Ting Ting Huang

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Paradoxical relationship between Mn superoxide dismutase deficiency and radiation-induced cognitive defects
    Rikki Corniola
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 7:e49367. 2012
  2. pmc Persistent expression of hepatitis C virus non-structural proteins leads to increased autophagy and mitochondrial injury in human hepatoma cells
    Victor C Chu
    Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, United States of America
    PLoS ONE 6:e28551. 2011
  3. pmc Oxidative stress and adult neurogenesis--effects of radiation and superoxide dismutase deficiency
    Ting Ting Huang
    Geriatric Research, Education, and Care Center GRECC, VA Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Semin Cell Dev Biol 23:738-44. 2012
  4. doi request reprint Redox balance- and radiation-mediated alteration in hippocampal neurogenesis
    Ting Ting Huang
    Geriatric Research, Education, and Care Center GRECC, VA Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Free Radic Res 46:951-8. 2012
  5. ncbi request reprint Genetic modifiers of the phenotype of mice deficient in mitochondrial superoxide dismutase
    Ting Ting Huang
    Department of Neurology and Neurological Sciences, Stanford University, CA 94305, USA
    Hum Mol Genet 15:1187-94. 2006
  6. pmc Extracellular superoxide dismutase is important for hippocampal neurogenesis and preservation of cognitive functions after irradiation
    Yani Zou
    Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94304, USA
    Proc Natl Acad Sci U S A 109:21522-7. 2012
  7. ncbi request reprint CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life
    Sailaja Elchuri
    Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA
    Oncogene 24:367-80. 2005
  8. pmc Effects of altered levels of extracellular superoxide dismutase and irradiation on hippocampal neurogenesis in female mice
    Yani Zou
    Department of Neurology and Neurological Sciences, Stanford University, Stanford, California
    Int J Radiat Oncol Biol Phys 87:777-84. 2013
  9. ncbi request reprint Selective neuronal vulnerability and inadequate stress response in superoxide dismutase mutant mice
    Stephen Lynn
    Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA
    Free Radic Biol Med 38:817-28. 2005
  10. pmc Lack of extracellular superoxide dismutase (EC-SOD) in the microenvironment impacts radiation-induced changes in neurogenesis
    Radoslaw Rola
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94110 0899, and GRECC, VA Palo Alto Health Care System, USA
    Free Radic Biol Med 42:1133-45; discussion 1131-2. 2007

Research Grants

  1. Oxidative Stress and Hepatocellular Carcinoma
    Ting Ting Huang; Fiscal Year: 2009
  2. Oxidative Stress and Hepatocellular Carcinoma
    Ting Ting Huang; Fiscal Year: 2010
  3. Oxidative Stress and Hepatocellular Carcinoma
    Ting Ting Huang; Fiscal Year: 2007
  4. Genetics Modifiers and Longevity of MnSOD Mutants
    Ting Ting Huang; Fiscal Year: 2004
  5. Genetics Modifiers and Longevity of MnSOD Mutant Mice
    Ting Ting Huang; Fiscal Year: 2007
  6. GENETIC MODIFIERS AND LONGEVITY OF MNSOD MUTANT MICE
    Ting Ting Huang; Fiscal Year: 2003
  7. GENETIC MODIFIERS AND LONGEVITY OF MNSOD MUTANT MICE
    Ting Ting Huang; Fiscal Year: 2002
  8. GENETIC MODIFIERS AND LONGEVITY OF MNSOD MUTANT MICE
    Ting Ting Huang; Fiscal Year: 2001
  9. Genetics Modifiers and Longevity of MnSOD Mutant Mice
    Ting Ting Huang; Fiscal Year: 2006
  10. Genetics Modifiers and Longevity of MnSOD Mutant Mice
    Ting Ting Huang; Fiscal Year: 2005

