S Y Hsu

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor
    S Y Hsu
    Division of Reproductive Biology, Department of Gynecology and Obstetrics Stanford University School of Medicine, Stanford, California, USA
    Nat Med 7:605-11. 2001
  2. ncbi request reprint Cloning of two novel mammalian paralogs of relaxin/insulin family proteins and their expression in testis and kidney
    S Y Hsu
    Department of Gynecology and Obstetrics, Stanford University School of Medicine, California 94305 5317, USA
    Mol Endocrinol 13:2163-74. 1999
  3. ncbi request reprint Characterization of the antiapoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) and the stimulation of its message by gonadotropins in the rat ovary
    C P Leo
    Department of Gynecology and Obstetrics, Stanford University Medical Center, California 94305 5317, USA
    Endocrinology 140:5469-77. 1999
  4. ncbi request reprint Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis
    J Bae
    Division of Reproductive Biology, Department of Gynecology and Obstetrics, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    Apoptosis 6:319-30. 2001
  5. ncbi request reprint MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain
    J Bae
    Division of Reproductive Biology, Department of Gynecology and Obstetrics, Stanford University School of Medicine, CA 94305 5317, USA
    J Biol Chem 275:25255-61. 2000
  6. ncbi request reprint BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members
    S Y Hsu
    Department of Gynecology and Obstetrics, Stanford University School of Medicine, California 94305 5317, USA
    Mol Endocrinol 12:1432-40. 1998
  7. ncbi request reprint The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7
    S Y Hsu
    Department of Gynecology and Obstetrics, Stanford University School of Medicine, California 94305 5317, USA
    Mol Endocrinol 14:1257-71. 2000
  8. ncbi request reprint DEFT, a novel death effector domain-containing molecule predominantly expressed in testicular germ cells
    C P Leo
    Department of Gynecology and Obstetrics, Stanford University School of Medicine, California 94305 5317, USA
    Endocrinology 139:4839-48. 1998
  9. ncbi request reprint Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11
    S Y Hsu
    Department of Gynecology and Obstetrics, Stanford University Medical School, California 94305 5317, USA
    Mol Endocrinol 11:1858-67. 1997
  10. ncbi request reprint Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region
    S Y Hsu
    Department of Gynecology and Obstetrics, Stanford University Medical School, California 94305 5317, USA
    Mol Endocrinol 12:1830-45. 1998

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor
    S Y Hsu
    Division of Reproductive Biology, Department of Gynecology and Obstetrics Stanford University School of Medicine, Stanford, California, USA
    Nat Med 7:605-11. 2001
    ..Thus SCP and SRP might represent endogenous ligands for maintaining homeostasis after stress, and could allow the design of drugs to ameliorate stress-related diseases...
  2. ncbi request reprint Cloning of two novel mammalian paralogs of relaxin/insulin family proteins and their expression in testis and kidney
    S Y Hsu
    Department of Gynecology and Obstetrics, Stanford University School of Medicine, California 94305 5317, USA
    Mol Endocrinol 13:2163-74. 1999
    ..Identification of RIF polypeptides expands the family of relaxin- and insulin-like hormones and allows future elucidation of the physiological role and hormonal mechanisms for these tissue-specific factors...
  3. ncbi request reprint Characterization of the antiapoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) and the stimulation of its message by gonadotropins in the rat ovary
    C P Leo
    Department of Gynecology and Obstetrics, Stanford University Medical Center, California 94305 5317, USA
    Endocrinology 140:5469-77. 1999
    ..In conclusion, rat Mcl-1 was identified as an ovarian BAD-interacting protein and the message for the antiapoptotic Mcl-1 protein was induced after treatment with gonadotropins in granulosa and thecal cells of growing follicles...
  4. ncbi request reprint Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis
    J Bae
    Division of Reproductive Biology, Department of Gynecology and Obstetrics, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    Apoptosis 6:319-30. 2001
    ..Thus, highly conserved BAD interacts with diverse antiapoptotic Bcl-2 members to regulate apoptosis...
  5. ncbi request reprint MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain
    J Bae
    Division of Reproductive Biology, Department of Gynecology and Obstetrics, Stanford University School of Medicine, CA 94305 5317, USA
    J Biol Chem 275:25255-61. 2000
    ..The fate of MCL-1-expressing cells could be regulated through alternative splicing mechanisms and interactions of the resulting anti- and proapoptotic gene products...
