Research Topics
| ANTONIO YOUSSEF HARDANSummaryAffiliation: Stanford University Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
A randomized controlled pilot trial of oral N-acetylcysteine in children with autismAntonio Y Hardan
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California 94305, USA
Biol Psychiatry 71:956-61. 2012..The goal of this pilot study was to assess the feasibility of using oral N-acetylcysteine (NAC), a glutamatergic modulator and an antioxidant, in the treatment of behavioral disturbance in children with autism...
An MRI study of increased cortical thickness in autismAntonio Y Hardan
Stanford University, Department of Psychiatry and Behavioral Sciences, 401 Quarry Rd, Stanford, CA 94305, USA
Am J Psychiatry 163:1290-2. 2006..The purpose of this study was to examine cortical thickness in autism in light of the postmortem evidence of cortical abnormalities of the disorder...- An MRI and proton spectroscopy study of the thalamus in children with autismAntonio Y Hardan
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA
Psychiatry Res 163:97-105. 2008..Further investigations of this structure are warranted, since it plays an important role in information processing as part of the cortico-thalamo-cortical pathways... 
An MRI study of minor physical anomalies in autismAntonio Y Hardan
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
J Autism Dev Disord 36:607-11. 2006..Hypotelorism is a MPA that may be present in a subgroup of individuals with autism. Additional research is warranted using large sample sizes with a wide range of intellectual functioning...- A preliminary longitudinal magnetic resonance imaging study of brain volume and cortical thickness in autismAntonio Y Hardan
Department of Psychiatry and Behavioral Sciences, Stanford University, California 94305, USA
Biol Psychiatry 66:320-6. 2009..This longitudinal study examined developmental changes in brain volume and cortical thickness (CT) using magnetic resonance imaging (MRI) in children with autism... - Brief report: abnormal association between the thalamus and brain size in Asperger's disorderAntonio Y Hardan
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Autism Dev Disord 38:390-4. 2008.... - Corpus callosum volume in children with autismAntonio Y Hardan
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA
Psychiatry Res 174:57-61. 2009..These findings support the aberrant connectivity hypothesis with possible decrease in interhemispheric communications... - Anatomic evaluation of the orbitofrontal cortex in major depressive disorderAcioly L T Lacerda
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Biol Psychiatry 55:353-8. 2004..Future studies examining the relationship between specific symptomatic dimensions of MDD and OFC volumes could be especially informative... - Increased frontal cortical folding in autism: a preliminary MRI studyAntonio Y Hardan
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Psychiatry Res 131:263-8. 2004..These preliminary findings suggest that the gyrification patterns in autism may be abnormal, which could be related to the various cortical anomalies observed in this disorder... - Corpus callosum volume and neurocognition in autismChristopher J Keary
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Autism Dev Disord 39:834-41. 2009..These findings provide further evidence for anatomical alterations in the corpus callosum in autism, but warrant additional studies examining the relationship of this structure and specific measures of interhemispheric connectivity... - Reduced cortical folding in individuals at high risk for schizophrenia: a pilot studyRoger J Jou
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
Schizophr Res 75:309-13. 2005..The left GI was lower in HR when compared to controls, but no difference in the right GI was observed. These results are consistent with studies of affected individuals, supporting genetic and neurodevelopmental models of schizophrenia... - Measurement of the orbitofrontal cortex: a validation study of a new methodAcioly L T Lacerda
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Neuroimage 19:665-73. 2003..996 and 0.998. This method appears to be a valid method for measuring the OFC with excellent reliability. This uncomplicated approach is easy to apply and has the potential to be a valuable alternative to the previously published methods... - Guanfacine in children with autism and/or intellectual disabilitiesBenjamin L Handen
University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