Collaborators

Detail Information

Publications30

  1. pmc Paradoxical relationship between Mn superoxide dismutase deficiency and radiation-induced cognitive defects
    Rikki Corniola
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 7:e49367. 2012
    ..The data suggest that maintenance of synaptic connections, via maintenance of dendritic spines, may be important for normal cognitive functions following cranial irradiation...
  2. pmc Persistent expression of hepatitis C virus non-structural proteins leads to increased autophagy and mitochondrial injury in human hepatoma cells
    Victor C Chu
    Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, United States of America
    PLoS ONE 6:e28551. 2011
    ..The population doubling time and cyclin D1 level were also comparable to that of control cells. Finally, the cytopathic effects of core protein appeared to focus on the mitochondria without remarkable disturbances in the cytosol...
  3. pmc Oxidative stress and adult neurogenesis--effects of radiation and superoxide dismutase deficiency
    Ting Ting Huang
    Geriatric Research, Education, and Care Center GRECC, VA Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Semin Cell Dev Biol 23:738-44. 2012
    ....
  4. doi request reprint Redox balance- and radiation-mediated alteration in hippocampal neurogenesis
    Ting Ting Huang
    Geriatric Research, Education, and Care Center GRECC, VA Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Free Radic Res 46:951-8. 2012
    ..15.1.1) isoforms, we have begun to determine the consequences of SOD deficiency in hippocampal neurogenesis and the related functions of learning and memory under normal condition and following cranial irradiation...
  5. ncbi request reprint Genetic modifiers of the phenotype of mice deficient in mitochondrial superoxide dismutase
    Ting Ting Huang
    Department of Neurology and Neurological Sciences, Stanford University, CA 94305, USA
    Hum Mol Genet 15:1187-94. 2006
    ..This action of NNT could explain its putative protective role in MnSOD-deficient mice...
  6. pmc Extracellular superoxide dismutase is important for hippocampal neurogenesis and preservation of cognitive functions after irradiation
    Yani Zou
    Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94304, USA
    Proc Natl Acad Sci U S A 109:21522-7. 2012
    ....
  7. ncbi request reprint CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life
    Sailaja Elchuri
    Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA
    Oncogene 24:367-80. 2005
    ..Increased cell proliferation in the presence of persistent oxidative damage to macromolecules likely contributes to hepatocarcinogenesis later in life...
  8. pmc Effects of altered levels of extracellular superoxide dismutase and irradiation on hippocampal neurogenesis in female mice
    Yani Zou
    Department of Neurology and Neurological Sciences, Stanford University, Stanford, California
    Int J Radiat Oncol Biol Phys 87:777-84. 2013
    ..Therefore, female mice were studied and the results compared with those generated in male mice from an earlier study...
  9. ncbi request reprint Selective neuronal vulnerability and inadequate stress response in superoxide dismutase mutant mice
    Stephen Lynn
    Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA
    Free Radic Biol Med 38:817-28. 2005
    ..Other major classes of differentially expressed genes include lipid biosynthesis and ROS metabolism...
  10. pmc Lack of extracellular superoxide dismutase (EC-SOD) in the microenvironment impacts radiation-induced changes in neurogenesis
    Radoslaw Rola
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94110 0899, and GRECC, VA Palo Alto Health Care System, USA
    Free Radic Biol Med 42:1133-45; discussion 1131-2. 2007
    ..This finding may have a major impact in developing strategies to reduce cognitive impairment after cranial irradiation...
  11. doi request reprint Genetic modifier of mitochondrial superoxide dismutase-deficient mice delays heart failure and prolongs survival
    Aekyong Kim
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mamm Genome 21:534-42. 2010
    ..The study results suggest that NNT is important for normal development and function of fetal hearts and that there may be other genetic modifier(s) important for postnatal survival of Sod2-/- mice...
  12. pmc A new mouse model for temporal- and tissue-specific control of extracellular superoxide dismutase
    Yani Zou
    Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, USA
    Genesis 47:142-54. 2009
    ..This mouse model, thus, provides the flexibility for on-off control of transgene expression in multiple target tissues...
  13. pmc Enhanced expression of mitochondrial superoxide dismutase leads to prolonged in vivo cell cycle progression and up-regulation of mitochondrial thioredoxin
    Aekyong Kim
    Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA
    Free Radic Biol Med 48:1501-12. 2010
    ....
  14. pmc Age-related defects in sensorimotor activity, spatial learning, and memory in C57BL/6 mice
    George Barreto
    Department of Anesthesia, Stanford University School of Medicine, Stanford University, Stanford, CA 94305 5117, USA
    J Neurosurg Anesthesiol 22:214-9. 2010
    ..These tests will be useful to assess outcome in neurodegenerative disease and postoperative cognitive dysfunction models carried out in aged mice...
  15. ncbi request reprint Transcriptional activation of hepatic ACSL3 and ACSL5 by oncostatin m reduces hypertriglyceridemia through enhanced beta-oxidation
    Yue Zhou
    VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, CA 94304, USA
    Arterioscler Thromb Vasc Biol 27:2198-205. 2007
    ..Interestingly, the OM effect of lowering plasma TG was more pronounced than LDL-cholesterol reduction, suggesting additional LDLR-independent actions. Here, we investigated mechanisms underlying the direct TG-lowering effect of OM...
