...
  7. ncbi request reprint Revised subunit structure of yeast transcription factor IIH (TFIIH) and reconciliation with human TFIIH
    Yuichiro Takagi
    Department of Structural Biology, Stanford University School of Medicine, California 94305 5400, USA
    J Biol Chem 278:43897-900. 2003
    ..This reassignment of subunits resolves a longstanding discrepancy between yeast and human TFIIH complexes...
  8. pmc Displacement of alpha-actinin from the NMDA receptor NR1 C0 domain By Ca2+/calmodulin promotes CaMKII binding
    Michelle A Merrill
    Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242 1109, USA
    Biochemistry 46:8485-97. 2007
    ..Our results reveal an intricate mechanism whereby Ca2+ functions to govern the complex interactions between the two most prevalent signaling molecules in synaptic plasticity, the NMDA receptor and CaMKII...
  9. doi request reprint Phosphorylation of sodium channel Na(v)1.8 by p38 mitogen-activated protein kinase increases current density in dorsal root ganglion neurons
    Andy Hudmon
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 28:3190-201. 2008
    ..Our study suggests a mechanism by which activated p38 contributes to inflammatory, and possibly neuropathic, pain through a p38-mediated increase of Na(v)1.8 current density...
  10. ncbi request reprint Voltage-gated sodium channel Nav1.6 is modulated by p38 mitogen-activated protein kinase
    Ellen K Wittmack
    Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 25:6621-30. 2005
    ..6 current density. This is the first demonstration of MAPK phosphorylation and modulation of a voltage-gated sodium channel, and this modulation may represent an additional role for MAPK in regulating the neuronal response to injury...
  11. ncbi request reprint Calmodulin regulates current density and frequency-dependent inhibition of sodium channel Nav1.8 in DRG neurons
    Jin Sung Choi
    Department of Neurology, Yale University School of Medicine, New Heaven, CT, USA
    J Neurophysiol 96:97-108. 2006
    ..8, in native neurons, and demonstrates a regulation of Nav1.8 currents that can significantly affect electrogenesis of DRG neurons in which Nav1.8 is normally expressed...
  12. pmc Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases
    Xiao Yu
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202
    Proc Natl Acad Sci U S A 104:19767-72. 2007
    ..Our data establish a mechanism by which PKC could attenuate the cellular function of Lyp, thereby augmenting T cell activation...