PHILIP COURTLAND HANAWALT

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Controlling the efficiency of excision repair
    P C Hanawalt
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    Mutat Res 485:3-13. 2001
  2. ncbi request reprint Paradigms for the three rs: DNA replication, recombination, and repair
    Philip C Hanawalt
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Mol Cell 28:702-7. 2007
  3. pmc Density matters: the semiconservative replication of DNA
    Philip C Hanawalt
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    Proc Natl Acad Sci U S A 101:17889-94. 2004
  4. ncbi request reprint Four decades of DNA repair: from early insights to current perspectives
    Philip C Hanawalt
    Institut Curie, Paris
    Biochimie 85:1043-52. 2003
  5. ncbi request reprint Functional characterization of global genomic DNA repair and its implications for cancer
    Philip C Hanawalt
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    Mutat Res 544:107-14. 2003
  6. pmc Emerging links between premature ageing and defective DNA repair
    Philip C Hanawalt
    Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305 5020, USA
    Mech Ageing Dev 129:503-5. 2008
  7. doi request reprint Transcription-coupled DNA repair: two decades of progress and surprises
    Philip C Hanawalt
    Department of Biology, Stanford University, 371 Serra Mall, Stanford, California 94305 5020, USA
    Nat Rev Mol Cell Biol 9:958-70. 2008
  8. doi request reprint Growing up with DNA repair and joining the EMS
    Philip Hanawalt
    Department of Biology, Stanford University, Stanford, California 94305 5020, USA
    Environ Mol Mutagen 51:890-6. 2010
  9. ncbi request reprint Subpathways of nucleotide excision repair and their regulation
    Philip C Hanawalt
    Department of Biological Sciences, Stanford University, Stanford, California, CA 94305 5020, USA
    Oncogene 21:8949-56. 2002
  10. ncbi request reprint Transcription arrest at a lesion in the transcribed DNA strand in vitro is not affected by a nearby lesion in the opposite strand
    Virginia S Kalogeraki
    Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
    J Biol Chem 278:19558-64. 2003

Research Grants

  1. 9th International Conference on Environmental Mutagens
    Philip Hanawalt; Fiscal Year: 2005
  2. Transcription Coupled DNA Repair and Human Disease
    Philip Hanawalt; Fiscal Year: 2006
  3. Transcription coupled DNA repair in E. Coli
    Philip Hanawalt; Fiscal Year: 2006
  4. Role of RNA Polymerase ll in DNA Repair
    Philip Hanawalt; Fiscal Year: 2007
  5. Role of transcription in genomic stability
    PHILIP COURTLAND HANAWALT; Fiscal Year: 2010
  6. RNA POLYMERASE II AND DNA REPAIR
    Philip Hanawalt; Fiscal Year: 2002
  7. Oxidative DNA damage processing; role in human pathology and aging
    PHILIP COURTLAND HANAWALT; Fiscal Year: 2010

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Controlling the efficiency of excision repair
    P C Hanawalt
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    Mutat Res 485:3-13. 2001
    ..That is where the field of DNA excision repair began four decades ago with studies on the recovery of DNA synthesis in UV-irradiated bacteria...
  2. ncbi request reprint Paradigms for the three rs: DNA replication, recombination, and repair
    Philip C Hanawalt
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Mol Cell 28:702-7. 2007
    ..The fundamental knowledge gained should lead to more effective clinical intervention in human disease...
  3. pmc Density matters: the semiconservative replication of DNA
    Philip C Hanawalt
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    Proc Natl Acad Sci U S A 101:17889-94. 2004
    ..These developments include the application of density labeling to discover the repair replication of damaged DNA, a "nonconservative" mode of synthesis in which faulty sections of DNA are replaced...
  4. ncbi request reprint Four decades of DNA repair: from early insights to current perspectives
    Philip C Hanawalt
    Institut Curie, Paris
    Biochimie 85:1043-52. 2003
    ....
  5. ncbi request reprint Functional characterization of global genomic DNA repair and its implications for cancer
    Philip C Hanawalt
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    Mutat Res 544:107-14. 2003
    ..Since rodents are used as surrogates for humans in environmental cancer risk assessment it is very important that we determine how they differ from humans with respect to DNA repair and oncogenic responses to environmental genotoxins...