  6. ncbi request reprint BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members
    S Y Hsu
    Department of Gynecology and Obstetrics, Stanford University School of Medicine, California 94305 5317, USA
    Mol Endocrinol 12:1432-40. 1998
    ..Identification of BOD expands the group of proapoptotic Bcl-2 proteins that only contains the BH3 domain and allows future elucidation of the intracellular mechanism for apoptosis regulation in ovary and other tissues...
  7. ncbi request reprint The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7
    S Y Hsu
    Department of Gynecology and Obstetrics, Stanford University School of Medicine, California 94305 5317, USA
    Mol Endocrinol 14:1257-71. 2000
    ....
  8. ncbi request reprint DEFT, a novel death effector domain-containing molecule predominantly expressed in testicular germ cells
    C P Leo
    Department of Gynecology and Obstetrics, Stanford University School of Medicine, California 94305 5317, USA
    Endocrinology 139:4839-48. 1998
    ..In conclusion, we have identified a novel DED-containing protein with high expression in testis germ cells. This protein may be important in the regulation of death factor-induced apoptosis in the testis and other tissues...
  9. ncbi request reprint Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11
    S Y Hsu
    Department of Gynecology and Obstetrics, Stanford University Medical School, California 94305 5317, USA
    Mol Endocrinol 11:1858-67. 1997
    ....
  10. ncbi request reprint Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region
    S Y Hsu
    Department of Gynecology and Obstetrics, Stanford University Medical School, California 94305 5317, USA
    Mol Endocrinol 12:1830-45. 1998
    ....
  11. ncbi request reprint Evolution and classification of cystine knot-containing hormones and related extracellular signaling molecules
    U A Vitt
    Division of Reproductive Biology Department of Gynecology and Obstetrics Stanford University School of Medicine Stanford, California 94305 5317, USA
    Mol Endocrinol 15:681-94. 2001
    ..All data retrieved by this study can be viewed at http://hormone.stanford.edu/...
  12. pmc Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members
    S Y Hsu
    Division of Reproductive Biology, Department of Gynecology and Obstetrics, Stanford University Medical School, Stanford, CA 94305 5317, USA
    Proc Natl Acad Sci U S A 94:12401-6. 1997
    ....
  13. ncbi request reprint Protective effects of the urocortin homologues stresscopin (SCP) and stresscopin-related peptide (SRP) against hypoxia/reoxygenation injury in rat neonatal cardiomyocytes
    A Chanalaris
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    J Mol Cell Cardiol 35:1295-305. 2003
    ..In addition, we showed that SCP and UCN are potent activators of the p42/44 MAPK pathway, with SRP able to induce phosphorylation of p42/44 MAPK as well, albeit not as pronounced...
  14. ncbi request reprint Expression of messenger ribonucleic acid for the antiapoptosis gene P11 in the rat ovary: gonadotropin stimulation in granulosa cells of preovulatory follicles
    S Y Chun
    Hormone Research Center, Chonnam National University, Kwangju 500-757, Republic of Korea
    Endocrinology 142:2311-7. 2001
    ....
  15. ncbi request reprint Impairment of spermatogenesis in transgenic mice with selective overexpression of Bcl-2 in the somatic cells of the testis
    C M Yamamoto
    Department of Medicine, Harbor-UCLA Medical Center and Research and Education Institute, Torrance, California 90509, USA
    J Androl 22:981-91. 2001
    ..Collectively, these results support the critical role of Bcl-2 in male germ cell development and are consistent with the gender-specific role of the Bcl-2 family members in reproduction...
  16. pmc Genetic heterogeneity of constitutively activating mutations of the human luteinizing hormone receptor in familial male-limited precocious puberty
    L Laue
    Department of Pediatrics, Georgetown University Medical Center, Washington, D C 20007
    Proc Natl Acad Sci U S A 92:1906-10. 1995
    ..We conclude that the region spanning nt 1624-1741 of exon 11 is a hotspot for heterogeneous point mutations that constitutively activate the hLHR and cause male-limited precocious puberty...