Research Topics
Genomes and GenesSpecies | Jill HelmsSummaryAffiliation: Stanford University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
New insights into craniofacial morphogenesisJill A Helms
Department of Plastic and Reconstructive Surgery, Stanford University, Stanford, CA 94305, USA
Development 132:851-61. 2005..Changes in craniofacial architecture also lie at the heart of evolutionary adaptation, as new studies in fish and fowl attest. Together, these findings reveal much about molecular and tissue interactions behind craniofacial development...- Bone voyage: an expedition into the molecular and cellular parameters affecting bone graft fateJ A Helms
Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford Medical School, Stanford, CA 94305, USA
Bone 41:479-85. 2007..Altogether, they form the foundation for survival of the bone graft and eventually for a positive clinical outcome of the procedure... - Embryonic origin and Hox status determine progenitor cell fate during adult bone regenerationPhilipp Leucht
Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
Development 135:2845-54. 2008..Thus, embryonic origin and Hox gene expression status distinguish neural crest-derived from mesoderm-derived skeletal progenitor cells, and both characteristics influence the process of adult bone regeneration... - Head, shoulders, knees, and toesLuis de la Fuente
The Department of Surgery, Stanford University School of Medicine, 257 Campus Drive, Stanford, CA 94305, USA
Dev Biol 282:294-306. 2005 - The molecular origins of species-specific facial patternSamantha A Brugmann
Department of Plastic and Reconstructive Surgery, Stanford University, California 94305, USA
Curr Top Dev Biol 73:1-42. 2006.... - Endochondral ossification is required for haematopoietic stem-cell niche formationCharles K F Chan
Department of Pathology, Developmental Biology and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, California, USA
Nature 457:490-4. 2009..Collectively, our data implicate endochondral ossification, bone formation that proceeds through a cartilage intermediate, as a requirement for adult HSC niche formation... - Molecular interactions coordinating the development of the forebrain and faceRalph S Marcucio
Department of Plastic and Reconstructive Surgery, Stanford University School of Medicine, 257 Campus Drive, Stanford, CA 94305, USA
Dev Biol 284:48-61. 2005.... - Primary cilia: cellular sensors for the skeletonCharles T Anderson
Department of Biological Sciences, Stanford University, Stanford, California, USA
Anat Rec (Hoboken) 291:1074-8. 2008..We also raise several unanswered questions regarding the role of primary cilia as mechanosensors and chemosensors and identify potential research avenues to address these questions... - Wnt and FGF signals interact to coordinate growth with cell fate specification during limb developmentDerk ten Berge
Howard Hughes Medical Institute, Department of Developmental Biology, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
Development 135:3247-57. 2008.... - A primary cilia-dependent etiology for midline facial disordersSamantha A Brugmann
Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University, Stanford, CA 94305, USA
Hum Mol Genet 19:1577-92. 2010..These data also raise the possibility that genes encoding ciliary proteins are candidates for human conditions of hypertelorism and FNDs... - It's all in your head: new insights into craniofacial development and deformationMinal D Tapadia
Department of Plastic and Reconstructive Surgery, Stanford University, Stanford, California 94305, USA
J Anat 207:461-77. 2005 - rBMP represses Wnt signaling and influences skeletal progenitor cell fate specification during bone repairSteve Minear
Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford School of Medicine, Stanford, CA 94305, USA
J Bone Miner Res 25:1196-207. 2010..These mechanistic insights may be particularly useful for optimizing the reparative potential of rBMPs while simultaneously minimizing their adverse outcomes... - A dermal HOX transcriptional program regulates site-specific epidermal fateJohn L Rinn
Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305, USA
Genes Dev 22:303-7. 2008..Thus, maintenance of appropriate HOX transcriptional program in adult fibroblasts may serve as a source of positional memory to differentially pattern the epithelia during homeostasis and regeneration... - Role of Wnt signaling in the biology of the periodontiumScott M Rooker
Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, California, USA
Dev Dyn 239:140-7. 2010..We discuss these findings in the context of dental tissue regeneration... - Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAsJohn L Rinn
Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