  6. pmc Emerging links between premature ageing and defective DNA repair
    Philip C Hanawalt
    Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305 5020, USA
    Mech Ageing Dev 129:503-5. 2008
  7. doi request reprint Transcription-coupled DNA repair: two decades of progress and surprises
    Philip C Hanawalt
    Department of Biology, Stanford University, 371 Serra Mall, Stanford, California 94305 5020, USA
    Nat Rev Mol Cell Biol 9:958-70. 2008
    ..Futile cycles of TCR at naturally occurring non-canonical DNA structures might contribute to genomic instability and genetic disease...
  8. doi request reprint Growing up with DNA repair and joining the EMS
    Philip Hanawalt
    Department of Biology, Stanford University, Stanford, California 94305 5020, USA
    Environ Mol Mutagen 51:890-6. 2010
    ..In return, the wisdom provided from basic research on cellular processing of damaged DNA is essential to mechanism-based decisions in the domain of genetic toxicology...
  9. ncbi request reprint Subpathways of nucleotide excision repair and their regulation
    Philip C Hanawalt
    Department of Biological Sciences, Stanford University, Stanford, California, CA 94305 5020, USA
    Oncogene 21:8949-56. 2002
    ..In the case of terminally differentiated mammalian cells, a new paradigm has appeared in which GGR is attenuated but both strands of expressed genes are repaired efficiently...
  10. ncbi request reprint Transcription arrest at a lesion in the transcribed DNA strand in vitro is not affected by a nearby lesion in the opposite strand
    Virginia S Kalogeraki
    Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
    J Biol Chem 278:19558-64. 2003
    ..Our results additionally indicate that the sequence context of a CPD affects the efficiency of T7 RNAP arrest more significantly than that of RNAP II...
  11. ncbi request reprint Behavior of T7 RNA polymerase and mammalian RNA polymerase II at site-specific cisplatin adducts in the template DNA
    Silvia Tornaletti
    Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
    J Biol Chem 278:35791-7. 2003
    ....
  12. pmc Malondialdehyde adducts in DNA arrest transcription by T7 RNA polymerase and mammalian RNA polymerase II
    Susan D Cline
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 101:7275-80. 2004
    ....
  13. pmc Mechanisms and implications of transcription blockage by guanine-rich DNA sequences
    Boris P Belotserkovskii
    Department of Biology, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 107:12816-21. 2010
    ..These structures are likely responsible for transcription-dependent replication blockage by G-rich sequences in vivo...
  14. pmc New applications of the Comet assay: Comet-FISH and transcription-coupled DNA repair
    Graciela Spivak
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    Mutat Res 681:44-50. 2009
    ..We review the existing evidence and discuss the implications in relation to current models for the molecular mechanism of TCR...
  15. pmc Transcription-coupled nucleotide excision repair of a gene transcribed by bacteriophage T7 RNA polymerase in Escherichia coli
    Ann K Ganesan
    Department of Biology, Stanford University, Stanford, CA 94305 5020, USA
    DNA Repair (Amst) 9:958-63. 2010
    ..This response was absent in an mfd-1 mutant, indicating that the underlying mechanism may be similar to that for the bacterial RNA polymerase...
  16. pmc G4-forming sequences in the non-transcribed DNA strand pose blocks to T7 RNA polymerase and mammalian RNA polymerase II
    Silvia Tornaletti
    Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
    J Biol Chem 283:12756-62. 2008
    ..The efficiency of arrest increases with negative supercoiling and also with multiple rounds of transcription compared with single events...
  17. pmc Transcription coupled nucleotide excision repair in Escherichia coli can be affected by changing the arginine at position 529 of the beta subunit of RNA polymerase
    Ann K Ganesan
    Department of Biological Sciences, Stanford University, Stanford, CA 94303 5020, USA
    DNA Repair (Amst) 6:1434-40. 2007
    ..Our results suggest that this interaction may be necessary but not sufficient to facilitate TCR...
  18. pmc Impaired nucleotide excision repair upon macrophage differentiation is corrected by E1 ubiquitin-activating enzyme
    Thierry Nouspikel
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    Proc Natl Acad Sci U S A 103:16188-93. 2006
    ..quot;..
  19. ncbi request reprint Transcription arrest at an abasic site in the transcribed strand of template DNA
    Silvia Tornaletti
    Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
    Chem Res Toxicol 19:1215-20. 2006
    ..Because the predominant model for TCR postulates that only lesions that block RNAP will be subject to TCR, our findings suggest that the abasic site may be sufficient to initiate TCR in vivo...
