Andrew R Hoffman

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Gene therapy for colorectal cancer by an oncolytic adenovirus that targets loss of the insulin-like growth factor 2 imprinting system
    Zhen Lin Nie
    Central Laboratory, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, Jiangsu Province, China
    Mol Cancer 11:86. 2012
  2. ncbi request reprint Efficacy of a long-acting growth hormone (GH) preparation in patients with adult GH deficiency
    Andrew R Hoffman
    Department of Veterans Affairs Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, California 94304, USA
    J Clin Endocrinol Metab 90:6431-40. 2005
  3. ncbi request reprint Treatment of the adult growth hormone deficiency syndrome: directions for future research
    Andrew R Hoffman
    Medical Service, Department of Veterans Affairs, Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, CA 94304, USA
    Growth Horm IGF Res 15:48-52. 2005
  4. ncbi request reprint Efficacy and tolerability of an individualized dosing regimen for adult growth hormone replacement therapy in comparison with fixed body weight-based dosing
    Andrew R Hoffman
    Medical Service, Veterans Affairs Palo Alto Health Care System and Stanford University, 3801 Miranda Avenue, Palo Alto, CA 94304, USA
    J Clin Endocrinol Metab 89:3224-33. 2004
  5. ncbi request reprint IGFs and aging: is there a rationale for hormone replacement therapy?
    Andrew R Hoffman
    Medical Service, VA Palo Alto Health Care System, CA 94304, USA
    Growth Horm IGF Res 14:296-300. 2004
  6. ncbi request reprint Growth hormone (GH) replacement therapy in adult-onset gh deficiency: effects on body composition in men and women in a double-blind, randomized, placebo-controlled trial
    Andrew R Hoffman
    Veterans Affairs Palo Alto Health Care System and Stanford University, Palo Alto, California 94304, USA
    J Clin Endocrinol Metab 89:2048-56. 2004
  7. ncbi request reprint Directing DNA methylation to inhibit gene expression
    Andrew R Hoffman
    Department of Medicine, Stanford University, Medical Service, VA Palo Alto Health Care System, Miranda Ave, Palo Alto, California 94304, USA
    Cell Mol Neurobiol 26:425-38. 2006
  8. ncbi request reprint The histone code regulating expression of the imprinted mouse Igf2r gene
    Youwen Yang
    Medical Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304
    Endocrinology 144:5658-70. 2003
  9. ncbi request reprint A novel orthotopic tumor model to study growth factors and oncogenes in hepatocarcinogenesis
    Xiaoming Yao
    Medical Service, VA Palo Alto Health Care System and Division of Endocrinology, Department of Medicine, Stanford University, Palo Alto, California 94304, USA
    Clin Cancer Res 9:2719-26. 2003
  10. ncbi request reprint Epigenetic regulation of Igf2/H19 imprinting at CTCF insulator binding sites
    Youwen Yang
    Medical Service, VA Palo Alto Health Care System, and Division of Endocrinology, Department of Medicine, Stanford University, Palo Alto, California 94304, USA
    J Cell Biochem 90:1038-55. 2003

Research Grants

  1. Role of Long-Range Chromatin Interactions in Genetic Disease
    Andrew R Hoffman; Fiscal Year: 2010
  2. MECHANISMS OF GENOMIC IMPRINTING
    Andrew Hoffman; Fiscal Year: 2002
  3. MECHANISMS OF GENOMIC IMPRINTING
    Andrew Hoffman; Fiscal Year: 2004
  4. MECHANISMS OF GENOMIC IMPRINTING
    Andrew Hoffman; Fiscal Year: 2005
  5. MECHANISMS OF GENOMIC IMPRINTING
    Andrew Hoffman; Fiscal Year: 2006
  6. MECHANISMS OF GENOMIC IMPRINTING
    Andrew Hoffman; Fiscal Year: 2005
  7. MECHANISMS OF GENOMIC IMPRINTING
    Andrew Hoffman; Fiscal Year: 2007
  8. Role of Long-Range Chromatin Interactions in Genetic Disease
    Andrew Hoffman; Fiscal Year: 2009
  9. MECHANISMS OF GENOMIC IMPRINTING
    Andrew Hoffman; Fiscal Year: 2001
  10. MECHANISMS OF GENOMIC IMPRINTING
    Andrew Hoffman; Fiscal Year: 2000

Detail Information

Publications51

  1. pmc Gene therapy for colorectal cancer by an oncolytic adenovirus that targets loss of the insulin-like growth factor 2 imprinting system
    Zhen Lin Nie
    Central Laboratory, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, Jiangsu Province, China
    Mol Cancer 11:86. 2012
    ..Our aim was to investigate the feasibility of using the IGF2 imprinting system for targeted gene therapy of colorectal cancer...
