SHEAU-YU T HSU

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi Evolution of glycoprotein hormone subunit genes in bilateral metazoa: identification of two novel human glycoprotein hormone subunit family genes, GPA2 and GPB5
    Sheau Yu Hsu
    Division of Reproductive Biology, Department of Gynecology and Obstetrics, Stanford University School of Medicine, Stanford, California 94305, USA
    Mol Endocrinol 16:1538-51. 2002
  2. ncbi Evolution of the signaling system in relaxin-family peptides
    Sheau Yu Teddy Hsu
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    Ann N Y Acad Sci 1041:520-9. 2005
  3. ncbi Bioinformatics in reproductive biology--functional annotation based on comparative sequence analysis
    Sheau Yu Teddy Hsu
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, 300 Pasteur Dr, Room A344E, Stanford, CA 94305 5317, USA
    J Reprod Immunol 63:75-83. 2004
  4. ncbi New insights into the evolution of the relaxin-LGR signaling system
    Sheau Yu Teddy Hsu
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, 300 Pasteur Drive, Room A344E, Stanford, CA 94305-5317, USA
    Trends Endocrinol Metab 14:303-9. 2003
  5. ncbi Relaxin signaling in reproductive tissues
    Sheau Yu Teddy Hsu
    Division of Reproductive Biology, Department of Gynecology and Obstetrics, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    Mol Cell Endocrinol 202:165-70. 2003
  6. ncbi Origin of INSL3-mediated testicular descent in therian mammals
    Jae Il Park
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305 5317, USA
    Genome Res 18:974-85. 2008
  7. ncbi GPCR genes are preferentially retained after whole genome duplication
    Jenia Semyonov
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 3:e1903. 2008
  8. ncbi New Insights into biological roles of relaxin and relaxin-related peptides
    Jae-Il Park
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, School of Medicine, Stanford University, CA 94305-5317, USA
    Rev Endocr Metab Disord 6:291-6. 2005
  9. ncbi Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes
    Jaesook Roh
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305 5317, USA
    J Biol Chem 279:7264-74. 2004
  10. ncbi Regulation of receptor signaling by relaxin A chain motifs: derivation of pan-specific and LGR7-specific human relaxin analogs
    Jae Il Park
    Reproductive Biology and Stem Cell Research Program, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305 5317, USA
    J Biol Chem 283:32099-109. 2008

Research Grants

  1. Role of RAMPs in Intermedin Signaling
    Sheau Yu Teddy Hsu; Fiscal Year: 2010
  2. PHYSIOLOGY OF RELAXIN-INSULIN-LIKE FACTORS
    Sheau Yu Hsu; Fiscal Year: 2002
  3. Identification of Relaxin Receptor Antagonists
    Sheau Yu Hsu; Fiscal Year: 2005
  4. Role of RAMPs in Intermedin Signaling
    Sheau Yu Hsu; Fiscal Year: 2009

Collaborators

  • Koji Nakabayashi
  • ORRIN SHERWOOD
  • R Bathgate
  • Jian Zhou
  • Eli Adashi
  • Kazuhiro Kawamura
  • James J Cai
  • Chia Lin Chang
  • Jae Il Park
  • Jae-Il Park
  • Jenia Semyonov
  • Jaesook Roh
  • Wei Yi
  • Friederike Kindt
  • Michiharu Horikawa
  • Cynthia Klein
  • Ho Yen Chueh
  • Po Jen Cheng
  • Wesley Warren
  • Silke Wiegand
  • Wolfgang Kummer
  • Christoph LOser
  • Martin Nilles
  • Volker Niemeier
  • Martin Steinhoff
  • Uwe Gieler
  • Rainer Viktor Haberberger
  • Rainer V Haberberger
  • Carolyn A Bondy
  • Nicole Cushman
  • Sabine M Mulders
  • Nikki J Kirkman
  • Gretchen J King
  • Kelley E Mayo
  • Alka Bhalla