  16. pmc Identification of biomarkers associated with the development of hepatocellular carcinoma in CuZn superoxide dismutase deficient mice
    Sailaja Elchuri
    Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA
    Proteomics 7:2121-9. 2007
    ....
  17. ncbi request reprint Manganese superoxide dismutase deficiency enhances cell turnover via tumor promoter-induced alterations in AP-1 and p53-mediated pathways in a skin cancer model
    Yunfent Zhao
    Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA
    Oncogene 21:3836-46. 2002
    ....
  18. ncbi request reprint Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress
    Holly Van Remmen
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78284 7762, USA
    Free Radic Biol Med 36:1625-34. 2004
    ....
  19. ncbi request reprint A biologically effective fullerene (C60) derivative with superoxide dismutase mimetic properties
    Sameh S Ali
    Center for the Study of Nervous System Injury CSNSI, Department of Neurology, Washington University, St Louis, MO 63130, USA
    Free Radic Biol Med 37:1191-202. 2004
    ..These data, coupled with evidence that C3 localizes to mitochondria, suggest that C3 functionally replaces MnSOD, acting as a biologically effective SOD mimetic...
  20. ncbi request reprint Effect of the reduction of superoxide dismutase 1 and 2 or treatment with alpha-tocopherol on tumorigenesis in Atm-deficient mice
    Laura Erker
    Departments of Pediatrics and Medicine, Center for Human Genetics and Genomics, UCSD School of Medicine, La Jolla, CA 92093, USA
    Free Radic Biol Med 41:590-600. 2006
    ....
  21. ncbi request reprint Transgenic and mutant mice for oxygen free radical studies
    Ting Ting Huang
    Department of Pediatrics, Genetics Division, University of California, San Francisco, California 94143, USA
    Methods Enzymol 349:191-213. 2002
  22. pmc Manganese superoxide dismutase-mediated gene expression in radiation-induced adaptive responses
    Guozheng Guo
    Radiation Biology, Division of Radiation Oncology, City of Hope National Medical Center, Duarte, California 91010, USA
    Mol Cell Biol 23:2362-78. 2003
    ..These results support the hypothesis that NF-kappa B is capable of regulating the expression of MnSOD, which in turn is capable of increasing the expression of genes that participate in radiation-induced adaptive responses...
  23. ncbi request reprint Effect of SOD1 overexpression on age- and noise-related hearing loss
    Donald E Coling
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, San Francisco, CA 94143 0526, USA
    Free Radic Biol Med 34:873-80. 2003
    ..The results indicate the complexity of oxidative metabolism in the cochlea is greater than previously hypothesized...
  24. ncbi request reprint Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging
    Holly Van Remmen
    Department of Cellular and Structural Biology at the University of Texas Health Science Center at San Antonio, San Antonio 78229 3900, USA
    Physiol Genomics 16:29-37. 2003
    ..Thus life-long reduction of MnSOD activity leads to increased levels of oxidative damage to DNA and increased cancer incidence but does not appear to affect aging...
  25. pmc Cell-density-dependent regulation of neural precursor cell function
    Charles L Limoli
    Departments of Radiation Oncology and Neurological Surgery, University of California, San Francisco, CA 94103
    Proc Natl Acad Sci U S A 101:16052-7. 2004
    ..These data showed that neural precursor cells were predisposed to microenvironmental cues that regulate redox-sensitive pathways to control cellular proliferation after CNS damage...
  26. ncbi request reprint A role for manganese superoxide dismutase in apoptosis after photosensitization
    Vladislav Dolgachev
    Department of Fundamental and Applied Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA
    Biochem Biophys Res Commun 332:411-7. 2005
    ..The data show that MnSOD affects sensitivity of cells to Pc 4-PDT-initiated apoptosis, and partly ceramide accumulation, suggesting that the processes are superoxide-mediated...
  27. ncbi request reprint Organ-specific increase in mutation accumulation and apoptosis rate in CuZn-superoxide dismutase-deficient mice
    Rita A Busuttil
    Departments of Physiology and Molecular Medicine, University of Texas Health Science Center, San Antonio, 78240, USA
    Cancer Res 65:11271-5. 2005
    ..5-fold was found not earlier than at 6 months. No increased mutation accumulation was observed in brain or spleen. These results support the hypothesis, that oxidative stress is an important causal factor of cancer in mammals...
  28. ncbi request reprint Alterations in mitochondrial function, hydrogen peroxide release and oxidative damage in mouse hind-limb skeletal muscle during aging
    Abdellah Mansouri
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3901, USA
    Mech Ageing Dev 127:298-306. 2006
    ..In addition, increased oxidative stress generated by reduced activity of MnSOD does not exacerbate these alterations during aging...
  29. ncbi request reprint Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy
    Florian L Muller
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Free Radic Biol Med 40:1993-2004. 2006
    ..Thus, the absence of CuZnSOD imposes elevated oxidative stress, loss of muscle mass, and physiological consequences that resemble an acceleration of normal age-related sarcopenia...
  30. ncbi request reprint Increased sensitivity of homozygous Sod2 mutant mice to oxygen toxicity
    Tiina M Asikainen
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Free Radic Biol Med 32:175-86. 2002
    ..We conclude that MnSOD is required for normal O2 tolerance and that in the absence of MnSOD there is a compensatory increase in pulmonary glutathione-dependent antioxidant defense in hyperoxia...