  2. ncbi request reprint Efficacy of a long-acting growth hormone (GH) preparation in patients with adult GH deficiency
    Andrew R Hoffman
    Department of Veterans Affairs Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, California 94304, USA
    J Clin Endocrinol Metab 90:6431-40. 2005
    ..Treatment of adult GH deficiency (AGHD) with daily injections of GH results in decreased adipose mass, increased lean body mass (LBM), increased bone mineral density, and improved quality of life...
  3. ncbi request reprint Treatment of the adult growth hormone deficiency syndrome: directions for future research
    Andrew R Hoffman
    Medical Service, Department of Veterans Affairs, Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, CA 94304, USA
    Growth Horm IGF Res 15:48-52. 2005
    ..The accumulation of long-term treatment data will be required to provide reassurance that GH treatment is a safe and necessary form of hormone replacement therapy for patients with AGHD...
  4. ncbi request reprint Efficacy and tolerability of an individualized dosing regimen for adult growth hormone replacement therapy in comparison with fixed body weight-based dosing
    Andrew R Hoffman
    Medical Service, Veterans Affairs Palo Alto Health Care System and Stanford University, 3801 Miranda Avenue, Palo Alto, CA 94304, USA
    J Clin Endocrinol Metab 89:3224-33. 2004
    ..We conclude that GH replacement therapy should be initiated at a low dose and titrated to a dose producing maximal benefits without adverse side effects and an IGF-I level within the age- and sex-adjusted normal range...
  5. ncbi request reprint IGFs and aging: is there a rationale for hormone replacement therapy?
    Andrew R Hoffman
    Medical Service, VA Palo Alto Health Care System, CA 94304, USA
    Growth Horm IGF Res 14:296-300. 2004
  6. ncbi request reprint Growth hormone (GH) replacement therapy in adult-onset gh deficiency: effects on body composition in men and women in a double-blind, randomized, placebo-controlled trial
    Andrew R Hoffman
    Veterans Affairs Palo Alto Health Care System and Stanford University, Palo Alto, California 94304, USA
    J Clin Endocrinol Metab 89:2048-56. 2004
    ..GH treatment was generally well tolerated. Subjects with AGHD should receive individualized GH therapy to maintain IGF-I between the mean value and +2 SD and improve body composition and cardiovascular risk factors...
  7. ncbi request reprint Directing DNA methylation to inhibit gene expression
    Andrew R Hoffman
    Department of Medicine, Stanford University, Medical Service, VA Palo Alto Health Care System, Miranda Ave, Palo Alto, California 94304, USA
    Cell Mol Neurobiol 26:425-38. 2006
    ..5. In principle, using this methodology, it should be possible to design methylated oligonucleotides that can methylate CpG islands and thereby downregulate any gene...
  8. ncbi request reprint The histone code regulating expression of the imprinted mouse Igf2r gene
    Youwen Yang
    Medical Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304
    Endocrinology 144:5658-70. 2003
    ....
  9. ncbi request reprint A novel orthotopic tumor model to study growth factors and oncogenes in hepatocarcinogenesis
    Xiaoming Yao
    Medical Service, VA Palo Alto Health Care System and Division of Endocrinology, Department of Medicine, Stanford University, Palo Alto, California 94304, USA
    Clin Cancer Res 9:2719-26. 2003
    ..This in situ tumor model thus provides a fast, reliable, and reproducible means to study the therapeutic effect of inhibitors of growth factors and oncogenes in liver cancer...