Detail Information

Publications19

  1. ncbi Evolution of glycoprotein hormone subunit genes in bilateral metazoa: identification of two novel human glycoprotein hormone subunit family genes, GPA2 and GPB5
    Sheau Yu Hsu
    Division of Reproductive Biology, Department of Gynecology and Obstetrics, Stanford University School of Medicine, Stanford, California 94305, USA
    Mol Endocrinol 16:1538-51. 2002
    ..Studies of the complete inventory of genes homologous to glycoprotein hormone subunits in the human genome and lower organisms will allow future functional characterization and identification of their respective receptors...
  2. ncbi Evolution of the signaling system in relaxin-family peptides
    Sheau Yu Teddy Hsu
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    Ann N Y Acad Sci 1041:520-9. 2005
    ....
  3. ncbi Bioinformatics in reproductive biology--functional annotation based on comparative sequence analysis
    Sheau Yu Teddy Hsu
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, 300 Pasteur Dr, Room A344E, Stanford, CA 94305 5317, USA
    J Reprod Immunol 63:75-83. 2004
    ..Thus, detailed studies on the characteristics and evolution of gene sequences have provided an inroad to the elucidation of novel signaling polypeptides and the associated signal transduction pathways...
  4. ncbi New insights into the evolution of the relaxin-LGR signaling system
    Sheau Yu Teddy Hsu
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, 300 Pasteur Drive, Room A344E, Stanford, CA 94305-5317, USA
    Trends Endocrinol Metab 14:303-9. 2003
  5. ncbi Relaxin signaling in reproductive tissues
    Sheau Yu Teddy Hsu
    Division of Reproductive Biology, Department of Gynecology and Obstetrics, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    Mol Cell Endocrinol 202:165-70. 2003
    ..Furthermore, future functional characterization of the specificity of these pluripoentent receptors with peptide ligands could lead to the understanding of related orphan ligands and receptors...
  6. ncbi Origin of INSL3-mediated testicular descent in therian mammals
    Jae Il Park
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305 5317, USA
    Genome Res 18:974-85. 2008
    ....
  7. ncbi GPCR genes are preferentially retained after whole genome duplication
    Jenia Semyonov
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 3:e1903. 2008
    ..These results demonstrate that gene retention is not uniform after WGD in vertebrates, and suggest a Darwinian selection of GPCR-mediated intercellular communication in metazoan organisms...
  8. ncbi New Insights into biological roles of relaxin and relaxin-related peptides
    Jae-Il Park
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, School of Medicine, Stanford University, CA 94305-5317, USA
    Rev Endocr Metab Disord 6:291-6. 2005
  9. ncbi Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes
    Jaesook Roh
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305 5317, USA
    J Biol Chem 279:7264-74. 2004
    ....
  10. ncbi Regulation of receptor signaling by relaxin A chain motifs: derivation of pan-specific and LGR7-specific human relaxin analogs
    Jae Il Park
    Reproductive Biology and Stem Cell Research Program, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305 5317, USA
    J Biol Chem 283:32099-109. 2008
    ....
  11. ncbi Conservation of the heterodimeric glycoprotein hormone subunit family proteins and the LGR signaling system from nematodes to humans
    Jae-Il Park
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, CA 94305-5317, USA
    Endocrine 26:267-76. 2005
    ..Taken together, both glycoprotein hormone alpha and beta subunits evolved before the evolution of nematodes, arthropods, and vertebrates...
  12. ncbi Relaxin research in the postgenomic era
    Kazuhiro Kawamura
    Division of Reproductive Health, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305-5317, USA
    Ann N Y Acad Sci 1041:1-7. 2005
    ..Our data demonstrate the importance of the INSL3-LGR8 paracrine system in mediating gonadotropic actions in both ovary and testis...
  13. ncbi The mouse germ-cell-specific leucine-rich repeat protein NALP14: a member of the NACHT nucleoside triphosphatase family
    Michiharu Horikawa
    Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, Utah 84112, USA
    Biol Reprod 72:879-89. 2005
    ..The structural attributes, expression pattern, and cellular localization of MATER and RNH2 largely conformed to those reported for NALP14...
  14. ncbi Identification of metabolic modifiers that underlie phenotypic variations in energy-balance regulation
    Chia Lin Chang
    Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital Linkou Medical Center, Chang Gung University, Kweishan, Taoyuan, Taiwan
    Diabetes 60:726-34. 2011
    ....
  15. ncbi Intermedin functions as a pituitary paracrine factor regulating prolactin release
    Chia Lin Chang
    Stanford University School of Medicine, Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford, California 94305 5317, USA
    Mol Endocrinol 19:2824-38. 2005
    ....
  16. ncbi Activation of calcitonin receptor and calcitonin receptor-like receptor by membrane-anchored ligands
    Chia Lin Chang
    Reproductive Biology and Stem Cell Research Program, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305 5317, USA
    J Biol Chem 285:1075-80. 2010
    ....
  17. ncbi Ancient evolution of stress-regulating peptides in vertebrates
    Chia Lin Chang
    Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Tao Yuan, Taiwan
    Peptides 25:1681-8. 2004
    ....
  18. ncbi Intermedin, a novel calcitonin family peptide that exists in teleosts as well as in mammals: a comparison with other calcitonin/intermedin family peptides in vertebrates
    Chia Lin Chang
    Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan
    Peptides 25:1633-42. 2004
    ..The combined results indicate that the physiology associated with each of these family peptides likely evolved during early vertebrate evolution and diverged to serve select physiological functions in different vertebrates...
  19. ncbi Intermedin: a skin peptide that is downregulated in atopic dermatitis
    Friederike Kindt
    Institute for Anatomy and Cell Biology, University of Giessen, Giessen, Germany
    J Invest Dermatol 127:605-13. 2007
    ..These data further point to a role of IMD expressed by pericytes in conferring higher susceptibility of the skin of AD patients to inflammatory stimuli...

Research Grants8

  1. Role of RAMPs in Intermedin Signaling
    Sheau Yu Teddy Hsu; Fiscal Year: 2010
    ....
  2. PHYSIOLOGY OF RELAXIN-INSULIN-LIKE FACTORS
    Sheau Yu Hsu; Fiscal Year: 2002
    ..Additionally, knowledge gathered from the proposed experiments would help the diagnosis and treatment of diseases associated with the dysfunction of these novel relaxin/insulin-like factors. ..
  3. Identification of Relaxin Receptor Antagonists
    Sheau Yu Hsu; Fiscal Year: 2005
    ..These antagonists could be used to block relaxin action during preterm labor as well as provide a tool for further research on the role of LGR7 and LGR8 in reproductive tract physiology. ..
  4. Role of RAMPs in Intermedin Signaling
    Sheau Yu Hsu; Fiscal Year: 2009
    ....