Research Grants15

  1. Oxidative Stress and Hepatocellular Carcinoma
    Ting Ting Huang; Fiscal Year: 2009
    ..In addition, different proteomic tools and procedures will be implemented to identify molecules that are vulnerable to oxidative modification in HCV transgenic and CuZnSOD deficient mice. ..
  2. Oxidative Stress and Hepatocellular Carcinoma
    Ting Ting Huang; Fiscal Year: 2010
    ..In addition, different proteomic tools and procedures will be implemented to identify molecules that are vulnerable to oxidative modification in HCV transgenic and CuZnSOD deficient mice. ..
  3. Oxidative Stress and Hepatocellular Carcinoma
    Ting Ting Huang; Fiscal Year: 2007
    ..In addition, different proteomic tools and procedures will be implemented to identify molecules that are vulnerable to oxidative modification in HCV transgenic and CuZnSOD deficient mice. ..
  4. Genetics Modifiers and Longevity of MnSOD Mutants
    Ting Ting Huang; Fiscal Year: 2004
    ..Aim 2: Mechanistic analysis of Nnt as the genetic modifier of Sod2-/-. Aim 3: Validation of Nnt as a longevity assurance gene (LAG). ..
  5. Genetics Modifiers and Longevity of MnSOD Mutant Mice
    Ting Ting Huang; Fiscal Year: 2007
    ..Aim 2: Mechanistic analysis of Nnt as the genetic modifier of Sod2-/-. Aim 3: Validation of Nnt as a longevity assurance gene (LAG). ..
  6. GENETIC MODIFIERS AND LONGEVITY OF MNSOD MUTANT MICE
    Ting Ting Huang; Fiscal Year: 2003
    ..Aim III - Functional studies of the genetic modifier by phenotype analyses of Sod2-/- mice. Aim IV - Identification of the major modifier gene leading to prolonged lifespan in MnSOD mutant mice. ..
  7. GENETIC MODIFIERS AND LONGEVITY OF MNSOD MUTANT MICE
    Ting Ting Huang; Fiscal Year: 2002
    ..Aim III - Functional studies of the genetic modifier by phenotype analyses of Sod2-/- mice. Aim IV - Identification of the major modifier gene leading to prolonged lifespan in MnSOD mutant mice. ..
  8. GENETIC MODIFIERS AND LONGEVITY OF MNSOD MUTANT MICE
    Ting Ting Huang; Fiscal Year: 2001
    ..Aim III - Functional studies of the genetic modifier by phenotype analyses of Sod2-/- mice. Aim IV - Identification of the major modifier gene leading to prolonged lifespan in MnSOD mutant mice. ..
  9. Genetics Modifiers and Longevity of MnSOD Mutant Mice
    Ting Ting Huang; Fiscal Year: 2006
    ..Aim 2: Mechanistic analysis of Nnt as the genetic modifier of Sod2-/-. Aim 3: Validation of Nnt as a longevity assurance gene (LAG). ..
  10. Genetics Modifiers and Longevity of MnSOD Mutant Mice
    Ting Ting Huang; Fiscal Year: 2005
    ..Aim 2: Mechanistic analysis of Nnt as the genetic modifier of Sod2-/-. Aim 3: Validation of Nnt as a longevity assurance gene (LAG). ..
  11. GENETIC MODIFIERS AND LONGEVITY OF MNSOD MUTANT MICE
    Ting Ting Huang; Fiscal Year: 2002
    ..Aim III - Functional studies of the genetic modifier by phenotype analyses of Sod2-/- mice. Aim IV - Identification of the major modifier gene leading to prolonged lifespan in MnSOD mutant mice. ..
  12. GENETIC MODIFIERS AND LONGEVITY OF MNSOD MUTANT MICE
    Ting Ting Huang; Fiscal Year: 2000
    ..Aim III - Functional studies of the genetic modifier by phenotype analyses of Sod2-/- mice. Aim IV - Identification of the major modifier gene leading to prolonged lifespan in MnSOD mutant mice. ..
  13. GENETIC MODIFIERS AND LONGEVITY OF MNSOD MUTANTS
    Ting Ting Huang; Fiscal Year: 1999
    ..Aim III - Functional studies of the genetic modifier by phenotype analyses of Sod2-/- mice. Aim IV - Identification of the major modifier gene leading to prolonged lifespan in MnSOD mutant mice. ..