  10. ncbi request reprint Epigenetic regulation of Igf2/H19 imprinting at CTCF insulator binding sites
    Youwen Yang
    Medical Service, VA Palo Alto Health Care System, and Division of Endocrinology, Department of Medicine, Stanford University, Palo Alto, California 94304, USA
    J Cell Biochem 90:1038-55. 2003
    ..Further studies should be focused on the identification of factors that are involved in histone methylation and CTCF-associated factors that may be needed to coordinate Igf2 imprinting...
  11. ncbi request reprint CTCF binding at the insulin-like growth factor-II (IGF2)/H19 imprinting control region is insufficient to regulate IGF2/H19 expression in human tissues
    Gary A Ulaner
    Medical Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
    Endocrinology 144:4420-6. 2003
    ....
  12. pmc CTCF regulates allelic expression of Igf2 by orchestrating a promoter-polycomb repressive complex 2 intrachromosomal loop
    Tao Li
    Medical Service, VA Palo Alto Health Care System, Palo Alto, California 94304, USA
    Mol Cell Biol 28:6473-82. 2008
    ....
  13. ncbi request reprint CTCF mediates interchromosomal colocalization between Igf2/H19 and Wsb1/Nf1
    Jian Qun Ling
    Medical Service, Department of Veterans Affairs, Palo Alto Health Care System, and Department of Medicine, Stanford University, Palo Alto, CA 94304, USA
    Science 312:269-72. 2006
    ....
  14. pmc A complex deoxyribonucleic acid looping configuration associated with the silencing of the maternal Igf2 allele
    Xinwen Qiu
    Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
    Mol Endocrinol 22:1476-88. 2008
    ..This silencing configuration exists in newborn liver, mouse embryonic fibroblast, and embryonic stem cells and persists during mitosis, conferring a mechanism for epigenetic memory...
  15. ncbi request reprint Divergent patterns of telomere maintenance mechanisms among human sarcomas: sharply contrasting prevalence of the alternative lengthening of telomeres mechanism in Ewing's sarcomas and osteosarcomas
    Gary A Ulaner
    Medical Service, VA Palo Alto Health Care System, and Department of Medicine, Stanford University, Palo Alto, California 94304, USA
    Genes Chromosomes Cancer 41:155-62. 2004
    ....
  16. ncbi request reprint IVF results in de novo DNA methylation and histone methylation at an Igf2-H19 imprinting epigenetic switch
    Tao Li
    Medical Service, VA Palo Alto Health Care System, CA 94304, USA
    Mol Hum Reprod 11:631-40. 2005
    ..We suggest that ART, which includes IVF and various culture media, might cause imprinting errors that involve both aberrant DNA methylation and histone methylation at an epigenetic switch of the Igf2-H19 gene region...
  17. ncbi request reprint Activating and silencing histone modifications form independent allelic switch regions in the imprinted Gnas gene
    Tao Li
    Medical Service, Veteran Affairs Palo Alta Health Care System and, Department of Medicine, Stanford University, Palo Alto, CA 94304, USA
    Hum Mol Genet 13:741-50. 2004
    ..We discuss these findings in light of recent progress in the conceptualization of nucleosome remodeling during transcriptional elongation and in the development of histone code...
  18. pmc Correction of aberrant imprinting of IGF2 in human tumors by nuclear transfer-induced epigenetic reprogramming
    Hui Ling Chen
    Medical Service, VA Palo Alto Health Care System, Palo Alto, CA, USA
    EMBO J 25:5329-38. 2006
    ....
  19. doi request reprint Long-range DNA interactions are specifically altered by locked nucleic acid-targeting of a CTCF binding site
    Jian Qun Ling
    Medical Service, VA Palo Alto Health Care System and Department of Medicine, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Biochim Biophys Acta 1809:24-33. 2011
    ..The use of specific Zorro LNA probes may facilitate our efforts to understand the interactions between chromatin architecture and gene expression...
