ANTONIO YOUSSEF HARDAN

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. doi request reprint A randomized controlled pilot trial of oral N-acetylcysteine in children with autism
    Antonio Y Hardan
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California 94305, USA
    Biol Psychiatry 71:956-61. 2012
  2. pmc An MRI study of increased cortical thickness in autism
    Antonio Y Hardan
    Stanford University, Department of Psychiatry and Behavioral Sciences, 401 Quarry Rd, Stanford, CA 94305, USA
    Am J Psychiatry 163:1290-2. 2006
  3. pmc An MRI and proton spectroscopy study of the thalamus in children with autism
    Antonio Y Hardan
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA
    Psychiatry Res 163:97-105. 2008
  4. ncbi request reprint An MRI study of minor physical anomalies in autism
    Antonio Y Hardan
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Autism Dev Disord 36:607-11. 2006
  5. pmc A preliminary longitudinal magnetic resonance imaging study of brain volume and cortical thickness in autism
    Antonio Y Hardan
    Department of Psychiatry and Behavioral Sciences, Stanford University, California 94305, USA
    Biol Psychiatry 66:320-6. 2009
  6. ncbi request reprint Brief report: abnormal association between the thalamus and brain size in Asperger's disorder
    Antonio Y Hardan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Autism Dev Disord 38:390-4. 2008
  7. pmc Corpus callosum volume in children with autism
    Antonio Y Hardan
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA
    Psychiatry Res 174:57-61. 2009
  8. ncbi request reprint Anatomic evaluation of the orbitofrontal cortex in major depressive disorder
    Acioly L T Lacerda
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Biol Psychiatry 55:353-8. 2004
  9. ncbi request reprint Increased frontal cortical folding in autism: a preliminary MRI study
    Antonio Y Hardan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Psychiatry Res 131:263-8. 2004
  10. pmc Corpus callosum volume and neurocognition in autism
    Christopher J Keary
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Autism Dev Disord 39:834-41. 2009

Research Grants

  1. NEUROIMAGING/DEVELOPMENTAL NEUROBIOLOGY OF AUTISM
    Antonio Hardan; Fiscal Year: 2005
  2. A neuroimaging study of twin pairs with autism
    Antonio Hardan; Fiscal Year: 2009
  3. A neuroimaging study of twin pairs with autism
    ANTONIO YOUSSEF HARDAN; Fiscal Year: 2010

