S Y Hsu

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor
    S Y Hsu
    Division of Reproductive Biology, Department of Gynecology and Obstetrics Stanford University School of Medicine, Stanford, California, USA
    Nat Med 7:605-11. 2001
  2. ncbi Cloning of two novel mammalian paralogs of relaxin/insulin family proteins and their expression in testis and kidney
    S Y Hsu
    Department of Gynecology and Obstetrics, Stanford University School of Medicine, California 94305 5317, USA
    Mol Endocrinol 13:2163-74. 1999
  3. ncbi Characterization of the antiapoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) and the stimulation of its message by gonadotropins in the rat ovary
    C P Leo
    Department of Gynecology and Obstetrics, Stanford University Medical Center, California 94305 5317, USA
    Endocrinology 140:5469-77. 1999
  4. ncbi Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis
    J Bae
    Division of Reproductive Biology, Department of Gynecology and Obstetrics, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    Apoptosis 6:319-30. 2001
  5. ncbi MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain
    J Bae
    Division of Reproductive Biology, Department of Gynecology and Obstetrics, Stanford University School of Medicine, CA 94305 5317, USA
    J Biol Chem 275:25255-61. 2000
  6. ncbi BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members
    S Y Hsu
    Department of Gynecology and Obstetrics, Stanford University School of Medicine, California 94305 5317, USA
    Mol Endocrinol 12:1432-40. 1998
  7. ncbi The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7
    S Y Hsu
    Department of Gynecology and Obstetrics, Stanford University School of Medicine, California 94305 5317, USA
    Mol Endocrinol 14:1257-71. 2000
  8. ncbi DEFT, a novel death effector domain-containing molecule predominantly expressed in testicular germ cells
    C P Leo
    Department of Gynecology and Obstetrics, Stanford University School of Medicine, California 94305 5317, USA
    Endocrinology 139:4839-48. 1998
  9. ncbi Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11
    S Y Hsu
    Department of Gynecology and Obstetrics, Stanford University Medical School, California 94305 5317, USA
    Mol Endocrinol 11:1858-67. 1997
  10. ncbi Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region
    S Y Hsu
    Department of Gynecology and Obstetrics, Stanford University Medical School, California 94305 5317, USA
    Mol Endocrinol 12:1830-45. 1998