  20. ncbi request reprint Promoter-restricted histone code, not the differentially methylated DNA regions or antisense transcripts, marks the imprinting status of IGF2R in human and mouse
    Thanh H Vu
    Medical Service, Veteran Affairs Palo Alto Health Care System and Department of Medicine, Stanford University, Palo Alto, CA 94304, USA
    Hum Mol Genet 13:2233-45. 2004
    ..We discuss these findings in light of recent progress in identifying specific components of the epigenetic marks in imprinted genes...
  21. ncbi request reprint Endocrine responses to acute and chronic high-altitude exposure (4,300 meters): modulating effects of caloric restriction
    Kimberly E Barnholt
    Clinical Studies Unit, VA Palo Alto Health Care System, 3801 Miranda Ave, Palo Alto, CA 94304, USA
    Am J Physiol Endocrinol Metab 290:E1078-88. 2006
    ..Such suppression results in the preservation of energy stores but may sacrifice the facilitation of oxygen delivery and the use of oxygen-efficient fuels...
  22. pmc A methylated oligonucleotide inhibits IGF2 expression and enhances survival in a model of hepatocellular carcinoma
    Xiaoming Yao
    Medical Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
    J Clin Invest 111:265-73. 2003
    ..This study demonstrates that a methylated sense oligonucleotide can be used to induce epigenetic changes in the IGF2 gene and that inhibition of IGF2 mRNA accumulation may lead to enhanced survival in a model of HCC...
  23. ncbi request reprint Epigenetic regulation of the taxol resistance-associated gene TRAG-3 in human tumors
    Xiaoming Yao
    Medical Service, Veterans Affairs Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, CA 94305, USA
    Cancer Genet Cytogenet 151:1-13. 2004
    ..These results indicate that DNA demethylation is an important epigenetic mechanism that regulates the TRAG-3 tumor antigen in human tumors...
  24. ncbi request reprint Three weeks of caloric restriction alters protein metabolism in normal-weight, young men
    Anne L Friedlander
    Geriatric Research Education and Clinical Center and Research and Medical Services, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Am J Physiol Endocrinol Metab 289:E446-55. 2005
    ..However, despite negative nitrogen balance and loss of lean mass, whole body exercise performance was well maintained in response to CR...
  25. pmc Loss of IGF2 imprinting is associated with abrogation of long-range intrachromosomal interactions in human cancer cells
    Thanh H Vu
    VA Palo Alto Health Care System and Stanford University, Palo Alto, CA 94301, USA
    Hum Mol Genet 19:901-19. 2010
    ....
  26. ncbi request reprint Loss of imprinting of IGF2 and H19 in osteosarcoma is accompanied by reciprocal methylation changes of a CTCF-binding site
    Gary A Ulaner
    Medical Service, VA Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Hum Mol Genet 12:535-49. 2003
    ..We propose a model in which incomplete gain or loss of methylation at this CTCF-binding site during tumorigenesis explains the complex and often conflicting expression patterns of IGF2 and H19 in tumors...
  27. ncbi request reprint Systematic review: the safety and efficacy of growth hormone in the healthy elderly
    Hau Liu
    Stanford University, Stanford, California 94305 6019, USA
    Ann Intern Med 146:104-15. 2007
    ..Human growth hormone (GH) is widely used as an antiaging therapy, although its use for this purpose has not been approved by the U.S. Food and Drug Administration and its distribution as an antiaging agent is illegal in the United States...
  28. ncbi request reprint An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa
    Tao Li
    Medical Service, Veterans Affairs Palo Alto Health Care System and the Department of Medicine, Stanford University School of Medicine, Palo Alto, California 94304, USA
    J Biol Chem 277:13518-27. 2002
    ..Of interest, PEG1-AS was expressed predominantly in testis and in mature motile spermatozoa, indicating a possible role for this transcript in human sperm physiology and fertilization...
  29. ncbi request reprint Five weeks of insulin-like growth factor-I treatment does not alter glucose kinetics or insulin sensitivity during a hyperglycemic clamp in older women
    Barry Braun
    Geriatric Research Education and Clinical Center and Medical Service, VA Palo Alto Health Care System, CA, USA
    Metabolism 52:1182-90. 2003
    ..The data suggest that 5 weeks of low-dose rhIGF-I treatment has no material influence on whole-body insulin sensitivity in normoglycemic postmenopausal women...