Cell 129:1311-23. 2007..Thus, transcription of ncRNA may demarcate chromosomal domains of gene silencing at a distance; these results have broad implications for gene regulation in development and disease states... - Stage-dependent craniofacial defects resulting from Sprouty2 overexpressionL Henry Goodnough
Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, California 94305, USA
Dev Dyn 236:1918-28. 2007..Collectively, these data suggest that Sprouty2 plays a role in the outgrowth of facial prominences independent of canonical Fgf signaling... - Bone regeneration is regulated by wnt signalingJae Beom Kim
Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University, Stanford, CA 94305 5148, USA
J Bone Miner Res 22:1913-23. 2007..Herein, we studied the role of Wnt signaling in skeletal tissue regeneration... - The fickle finger of fateLuis de la Fuente
Department of Surgery, Stanford University, Stanford, California 94305, USA
J Clin Invest 115:833-6. 2005..The existence of such a repressor provides a window into the distant past, revealing that Shh and Ihh must once have shared responsibilities in establishing tissue boundaries and orchestrating vertebrate tissue morphogenesis... - Cranial suture biologyKelly A Lenton
Children's Surgical Research Program, Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, California 94305-5148, USA
Curr Top Dev Biol 66:287-328. 2005 - CHD7 cooperates with PBAF to control multipotent neural crest formationRuchi Bajpai
Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California 94305, USA
Nature 463:958-62. 2010.... - Markers of osteoblast differentiation in fusing and nonfusing cranial suturesRandall P Nacamuli
Department of Surgery, Stanford University School of Medicine, CA 94305, USA
Plast Reconstr Surg 112:1328-35. 2003.... - Wnt proteins promote bone regenerationSteven Minear
Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford School of Medicine, Stanford, CA 94305, USA
Sci Transl Med 2:29ra30. 2010..The end result was faster bone regeneration. Because Wnt signaling is conserved in mammalian tissue repair, this protein-based approach may have widespread applications in regenerative medicine... - Wnt signaling mediates regional specification in the vertebrate faceSamantha A Brugmann
Department of Plastic and Reconstructive Surgery, Stanford University, Stanford, CA 94305, USA
Development 134:3283-95. 2007..Collectively, these data elucidate a new role for Wnt signaling in regional specification of the vertebrate face, and suggest possible mechanisms whereby species-specific facial features are generated... - Effect of mechanical stimuli on skeletal regeneration around implantsPhilipp Leucht
Department of Plastic and Reconstructive Surgery, Stanford University, 257 Campus Drive, PSRL Building, Stanford, CA 94305, USA
Bone 40:919-30. 2007..By comparing strain measurements with cellular and molecular analyses, we developed an understanding of the correlation between strain magnitudes and fate decisions of cells shaping the skeletal regenerate... - Accelerated bone repair after plasma laser corticotomiesPhilipp Leucht
Department of Surgery, Stanford University, Stanford, CA
Ann Surg 246:140-50. 2007..To reveal, on a cellular and molecular level, how skeletal regeneration of a corticotomy is enhanced when using laser-plasma mediated ablation compared with conventional mechanical tissue removal... - Beta-catenin-dependent Wnt signaling in mandibular bone regenerationPhilipp Leucht
Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University Medical School, 257 Campus Drive, Stanford, CA 94305 5148, USA
J Bone Joint Surg Am 90:3-8. 2008..Taken together, these data underscore the functional requirement for Wnt signaling in cranial skeletal healing... - FAK-Mediated mechanotransduction in skeletal regenerationPhilipp Leucht
Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University, Stanford, California, United States of America
PLoS ONE 2:e390. 2007..Our data provide a new framework in which to consider how physical forces and molecular signals are synchronized during the program of skeletal regeneration... - Cross-regulatory interactions between Fgf8 and Shh in the avian frontonasal prominenceArhat Abzhanov
Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
Congenit Anom (Kyoto) 47:136-48. 2007..Our experiments revealed mutual antagonism between the two molecules, which aids in establishing and maintaining a molecular boundary that subsequently influences patterning and growth of the middle and upper face... - Mepe is expressed during skeletal development and regenerationChuanyong Lu
Department of Orthopaedic Surgery, University of California at San Francisco, 533 Parnassus Avenue, San Francisco, CA 94143 0514, USA
Histochem Cell Biol 121:493-9. 2004..Thus, Mepe appears to play a role in both long bone regeneration and the latter stages of skeletogenesis... - Conserved molecular program regulating cranial and appendicular skeletogenesisB Frank Eames