Detail Information

Publications23

  1. doi request reprint A randomized controlled pilot trial of oral N-acetylcysteine in children with autism
    Antonio Y Hardan
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California 94305, USA
    Biol Psychiatry 71:956-61. 2012
    ..The goal of this pilot study was to assess the feasibility of using oral N-acetylcysteine (NAC), a glutamatergic modulator and an antioxidant, in the treatment of behavioral disturbance in children with autism...
  2. pmc An MRI study of increased cortical thickness in autism
    Antonio Y Hardan
    Stanford University, Department of Psychiatry and Behavioral Sciences, 401 Quarry Rd, Stanford, CA 94305, USA
    Am J Psychiatry 163:1290-2. 2006
    ..The purpose of this study was to examine cortical thickness in autism in light of the postmortem evidence of cortical abnormalities of the disorder...
  3. pmc An MRI and proton spectroscopy study of the thalamus in children with autism
    Antonio Y Hardan
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA
    Psychiatry Res 163:97-105. 2008
    ..Further investigations of this structure are warranted, since it plays an important role in information processing as part of the cortico-thalamo-cortical pathways...
  4. ncbi request reprint An MRI study of minor physical anomalies in autism
    Antonio Y Hardan
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Autism Dev Disord 36:607-11. 2006
    ..Hypotelorism is a MPA that may be present in a subgroup of individuals with autism. Additional research is warranted using large sample sizes with a wide range of intellectual functioning...
  5. pmc A preliminary longitudinal magnetic resonance imaging study of brain volume and cortical thickness in autism
    Antonio Y Hardan
    Department of Psychiatry and Behavioral Sciences, Stanford University, California 94305, USA
    Biol Psychiatry 66:320-6. 2009
    ..This longitudinal study examined developmental changes in brain volume and cortical thickness (CT) using magnetic resonance imaging (MRI) in children with autism...
  6. ncbi request reprint Brief report: abnormal association between the thalamus and brain size in Asperger's disorder
    Antonio Y Hardan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Autism Dev Disord 38:390-4. 2008
    ....
  7. pmc Corpus callosum volume in children with autism
    Antonio Y Hardan
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA
    Psychiatry Res 174:57-61. 2009
    ..These findings support the aberrant connectivity hypothesis with possible decrease in interhemispheric communications...
  8. ncbi request reprint Anatomic evaluation of the orbitofrontal cortex in major depressive disorder
    Acioly L T Lacerda
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Biol Psychiatry 55:353-8. 2004
    ..This study examined the OFC and its subdivisions in patients with MDD and matched healthy control subjects...
  9. ncbi request reprint Increased frontal cortical folding in autism: a preliminary MRI study
    Antonio Y Hardan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Psychiatry Res 131:263-8. 2004
    ..These preliminary findings suggest that the gyrification patterns in autism may be abnormal, which could be related to the various cortical anomalies observed in this disorder...
  10. pmc Corpus callosum volume and neurocognition in autism
    Christopher J Keary
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Autism Dev Disord 39:834-41. 2009
    ..These findings provide further evidence for anatomical alterations in the corpus callosum in autism, but warrant additional studies examining the relationship of this structure and specific measures of interhemispheric connectivity...
  11. ncbi request reprint Reduced cortical folding in individuals at high risk for schizophrenia: a pilot study
    Roger J Jou
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Schizophr Res 75:309-13. 2005
    ..The left GI was lower in HR when compared to controls, but no difference in the right GI was observed. These results are consistent with studies of affected individuals, supporting genetic and neurodevelopmental models of schizophrenia...
  12. ncbi request reprint Measurement of the orbitofrontal cortex: a validation study of a new method
    Acioly L T Lacerda
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Neuroimage 19:665-73. 2003
    ..996 and 0.998. This method appears to be a valid method for measuring the OFC with excellent reliability. This uncomplicated approach is easy to apply and has the potential to be a valuable alternative to the previously published methods...
  13. doi request reprint Guanfacine in children with autism and/or intellectual disabilities
    Benjamin L Handen
    University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Dev Behav Pediatr 29:303-8. 2008
    ..In addition, evidence suggests that children with developmental disabilities experience higher rates of adverse events. Guanfacine, an alpha2-adrenergic receptor agonist, has shown some promise as an alternative to psychostimulants...
  14. ncbi request reprint Abnormal brain size effect on the thalamus in autism
    Antonio Y Hardan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Psychiatry Res 147:145-51. 2006
    ....
  15. ncbi request reprint Magnetic resonance imaging study of the orbitofrontal cortex in autism
    Antonio Y Hardan
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA
    J Child Neurol 21:866-71. 2006
    ..The present study suggests the absence of global volumetric abnormalities in the orbitofrontal cortex in autism and indicates that the functional disturbances in this structure might not be related to anatomic alterations...
  16. ncbi request reprint Open-label, prospective trial of olanzapine in adolescents with subaverage intelligence and disruptive behavioral disorders
    Benjamin L Handen
    University of Pittsburgh School of Medicine and Western Psychiatric Institute and Clinic, Pittsburgh, PA 15203, USA
    J Am Acad Child Adolesc Psychiatry 45:928-35. 2006
    ..This prospective, open-label study was conducted to examine the safety and usefulness of olanzapine in treating disruptive behavior disorders in adolescents with subaverage intelligence...
  17. pmc Volumetric alterations of the orbitofrontal cortex in autism
    Ragy R Girgis
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York State Psychiatric Institute, New York, NY, USA
    Prog Neuropsychopharmacol Biol Psychiatry 31:41-5. 2007
    ..These findings support the role of OFC in autism and warrant further investigations of this structure using structural and functional methodologies...
  18. ncbi request reprint Risperidone in first-episode psychosis: a longitudinal, exploratory voxel-based morphometric study
    Ragy R Girgis
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Schizophr Res 82:89-94. 2006
    ..No areas of change were found in controls. The results of this exploratory investigation support the possibility that risperidone has short-term effects on brain parenchyma in individuals with first-episode psychosis...
  19. ncbi request reprint Neuropsychiatric problems in tuberous sclerosis complex
    Miya R Asato
    Laboratory of Neurocognitive Development, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Child Neurol 19:241-9. 2004
    ..Treatment of neuropsychiatric symptoms, including autism-like features, attention deficits, and sleep disorders, is also discussed...
  20. ncbi request reprint Motor performance and anatomic magnetic resonance imaging (MRI) of the basal ganglia in autism
    Antonio Y Hardan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Child Neurol 18:317-24. 2003
    ....
  21. ncbi request reprint A retrospective open trial of adjunctive donepezil in children and adolescents with autistic disorder
    Antonio Y Hardan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Child Adolesc Psychopharmacol 12:237-41. 2002
    ..Double-blind, placebo-controlled investigations are needed to provide further evidence of the potential benefits of donepezil to patients with autistic disorder...
  22. ncbi request reprint Morphology of the orbitofrontal cortex in first-episode schizophrenia: relationship with negative symptomatology
    Acioly L T Lacerda
    Interdisciplinary Lab of Neuroimaging and Cognition LiNC, Department of Psychiatry, Federal University of Sao Paulo, Sao Paulo, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 31:510-6. 2007
    ..Future follow-up studies examining high-risk individuals who subsequently develop schizophrenia at different stages of disease could be especially instructive...
  23. ncbi request reprint The functional neuroanatomy of autism
    Paolo Brambilla
    Biological Psychiatry Unit, IRCCS S Giovanni di Dio, Fatebenefratelli, Brescia, Italy
    Funct Neurol 19:9-17. 2004
    ..Such studies will be instrumental in furthering understanding of the pathophysiology of autism and in exploring the importance of dimensional measures of the broader phenotype currently defined as autism...

Research Grants3

  1. NEUROIMAGING/DEVELOPMENTAL NEUROBIOLOGY OF AUTISM
    Antonio Hardan; Fiscal Year: 2005
    ..Course work and directed reading in biostatistcs, data management, research ethics, neuroanatorny, neuroimaging and developmental neuroscience will complement the research training. ..
  2. A neuroimaging study of twin pairs with autism
    Antonio Hardan; Fiscal Year: 2009
    ..A better understanding of the pathophysiology of autism will be instrumental in the development of effective therapeutic strategies that aim at targeting the core symptoms of social and communication deficits. ..
  3. A neuroimaging study of twin pairs with autism
    ANTONIO YOUSSEF HARDAN; Fiscal Year: 2010
    ..A better understanding of the pathophysiology of autism will be instrumental in the development of effective therapeutic strategies that aim at targeting the core symptoms of social and communication deficits. ..