  30. ncbi request reprint Cyclic hypobaric hypoxia improves markers of glucose metabolism in middle-aged men
    Juan L Marquez
    1 Clinical Studies Unit, VA Palo Alto Health Care System, Palo Alto, California
    High Alt Med Biol 14:263-72. 2013
    ..Cyclic Variations in Altitude Conditioning (CVAC) is a novel technology that provides exposure to rapidly fluctuating cyclic hypobaric hypoxia (CHH)...
  31. pmc Association between insulin resistance and lean mass loss and fat mass gain in older men without diabetes mellitus
    Christine G Lee
    Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine, Oregon Health and Science University, Portland, OR 97239, USA
    J Am Geriatr Soc 59:1217-24. 2011
    ..To examine the associations between insulin resistance and changes in body composition in older men without diabetes mellitus...
  32. ncbi request reprint Visualization of telomerase reverse transcriptase (hTERT) promoter activity using a trimodality fusion reporter construct
    Parasuraman Padmanabhan
    Department of Radiology and Molecular Imaging Program at Stanford MIPS, Stanford University, Stanford, California, USA
    J Nucl Med 47:270-7. 2006
    ..To achieve this goal, we used radionuclide and optical methods to measure changes in human telomerase reverse transcriptase (hTERT) gene expression in tumor cells before and after 5-fluorouracil treatment...
  33. ncbi request reprint Loss of imprinting of IGF2 sense and antisense transcripts in Wilms' tumor
    Thanh H Vu
    Medical Service, VA Palo Alto Health Care System and the Department of Medicine, Stanford University School of Medicine, Palo Alto, California 94304, USA
    Cancer Res 63:1900-5. 2003
    ..The discrepancy between IGF2 and IGF2-AS loss of imprinting in some tumors demonstrates the control complexity of the imprinting status of the various transcripts derived from the IGF2 gene...
  34. ncbi request reprint The endocrine system and sarcopenia: potential therapeutic benefits
    Kevin L McIntire
    Stanford School of Medicine, Division of Nephrology, VA Palo Alto HCS 111R, Palo Alto, CA 94304, USA
    Curr Aging Sci 4:298-305. 2011
    ..This review will focus on the complex interplay between the endocrine system, aging and skeletal muscle and will present possible benefits of therapeutic interventions for sarcopenia...
  35. ncbi request reprint Absence of a telomere maintenance mechanism as a favorable prognostic factor in patients with osteosarcoma
    Gary A Ulaner
    Medical Service, Veterans Administration Palo Alto Health Care System, and Department of Medicine, Stanford University, Palo Alto, California 94304, USA
    Cancer Res 63:1759-63. 2003
    ..Finally, we note that OS cases with a TA-/ALT+ phenotype seem to be as clinically aggressive as TA+ cases in terms of stage and clinical outcome...
  36. pmc Validation of FRC, a fracture risk assessment tool, in a cohort of older men: the Osteoporotic Fractures in Men (MrOS) Study
    Bruce Ettinger
    Department of Medicine, University of California, San Francisco, CA, USA
    J Clin Densitom 15:334-42. 2012
    ..01) for major osteoporotic fracture. We conclude that the FRC calibrates well with hip and major osteoporotic fractures observed among older men. Further, addition of BMD to the fracture risk calculation improves the tool's performance...
  37. pmc Thyroid function and mortality in older men: a prospective study
    Avantika C Waring
    Department of Medicine, University of California, San Francisco, 400 Parnassus Avenue, A 550, San Francisco, California 94143, USA
    J Clin Endocrinol Metab 97:862-70. 2012
    ..Mild abnormalities of thyroid function have been associated with both beneficial and detrimental effects on mortality...
  38. ncbi request reprint Epigenetics of long-range chromatin interactions
    Jian Qun Ling
    VA Palo Alto Health Care System, CA 94304, USA
    Pediatr Res 61:11R-16R. 2007
    ..These findings emphasize the importance of studying the geography and architecture of the nucleus as an important factor in the regulation of gene transcription...