J Dev Behav Pediatr 29:303-8. 2008..In addition, evidence suggests that children with developmental disabilities experience higher rates of adverse events. Guanfacine, an alpha2-adrenergic receptor agonist, has shown some promise as an alternative to psychostimulants... - Abnormal brain size effect on the thalamus in autismAntonio Y Hardan
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Psychiatry Res 147:145-51. 2006.... - Magnetic resonance imaging study of the orbitofrontal cortex in autismAntonio Y Hardan
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA
J Child Neurol 21:866-71. 2006..The present study suggests the absence of global volumetric abnormalities in the orbitofrontal cortex in autism and indicates that the functional disturbances in this structure might not be related to anatomic alterations... - Open-label, prospective trial of olanzapine in adolescents with subaverage intelligence and disruptive behavioral disordersBenjamin L Handen
University of Pittsburgh School of Medicine and Western Psychiatric Institute and Clinic, Pittsburgh, PA 15203, USA
J Am Acad Child Adolesc Psychiatry 45:928-35. 2006..However, side effects, especially weight gain, are a significant issue. Future double-blind, placebo-controlled studies need to confirm these findings and assess long-term safety and outcome of olanzapine treatment... - Volumetric alterations of the orbitofrontal cortex in autismRagy R Girgis
Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York State Psychiatric Institute, New York, NY, USA
Prog Neuropsychopharmacol Biol Psychiatry 31:41-5. 2007..These findings support the role of OFC in autism and warrant further investigations of this structure using structural and functional methodologies... - Risperidone in first-episode psychosis: a longitudinal, exploratory voxel-based morphometric studyRagy R Girgis
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara St, Pittsburgh, PA 15213, USA
Schizophr Res 82:89-94. 2006..No areas of change were found in controls. The results of this exploratory investigation support the possibility that risperidone has short-term effects on brain parenchyma in individuals with first-episode psychosis... - Neuropsychiatric problems in tuberous sclerosis complexMiya R Asato
Laboratory of Neurocognitive Development, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
J Child Neurol 19:241-9. 2004..Treatment of neuropsychiatric symptoms, including autism-like features, attention deficits, and sleep disorders, is also discussed... - Motor performance and anatomic magnetic resonance imaging (MRI) of the basal ganglia in autismAntonio Y Hardan
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
J Child Neurol 18:317-24. 2003.... - A retrospective open trial of adjunctive donepezil in children and adolescents with autistic disorderAntonio Y Hardan
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Child Adolesc Psychopharmacol 12:237-41. 2002..Double-blind, placebo-controlled investigations are needed to provide further evidence of the potential benefits of donepezil to patients with autistic disorder... - Morphology of the orbitofrontal cortex in first-episode schizophrenia: relationship with negative symptomatologyAcioly L T Lacerda
Interdisciplinary Lab of Neuroimaging and Cognition LiNC, Department of Psychiatry, Federal University of Sao Paulo, Sao Paulo, Brazil
Prog Neuropsychopharmacol Biol Psychiatry 31:510-6. 2007..Future follow-up studies examining high-risk individuals who subsequently develop schizophrenia at different stages of disease could be especially instructive... - The functional neuroanatomy of autismPaolo Brambilla
Biological Psychiatry Unit, IRCCS S Giovanni di Dio, Fatebenefratelli, Brescia, Italy
Funct Neurol 19:9-17. 2004..Such studies will be instrumental in furthering understanding of the pathophysiology of autism and in exploring the importance of dimensional measures of the broader phenotype currently defined as autism...
Research Grants
- NEUROIMAGING/DEVELOPMENTAL NEUROBIOLOGY OF AUTISMAntonio Hardan; Fiscal Year: 2005..Course work and directed reading in biostatistcs, data management, research ethics, neuroanatorny, neuroimaging and developmental neuroscience will complement the research training. ..
- A neuroimaging study of twin pairs with autismAntonio Hardan; Fiscal Year: 2009..A better understanding of the pathophysiology of autism will be instrumental in the development of effective therapeutic strategies that aim at targeting the core symptoms of social and communication deficits. ..
- A neuroimaging study of twin pairs with autismANTONIO YOUSSEF HARDAN; Fiscal Year: 2010..A better understanding of the pathophysiology of autism will be instrumental in the development of effective therapeutic strategies that aim at targeting the core symptoms of social and communication deficits. ..