Collaborators

Detail Information

Publications16

  1. ncbi Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor
    S Y Hsu
    Division of Reproductive Biology, Department of Gynecology and Obstetrics Stanford University School of Medicine, Stanford, California, USA
    Nat Med 7:605-11. 2001
    ..Thus SCP and SRP might represent endogenous ligands for maintaining homeostasis after stress, and could allow the design of drugs to ameliorate stress-related diseases...
  2. ncbi Cloning of two novel mammalian paralogs of relaxin/insulin family proteins and their expression in testis and kidney
    S Y Hsu
    Department of Gynecology and Obstetrics, Stanford University School of Medicine, California 94305 5317, USA
    Mol Endocrinol 13:2163-74. 1999
    ..Identification of RIF polypeptides expands the family of relaxin- and insulin-like hormones and allows future elucidation of the physiological role and hormonal mechanisms for these tissue-specific factors...
  3. ncbi Characterization of the antiapoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) and the stimulation of its message by gonadotropins in the rat ovary
    C P Leo
    Department of Gynecology and Obstetrics, Stanford University Medical Center, California 94305 5317, USA
    Endocrinology 140:5469-77. 1999
    ..In conclusion, rat Mcl-1 was identified as an ovarian BAD-interacting protein and the message for the antiapoptotic Mcl-1 protein was induced after treatment with gonadotropins in granulosa and thecal cells of growing follicles...
  4. ncbi Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis
    J Bae
    Division of Reproductive Biology, Department of Gynecology and Obstetrics, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    Apoptosis 6:319-30. 2001
    ..Thus, highly conserved BAD interacts with diverse antiapoptotic Bcl-2 members to regulate apoptosis...
  5. ncbi MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain
    J Bae
    Division of Reproductive Biology, Department of Gynecology and Obstetrics, Stanford University School of Medicine, CA 94305 5317, USA
    J Biol Chem 275:25255-61. 2000
    ..The fate of MCL-1-expressing cells could be regulated through alternative splicing mechanisms and interactions of the resulting anti- and proapoptotic gene products...
  6. ncbi BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members
    S Y Hsu
    Department of Gynecology and Obstetrics, Stanford University School of Medicine, California 94305 5317, USA
    Mol Endocrinol 12:1432-40. 1998
    ..Identification of BOD expands the group of proapoptotic Bcl-2 proteins that only contains the BH3 domain and allows future elucidation of the intracellular mechanism for apoptosis regulation in ovary and other tissues...
  7. ncbi The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7
    S Y Hsu
    Department of Gynecology and Obstetrics, Stanford University School of Medicine, California 94305 5317, USA
    Mol Endocrinol 14:1257-71. 2000
    ....
  8. ncbi DEFT, a novel death effector domain-containing molecule predominantly expressed in testicular germ cells
    C P Leo
    Department of Gynecology and Obstetrics, Stanford University School of Medicine, California 94305 5317, USA
    Endocrinology 139:4839-48. 1998
    ..In conclusion, we have identified a novel DED-containing protein with high expression in testis germ cells. This protein may be important in the regulation of death factor-induced apoptosis in the testis and other tissues...
  9. ncbi Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11
    S Y Hsu
    Department of Gynecology and Obstetrics, Stanford University Medical School, California 94305 5317, USA
    Mol Endocrinol 11:1858-67. 1997
    ....
  10. ncbi Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region
    S Y Hsu
    Department of Gynecology and Obstetrics, Stanford University Medical School, California 94305 5317, USA
    Mol Endocrinol 12:1830-45. 1998
    ....
  11. ncbi Evolution and classification of cystine knot-containing hormones and related extracellular signaling molecules
    U A Vitt
    Division of Reproductive Biology Department of Gynecology and Obstetrics Stanford University School of Medicine Stanford, California 94305 5317, USA
    Mol Endocrinol 15:681-94. 2001
    ..All data retrieved by this study can be viewed at http://hormone.stanford.edu/...
  12. ncbi Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members
    S Y Hsu
    Division of Reproductive Biology, Department of Gynecology and Obstetrics, Stanford University Medical School, Stanford, CA 94305 5317, USA
    Proc Natl Acad Sci U S A 94:12401-6. 1997
    ....
  13. ncbi Protective effects of the urocortin homologues stresscopin (SCP) and stresscopin-related peptide (SRP) against hypoxia/reoxygenation injury in rat neonatal cardiomyocytes
    A Chanalaris
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    J Mol Cell Cardiol 35:1295-305. 2003
    ..In addition, we showed that SCP and UCN are potent activators of the p42/44 MAPK pathway, with SRP able to induce phosphorylation of p42/44 MAPK as well, albeit not as pronounced...
  14. ncbi Expression of messenger ribonucleic acid for the antiapoptosis gene P11 in the rat ovary: gonadotropin stimulation in granulosa cells of preovulatory follicles
    S Y Chun
    Hormone Research Center, Chonnam National University, Kwangju 500-757, Republic of Korea
    Endocrinology 142:2311-7. 2001
    ....
  15. ncbi Impairment of spermatogenesis in transgenic mice with selective overexpression of Bcl-2 in the somatic cells of the testis
    C M Yamamoto
    Department of Medicine, Harbor-UCLA Medical Center and Research and Education Institute, Torrance, California 90509, USA
    J Androl 22:981-91. 2001
    ..Collectively, these results support the critical role of Bcl-2 in male germ cell development and are consistent with the gender-specific role of the Bcl-2 family members in reproduction...
  16. ncbi Genetic heterogeneity of constitutively activating mutations of the human luteinizing hormone receptor in familial male-limited precocious puberty
    L Laue
    Department of Pediatrics, Georgetown University Medical Center, Washington, D C 20007
    Proc Natl Acad Sci U S A 92:1906-10. 1995
    ..We conclude that the region spanning nt 1624-1741 of exon 11 is a hotspot for heterogeneous point mutations that constitutively activate the hLHR and cause male-limited precocious puberty...