  20. ncbi request reprint Nucleotide excision repair phenotype of human acute myeloid leukemia cell lines at various stages of differentiation
    Pei hsin Hsu
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    Mutat Res 614:3-15. 2007
    ..Here we show that it also can occur in actively growing cells that display poor GGR...
  21. pmc Role of DNA replication and repair in thymineless death in Escherichia coli
    Pamela A Morganroth
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    J Bacteriol 188:5286-8. 2006
    ..Hydroxyurea experiments and thymine starvation of lexA3 and uvrA DNA repair mutants rule out unbalanced growth, the SOS response, and nucleotide excision repair as explanations for TLD...
  22. pmc Anchoring nascent RNA to the DNA template could interfere with transcription
    Boris P Belotserkovskii
    Department of Biology, Stanford University, Stanford, California, USA
    Biophys J 100:675-84. 2011
    ..Potential biological consequences of these effects are discussed...
  23. ncbi request reprint DNA repair in terminally differentiated cells
    Thierry Nouspikel
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    DNA Repair (Amst) 1:59-75. 2002
    ..It is conceivable that DAR is necessary to maintain the integrity of the template strand that is needed by TCR to complete the repair of lesions in the TS of essential expressed genes with high fidelity...
  24. ncbi request reprint When parsimony backfires: neglecting DNA repair may doom neurons in Alzheimer's disease
    Thierry Nouspikel
    Department of Biological Sciences, Stanford University, CA 94305 5020, USA
    Bioessays 25:168-73. 2003
    ....
  25. ncbi request reprint Who's on first in the cellular response to DNA damage?
    Susan D Cline
    Department of Biological Sciences, Stanford University, 371 Serra Mall, Stanford, California 94305 5020, USA
    Nat Rev Mol Cell Biol 4:361-72. 2003
    ..The outcome for the cell, and ultimately for the organism, might depend on which proteins arrive first at sites of DNA damage...
  26. ncbi request reprint RecA-dependent recovery of arrested DNA replication forks
    Justin Courcelle
    Department of Biological Sciences, Box GY, Mississippi State University, Mississippi State, Mississippi 39762, USA
    Annu Rev Genet 37:611-46. 2003
    ..In this review, we examine the significant experimental approaches that have led to our current understanding of the RecA-mediated processes that restore replication following encounters with DNA damage...
  27. ncbi request reprint Effect of 8-oxoguanine on transcription elongation by T7 RNA polymerase and mammalian RNA polymerase II
    Silvia Tornaletti
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    DNA Repair (Amst) 3:483-94. 2004
    ..These results are discussed in the context of possible models for TCR...
  28. ncbi request reprint Host cell reactivation of plasmids containing oxidative DNA lesions is defective in Cockayne syndrome but normal in UV-sensitive syndrome fibroblasts
    Graciela Spivak
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    DNA Repair (Amst) 5:13-22. 2006
    ..Repair of thymine glycols in the lacZ gene was measured in plasmids extracted from transfected cells; removal of the lesions is efficient and without strand bias in all the cell lines tested...
  29. pmc Peptide nucleic acid (PNA) binding and its effect on in vitro transcription in friedreich's ataxia triplet repeats
    Boris P Belotserkovskii
    Department of Biology, Stanford University, Stanford, California
    Mol Carcinog 48:299-308. 2009
    ..Biological implications of these results are discussed...
  30. ncbi request reprint Topoisomerase deficiencies subtly enhance global genomic repair of ultraviolet-induced DNA damage in Saccharomyces cerevisiae
    Susan D Cline
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    DNA Repair (Amst) 5:611-7. 2006
    ..While the physiological role of topoisomerase association with DNA damage has yet to be determined, these enzymes do not play a direct role in the NER pathways for removing UV-induced lesions in yeast...
  31. ncbi request reprint Comparative TFIIS-mediated transcript cleavage by mammalian RNA polymerase II arrested at a lesion in different transcription systems
    Virginia S Kalogeraki
    Department of Biological Sciences, Stanford University, 371 Serra Mall, Stanford, CA 94305 5020, USA
    DNA Repair (Amst) 4:1075-87. 2005
    ..Our results suggest that the extent of TFIIS-mediated transcript cleavage is a well-orchestrated process, depending upon other factors (or their effects on RNAPII), in addition to TFIIS itself...