Dev Dyn 231:4-13. 2004.... - Sonic hedgehog in the pharyngeal endoderm controls arch pattern via regulation of Fgf8 in head ectodermKim E Haworth
Department of Craniofacial Development, Dental Institute, Kings College London, London SE1 9RT, UK
Dev Biol 303:244-58. 2007..Shh from the pharyngeal endoderm thus regulates Fgf8 in the ectoderm and the role of the endoderm in pharyngeal arch patterning may thus be indirectly mediated by the ectoderm... - Hierarchy revealed in the specification of three skeletal fates by Sox9 and Runx2B Frank Eames
UCSF Orthopaedic Surgery, San Francisco, CA 94143-0514, USA
Dev Biol 274:188-200. 2004..Finally, these data provide insights into the roles that master regulatory genes play during evolutionary change of the vertebrate skeleton... - Effects of delayed stabilization on fracture healingTheodore Miclau
Department of Orthopaedic Surgery, University of California at San Francisco, 1001 Potrero Avenue, San Francisco, California 94110, USA
J Orthop Res 25:1552-8. 2007.... - Indian hedgehog synchronizes skeletal angiogenesis and perichondrial maturation with cartilage developmentCeline Colnot
Department of Orthopaedic Surgery, University of California, San Francisco, California 94143 0514, USA
Development 132:1057-67. 2005.... - Prenatal morphogenesis of the human mental foramenRalf J Radlanski
Freie Universitat Berlin, University Clinic Benjamin Franklin, Department of Experimental Dentistry and Oral Structural Biology, Berlin Wilmersdorf, Germany
Eur J Oral Sci 110:452-9. 2002..In the future, to understand the mechanisms regulating this complex system, where a nerve and blood vessels became successively surrounded by bone, molecular biological data have to be correlated with morphological findings... - A zone of frontonasal ectoderm regulates patterning and growth in the faceDiane Hu
Department of Orthopaedic Surgery, 533 Parnassus Avenue, Suite U-453, University of California at San Francisco, San Francisco, CA 94143, USA
Development 130:1749-58. 2003..We discuss these data in the context of boundary/morphogen models of patterning, and in view of the recent controversy regarding neural crest pre-patterning versus neural crest plasticity... - A model for intramembranous ossification during fracture healingZachary Thompson
Department of Orthopaedic Surgery, University of California at San Francisco, 94143-0514, USA
J Orthop Res 20:1091-8. 2002..Future studies will use this murine model of intramembranous fracture healing to explore, at a molecular level, how the mechanical environment exerts its influence on healing of a fracture... - Altered fracture repair in the absence of MMP9Celine Colnot
Department of Orthopaedic Surgery, University of California San Francisco, San Francisco, CA 94143 0514, USA
Development 130:4123-33. 2003.... - Molecular ontogeny of the skeletonB Frank Eames
Department of Orthopaedic Surgery, University of California at San Francisco, California, USA
Birth Defects Res C Embryo Today 69:93-101. 2003..In this review, we survey these molecules and the tissue interactions that may regulate their expression. What emerges is a new paradigm, by which we can explain and understand the process of normal- and abnormal-skeletal development... - Temporal perturbations in sonic hedgehog signaling elicit the spectrum of holoprosencephaly phenotypesDwight Cordero
University of California at San Francisco, San Francisco, California, USA
J Clin Invest 114:485-94. 2004..Collectively, these data reveal one mechanism by which the variable expressivity of a disorder such as HPE can be produced through temporal disruption of a single molecular pathway... - Distinguishing the contributions of the perichondrium, cartilage, and vascular endothelium to skeletal developmentCeline Colnot
Department of Orthopaedic Surgery, University of California, San Francisco, CA 94143 0514, USA
Dev Biol 269:55-69. 2004..Collectively, these studies clarify further the contributions of the cartilage, perichondrium, and vascular endothelium to long bone development...
Research Grants
- BIOMIMETICS OF BONE REGENERATIONJill Helms; Fiscal Year: 2002..Collectively, these results on the biomimetics of bone regeneration will provide a sound scientific basis for the treatment of musculoskeletal diseases and injuries. ..
- MORPHOGENESIS OF CRANIOFACIAL PRIMORDIAJill Helms; Fiscal Year: 2007..Taken together, results from these experiments will provide us with new clues as to how the vertebrate face achieves its extraordinarily intricate pattern. ..
- Marrow-derived stem cells in cranial skeletal repairJill Helms; Fiscal Year: 2003..This project is significant in using a novel approach to investigate regulation of fracture repair and will provide valuable insights on healing defect. ..
- MECHANISMS OF NORMAL AND ABNORMAL CRANIOFACIAL MORPHOGENJill Helms; Fiscal Year: 2004..abstract_text> ..