  39. ncbi request reprint Generation of novel adipocyte monolayer cultures from embryonic stem cells
    Theresa L Chen
    Veterans Affairs, Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Stem Cells Dev 16:371-80. 2007
    ..The adipocytes are functionally active, as evidenced by their response to lipolytic agents, such as forskolin, Bt2-cAMP, and isoproterenol, with more than 20-fold increases in glycerol release...
  40. ncbi request reprint Systematic review: the effects of growth hormone on athletic performance
    Hau Liu
    Santa Clara Valley Medical Center, San Jose, California 95128, USA
    Ann Intern Med 148:747-58. 2008
    ..Human growth hormone is reportedly used to enhance athletic performance, although its safety and efficacy for this purpose are poorly understood...
  41. pmc Genomic interaction profiles in breast cancer reveal altered chromatin architecture
    Michael J Zeitz
    Department of Medicine, Veterans Affairs Palo Alto Health Care System, Stanford University Medical School, Palo Alto, California, United States of America
    PLoS ONE 8:e73974. 2013
    ..Overall, our data from multiple lines of evidence suggest an important role for long-range chromosomal interactions in the pathogenesis of cancer. ..
  42. ncbi request reprint Antioxidant supplementation does not attenuate oxidative stress at high altitude
    Andrew W Subudhi
    VA Palo Alto Health Care System, 3801 Miranda Ave, Palo Alto, CA 94304 1290, USA
    Aviat Space Environ Med 75:881-8. 2004
    ..Hypobaric hypoxia and heightened metabolic rate increase free radical production...
  43. ncbi request reprint Visceral obesity, impaired glucose tolerance, metabolic syndrome, and growth hormone therapy
    Hamdee Attallah
    Department of Medicine, Wayne State University, Detroit, MI, USA
    Growth Horm IGF Res 16:S62-7. 2006
    ..The effects of GH used in conjunction with insulin sensitizers on glycemic control and VAT in patients with impaired glucose tolerance will be reviewed...
  44. pmc Mortality risk in older men associated with changes in weight, lean mass, and fat mass
    Christine G Lee
    Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine, Oregon Health and Science University, Portland, Oregon, USA
    J Am Geriatr Soc 59:233-40. 2011
    ..To evaluate risk of all-cause mortality associated with changes in body weight, total lean mass, and total fat mass in older men...
  45. doi request reprint The impact of hypopituitarism on function and performance in subjects with recent history of traumatic brain injury and aneurysmal subarachnoid haemorrhage
    Lakshmi Srinivasan
    Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Brain Inj 23:639-48. 2009
    ..To correlate deficient pituitary function with life satisfaction and functional performance in subjects with a recent history of traumatic brain injury (TBI) and subarachnoid haemorrhage (SAH)...
  46. ncbi request reprint Growth hormone replacement therapy in adults with growth hormone deficiency improves maximal oxygen consumption independently of dosing regimen or physical activity
    Mark L Hartman
    Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, Indiana 46285, USA
    J Clin Endocrinol Metab 93:125-30. 2008
    ..Several studies have demonstrated an improvement in aerobic exercise capacity with 6 months of GH replacement in adults with GH deficiency (GHD)...
  47. ncbi request reprint Long-term safety of recombinant human growth hormone in turner syndrome
    Katrina Bolar
    University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Clin Endocrinol Metab 93:344-51. 2008
    ..The National Cooperative Growth Study (NCGS) has collected efficacy and safety data for 5220 TS children treated with recombinant human GH (rhGH) during the last 20 yr...
  48. ncbi request reprint Treatment of diabetic ketoacidosis: should mode of insulin administration dictate use of intensive care facilities?
    Romana M Haas
    Am J Med 117:357-8. 2004
  49. ncbi request reprint Insulin-like growth factor 1 as a predictor of ischemic stroke outcome in the elderly
    Licia Denti
    Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, University of Parma, Parma, Italy
    Am J Med 117:312-7. 2004
    ..To examine whether serum insulin-like growth factor 1 (IGF-1) and IGF binding protein 3 (IGFBP-3) concentrations, determined early after the onset of stroke, are predictive of clinical outcome in elderly patients...
