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Genomes and GenesSpecies | Andrew D HubermanSummaryAffiliation: Stanford University Country: USA Publications
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Publications
Decoupling eye-specific segregation from lamination in the lateral geniculate nucleusAndrew D Huberman
Center for Neuroscience, University of California, Davis, California 95616, USA
J Neurosci 22:9419-29. 2002..Clusters of ON-center and OFF-center LGN cells were segregated from one another as in normal animals. However, the organization of ON and OFF sublaminas in the treated animals was disrupted...
Nob mice wave goodbye to eye-specific segregationAndrew D Huberman
Department of Neurobiology, Stanford University School of Medicine, Palo Alto, California 94305, USA
Neuron 50:175-7. 2006..These results provide important new insight into the mechanisms that drive eye-specific refinement and stabilization...- Spontaneous retinal activity mediates development of ocular dominance columns and binocular receptive fields in v1Andrew D Huberman
Center for Neuroscience, University of California, Davis, Davis, California 95616, USA
Neuron 52:247-54. 2006.... - Genetic identification of an On-Off direction-selective retinal ganglion cell subtype reveals a layer-specific subcortical map of posterior motionAndrew D Huberman
Department of Neurobiology, Stanford University School of Medicine, Palo Alto, CA 94305, USA
Neuron 62:327-34. 2009..This suggests that each RGC subtype represents a unique parallel pathway whose synaptic specificity in the retina is recapitulated in central targets... 
Mammalian DSCAMs: they won't help you find a partner, but they'll guarantee you some personal spaceAndrew D Huberman
Department of Neurobiology, Stanford University School of Medicine, Palo Alto, CA 94305, USA
Neuron 64:441-3. 2009..The results unveil critical features regarding the type and scope of molecular interactions that guide neural circuit assembly in the mammalian CNS...- Mechanisms underlying development of visual maps and receptive fieldsAndrew D Huberman
Department of Neurobiology, Stanford University School of Medicine, Palo Alto, California 94305, USA
Annu Rev Neurosci 31:479-509. 2008..A major goal now is to determine how these molecules cooperate with spontaneous and visually evoked activity to give rise to the circuits underlying precise receptive field tuning and orderly visual maps... - Architecture and activity-mediated refinement of axonal projections from a mosaic of genetically identified retinal ganglion cellsAndrew D Huberman
Department of Neurobiology, Fairchild Science Building D235, Stanford University School of Medicine, Palo Alto, CA 94305, USA
Neuron 59:425-38. 2008..Our findings reveal that in a genetically identified sensory map, spontaneous activity promotes synaptic specificity by segregating axons arising from RGCs of the same subtype... - Mechanisms of eye-specific visual circuit developmentAndrew D Huberman
Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA
Curr Opin Neurobiol 17:73-80. 2007..Although many outstanding questions remain, the mechanisms that instruct eye-specific circuit development are becoming clear... - Early and rapid targeting of eye-specific axonal projections to the dorsal lateral geniculate nucleus in the fetal macaqueAndrew D Huberman
Center for Neuroscience, University of California, Davis, Davis, California 95616, USA
J Neurosci 25:4014-23. 2005.... - Transgenic mice reveal unexpected diversity of on-off direction-selective retinal ganglion cell subtypes and brain structures involved in motion processingMichal Rivlin-Etzion
Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3200, USA
J Neurosci 31:8760-9. 2011..Our findings reveal unexpected diversity among mouse On-Off DSGC subtypes that uniquely process and convey image motion to the brain... - The Down syndrome critical region regulates retinogeniculate refinementMartina Blank
Department of Psychiatry, Stanford University School of Medicine, Stanford, California, 94305, USA
J Neurosci 31:5764-76. 2011..Thus, altered developmental refinement of visual circuits that occurs before sensory experience is likely to contribute to visual impairment in individuals with Down syndrome... - Ephrin-As mediate targeting of eye-specific projections to the lateral geniculate nucleusAndrew D Huberman
Center for Neuroscience, 1544 Newton Ct, University of California, Davis, California 95616, USA
Nat Neurosci 8:1013-21. 2005..These findings represent the first demonstration of eye-specific pathfinding mediated by axon guidance cues and, taken with other reports, indicate that ephrin-As can mediate several mapping functions within individual target structures... - Pathway-specific genetic attenuation of glutamate release alters select features of competition-based visual circuit refinementSelina M Koch
Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA
Neuron 71:235-42. 2011.... - Eye-specific retinogeniculate segregation independent of normal neuronal activityAndrew D Huberman
Center for Neuroscience, School of Medicine, University of California, Davis, CA 95616, USA
Science 300:994-8. 2003..Thus, certain features of normal neural activity patterns are not required for the formation of eye-specific projections to the DLGN... - Dynamics of spontaneous activity in the fetal macaque retina during development of retinogeniculate pathwaysDavid K Warland
Department of Ophthalmology and Visual Science, University of California, Davis, California 95616, USA
J Neurosci 26:5190-7. 2006.... - The developmental remodeling of eye-specific afferents in the ferret dorsal lateral geniculate nucleusColenso M Speer
Center for Neuroscience, University of California, Davis, Davis, California 95618, USA
Anat Rec (Hoboken) 293:1-24. 2010..The emergence of On/Off sublaminae occurs following eye-specific segregation in this species. On the basis of these findings, we constructed a three-dimensional map of eye-specific channels in the developing and mature ferret dLGN... - Emergence of lamina-specific retinal ganglion cell connectivity by axon arbor retraction and synapse eliminationTing Wen Cheng
Center for Neuroscience, University of California, Davis, California 95618, USA
J Neurosci 30:16376-82. 2010.... - Cadherin-6 mediates axon-target matching in a non-image-forming visual circuitJessica A Osterhout
Neurosciences Department, School of Medicine, and Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
Neuron 71:632-9. 2011..These findings provide functional evidence that classical cadherins promote mammalian CNS circuit development by ensuring that axons of specific cell types connect to their appropriate synaptic targets... - Neurotrophins and visual cortical plasticityAndrew D Huberman
Center for Neuroscience, University of California, Davis, 1544 Newton Court, Davis, CA 95616, USA
Prog Brain Res 138:39-51. 2002 - The classical complement cascade mediates CNS synapse eliminationBeth Stevens
Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA
Cell 131:1164-78. 2007..These findings support a model in which unwanted synapses are tagged by complement for elimination and suggest that complement-mediated synapse elimination may become aberrantly reactivated in neurodegenerative disease... - Molecular and cellular mechanisms of lamina-specific axon targetingAndrew D Huberman
Department of Neurobiology, Stanford University School of Medicine, Palo Alto, California 94305, USA
Cold Spring Harb Perspect Biol 2:a001743. 2010..Here, we focus on one of the final steps of synaptic matchmaking: the targeting of synaptic layers and the mutual recognition of axons and dendrites within these layers... - Target-derived cues instruct synaptic differentiationAndrew D Huberman
Department of Neurobiology, Stanford University School of Medicine, Stanford, California 94305, USA
J Neurosci 26:1063-4. 2006 - Neuronal pentraxins mediate synaptic refinement in the developing visual systemLisa Bjartmar
Department of Neurosciences, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Neurosci 26:6269-81. 2006..We speculate that NPs exert their effects through mechanisms that parallel the known role of short pentraxins outside the CNS... - Crossed and uncrossed retinal projections to the hamster circadian systemLouise Muscat
Graduate Program in Neurobiology and Behavior, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
J Comp Neurol 466:513-24. 2003..This issue is discussed in the context of the melanopsin-containing retinal ganglion cell projections to several nuclei in the circadian visual system...