  32. ncbi request reprint A triplex-forming sequence from the human c-MYC promoter interferes with DNA transcription
    Boris P Belotserkovskii
    Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
    J Biol Chem 282:32433-41. 2007
    ..We suggest that transcription-induced triplex formation enhances pre-existing weak transcription pause sites within the flanking sequences by creating steric obstacles for the transcription machinery...
  33. pmc Inhibitory effect of a short Z-DNA forming sequence on transcription elongation by T7 RNA polymerase
    Jennifer V Ditlevson
    Department of Biological Sciences, Stanford University, Stanford, CA, 94305, USA
    Nucleic Acids Res 36:3163-70. 2008
    ....
  34. ncbi request reprint p53 controls global nucleotide excision repair of low levels of structurally diverse benzo(g)chrysene-DNA adducts in human fibroblasts
    Daniel R Lloyd
    Department of Biological Sciences, Stanford University, 371 Serra Mall, Stanford, CA 94305 5020, USA
    Cancer Res 62:5288-94. 2002
    ..e., <100 adducts/10(8) nucleotides) because of environmental factors such as smoking is particularly significant with respect to human carcinogenesis related to environmental exposure...
  35. pmc Transcription domain-associated repair in human cells
    Thierry P Nouspikel
    Institute for Cancer Studies, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, United Kingdom
    Mol Cell Biol 26:8722-30. 2006
    ....
  36. ncbi request reprint Nucleotide excision repair activity varies among murine spermatogenic cell types
    Guogang Xu
    Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, 78229, USA
    Biol Reprod 73:123-30. 2005
    ..Overall, the data suggest cell type-specific NER activity during murine spermatogenesis, and our results have possible implications for germ cell aging...
  37. ncbi request reprint Transcriptional inhibition by an oxidized abasic site in DNA
    Yingli Wang
    Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208 3113, USA
    Chem Res Toxicol 19:234-41. 2006
    ..A dL in the nontranscribed strand did not block either polymerase...
  38. pmc A cut above: discovery of an alternative excision repair pathway in bacteria
    Bennett Van Houten
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 99:2581-3. 2002
  39. ncbi request reprint DNA repair: from molecular mechanism to human disease
    Errol C Friedberg
    Department of Pathology, University of Texas Southwestern, Medical Center at Dallas, 75390, USA
    DNA Repair (Amst) 5:986-96. 2006
  40. ncbi request reprint Reminiscences of a long-time colleague and friend, Philip C. Hanawalt
    Errol C Friedberg
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    Mutat Res 577:9-13. 2005
    ..Philip Hanawalt is a long time contributor to many areas of the DNA repair field. This article summarizes aspect of his relationship with the author over the past 36 years...

Research Grants24

  1. 9th International Conference on Environmental Mutagens
    Philip Hanawalt; Fiscal Year: 2005
    ..The new scientific information and insights from this Conference will be of importance to wise policy decisions to protect the public from significant environmental health hazards. ..
  2. Transcription Coupled DNA Repair and Human Disease
    Philip Hanawalt; Fiscal Year: 2006
    ..New genes implicated in TCR may be discovered. Novel interactions may be revealed that will clarify relationships between cellular DNA transactions. ..
  3. Transcription coupled DNA repair in E. Coli
    Philip Hanawalt; Fiscal Year: 2006
    ..Gene expression profiles during thymine deprivation will be assessed by microarrays. The results of these experiments are relevant to an understanding of the adverse consequences of folate deprivation in humans. ..
  4. Role of RNA Polymerase ll in DNA Repair
    Philip Hanawalt; Fiscal Year: 2007
    ..This research is relevant to an understanding of the relationship between DNA repair and oncogenesis, as well as the possible application of such understanding to more effective cancer therapy. ..
  5. Role of transcription in genomic stability
    PHILIP COURTLAND HANAWALT; Fiscal Year: 2010
    ....
  6. RNA POLYMERASE II AND DNA REPAIR
    Philip Hanawalt; Fiscal Year: 2002
    ..It is hoped that an analysis of different types of arrested RNA pol II complexes will provide an understanding of the recognition process used to attract DNA repair enzymes and initiate TCR. ..
  7. Oxidative DNA damage processing; role in human pathology and aging
    PHILIP COURTLAND HANAWALT; Fiscal Year: 2010
    ..They will also further the development of effective strategies for therapeutic intervention in human disease. ..