  50. ncbi request reprint Bone mineral density in pediatric transplant recipients
    Mark W Daniels
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA
    Transplantation 76:673-8. 2003
    ..Reduced bone mass and fragility fractures are known complications after transplantation in adults. Far less is known about the skeletal effects of transplantation in children and adolescents...

Research Grants20

  1. Role of Long-Range Chromatin Interactions in Genetic Disease
    Andrew R Hoffman; Fiscal Year: 2010
    ..By examining the network of long range interactions among genes, we will learn how diseases are caused by the change in the expression of many genes which become abnormally regulated when the interactions are lost. ..
  2. MECHANISMS OF GENOMIC IMPRINTING
    Andrew Hoffman; Fiscal Year: 2002
    ..In particular, we will examine how DNA methylation, histone acetylation and antisense regulate the expression of this imprinted gene. ..
  3. MECHANISMS OF GENOMIC IMPRINTING
    Andrew Hoffman; Fiscal Year: 2004
    ..Ultimately, it will be possible to develop a comprehensive chromatin/DNA model of imprinting. ..
  4. MECHANISMS OF GENOMIC IMPRINTING
    Andrew Hoffman; Fiscal Year: 2005
    ..Ultimately, it will be possible to develop a comprehensive chromatin/DNA model of imprinting. ..
  5. MECHANISMS OF GENOMIC IMPRINTING
    Andrew Hoffman; Fiscal Year: 2006
    ..Ultimately, it will be possible to develop a comprehensive chromatin/DNA model of imprinting. ..
  6. MECHANISMS OF GENOMIC IMPRINTING
    Andrew Hoffman; Fiscal Year: 2005
    ..Ultimately, it will be possible to develop a comprehensive chromatin/DNA model of imprinting. ..
  7. MECHANISMS OF GENOMIC IMPRINTING
    Andrew Hoffman; Fiscal Year: 2007
    ..Ultimately, it will be possible to develop a comprehensive chromatin/DNA model of imprinting. ..
  8. Role of Long-Range Chromatin Interactions in Genetic Disease
    Andrew Hoffman; Fiscal Year: 2009
    ..By examining the network of long range interactions among genes, we will learn how diseases are caused by the change in the expression of many genes which become abnormally regulated when the interactions are lost. ..
  9. MECHANISMS OF GENOMIC IMPRINTING
    Andrew Hoffman; Fiscal Year: 2001
    ..In particular, we will examine how DNA methylation, histone acetylation and antisense regulate the expression of this imprinted gene. ..
  10. MECHANISMS OF GENOMIC IMPRINTING
    Andrew Hoffman; Fiscal Year: 2000
    ..In particular, we will examine how DNA methylation, histone acetylation and antisense regulate the expression of this imprinted gene. ..
  11. MECHANISMS OF GENOMIC IMPRINTING
    Andrew Hoffman; Fiscal Year: 1999
    ..In particular, we will examine how DNA methylation, histone acetylation and antisense regulate the expression of this imprinted gene. ..
  12. SOMATOMEDIN AND INSULIN REGULATION OF THE PITUITARY
    Andrew Hoffman; Fiscal Year: 1991
    ..The effect of IGF-I and IGF-II on brain IGF receptors and binding proteins will be examined. The acute and chronic effects of IGF administration on glucose homeostasis will be studied using the glucose clamp technique...
  13. SOMATOMEDIN AND INSULIN REGULATION OF THE PITUITARY
    Andrew Hoffman; Fiscal Year: 1992
    ..The effect of IGF-I and IGF-II on brain IGF receptors and binding proteins will be examined. The acute and chronic effects of IGF administration on glucose homeostasis will be studied using the glucose clamp technique...
  14. SOMATOMEDIN AND INSULIN REGULATION OF THE PITUITARY
    Andrew Hoffman; Fiscal Year: 1993
    ..The effect of IGF-I and IGF-II on brain IGF receptors and binding proteins will be examined. The acute and chronic effects of IGF administration on glucose homeostasis will be studied using the glucose clamp technique...